Cited by 139Regulation of Appetite and ObesityNeuroscience of respiration and sleepAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Leptin Signaling in the Nucleus Tractus Solitarii Increases Sympathetic Nerve Activity to the Kidney

Open access

Mark, Allyn L., Agassandian, Khristofor, Morgan, Donald A., Liu, Xuebo, Cassell, Martin D., Rahmouni, Kamal·2009·Hypertension

DOI 10.1161/hypertensionaha.108.124255PMC PMC2688398

Open this paper in CoChat — free account

Abstract

The hypothalamic arcuate nucleus was initially regarded as the principal site of leptin action, but there is increasing evidence for functional leptin receptors in extrahypothalamic sites, including the nucleus tractus solitarii (NTS). We demonstrated previously that arcuate injection of leptin increases sympathetic nerve activity (SNA) to brown adipose tissue and kidney. In this study, we tested the hypothesis that leptin signaling in the NTS affects sympathetic neural outflow. Using a stereotaxic device in anesthetized rats, we microinjected leptin (0.25 to 1.00 μg) or saline into the NTS while recording SNA to kidney and brown adipose tissue. Microinjection of leptin into the commissural and medial subnuclei of the caudal NTS at the level of the area postrema in Sprague-Dawley rats produced a dose-related increase in renal SNA (+112±15% with leptin 1 μg; n=7; P <0.001) but did not increase SNA to brown adipose tissue (−15±12%; P value not significant). This effect depended on intact functional leptin receptors, because it was not observed in Zucker obese rats that have a missense mutation in the leptin receptor. Rostral NTS injection of leptin failed to increase SNA, indicating that leptin signaling in the NTS is probably confined to the caudal NTS at the level of the area postrema. In summary, this study demonstrates that leptin signaling in the caudal NTS increases SNA to the kidney but not to the brown adipose tissue. The study strengthens the concept of a distributed brain network of leptin action and demonstrates that these distributed brain sites can mediate contrasting sympathetic responses to leptin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.108.124255

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Self-citation
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Leptin receptor missense mutation in the fatty Zucker rat
Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822
Role of leptin in fat regulation
Collins, S., Kuhn, C. M., Petro, A. E., Swick, A. G., Chrunyk, B. A., & Surwit, R. S. (1996) · Nature · doi:10.1038/380677a0 · Cited by 520
Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem
Elmquist, J. K., Ahima, R. S., Maratos–Flier, E., Flier, J. S., & Saper, C. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.5033 · Cited by 438
Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats
Dunbar, J. C., Hu, Y., & Lu, H. (1997) · Diabetes · doi:10.2337/diab.46.12.2040 · Cited by 414
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395 · cited 1×
“Discussion The major new findings from this study are as follows: (1) leptin receptor signaling in the NTS increases SNA to kidney but not to BAT; (2) sympathoactivation to microinjection of leptin into the NTS was associated with an increase in arterial pressure; and (3) the renal sympathetic nerve responses to NTS l…”
Background
Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure
Cano, G., Passerin, A. M., Schiltz, J. C., Card, J. P., Morrison, S. F., & Sved, A. F. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10643 · Cited by 337
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328
Brainstem projections of aortic baroreceptor afferent fibers in the rat
Ciriello, J. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90482-2 · Cited by 315

