Chronic Inflammatory Diseases and Endothelial Dysfunction
Open accessAbstract
Chronic inflammatory diseases are associated with increases in cardiovascular diseases (CVD) and subclinical atherosclerosis as well as early-stage endothelial dysfunction screening using the FMD method (Flow Mediated Dilation). This phenomenon, referred to as accelerated pathological remodeling of arterial wall, could be attributed to traditional risk factors associated with atherosclerosis. Several new non-invasive techniques have been used to study arterial wall's structural and functional alterations. These techniques (based of Radio Frequency, RF) allow for an assessment of artery age through calculations of intima-media thickness (RF- QIMT), pulse wave rate (RF- QAS) and endothelial dysfunction degree (FMD). The inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors, result of the major consequences of oxidative stress and RAS (Renin Angiotensin System) imbalance associated with the deleterious effect of known risk factors that lead to the alteration of the arterial wall. Inflammation plays a key role in all stages of the formation of vascular lesions maintained and exacerbated by the risk factors. The consequence of chronic inflammation is endothelial dysfunction that sets in and we can define it as an integrated marker of the damage to arterial walls by classic risk factors. The atherosclerosis, which develops among these patients, is the main cause for cardiovascular morbi-mortality and uncontrolled chronic biological inflammation, which quickly favors endothelial dysfunction. These inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors.
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Advanced signs of cardiovascular aging such as tissue remodeling and cardiac hypertrophy are often preceded and may be initiated by malfunctioning aged endothelia.
“More recent work has also shown that advanced signs of cardiovascular aging such as tissue remodeling and cardiac hypertrophy are often preceded and may be initiated by the malfunctioning of aged endothelia50–52.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [50]
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“As well as in other inflammatory diseases it was shown that ED is closely related to chronic inflammatory disease such as inflammatory arthritis and connective tissue disease.(103) In patients with connective tissue disease, the presence of inflammation and autoantibodies provokes endothelial cell activation and injur…”
BackgroundThe Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?
Kordinas, V., Ioannidis, A., & Chatzipanagiotou, S. (2016) · Genes · doi:10.3390/genes7090060 · Cited by 139 · see citing works
Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases
Zuo, W., Yan, F., Zhang, B., Li, J., & Mei, D. F. (2017) · Aging and Disease · doi:10.14336/ad.2017.0615 · Cited by 125 · see citing works
“Chronic inflammatory diseases are associated with increases in cardiovascular diseases [68].”
BackgroundJiang, H., Wang, L., Wang, D., Yan, N., Li, C., Wu, M., Wang, F., Mi, B., Chen, F., Jia, W., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.06.034 · Cited by 116 · see citing works
Guan, L., Geng, X., Stone, C., Cosky, E. E. P., Ji, Y., Du, H., Zhang, K., Sun, Q., & Ding, Y. (2019) · Environmental Toxicology · doi:10.1002/tox.22707 · Cited by 114 · see citing works
LncRNA Meg3 protects endothelial function by regulating the DNA damage response
Ali, M. S. S. H., Cheng, X., Moran, M., Haemmig, S., Naldrett, M. J., Alvarez, S., Feinberg, M. W., & Sun, X. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1190 · Cited by 113 · see citing works
Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
Lin, Z., Ge, J., Wang, Z., Ren, J., Wang, X., Xiong, H., Gao, J., Zhang, Y., & Zhang, Q. (2017) · Scientific Reports · doi:10.1038/srep42498 · Cited by 93 · see citing works
Zhang, H., Zhao, Z., Pang, X.-F., Yang, J., Yu, H., Zhang, Y., Zhou, H. M., & Zhao, J. (2017) · Inflammation · doi:10.1007/s10753-017-0588-3 · Cited by 81 · see citing works
Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages
Tian, Y., Yang, C., Yao, Q., Lei, Q., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01895 · Cited by 79 · see citing works
“Chronic inflammation is an important pathological feature of obesity, T2DM as well as cardiovascular diseases (45).”
BackgroundCOVID-19 and Hypertension: The What, the Why, and the How
Muhamad, S.-A., Ugusman, A., Kumar, J., Skiba, D. S., Hamid, A. A., & Aminuddin, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.665064 · Cited by 74 · see citing works
“Chronic inflammation results in changes in the arterial wall, such as geometric vascular remodeling, increase in intima-media thickness and functional remodeling (Castellon and Bogdanova, 2016).”
