The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
Open accessAbstract
Restenosis, a frequent complication of coronary angioplasty, is associated with increased superoxide (O 2 · − ) production. Although the molecular identity of the responsible oxidase is unclear, an NAD(P)H oxidase appears to be involved. In smooth muscle, p22phox and 2 homologues of gp91phox, nox1 and nox4, are expressed, whereas fibroblasts contain gp91phox. To begin investigating the possibility that these oxidase components might contribute to the increased O 2 · − that accompanies neointimal formation, we measured their expression after balloon injury of the rat carotid artery. The increase in O 2 · − production 3 to 15 days after surgery was not due to inflammatory cell infiltration but appeared to be derived from medial and neointimal smooth muscle cells and adventitial fibroblasts. Nox1 and p22phox mRNAs were increased 2.7- and 3.6-fold, respectively, at day 3 after injury and remained elevated for 15 days. gp91Phox was increased 7 to 15 days after injury, and nox4 expression was increased 2-fold, but only at day 15 after surgery. These results confirm and extend our previous in vitro data and suggest that in the vasculature, the nox-based NAD(P)H oxidases serve different functions. This dynamic regulation of oxidase components may be critical to smooth muscle phenotypic modulation in restenosis and atherosclerosis.
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Cites
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
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Self-citationAngiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
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Self-citationRequirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
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Cell transformation by the superoxide-generating oxidase Mox1
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Self-citationClowes, A. W., Reidy, M. A., & Clowes, M. M. (1983) · PubMed · Cited by 1,437
Identification of Renox, an NAD(P)H oxidase in kidney
Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 842
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839
Self-citationRespiratory burst in human neutrophils
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Cited by
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Self-citationOxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899
Self-citationSuperoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
Self-citation
Metadata
- Authors
- Szöcs, K., Lassègue, B., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2002-01
- Volume
- 22
- Issue
- 1
- Pages
- 21-27
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2146960356
- Cited by
- 444
- References
- 30
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury. https://app.cochat.ai/papers/10.1161/hq0102.102189
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- Szöcs, K., Lassègue, B., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002). Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/hq0102.102189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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