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Aortic Distensibility and Retinal Arteriolar Narrowing: The Multi-Ethnic Study of Atherosclerosis
Open accessAbstract
Increased aortic stiffness and retinal arteriolar narrowing are subclinical vascular effects of chronic hypertension and predict future cardiovascular events. The relationship between these 2 vascular measures is uncertain and is examined in the Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis involves 3425 participants (aged 45 to 85 years) free of clinical cardiovascular disease. Retinal vascular caliber was quantified from digital retinal photographs using standardized protocols. Aortic distensibility was determined from chest MRI. After controlling for age, squared age, gender, race, study center, height, weight, heart rate, cigarette smoking, past and current systolic blood pressure, use of antihypertensive medications, diabetes, fasting glucose, lipid profile, and C-reactive protein, reduced aortic distensibility (first versus fourth distensibility quartile) was associated with increased odds of retinal arteriolar narrowing (odds ratio: 1.72; 95% CI: 1.15 to 2.58, comparing lowest to highest quartile of arteriolar caliber). Further adjustments for atherosclerotic measures (carotid intima-media thickness, coronary calcium score, and ankle brachial index) had minimal impact on this association (odds ratio: 1.70; 95% CI: 1.13 to 2.55). Reduced aortic distensibility was not associated with retinal venular caliber. We conclude that increased aortic stiffness is associated with retinal arteriolar narrowing, independent of measured blood pressure levels and vascular risk factors. These data suggest that changes in the microvasculature may play a role linking aortic stiffness with clinical cardiovascular events.
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“Retinal arterial narrowing correlates with increased arterial stiffness219 and cerebral small-vessel disease.218,220,221”
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Cites
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Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942
Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
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Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914
Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness
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Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493
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Self-citationAortic input impedance in normal man: relationship to pressure wave forms.
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Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Mitchell, G. F. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90549.2008 · Cited by 764
Retinal Vascular Caliber: Systemic, Environmental, and Genetic Associations
Sun, C., Wang, J. J., Mackey, D. A., & Wong, T. Y. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.10.003 · Cited by 426
Self-citationMeta-analysis: Retinal Vessel Caliber and Risk for Coronary Heart Disease
McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Klein, B. E. K., Wang, J. J., Mitchell, P., Vingerling, J. R., deJong, P. T. V. M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-6-200909150-00005 · Cited by 342
Self-citationMicrovascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences
Stehouwer, C. D. A. (2018) · Diabetes · doi:10.2337/dbi17-0044 · Cited by 317
Metadata
- Authors
- Cheung, N., Sharrett, A. R., Klein, R., Criqui, M. H., Islam, F. M. A., Macura, K. J., Cotch, M. F., Klein, B. E. K., & Wong, T. Y.
- Affiliations
- National Institutes of Health (US)
- From the Centre for Eye Research Australia (N.C., F.M.A.I., T.Y.W.), University of Melbourne, Melbourne, Victoria, Australia; the Department of Epidemiology (A.R.S.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Md; the Department of Ophthalmology and Visual Science (R.K., B.E.K.K.), University of Wisconsin School of Medicine and Public Health, Madison; the Department of Family and Preventive Medicine (M.H.C.), University of California San Diego; the Departments of Radiology (K.J.M.),...
- Venue
- Hypertension
- Published
- 2007-10
- Volume
- 50
- Issue
- 4
- Pages
- 617-622
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2096439317
- Cited by
- 124
- References
- 50
- Citations by year
- 2025: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 14
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- National Institutes of Health (n01hc95164-17-0-1, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, Z99 EY999999, n01hc95162-31-0-1, n01hc95160-18-0-1, n01hc95163-22-0-1, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC-95160, (N01-HC-95163, HL6997903, N01 HC-95161, N01 HC95165, N01HC95164, R01HL069979, N01-HC, HL69979, N01 HC-95162, HC95159, N01 HC95169)
- National Eye Institute (Z01EY000403, ZIAEY000403)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- aortic distensibility, retinal arteriolar narrowing, aortic stiffness, chronic hypertension, retinal microvasculature, cardiovascular risk prediction, carotid intima-media thickness, coronary artery calcium, ankle-brachial index, Multi-Ethnic Study of Atherosclerosis
- MeSH terms
- Aged, Aged, 80 and over, Aorta, Arterioles, Asian, Black or African American, Blood Pressure, Cross-Sectional Studies, Elasticity, Female, Hispanic or Latino, Humans, Hypertension, Male, Microcirculation, Middle Aged, Prospective Studies, Retinal Artery, Risk Factors, Cohort Studies, White People, Atherosclerosis
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