BackgroundInfluentialThe Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke
Li, X., Lin, S., Chen, X., Huang, W., Li, Q., Zhang, H., Chen, X., Yang, S., Jin, K., & Shao, B. (2018) · Aging and Disease · doi:10.14336/ad.2018.0820 · Cited by 74 · see citing works
“On the other hand, an increasing number of reports have showed that the inflammatory response after stroke plays a critical role for functional recovery in the later stages [9, 10].”
BackgroundVascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions
de Lima, E. P., Tanaka, M., Lamas, C. B., Quesada, K. R., Detregiachi, C. R. P., Araújo, A. C., Guiguer, É. L., Catharin, V. M. C. S., de Castro, M. V. M., Baldi, E., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12092096 · Cited by 78 · see citing works
From Microbiome to Inflammation: The Key Drivers of Cervical Cancer
Zhou, Z., Long, H., Cheng, Y., Luo, H., Wen, D., & Gao, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.767931 · Cited by 76 · see citing works
The biological and pharmacological roles of polyphenol flavonoid tilianin
Akanda, M. R., Uddin, M. N., Kim, I., Ahn, D., Tae, H., & Park, B. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.10.044 · Cited by 67 · see citing works
Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs
Sun, H., Hou, B., Wang, X., Zhu, X., Li, K., & Qiu, L.-Y. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.11.005 · Cited by 66 · see citing works
Endothelial Cell Dysfunction: Onset, Progression, and Consequences
Naderi‐Meshkin, H., & Setyaningsih, W. A. W. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906223 · Cited by 74 · see citing works
“Abnormal aging conditions, on the other hand, may accelerate these processes, leading to more pronounced endothelial dysfunction and an elevated risk of cardiovascular complications [2,46].”
BackgroundLinghu, K., Wu, G., Fu, L., Yang, H. S., Li, H.-Z., Chen, Y., Yu, H., Tao, L., & Shen, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00178 · Cited by 62 · see citing works
“It is well known that inflammation in the pathophysiological process of injured endothelium would deteriorate the damage of endothelial cells and go through the whole process of CVDs (Castellon and Bogdanova, 2016).”
BackgroundEhlers, H., Nicolas, A., Schavemaker, F., Heijmans, J. P. M., Bulst, M., Trietsch, S. J., & van den Broek, L. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1118624 · Cited by 59 · see citing works
“Chronic inflammation can affect the vasculature and is associated with increased risk of cardiovascular diseases like endothelial dysfunction and atherosclerosis (3).”
BackgroundLipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
Liu, G. W., Guzman, E. B., Menon, N., & Langer, R. (2023) · Pharmaceutical Research · doi:10.1007/s11095-023-03471-7 · Cited by 57 · see citing works
Bai, Y.-H., Li, Z., Chang, D., Chen, M., Kallenberg, C. G. M., & Zhao, M. (2017) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2017.07.004 · Cited by 57 · see citing works
Reinhart, W. H. (2016) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-168032 · Cited by 56 · see citing works
Ekholm, M., & Kahan, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.640185 · Cited by 56 · see citing works
The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?
Clarke, H. E., Kim, D., Meza, C., Ormsbee, M. J., & Hickner, R. C. (2020) · Nutrients · doi:10.3390/nu12092834 · Cited by 54 · see citing works
“Like many biological targets, ECs can be damaged by varying factors such as ROS [92] and chronic inflammation [93], both of which can be augmented by, or a result of, hyperglycemia [94], dyslipidemia [95], obesity [96], smoking [97], alcohol abuse [98], and aging [99].”
BackgroundLi, X., Li, X., Lin, J., Sun, X., & Ding, Q. (2018) · Journal of Ultrasound in Medicine · doi:10.1002/jum.14898 · Cited by 54 · see citing works
“Chronic inflammation diseases of the vessel wall are associated with increases in atherosclerosis and early-stage endothelial dysfunction.(3) Dendritic cells (DCs) are specialized Received March 2, 2018, from the Department of Ultrasonography, Jining No.”
BackgroundZeng, J., Deng, Z., Zou, Y., Liu, C., Fu, H., Gu, Y., & Chang, H. (2021) · Phytotherapy Research · doi:10.1002/ptr.7064 · Cited by 53 · see citing works
“Studies have confirmed that the injury of vascular endothelial cells and the resulting inflammatory response are considered to be the initial link of AS, and run through its whole development process (Canpolat, Kocyigit, & Yildirim, 2020; Castellon & Bogdanova, 2016).”
