CoChat
Sign Up
Cited by 76Cardiovascular Disease and AdiposityCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Effects of Weight Loss on Structural and Functional Alterations of Subcutaneous Small Arteries in Obese Patients

De Ciuceis, Carolina, Porteri, Enzo, Rizzoni, Damiano, Corbellini, Claudia, La Boria, Elisa, Boari, Gianluca E.M., Pilu, Annamaria, Mittempergher, Francesco +7 more·2011·Hypertension
DOI 10.1161/hypertensionaha.111.171082
Open this paper in CoChat — free account

Abstract

Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media:lumen ratio, are frequently present in hypertensive and/or diabetic patients and may represent the earliest alteration observed. In addition, media:lumen ratios of small arteries have a strong prognostic significance. However, no data are available about the structure of small resistance arteries of obese patients, particularly after weight loss. We have investigated 27 patients with severe obesity. Twelve of them were normotensive, and 15 were hypertensive. All of the obese patients underwent bariatric surgery. We compared results obtained with those observed in 13 normotensive lean controls and in 13 hypertensive lean patients. All of the subjects and patients underwent a biopsy of subcutaneous fat during surgical intervention. In 8 obese patients, a second biopsy was obtained after consistent weight loss, during a surgical intervention for abdominoplasty. Subcutaneous small resistance arteries were dissected and mounted on a wire myograph, and structural parameters were measured. A concentration-response curve to acetylcholine was performed to evaluate endothelial function. Obese patients, independent from the presence of hypertension, show the presence of an increased media:lumen ratio and media cross-sectional area, together with an impaired endothelial-dependent vasodilatation. After surgical correction of obesity and consistent weight loss, a significant improvement of microvascular structure and of some oxidative stress/inflammation markers were observed. In conclusion, our data suggest that the presence of obesity is associated with structural alterations of subcutaneous small resistance arteries, mainly characterized by hypertrophic remodeling. Weight loss may improve microvascular structure.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.111.171082

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
De Ciuceis, C., Porteri, E., Rizzoni, D., Corbellini, C., La Boria, E., Boari, G. E. M., Pilu, A., Mittempergher, F., Di Betta, E., Casella, C., Nascimbeni, R., Rosei, C. A., Ruggeri, G., Caimi, L., & Rosei, E. A.
Affiliations
  • From the Clinica Medica, Department of Medical and Surgical Sciences (C.D.C., E.P., D.R., C.Co., E.L.B., G.E.M.B., A.P., C.A.R., E.A.R.) and the Chair of General Surgery, Department of Medical and Surgical Sciences (F.M., E.D.B., C.Ca., R.N.) and the Chair of Clinical Biochemistry, Department of Biomedical Sciences and Biotechnology (G.R., L.C.), University of Brescia, Brescia, Italy.
  • University of Brescia (IT)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-07
Volume
58
Issue
1
Pages
29-36
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.111.171082
OpenAlex
W2099415914
Cited by
76
References
46
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 5 · 2012: 8
FWCI
5.50
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
obesity, weight loss, media-to-lumen ratio, arterial remodeling, endothelial function, endothelium-dependent vasodilatation, bariatric surgery, oxidative stress, inflammation, microvascular structure
MeSH terms
Adult, Arterioles, Biopsy, Blood Pressure, Female, Follow-Up Studies, Humans, Hypertension, Male, Middle Aged, Myography, Obesity, Morbid, Prognosis, Retrospective Studies, Vascular Resistance, Weight Loss, Body Mass Index, Incidence, Disease Progression, Subcutaneous Tissue

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review