Show all 24 references

Sorted by citations

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654
Structure, production and signaling of leptin
Münzberg, H., & Morrison, C. D. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.010 · Cited by 486
Obesity-Related Hypertension: Epidemiology, Pathophysiology, and Clinical Management
Kotchen, T. A. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.172 · Cited by 418
Obesity, kidney dysfunction, and inflammation: interactions in hypertension
Hall, J. E., Mouton, A. J., da Silva, A. A., Omoto, A. C. M., Wang, Z., Li, X., & do Carmo, J. M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa336 · Cited by 290
Physiology of Kidney Renin
Castrop, H., Höcherl, K., Kurtz, A., Schweda, F., Todorov, V., & Wagner, C. (2010) · Physiological Reviews · doi:10.1152/physrev.00011.2009 · Cited by 265
The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities
Zoccal, D. B., Furuya, W. I., Bassi, M., Colombari, D. S. A., & Colombari, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00238 · Cited by 265
Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits
Zhang, Y., Kerman, I. A., Laque, A., Nguyen, P., Faouzi, M., Louis, G. W., Jones, J. C., Rhodes, C. J., & Münzberg, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3223-10.2011 · Cited by 240
Obesity and adipokines: effects on sympathetic overactivity
Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 245
Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease
Kunkel, S. D., Elmore, C., Bongers, K. S., Ebert, S. M., Fox, D. K., Dyle, M. C., Bullard, S. A., & Adams, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039332 · Cited by 225
The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?
Lansdown, A., & Rees, A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12003 · Cited by 167
Selective leptin resistance revisited
Mark, A. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00180.2013 · Cited by 162
Self-citation
Exposure to a High-Fat Diet Alters Leptin Sensitivity and Elevates Renal Sympathetic Nerve Activity and Arterial Pressure in Rabbits
Prior, L. J., Eikelis, N., Armitage, J. A., Davern, P. J., Burke, S. L., Montani, J.-P., Barzel, B., & Head, G. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.141119 · Cited by 157
Obesity and cardiovascular risk in children and adolescents
Raj, M. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.91176 · Cited by 153
Central Nervous System Regulation of Brown Adipose Tissue
Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140013 · Cited by 161
Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders
Farr, O. M., Tsoukas, M. A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.004 · Cited by 153
Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats
Samuelsson, A.-M., Morris, A., Igosheva, N., Kirk, S. L., Pombo, J. M. C., Coen, C. W., Poston, L., & Taylor, P. D. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.139402 · Cited by 138
Leptin as a Mediator of Obesity-Induced Hypertension
Bell, B., & Rahmouni, K. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0231-x · Cited by 128
Self-citation
Gender differences in developmental programming of cardiovascular diseases
Dasinger, J. H., & Alexander, B. T. (2016) · Clinical Science · doi:10.1042/cs20150611 · Cited by 120
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity
Hilzendeger, A. M., Morgan, D. A., Brooks, L. A., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D., & Mark, A. L. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00974.2011 · Cited by 118
Self-citation
Brain inflammation and hypertension: the chicken or the egg?
Winklewski, P. J., Radkowski, M., Wszedybyl-Winklewska, M., & Demkow, U. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0306-8 · Cited by 116
The Leptin Resistance
Liu, J., Yang, X., Yu, S., & Zheng, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_8 · Cited by 113
Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Balasubramanian, P., Hall, D., & Subramanian, M. (2018) · GeroScience · doi:10.1007/s11357-018-0048-5 · Cited by 111
Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects
Harlan, S. M., Guo, D., Morgan, D. A., Fernandes‐Santos, C., & Rahmouni, K. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.017 · Cited by 103
Self-citation
Leptin Mediates High-Fat Diet Sensitization of Angiotensin II–Elicited Hypertension by Upregulating the Brain Renin–Angiotensin System and Inflammation
Xue, B., Yu, Y., Zhang, Z., Guo, F., Beltz, T. G., Thunhorst, R. L., Felder, R. B., & Johnson, A. K. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06736 · Cited by 100
Renal Denervation Abolishes the Age-Dependent Increase in Blood Pressure in Female Intrauterine Growth-Restricted Rats at 12 Months of Age
Intapad, S., Tull, F. L., Brown, A. D., Dasinger, J. H., Ojeda, N. B., Fahling, J. M., & Alexander, B. T. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00645 · Cited by 94
Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis
Tupone, D., Madden, C. J., & Morrison, S. F. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00014 · Cited by 88
Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors
Hay, M. (2015) · Clinical Science · doi:10.1042/cs20150654 · Cited by 75