BackgroundHausen, H. Z., Bund, T., & de Villiers, E. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_3 · Cited by 51 · see citing works
Li, X., Ren, C., Li, S., Han, R., Gao, J., Huang, Q., Jin, K., Luo, Y., & Ji, X. (2017) · Aging and Disease · doi:10.14336/ad.2016.1227 · Cited by 50 · see citing works
“The pathogenic mechanisms responsible for hypoperfusionmediated white matter lesions include blood-brain barrier (BBB) leakage [9, 10], inflammation [11, 12] and oxidative stress [13], which collectively lead to apoptosis of oligodendrocyte cells and demyelination.”
BackgroundEllinger, S., & Stehle, P. (2016) · Nutrients · doi:10.3390/nu8060321 · Cited by 48 · see citing works
JNK and cardiometabolic dysfunction
Craige, S. M., Chen, K., Blanton, R. M., Keaney, J. F., & Kant, S. (2019) · Bioscience Reports · doi:10.1042/bsr20190267 · Cited by 47 · see citing works
Loss of Mitochondrial Control Impacts Renal Health
Srivastava, S. P., Kanasaki, K., & Goodwin, J. E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.543973 · Cited by 46 · see citing works
Rossin, D., Barbosa‐Pereira, L., Iaia, N., Testa, G., Sottero, B., Poli, G., Zeppa, G., & Biasi, F. (2019) · Antioxidants · doi:10.3390/antiox8060151 · Cited by 43 · see citing works
Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies
Taneja, G., Sud, A., Pendse, N., Panigrahi, B. P., Kumar, A., & Sharma, A. K. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-018-9491-x · Cited by 41 · see citing works
Endothelial progenitor cells in cardiovascular diseases
Qiu, Y., Zhang, C., Zhang, G., & Tao, J. (2018) · Aging Medicine · doi:10.1002/agm2.12041 · Cited by 40 · see citing works
The Potential Role of Creatine in Vascular Health
Clarke, H. E., Hickner, R. C., & Ormsbee, M. J. (2021) · Nutrients · doi:10.3390/nu13030857 · Cited by 43 · see citing works
“Despite their complex contribution to vascular health, ECs are delicate and can be easily damaged by varying factors such as free radicals or reaction oxygen species (ROS) [25] and chronic inflammation [26], both of which can be augmented by, or a result of, risk factors such as dyslipidemia [27], hyperglycemia [28],…”
BackgroundFlaskamp, L., Roubal, C., Uddin, S., Sotzny, F., Kedor, C., Bauer, S., Scheibenbogen, C., & Seifert, M. (2022) · Cells · doi:10.3390/cells11152376 · Cited by 35 · see citing works
Pasqualetto, M. C., Tuttolomondo, D., Cutruzzolà, A., Niccoli, G., Dey, D., Greco, A., Martini, C., Irace, C., Rigo, F., & Gaibazzi, N. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.05.040 · Cited by 37 · see citing works
Linghu, K., Lin, D., Yang, H. S., Xu, Y., Zhang, Y., Tao, L., Chen, Y., & Shen, X. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.07.039 · Cited by 36 · see citing works
Ngum, J. A., Tatang, F. J., Toumeni, M. H., Nguengo, S. N., Simo, U. S. F., Mezajou, C. F., Kameni, C., Ngongang, N. N., Tchinda, M. F., Dongmo, F. F. D., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1144836 · Cited by 35 · see citing works
“The presence of chronic inflammation contributes to the progression of certain diseases like type 2 diabetes (Donath, 2021), cancers, cardiovascular diseases, atherosclerosis (Castellon and Bogdanova, 2016), the pathogenesis of hypertension (Liang X.”
BackgroundAssociations between Dietary Patterns and Inflammatory Markers during Pregnancy: A Systematic Review
Yeh, K., Kautz, A., Lohse, B., & Groth, S. W. (2021) · Nutrients · doi:10.3390/nu13030834 · Cited by 35 · see citing works
“In the non-pregnant population, chronic inflammation has been shown to contribute to the development of autoimmune disorders [20], endothelial dysfunction [21], cardiometabolic disorders [20,22,23], and increased risk of cardiovascular morbidity and mortality [24].”
BackgroundKhattulanuar, F. S., Sekar, M., Fuloria, S., Gan, S. H., Rani, N. N. I. M., Ravi, S., Chidambaram, K., Begum, M. Y., Azad, A. K., Jeyabalan, S., et al. (2022) · Molecules · doi:10.3390/molecules27030673 · Cited by 35 · see citing works
“Atherosclerosis has several pathophysiological processes and causes, the most significant of which are chronic inflammation and endothelial dysfunction [27].”
BackgroundInflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV
Hmiel, L., Zhang, S., Obare, L. M., Santana, M. A. D. O., Wanjalla, C. N., Titanji, B. K., Hileman, C. O., & Bagchi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137266 · Cited by 34 · see citing works
Cai, H. Q., Weickert, T. W., Catts, V. S., Balzan, R. P., Galletly, C. A., Liu, D., O׳Donnell, M., & Weickert, C. S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.017 · Cited by 34 · see citing works
Nallasamy, P., Kang, Z. Y., Sun, X., Babu, P. V. A., Liu, D., & Jia, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212486 · Cited by 34 · see citing works
Osteoarthritis & stroke: a bidirectional mendelian randomization study
Zhao, H., Zhu, J., Ju, L., Sun, L., Tse, L. A., Kinra, S., & Li, Y. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.06.006 · Cited by 33 · see citing works
Yamagata, K. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106704 · Cited by 34 · see citing works
Anti-Inflammatory Effect of the Natural H2S-Donor Erucin in Vascular Endothelium
Ciccone, V., Piragine, E., Gorica, E., Citi, V., Testai, L., Pagnotta, E., Matteo, R., Pecchioni, N., Montanaro, R., Mannelli, L. D. C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415593 · Cited by 32 · see citing works
“It is prodromic for the development of hypertension, atherosclerosis, and other CV disorders [24], also representing a major trigger for non-CV diseases.”
BackgroundBirudaraju, D., Cherukuri, L., Kinninger, A., Chaganti, B. T., Shaikh, K. A., Hamal, S. A., Flores, F. R., Roy, S. K., & Budoff, M. J. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.09.011 · Cited by 32 · see citing works
Zhang, G., Liu, Y., Qiu, Y., Zhang, J., Sun, J., Zhou, Z., Wang, Z., Zeng, P., Tao, J., & He, J. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002715 · Cited by 31 · see citing works
“Chronic inflammation is one the most critical mechanisms of endothelial dysfunction [4,8].”
BackgroundOruç, Ç. U., Akpınar, Y. E., Dervişoğlu, E., Amikishiyev, S., Salmaslıoğlu, A., Gürdöl, F., & Ömer, B. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0329 · Cited by 30 · see citing works
Zhang, Q., Arney, D. E., Goldman, J. M., Isselbacher, E. M., & Armoundas, A. A. (2020) · Sensors · doi:10.3390/s20226581 · Cited by 28 · see citing works
Similarities and Differences Between Carotid Artery and Coronary Artery Function
Peace, A., van Mil, A. C. C. M., Jones, H., & Thijssen, D. H. J. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x14666180910125638 · Cited by 27 · see citing works
“Similarly, oxidative stress [19, 20] and inflammation [21] lead to lower NObioavailability and, consequently, impaired endothelial function.”
BackgroundChen, W. A., & Boskovic, D. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053025 · Cited by 28 · see citing works
“Chronic inflammation from persistent ongoing infections can induce endothelial dysfunction, which then downregulates vascular protective mechanisms, potentially leading to endothelial/vascular lesions [182].”
BackgroundApremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
Wang, H., Yang, G., Zhang, Q., Xiao, L., Liu, Y., Gao, M., Guo, Y., & Chen, L. (2020) · Aging · doi:10.18632/aging.103665 · Cited by 26 · see citing works
Jain, A., Puri, R., & Nair, D. R. (2017) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000411 · Cited by 25 · see citing works
Villalobos-Labra, R., Liu, R., Spaans, F., Sáez, T., Quon, A., Wong, M. E., Pink, D., Lewis, J. D., Vatish, M., Davidge, S. T., et al. (2022) · Bioscience Reports · doi:10.1042/bsr20222185 · Cited by 22 · see citing works
Geng, J., Xu, H., Yu, X., Xu, G., Cao, H., Lin, G., & Sui, D. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9666 · Cited by 24 · see citing works
“Oxidative stress is due to an imbalance between the enzymatic activity of antioxidants and free radicals, which causes the decreased bioavailability of the endothelial protective factor NO (20).”
