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Cited by 138Birth, Development, and HealthBlood Pressure and Hypertension StudiesPregnancy and preeclampsia studies

Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats

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Samuelsson, Anne-Maj, Morris, Abigail, Igosheva, Natalia, Kirk, Shona L., Pombo, Joaquim M.C., Coen, Clive W., Poston, Lucilla, Taylor, Paul D.·2010·Hypertension
DOI 10.1161/hypertensionaha.109.139402
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Abstract

Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, males: OffOb, 121.8±0.6 mm Hg versus OffCon, 115.0±0.5 mm Hg, n=6, P <0.01; females: OffOb, 125.4±0.4 mm Hg versus OffCon, 114.4±0.5 mm Hg, n=6, P <0.001), as was the mean arterial pressure response to restraint stress ( P <0.01). The pressor response to a leptin challenge was enhanced in OffOb rats (Δmean arterial pressure: OffOb, 9.7±0.8 mm Hg versus OffCon, 5.3±1.3 mm Hg; n=8; P <0.05). Renal tissue norepinephrine content ( P <0.001) and renin expression ( P <0.05) were markedly raised. Analysis of heart rate variability revealed an increased low:high frequency ratio in OffOb versus OffCon rats ( P <0.05). At 90 days, hypertension in OffOb rats persisted and was abolished by α1- and β-adrenergic blockade, and cardiovascular responses to phenylephrine or sodium nitroprusside indicated altered baroreceptor function. The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development.

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Crossref · 10.1161/hypertensionaha.109.139402

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  • Cardiac afterload-dependent effects could be influencing the development of cardiac hypertrophy in adult offspring of obese dams.

    “This suggests that cardiac afterload-dependent effects could be influencing the development of cardiac hypertrophy in adult offspring of obese dams.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]

    The Discussion reports persistent hypertension in adult offspring of obese dams, which provides a basis for the citing authors’ suggested afterload effect. It does not address cardiac hypertrophy or test whether afterload influences its development (searched: cardiac hypertrophy, heart weight, afterload). (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • Samuelsson et al. identified reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.

    “Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]

    The Baroreflex Sensitivity section reports reduced baroreflex sensitivity and enhanced responses to sodium nitroprusside and phenylephrine in 90-day-old offspring of obese dams. It does not report those baroreflex findings at 30 days; the Autonomic Function section describes different measurements at that age. (LLM, conf=0.91)

    Experimental — accuracy not yet measured

  • Samuelsson et al. identified an enhanced pressor response to phenylephrine in the 30- and 90-day-old offspring of obese dams.

    “Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]

    The Baroreflex Sensitivity section reports an enhanced pressor response to phenylephrine in offspring of obese dams at 90 days. It does not report that response at 30 days, so the claim extends the finding to an unsupported age. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Samuelsson et al. identified an enhanced response to sodium nitroprusside in the 30- and 90-day-old offspring of obese dams.

    “Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]

    The Baroreflex Sensitivity section reports an exaggerated fall in mean arterial pressure after sodium nitroprusside in offspring of obese dams at 90 days. It does not report that response at 30 days; the Radiotelemetry section says the IV infusion method was not feasible in 30-day-old offspring. (LLM, conf=0.91)

    Experimental — accuracy not yet measured

  • The expression of renin was increased in the kidneys from offspring of obese dams.

    “Beyond the vasculature, the activity of the sodium-potassium ATPase [130] was significantly reduced, and the expression of renin [129] was increased in the kidneys from offspring of obese dams, which could also influence blood pressure.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]

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Authors
Samuelsson, A.-M., Morris, A., Igosheva, N., Kirk, S. L., Pombo, J. M. C., Coen, C. W., Poston, L., & Taylor, P. D.
Affiliations
King's College London (GB)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-01
Volume
55
Issue
1
Pages
76-82
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.109.139402
OpenAlex
W2154990899
Cited by
138
References
39
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 22 · 2012: 9
FWCI
8.27
Type
journal article
Language
en
Open access
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • British Heart Foundation (PG/06/067, FS/10/003/28163)
  • Biotechnology and Biological Sciences Research Council (BB/H008845/1, BB/D523186/1)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
maternal obesity, offspring hypertension, sympathetic nervous system, leptin, norepinephrine, renin-angiotensin system, baroreceptor function, heart rate variability, restraint stress, alpha-1 adrenergic blockade, beta-adrenergic blockade, developmental programming, energy-dense diet
MeSH terms
Analysis of Variance, Animals, Animals, Newborn, Blood Pressure, Body Weight, Dietary Fats, Female, Hypertension, Kidney, Peptidyl-Dipeptidase A, Male, Norepinephrine, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Renin, RNA, Messenger, Sex Factors, Sympathetic Nervous System, Time Factors, Weaning, Rats, Sprague-Dawley, Baroreflex, Rats

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