Leptin Impairs Cardiovagal Baroreflex Function at the Level of the Solitary Tract Nucleus
Arnold, A. C., Shaltout, H. A., Gallagher, P. E., & Diz, D. I. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138065 · Cited by 71
Obesity-Induced Hypertension: Brain Signaling Pathways
do Carmo, J. M., da Silva, A. A., Wang, Z., Fang, T., Aberdein, N., Rodriguez, C. E. P. D. L., & Hall, J. E. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0658-1 · Cited by 67
Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus
Shi, Z., Pelletier, N. E., Wong, J., Li, B., Sdrulla, A. D., Madden, C. J., Marks, D. L., & Brooks, V. L. (2020) · eLife · doi:10.7554/elife.55357 · Cited by 61
Developmental programming by maternal obesity in 2015: Outcomes, mechanisms, and potential interventions
Penfold, N., & Ozanne, S. E. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.015 · Cited by 62
Brain renin–angiotensin system in the nexus of hypertension and aging
Arnold, A. C., Gallagher, P. E., & Diz, D. I. (2012) · Hypertension Research · doi:10.1038/hr.2012.161 · Cited by 61
The Brain Subfornical Organ Mediates Leptin-induced Increases in Renal Sympathetic Activity but not its Metabolic Effects
Young, C. N., Morgan, D. A., Butler, S. D., Mark, A. L., & Davisson, R. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00405 · Cited by 58
Self-citation
Incendiary Leptin
Seoane‐Collazo, P., Martínez‐Sánchez, N., Milbank, E., & Contreras, C. (2020) · Nutrients · doi:10.3390/nu12020472 · Cited by 61
Leptin signaling and leptin resistance
Liu, J., Lai, F., Hou, Y., & Zheng, R. (2022) · Medical Review · doi:10.1515/mr-2022-0017 · Cited by 61
Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin‐deficient (ob/ob) mice
Bassi, M., Furuya, W. I., Menani, J. V., Colombari, D. S. A., do Carmo, J. M., da Silva, A. A., Hall, J. E., Moreira, T. S., Wenker, I. C., Mulkey, D. K., et al. (2014) · Acta Physiologica · doi:10.1111/apha.12257 · Cited by 55
Role of adipokines in obesity‐associated hypertension
Vlasova, M. A., Purhonen, A., Järvelin, M., Rodilla, E., Pascual, J., & Herzig, K. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02171.x · Cited by 53
Experimental Hyperleptinemia in Neonatal Rats Leads to Selective Leptin Responsiveness, Hypertension, and Altered Myocardial Function
Samuelsson, A., Clark, J., Rudyk, O., Shattock, M. J., Bae, S., South, T., Pombo, J., Redington, K. L., Uppal, E., Coen, C. W., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00691 · Cited by 49
Hypertension in obesity: is leptin the culprit?
Simonds, S. E., & Cowley, M. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.004 · Cited by 50
Neuroimmune communication in hypertension and obesity: A new therapeutic angle?
de Kloet, A. D., Krause, E. G., Shi, P. D., Zubcevic, J. A., Raizada, M. K., & Sumners, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.005 · Cited by 46
Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight
Bassi, M., Giusti, H., Leite, C. M., Anselmo-Franci, J. A., do Carmo, J. M., da Silva, A. A., Hall, J. E., Colombari, E., & Glass, M. L. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1111-1 · Cited by 46
Obesity Hypertension: The Regulatory Role of Leptin
Kshatriya, S., Liu, K., Salah, A., Szombathy, T., Freeman, R. H., Reams, G. P., Spear, R. M., & Villarreal, D. (2011) · International Journal of Hypertension · doi:10.4061/2011/270624 · Cited by 45
Novel Aspects of Brown Adipose Tissue Biology
Heeren, J., & Münzberg, H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.004 · Cited by 43
Intermittent hypoxia and systemic leptin administration induces pSTAT3 and Fos/Fra-1 in the carotid body
Messenger, S. A., Moreau, J. M., & Ciriello, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.074 · Cited by 41
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin
Harlan, S. M., & Rahmouni, K. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0168-4 · Cited by 39
Self-citation
Obesity: sex and sympathetics
Shi, Z., Wong, J., & Brooks, V. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00286-8 · Cited by 37
Obesity, Hypertension, and Bariatric Surgery
Samson, R., Ayinapudi, K., Jemtel, T. H. L., & Oparil, S. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01049-x · Cited by 38
Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure
Barnes, M. J., & McDougal, D. H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00232 · Cited by 38
History and future of leptin: Discovery, regulation and signaling
Münzberg, H., Heymsfield, S. B., Berthoud, H., & Morrison, C. D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156026 · Cited by 37
New Obesity Indices and Adipokines in Normotensive Patients and Patients With Hypertension
Stȩpień, M., Stępień, A., Banach, M., Wlazeł, R. N., Paradowski, M. T., Rizzo, M., Toth, P. P., & Rysz, J. (2013) · Angiology · doi:10.1177/0003319713485807 · Cited by 38
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity
Badoer, E., Kosari, S., & Stebbing, M. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00321 · Cited by 36
Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways
Toorie, A. M., & Nillni, E. A. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1115 · Cited by 35