BackgroundScott, X. O., Chen, S. H., Hadad, R., Yavagal, D. R., Peterson, E. C., Starke, R. M., Dietrich, W. D., Keane, R. W., & Vaccari, J. P. D. R. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221106956 · Cited by 23 · see citing works
Tourki, B., Kain, V., Shaikh, S. R., Leroy, X., Serhan, C. N., & Halade, G. V. (2020) · The FASEB Journal · doi:10.1096/fj.202000495rr · Cited by 23 · see citing works
Choi, H., Uceda, D. E., Dey, A. K., & Mehta, N. N. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0875-0 · Cited by 22 · see citing works
Endothelial inflammation and dysfunction in COVID-19
Sbirkov, Y., Dzharov, V., Todorova, K. O., Hayrabedyan, S., & Sarafian, V. S. (2022) · VASA · doi:10.1024/0301-1526/a000991 · Cited by 21 · see citing works
MacGirlley, R., Phoswa, W. N., & Mokgalaboni, K. (2023) · Nutrients · doi:10.3390/nu15214575 · Cited by 21 · see citing works
Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis
Wang, H. H., & Wang, Q. F. (2016) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20165231 · Cited by 20 · see citing works
“Insulin resistance (IR) and chronic inflammation play an important role in the development of cardiovascular diseases (8,9).”
BackgroundWang, J., Li, X., Hou, W., Dong, L., & Cao, J. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000312 · Cited by 20 · see citing works
Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
Ferrante, A., Guggino, G., Liberto, D. D., Ciccia, F., Cipriani, P., Balistreri, C. R., Sireci, G., Giacomelli, R., & Triolo, G. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.05.001 · Cited by 19 · see citing works
“Based on biopsy findings, also nflammation in the myocardium and small vessels may contribute o premature CVD in ARDs (cardiac ischemia and heart failure) Castellon and Bogdanova, 2016) There is an enormous need for an mproved CVD prevention in ARDs.”
BackgroundTestosterone and dihydrotestosterone modulate the redox homeostasis of endothelium
KOUKOULIS, G. N., Filiponi, Μ., Gougoura, S. G., Befani, C. D., Liakos, P., & Bargiota, Α. (2022) · Cell Biology International · doi:10.1002/cbin.11768 · Cited by 17 · see citing works
“Atherosclerosis, a progressive arterial disorder caused by several factors and characterized by chronic subclinical inflammation of the endothelium (Castellon & Bogdanova, 2016), a crucial major risk factor for increased cardiovascular morbidity and mortality (Lerner & Kannel, 1986).”
BackgroundStark, R. J., Koch, S. R., Choi, H., Mace, E. H., Dikalov, S., Sherwood, E. R., & Lamb, F. S. (2017) · The FASEB Journal · doi:10.1096/fj.201700410r · Cited by 17 · see citing works
“The chronic inflammation that induces that injury comes in many forms, from pure vascular pathologies, such as hypertension and atherosclerosis, to more systemic autoimmune diseases (1, 2).”
BackgroundRole of bioactive lipofishins in prevention of inflammation and colon cancer
Lombardi, V., Carrera, I., Corzo, L., & Cacabelos, R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.012 · Cited by 17 · see citing works
Park, J. H., Choi, J., Lee, H., Jo, C., & Koh, Y. H. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02942-9 · Cited by 17 · see citing works
Long COVID Syndrome: A Case-Control Study
Xuereb, R. A., Borg, M., Vella, K., Gatt, A., Xuereb, R. G., Barbara, C., Fava, S., & Magri, C. J. (2023) · The American Journal of Medicine · doi:10.1016/j.amjmed.2023.04.022 · Cited by 16 · see citing works
Osteonecrosis: A More Appropriate Term than Avascular Necrosis–Pathophysiologic Rationale
Cheng, E. Y., Mirzaei, A., Sugano, N., Hernigou, P., Jones, L. C., Koo, K., Drescher, W., Cui, Q., Sierra, R. J., Goodman, S. B., et al. (2025) · The Journal of Arthroplasty · doi:10.1016/j.arth.2025.05.064 · Cited by 15 · see citing works
Altered Tregs Differentiation and Impaired Autophagy Correlate to Atherosclerotic Disease
Mandatori, S., Pacella, I., Marzolla, V., Mammi, C., Starace, D., Padula, F., Vitiello, L., Armani, A., Savoia, C., Taurino, M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00350 · Cited by 15 · see citing works
“It is commonly known that preserving tolerance, while preventing autoimmunity and chronic inflammation, is decisive for slowing down the onset of atherosclerosis (10, 11).”
Backgroundvan den Boom, B. P., Stamouli, M., Timon, J., Bernal, W. E., Blasi, A., Adelmeijer, J., Fernández, J., Lisman, T., & Patel, V. (2023) · Liver International · doi:10.1111/liv.15728 · Cited by 14 · see citing works
“6 Increasing evidence also suggests a role of endothelial dysfunction in the pathophysiology of cirrhosis.”
