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Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation
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Reelin in the circulation promotes vascular inflammation and atherosclerosis.
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Reelin controls inflammatory responses in the colon.
“These recent findings have demonstrated that Reelin controls inflammatory responses in the vascular wall or colon, respectively (99, 100).”
From Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses (2017) · cites this paper as [100]
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Self-citation
Metadata
- Authors
- Ding, Y., Huang, L., Xian, X., Yuhanna, I. S., Wasser, C. R., Frotscher, M., Mineo, C., Shaul, P. W., & Herz, J.
- Affiliations
- Ministry of Education of the People's Republic of China (CN)
- The University of Texas Southwestern Medical Center (US)
- Zentrum für Molekulare Neurobiologie Hamburg, Falkenried 94, 20251 Hamburg, Germany.
- University of Freiburg (DE)
- Corresponding author
- Ding, Yinyuan
- Huang, Linzhang
- Xian, Xunde
- Shaul, Philip W.
- Herz, Joachim
- ORCID
- Venue
- Science Signaling
- Published
- 2016-03-15
- Volume
- 9
- Issue
- 419
- Pages
- ra29-ra29
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5053773
- OpenAlex
- W2302528395
- Cited by
- 72
- References
- 59
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R37 HL063762, HL118001)
- Hertie Foundation
- American Health Assistance Foundation
- Consortium for Frontotemporal Dementia Research
- BrightFocus Foundation
- Lupe Murchison Foundation
- Ted Nash Long Life Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- reelin, atherosclerosis, leukocyte-endothelial adhesion, macrophage accumulation, ApoER2, VLDLR, Ldlr-deficient mice, endothelial inflammation, ICAM-1, VCAM-1, E-selectin, endothelial nitric oxide synthase, NF-κB, vascular inflammation
- MeSH terms
- Reelin Protein, Animals, Cell Adhesion, Humans, Macrophages, Nerve Tissue Proteins, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, NF-kappa B, Mice, Knockout, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, E-Selectin, LDL-Receptor Related Proteins, Endothelial Cells, Atherosclerosis, Mice
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