Leptin Acts in the Forebrain to Differentially Influence Baroreflex Control of Lumbar, Renal, and Splanchnic Sympathetic Nerve Activity and Heart Rate
Li, B., Shi, Z., Cassaglia, P. A., & Brooks, V. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00518 · Cited by 34
Activation of the brain melanocortin system is required for leptin‐induced modulation of chemorespiratory function
Bassi, M., Nakamura, N. B., Furuya, W. I., Colombari, D. S. A., Menani, J. V., do Carmo, J. M., da Silva, A. A., Hall, J. E., & Colombari, E. (2014) · Acta Physiologica · doi:10.1111/apha.12394 · Cited by 34
Leptin signaling in the nucleus of the solitary tract alters the cardiovascular responses to activation of the chemoreceptor reflex
Ciriello, J., & Moreau, J. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00068.2012 · Cited by 33
Mechanisms of Adverse Cardiometabolic Consequences of Obesity
Diaz-Melean, C. M., Somers, V. K., Rodríguez-Escudero, J. P., Singh, P., Sochor, O., Llano, E. M., & López-Jiménez, F. A. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0364-2 · Cited by 37
Control of respiratory and cardiovascular functions by leptin
Bassi, M., Furuya, W. I., Zoccal, D. B., Menani, J. V., Colombari, E., Hall, J. E., da Silva, A. A., do Carmo, J. M., & Colombari, D. S. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.019 · Cited by 34
Facilitation of breathing by leptin effects in the central nervous system
Bassi, M., Furuya, W. I., Zoccal, D. B., Menani, J. V., Colombari, D. S. A., Mulkey, D. K., & Colombari, E. (2015) · The Journal of Physiology · doi:10.1113/jp270308 · Cited by 35
Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat
Ciriello, J., & Moreau, J. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.065 · Cited by 32
Leptin: Master Regulator of Biological Functions that Affects Breathing
Gauda, E. B., Conde, S. V., Bassi, M., Zoccal, D. B., Colombari, D. S. A., Colombari, E., & Despotovic, N. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190031 · Cited by 32
Influence of Maternal Nutritional Status on Vascular Function in the Offspring
Poston, L. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00086.x · Cited by 33
Effects of intermittent hypoxia on leptin signalling in the carotid body
Messenger, S. A., & Ciriello, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.018 · Cited by 31
Possible promoting effects of melatonin, leptin and alcar on regeneration of the sciatic nerve
Önger, M. E., Kaplan, S., Deniz, Ö. G., Altun, G., Altunkaynak, B. Z., Balcı, K., Raimondo, S., & Geuna, S. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.02.003 · Cited by 27
Leptin Is Not Essential for Obesity-Associated Hypertension
von Schnurbein, J., Manzoor, J., Brandt, S., Denzer, F., Kohlsdorf, K., Fischer‐Posovszky, P., Weißenberger, M., Frank, S., Mahmood, S., & Wabitsch, M. (2019) · Obesity Facts · doi:10.1159/000501319 · Cited by 26
Regional Cerebral Activation Accompanies Sympathoexcitation in Women With Polycystic Ovary Syndrome
Lansdown, A., Warnert, E. A. H., Sverrisdóttir, Y. B., Wise, R. G., & Rees, A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00065 · Cited by 25
Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases
de Chantemèle, E. J. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_6 · Cited by 27
The role of perirenal adipose tissue deposition in chronic kidney disease progression: Mechanisms and therapeutic implications
Qiu, X., Lan, X., Li, L., Chen, H., ZHANG, N., Zheng, X., & Xie, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122866 · Cited by 25
Obesity hypertension: the emerging role of leptin in renal and cardiovascular dyshomeostasis
Kshatriya, S., Reams, G. P., Spear, R. M., Freeman, R. H., Dietz, J. R., & Villarreal, D. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328332fb49 · Cited by 24
Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice
Nguyen, L. V., Ta, Q. V., Dang, T. B., Nguyen, P. H., Nguyen, T. N., Pham, T. V. H., Nguyen, T., Baker, S. G., Tran, T. L., Yang, D. J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224674 · Cited by 24
Importance of AT1 and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet
Speretta, G. F. F., Ruchaya, P. J., Delbin, M. A., Melo, M., Li, H., Menani, J. V., Sumners, C., Colombari, E., Bassi, M., & Colombari, D. S. A. (2019) · Hypertension Research · doi:10.1038/s41440-018-0196-0 · Cited by 23
Obesity Hypertension: Pathophysiological Role of Leptin in Neuroendocrine Dysregulation
Go, O., Liu, K., Villarreal, D., Spear, R. M., Freeman, R. H., Reams, G. P., & Weber, K. T. (2013) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31827ad5cf · Cited by 22
Effects of acute intermittent hypoxia on energy balance and hypothalamic feeding pathways
Moreau, J. M., & Ciriello, J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.007 · Cited by 21
Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction
Thangaratnarajah, C., Dinger, K., Vohlen, C., Klaudt, C., Nawabi, J., Garcia, E. L., Kwapiszewska, G., Dobner, J., Nüsken, K., Koningsbruggen-Rietschel, S. V., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00432.2016 · Cited by 21
Sirtuin 6 supra‐physiological overexpression in hypothalamic pro‐opiomelanocortin neurons promotes obesity via the hypothalamus‐adipose axis