BackgroundPosttransplant complications: molecular mechanisms and therapeutic interventions
Liu, X., Shen, J., Yan, H., Hu, J., Liao, G., Ding, L., Zhou, S., Zhang, J., Liao, J., Guo, Z., et al. (2024) · MedComm · doi:10.1002/mco2.669 · Cited by 14 · see citing works
“210–211 Moreover, direct infection of cardiovascular tissues by HCV may also play a significant role.”
BackgroundMangoni, A. A., Tommasi, S., Zinellu, A., Sotgia, S., Bassu, S., Piga, M., Erre, G. L., & Carru, C. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191112091700 · Cited by 14 · see citing works
Annett, S., Spence, S., Garciarena, C. D., Campbell, C., Dennehy, M., Drakeford, C., Lai, J. C. Y., Dowling, J. K., Moore, G., Yakkundi, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.24.431422 · Cited by 14 · see citing works
“Endothelial barrier dysfunction occurs during stimulation by inflammatory agents or in inflammation-related disease states (40) and therefore we investigated if FKBPL had a role regulating LPS-induced endothelial permeability by utilizing the XCELLigence system to measure cell impedence (41).”
MethodValdenegro, M., Bernales, M., Knox, M., Vinet, R., Caballero, E., Ayala-Raso, A., Kučerová, D., Kumar, R., Viktorová, J., Ruml, T., et al. (2021) · Antioxidants · doi:10.3390/antiox10121997 · Cited by 13 · see citing works
“Inflammation is one of the newly recognized cardiovascular risk factors resulting from the major consequences of oxidative stress [57].”
BackgroundImmunomodulation in age‐related disorders and nanotechnology interventions
Chintapula, U. K., Chikate, T., Sahoo, D., Kieu, A., Guerrero-Rodriguez, I. D., Nguyen, K. T., & Trott, D. W. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1840 · Cited by 14 · see citing works
From ACE2 to COVID-19: A multiorgan endothelial disease
Stein, R. A., & Young, L. M. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.08.083 · Cited by 13 · see citing works
Yadav, V., Sharma, S., Kumar, A., Singh, S., & Ravichandiran, V. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030142 · Cited by 12 · see citing works
Ni, A., Chen, L., Huang, X., Ma, Y., Lan, L., Ren, P., Wang, Y., Zhu, Y., Xu, Y., Chen, J., et al. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-021-00690-3 · Cited by 12 · see citing works
“Meanwhile, endothelial dysfunction due to inflammation may accelerate atherosclerosis and thrombosis [37, 38].”
BackgroundMahdy, A., Stradner, M. H., Roessler, A., Brix, B., Lackner, A., Saloň, A., & Goswami, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184067 · Cited by 12 · see citing works
L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells
Buie, J. N. J., Jenkins, D. P., Muise‐Helmericks, R. C., & Oates, J. C. (2019) · Lupus Science & Medicine · doi:10.1136/lupus-2018-000294 · Cited by 12 · see citing works
“Chronic inflammation promotes endothelial cell injury leading to generation of superoxide and expression of cell adhesion markers.(6) 7 These perturbations in endothelial cell function promote oedema, leucocyte trafficking and organ damage.”
BackgroundFan, Z., Zhang, Y., Zou, F., Xu, T., Pan, P., Hu, C., & Su, X. (2020) · Sleep And Breathing · doi:10.1007/s11325-020-02072-7 · Cited by 12 · see citing works
An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in HumansPreprint
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“Similarly, inflammation has been reported to be associated with atherosclerosis (Libby, 2002) and endothelial dysfunction (Castellon and Bogdanova, 2016).”
Background
- Authors
- Castellon, X., & Bogdanova, V.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Castellon, Xavier
- Venue
- Aging and disease
- Publisher
- Aging and Disease
- Published
- 2016
- Volume
- 7
- Issue
- 1
- Pages
- 81
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC4723236
- OpenAlex
- W2254228868
- Cited by
- 191
- References
- 62
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 25 · 2023: 19 · 2022: 24 · 2021: 21 · 2020: 21 · 2019: 16 · 2018: 10 · 2017: 13 · 2016: 12
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- chronic inflammatory diseases, endothelial dysfunction, atherosclerosis, cardiovascular risk factors, flow-mediated dilation, intima-media thickness, arterial stiffness, arterial aging, renin-angiotensin system, oxidative stress, autoimmune disease, arterial remodeling
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