Tang, Q., Liu, Q., Yang, X., Wu, T., Huang, C., Zhang, J., Zhang, Z., Zhang, G., Zhao, Y., Zhou, J., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002607 · Cited by 20
Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats
Chen, H., Chu, C.-H., Wen, S.-W., Lai, C.-C., Cheng, P., & Tseng, C. (2019) · Nutrients · doi:10.3390/nu11112581 · Cited by 20
Does leptin cause an increase in blood pressure in animals and humans?
Simonds, S. E., Pryor, J. T., & Cowley, M. A. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000287 · Cited by 20
Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019
King, H., Reiber, M., Philippi, V., Stirling, H., Aulehner, K., Bankstahl, M., Bleich, A., Buchecker, V., Glasenapp, A., Jirkof, P., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1143109 · Cited by 19
New Approaches to Quantifying Sympathetic Nerve Activity
Burke, S. L., Lambert, É., & Head, G. A. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0196-9 · Cited by 19
Leptin in nucleus of the solitary tract alters the cardiovascular responses to aortic baroreceptor activation
Ciriello, J. (2013) · Peptides · doi:10.1016/j.peptides.2013.03.021 · Cited by 19
Leptin and Associated Neural Pathways Underlying Obesity‐Induced Hypertension
Laule, C. F., & Rahmouni, K. (2024) · Comprehensive physiology · doi:10.1002/cph4.8 · Cited by 19
Self-citation
In vivo assessment of neurocardiovascular regulation in the mouse: principles, progress, and prospects
Young, C. N., & Davisson, R. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00355.2011 · Cited by 18
Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility
Idrizaj, E., Garella, R., Squecco, R., & Baccari, M. C. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190121115356 · Cited by 18
Leptin stimulates sympathetic axon outgrowth
Pellegrino, M. J., McCully, B. H., & Habecker, B. A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.014 · Cited by 17
Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice
Zhong, B., Ma, S., & Wang, D. H. (2018) · Current Hypertension Reviews · doi:10.2174/1573402114666181031141840 · Cited by 17
Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension
Bhunu, B., Riccio, I., & Intapad, S. (2021) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s312868 · Cited by 12
Neural Control of Non-vasomotor Organs in Hypertension
Hurr, C., & Young, C. N. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0635-8 · Cited by 17
CNS Targets of Adipokines
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16
The influence of reduced insulin sensitivity via short-term reductions in physical activity on cardiac baroreflex sensitivity during acute hyperglycemia
Holwerda, S. W., Reynolds, L. J., Restaino, R. M., Credeur, D. P., Leidy, H. J., Thyfault, J. P., & Fadel, P. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00584.2015 · Cited by 15
Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores
Gomart, S., Gaudreau-Ménard, C., Jespers, P., Dilek, Ö. G., Hupkens, E., Hanthazi, A., Naeije, R., Mélot, C., Labranche, N., Dewachter, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169205 · Cited by 15
Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism
Haze, T., Hatakeyama, M., Komiya, S., Kawano, R., Ohki, Y., Suzuki, S., Kobayashi, Y., Fujiwara, A., Saka, S., Tamura, K., et al. (2021) · Hypertension Research · doi:10.1038/s41440-021-00719-w · Cited by 15
Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts
Nguyen, V. T.-T., Vu, V. V., & Pham, P. V. (2023) · Adipocyte · doi:10.1080/21623945.2023.2237164 · Cited by 15
Carotid chemoreceptor afferent projections to leptin receptor containing neurons in nucleus of the solitary tract
Ciriello, J., & Caverson, M. M. (2014) · Peptides · doi:10.1016/j.peptides.2014.05.014 · Cited by 13
Exercise prevents leptin-induced increase in blood pressure in Sprague–Dawley rats
Farhana, K., Effendi, I., Caszo, B. A., Satar, N. A., & Singh, H. R. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0319-2 · Cited by 13
Renal sympathetic nerve activity is increased in monosodium glutamate induced hyperadipose rats
Mattos, A. M. D. S., Xavier, C. H., Karlen‐Amarante, M., da Cunha, N. V., Fontes, M. A. P., & Martins‐Pinge, M. C. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.06.021 · Cited by 12
Electroacupuncture Regulates Sympathetic Nerve Through the NTSGlu ‐ RVLM Circuit to Relieve Spontaneous Pain in SNI Rats
Chen, W. C., Ma, X., Fu, Y., Liu, C., Li, H., & Shi, G. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70327 · Cited by 11
Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem
Haspula, D., & Cui, Z. (2023) · Cells · doi:10.3390/cells12131801 · Cited by 12
Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats
Arnold, A. C., & Diz, D. I. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00282.2014 · Cited by 11
Conséquences rénales de l’obésité
Laville, M. (2011) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2010.11.007 · Cited by 11
Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the ‘obesity paradox’
Diong, C. T., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., Fujii, Y., Umetani, K., Shirai, M., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.33 · Cited by 11

Authors: Mark, A. L., Agassandian, K., Morgan, D. A., Liu, X., Cassell, M. D., & Rahmouni, K.
Affiliations: University of Iowa (US)
ORCID: Mark, Allyn L.
Agassandian, Khristofor
Morgan, Donald A.
Liu, Xuebo
Rahmouni, Kamal
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-02
Volume: 53
Issue: 2
Pages: 375-380
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.108.124255
PMC: PMC2688398
OpenAlex: W2152899311
Cited by: 139
References: 24
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 16 · 2013: 20 · 2012: 14
FWCI: 2.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association
National Institutes of Health
National Heart, Lung, and Blood Institute (HL-084207, P01HL084207)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, nucleus tractus solitarius, sympathetic activity, renal sympathetic nerve activity, brown adipose tissue, leptin receptor, area postrema, distributed brain networks, leptin signaling, Zucker fatty rats, leptin receptor mutation
MeSH terms: Animals, Adipose Tissue, Brown, Disease Models, Animal, Dose-Response Relationship, Drug, Kidney, Microinjections, Obesity, Rats, Zucker, Sympathetic Nervous System, Signal Transduction, Rats, Sprague-Dawley, Solitary Nucleus, Mutation, Missense, Leptin, Rats, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Leptin Signaling in the Nucleus Tractus Solitarii Increases Sympathetic Nerve Activity to the Kidney

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks