Cited by 207Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Cardiovascular Effects of Physiological and Standard Sex Steroid Replacement Regimens in Premature Ovarian Failure

Langrish, Jeremy P., Mills, Nicholas L., Bath, Louise E., Warner, Pamela, Webb, David J., Kelnar, Christopher J., Critchley, Hilary O.D., Newby, David E., Wallace, W. Hamish B.·2009·Hypertension

DOI 10.1161/hypertensionaha.108.126516

Open this paper in CoChat — free account

Abstract

Current hormone replacement therapy may not optimize cardiovascular health in women with premature ovarian failure. We compared the effects of physiological and standard sex steroid replacement regimens on cardiovascular health in these women. In an open-label, randomized, controlled crossover trial, 34 women with premature ovarian failure were randomly assigned to 4-week cycles of physiological (transdermal estradiol and vaginal progesterone) and standard (oral ethinylestradiol and norethisterone) therapy for 12 months. Cardiovascular health was assessed by 24-hour ambulatory blood pressure, arterial stiffness, and renal and humoral factors. Eighteen women (19 to 39 years of age) completed the 28-month protocol. Both regimens caused similar suppression of luteinizing hormone and follicle-stimulating hormone and provided symptom relief. In comparison with the standard regimen, physiological sex steroid replacement caused lower mean 24-hour systolic and diastolic blood pressures throughout the 12-month treatment period (ANOVA; P ≤0.0001 for both): systolic blood pressure was 7.3 mm Hg (95% CI: 2.5 to 12.0 mm Hg) and diastolic was 7.4 mm Hg (95% CI: 3.9 to 11.0 mm Hg) lower at 12 months. Although there were no differences in arterial stiffness, physiological sex steroid replacement reduced plasma angiotensin II (ANOVA; P =0.007) and serum creatinine (ANOVA; P =0.015) concentrations without altering plasma aldosterone concentrations. In comparison with a standard regimen, physiological sex steroid replacement in women with premature ovarian failure results in lower blood pressure, better renal function, and less activation of the renin-angiotensin system. These findings have major implications for the future cardiovascular health of young women who require long-term sex steroid replacement therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.108.126516

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
The Pharmacological Basis of Therapeutics
(1976) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/33.4.373a · Cited by 9,216
Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy: The Women's Health Initiative Randomized Controlled Trial
(2004) · JAMA · doi:10.1001/jama.291.14.1701 · Cited by 4,534
Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women
Wassertheil-Smoller, S. W., Hendrix, S. L., Limacher, M. C., HEISS, G. M., Kooperberg, C. L., Baird, A. E., Kotchen, T. A., Curb, J. D., Black, H. R., Rossouw, J. E., et al. (2003) · JAMA · doi:10.1001/jama.289.20.2673 · Cited by 1,160
A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke
Viscoli, C. M., Brass, L. M., Kernan, W. N., Sarrel, P. M., Suissa, S., & Horwitz, R. I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010534 · Cited by 919
Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
Rocca, W. A., Bower, J. H., Maraganore, D. M., Ahlskog, J. E., Grossardt, B. R., de Andrade, M., & Melton, L. J. (2007) · Neurology · doi:10.1212/01.wnl.0000276984.19542.e6 · Cited by 827
Acute vascular effects of estrogen in postmenopausal women.
Gilligan, D. M., Badar, D. M., Panza, J. A., Quyyumi, A. A., & Cannon, R. O. (1994) · Circulation · doi:10.1161/01.cir.90.2.786 · Cited by 554
Effects of Estrogen Replacement Therapy on the Renin-Angiotensin System in Postmenopausal Women
Schunkert, H., Danser, A. H. J., Hense, H.-W., Derkx, F. H. M., Ku¨rzinger, S., & Riegger, G. A. J. (1997) · Circulation · doi:10.1161/01.cir.95.1.39 · Cited by 438
Age at Natural Menopause and Risk of Cardiovascular Disease
Hu, F. B., Grodstein, F., Hennekens, C. H., Colditz, G. A., Johnson, M., Manson, J. E., ROSNER, B. A., & Stampfer, M. J. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.10.1061 · Cited by 414
Postmenopausal Hormone Therapy and Risk of Stroke
Simon, J. A., Hsia, J. A., Cauley, J. A., Richards, C., Harris, F., Fong, J., Barrett-Connor, E. L., & Hulley, S. B. (2001) · Circulation · doi:10.1161/01.cir.103.5.638 · Cited by 402

Show all 37 references

Research works printed but not linked: 4

10.1161/circ.95.1.39 · DOI
10.1161/circ.103.5.638 · DOI
10.1161/circ.90.2.8044949 · DOI
10.1161/circ.76.4.3308164 · DOI

Sorted by citations

ESHRE Guideline: management of women with premature ovarian insufficiency
The ESHRE Guideline Group on POI, Webber, L. J., Davies, M. C., Anderson, R. A., Bartlett, J., Braat, D. D. M., Cartwright, B., Cífková, R., Keizer‐Schrama, S. D. M., Hogervorst, E., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew027 · Cited by 1,603
Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner syndrome meeting
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101
Primary ovarian insufficiency
Vos, M. D., Devroey, P., & Fauser, B. C. J. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60355-8 · Cited by 781
Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause
Sullivan, S. D., Sarrel, P. M., & Nelson, L. M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.09.046 · Cited by 519
Turner syndrome: mechanisms and management
Gravholt, C. H., Viuff, M. H., Brun, S., Stochholm, K., & Andersen, N. H. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0224-4 · Cited by 356
Cardiovascular health after menopause transition, pregnancy disorders, and other gynaecologic conditions: a consensus document from European cardiologists, gynaecologists, and endocrinologists
Maas, A. H. E. M., Rosano, G. M. C., Cífková, R., Chieffo, A., van Dijken, D., Hamoda, H., Kunadian, V., Laan, E. T. M., Lambrinoudaki, I. V., Maclaran, K., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1044 · Cited by 382
Premature ovarian insufficiency: an international menopause society white paper
Panay, N., Anderson, R. A., Nappi, R. E., Vincent, A. J., Vujovic, S., Webber, L., & Wolfman, W. (2020) · Climacteric · doi:10.1080/13697137.2020.1804547 · Cited by 297
Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults
Anderson, R. A., Mitchell, R. T., Kelsey, T., Spears, N., Telfer, E. E., & Wallace, W. H. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00039-x · Cited by 297
Self-citation
Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science
McSweeney, J. C., Rosenfeld, A. G., Abel, W. M., Braun, L. T., Burke, L. E., Daugherty, S. L., Fletcher, G. F., Gulati, M., Mehta, L. S., Bricker, C., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000381 · Cited by 276
Hypertension in Postmenopausal Women
Lima, R., Wofford, M. R., & Reckelhoff, J. F. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0260-0 · Cited by 266
Arterial Stiffness and Hypertension
Payne, R., Wilkinson, I. B., & Webb, D. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.107.090464 · Cited by 245
Self-citation
Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium
van Dorp, W., Mulder, R. L., Kremer, L. C. M., Hudson, M. M., van den Heuvel‐Eibrink, M. M., van den Berg, M. H., Levine, J. M., Broeder, E. V. D., Iorgi, N. D., Albanese, A., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.3288 · Cited by 243
Self-citation
Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review
van Dorp, W., Haupt, R., Anderson, R. A., Mulder, R. L., van den Heuvel‐Eibrink, M. M., Broeder, E. V. D., Su, H.-C. I., Winther, J. F., Hudson, M. M., Levine, J. M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.3441 · Cited by 231
Self-citation
Postmenopausal Hypertension
Barton, M., & Meyer, M. R. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.120022 · Cited by 231
Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224
Premature Ovarian Insufficiency - an update on recent advances in understanding and management
Torrealday, S., Kodaman, P. H., & Pal, L. (2017) · F1000Research · doi:10.12688/f1000research.11948.1 · Cited by 224
Cardiovascular Phenotype in Turner Syndrome—Integrating Cardiology, Genetics, and Endocrinology
Mortensen, K. H., Andersen, N. H., & Gravholt, C. H. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1059 · Cited by 221
Gender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences
Pérez-López, F. R., Larrad-Mur, L., Kallen, A. N., Chedraui, P. A., & Taylor, H. S. (2010) · Reproductive Sciences · doi:10.1177/1933719110367829 · Cited by 204
The British Menopause Society & Women’s Health Concern 2020 recommendations on hormone replacement therapy in menopausal women
Hamoda, H., Panay, N., Pedder, H., Arya, R., & Savvas, M. (2020) · Post Reproductive Health · doi:10.1177/2053369120957514 · Cited by 192
Postmenopausal Hypertension
Yanes, L. L., & Reckelhoff, J. F. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.71 · Cited by 190
Estrogen replacement in Turner syndrome: literature review and practical considerations
Klein, K. O., Rosenfield, R. L., Santen, R. J., Gawlik, A. M., Backeljauw, P. F., Gravholt, C. H., Sas, T. C. J., & Mauras, N. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02183 · Cited by 151
Physiological versus standard sex steroid replacement in young women with premature ovarian failure: effects on bone mass acquisition and turnover
Crofton, P. M., Evans, N., Bath, L., Warner, P., Whitehead, T. J., Critchley, H., Kelnar, C. J. H., & Wallace, W. H. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03868.x · Cited by 150
Self-citation
The changing face of Turner syndrome
Gravholt, C. H., Viuff, M., Just, J., Sandahl, K., Brun, S., van der Velden, J., Andersen, N. H., & Skakkebaek, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac016 · Cited by 149
Pharmacological Modulation of Arterial Stiffness
Boutouyrie, P., Lacolley, P. J., Briet, M. B., Regnault, V., Stanton, A. V., Laurent, S., & Mahmud, A. (2011) · Drugs · doi:10.2165/11593790-000000000-00000 · Cited by 147
HRT for women with premature ovarian insufficiency: a comprehensive review
Webber, L., Anderson, R. A., Davies, M., Janse, F., & Vermeulen, N. (2017) · Human Reproduction Open · doi:10.1093/hropen/hox007 · Cited by 141
Current Concepts in Premature Ovarian Insufficiency
Maclaran, K., & Panay, N. (2015) · Women s Health · doi:10.2217/whe.14.82 · Cited by 135
Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency
(2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002044 · Cited by 125
Premature Ovarian Insufficiency and Long-Term Health Consequences
Tsiligiannis, S., Panay, N., & Stevenson, J. C. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190122101611 · Cited by 113
Ovarian tissue cryopreservation for fertility preservation: clinical and research perspectives
Anderson, R. A., Wallace, W. H., & Telfer, E. E. (2017) · Human Reproduction Open · doi:10.1093/hropen/hox001 · Cited by 107
Self-citation
Can ovarian aging be delayed by pharmacological strategies?
Zhang, J., Chen, Q., Du, D., Wu, T., Wen, J., Wu, M., Zhang, Y., Yan, W., Zhou, S., Li, Y., et al. (2019) · Aging · doi:10.18632/aging.101784 · Cited by 103
Premature ovarian insufficiency
Nash, Z., & Davies, M. C. (2024) · BMJ · doi:10.1136/bmj-2023-077469 · Cited by 106
Premature ovarian insufficiency, early menopause, and induced menopause
Hamoda, H., & Sharma, A. (2023) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2023.101823 · Cited by 103
The British Menopause Society and Women’s Health Concern recommendations on the management of women with premature ovarian insufficiency
Hamoda, H. (2017) · Post Reproductive Health · doi:10.1177/2053369117699358 · Cited by 84
The 2023 Practitioner’s Toolkit for Managing Menopause
Davis, S. R., Taylor, S., Hemachandra, C., Magraith, K. S., Ebeling, P. R., Jane, F., & Islam, R. M. (2023) · Climacteric · doi:10.1080/13697137.2023.2258783 · Cited by 108
Primary ovarian insufficiency: update on clinical and genetic findings
Federici, S., Rossetti, R., Moleri, S., Munari, E. V., Frixou, M., Bonomi, M., & Persani, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1464803 · Cited by 96
Premature ovarian insufficiency: A toolkit for the primary care physician
Lambrinoudaki, I. V., Paschou, S. Α., Lumsden, M. A., Faubion, S. S., Makrakis, E., Kalantaridou, S., & Panay, N. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.11.004 · Cited by 80
Physiological sex steroid replacement in premature ovarian failure: randomized crossover trial of effect on uterine volume, endometrial thickness and blood flow, compared with a standard regimen
O'Donnell, R. L., Warner, P., Lee, R. J., Walker, J., Bath, L., Kelnar, C. J. H., Wallace, W. H., & Critchley, H. (2012) · Human Reproduction · doi:10.1093/humrep/des004 · Cited by 68
Self-citation
Arterial hypertension in Turner syndrome
Groote, K. D., Demulier, L., Backer, J. F. A. D., Wolf, D. D., Schepper, J. D., T'Sjoen, G. G., & Backer, T. L. M. D. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000599 · Cited by 66
Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer
Gargus, E. S., Deans, R., Anazodo, A. C., & Woodruff, T. K. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.7023 · Cited by 67
Hormone supplementation for pubertal induction in girls
Matthews, D., Bath, L., Högler, W., Mason, A., Smyth, A., & Skae, M. S. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-311372 · Cited by 65
Self-citation
New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature
Federici, S., Goggi, G., Quinton, R., Giovanelli, L., Persani, L., Cangiano, B., & Bonomi, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab043 · Cited by 65
Endocrine disorders and fertility and pregnancy: An update
Bednarska‐Czerwińska, A., Zmarzły, N., Morawiec, E., Panfil, A., Bryś, K., Czarniecka, J., Остенда, А., Dziobek, K., Sagan, D., Boroń, D., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.970439 · Cited by 73
Sex hormone replacement therapy in Turner syndrome—impact on morbidity and mortality
Viuff, M. H., Berglund, A., Juul, S., Andersen, N. H., Stochholm, K., & Gravholt, C. H. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz039 · Cited by 62
The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up
Wijnen, M., Olsson, D. S., van den Heuvel‐Eibrink, M. M., Hammarstrand, C., Janssen, J. A. M. J. L., van der Lely, A. J., Johannsson, G., & Neggers, S. J. C. M. M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0387 · Cited by 59
Physiological Estrogen Replacement Therapy for Puberty Induction in Girls: A Clinical Observational Study
Ankarberg‐Lindgren, C., Kriström, B., & Norjavaara, E. (2014) · Hormone Research in Paediatrics · doi:10.1159/000356922 · Cited by 56
Assessing and addressing cardiovascular risk in adults with Turner syndrome
Turtle, E. J., Sule, A. A., Bath, L., Denvir, M. A., Gebbie, A. E., Mirsadraee, S., & Webb, D. J. (2012) · Clinical Endocrinology · doi:10.1111/cen.12104 · Cited by 54
Self-citation
Diagnosis and management of premature ovarian insufficiency
Rahman, R., & Panay, N. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101600 · Cited by 58
Sex hormone replacement in ovarian failure – new treatment concepts
Sassarini, J., Lumsden, M. A., & Critchley, H. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.010 · Cited by 51
Self-citation
Optimal Pubertal Induction in Girls with Turner Syndrome Using Either Oral or Transdermal Estradiol: A Proposed Modern Strategy
Donaldson, M., Kriström, B., Ankarberg‐Lindgren, C., Verlinde, S., van der Velden, J. A. E. M., Gawlik, A., van Gelder, M. M. H. J., Sas, T., & on behalf of the European Society for Paediatric Endocrinology Turner Syndrome Working Group (2019) · Hormone Research in Paediatrics · doi:10.1159/000500050 · Cited by 54
Cardiometabolic health in premature ovarian insufficiency
Stevenson, J. C., Collins, P. D., Hamoda, H., Lambrinoudaki, I. V., Maas, A. H. E. M., Maclaran, K., & Panay, N. (2021) · Climacteric · doi:10.1080/13697137.2021.1910232 · Cited by 56
Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows
Antza, C., Gallo, A., Boutari, C., Ershova, A. I., Gürses, K. M., Lewek, J., Mirmaksudov, M., Silbernagel, G., Sandstedt, J., & Lebedeva, А. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117272 · Cited by 70
Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists
Miller, V. M., Kaplan, J. R., Schork, N. J., Ouyang, P., Berga, S. L., WENGER, N. K., Shaw, L. J., Webb, R. C., Mallampalli, M. P., Steiner, M. S., et al. (2011) · Biology of Sex Differences · doi:10.1186/2042-6410-2-14 · Cited by 51
Hormonal replacement therapy in adolescents and young women with chemo- or radio-induced premature ovarian insufficiency: Practical recommendations
Cattoni, A., Parissone, F., Porcari, I., Molinari, S., Masera, N., Franchi, M. P., Cesaro, S., Gaudino, R., Passoni, P., & Balduzzi, A. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100730 · Cited by 51
Turner's syndrome: challenges of late diagnosis
Lee, M. C., & Conway, G. S. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70153-0 · Cited by 48
An Approach to the Patient With Delayed Puberty
Harrington, J., & Palmert, M. R. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac054 · Cited by 47
Fragile X Associated Primary Ovarian Insufficiency (FXPOI): Case Report and Literature Review
Fink, D. A., Nelson, L. M., Pyeritz, R. E., Johnson, J., Sherman, S. L., Cohen, Y., & Elizur, S. E. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00529 · Cited by 47
Epidemiology, Genetic Etiology, and Intervention of Premature Ovarian Insufficiency
Guo, T., Liu, H., Xu, B., Qi, Y., Xu, K., Wu, X., He, X., Qin, Y., & Chen, Z. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf011 · Cited by 48
Poor Compliance to Hormone Therapy and Decreased Bone Mineral Density in Women with Premature Ovarian Insufficiency
Bachelot, A., Nicolas, C., Gricourt, S., Dulon, J., Leban, M., Golmard, J. L., & Touraine, P. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164638 · Cited by 44
The British Menopause Society & Women’s Health Concern 2016 recommendations on hormone replacement therapy in menopausal women
Hamoda, H., Panay, N., Arya, R., Savvas, M., & on behalf of The British Menopause Society and Women’s Health Concern (2016) · Post Reproductive Health · doi:10.1177/2053369116680501 · Cited by 43
Reproductive Complications in Childhood Cancer Survivors
van Santen, H. M., van de Wetering, M. D., Bos, A. M. E., vd Heuvel-Eibrink, M. M., van der Pal, H. J., & Wallace, W. H. (2020) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2020.08.003 · Cited by 42
Self-citation
Heat-related mortality at the beginning of the twenty-first century in Rio de Janeiro, Brazil
Geirinhas, J. L., Russo, A., Libonati, R., Trigo, R. M., de Castro, L. C. O., Peres, L. F., Magalhães, M. D. A. F. M., & Nunes, B. (2020) · International Journal of Biometeorology · doi:10.1007/s00484-020-01908-x · Cited by 47
Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis
Cai, W.-Y., Luo, X., Wu, W., Song, J., Xie, N.-N., Duan, C., Wu, X., & Xu, J. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01041-w · Cited by 49
Bone and heart health in menopause
Nash, Z., Wattar, B. H. A., & Davies, M. C. (2022) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2022.03.002 · Cited by 43
Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism
Jayasena, C. N., Devine, K., Barber, K., Comninos, A. N., Conway, G. S., Crown, A. L., Davies, M. C., Ewart, A., Seal, L., Smyth, A., et al. (2024) · Clinical Endocrinology · doi:10.1111/cen.15097 · Cited by 45
Premature ovarian insufficiency – hormone replacement therapy and management of long-term consequences
Machura, P., Grymowicz, M., Rudnicka, E., Pięta, W., Calik-Ksepka, A., Skórska, J., & Smolarczyk, R. (2018) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2018.78559 · Cited by 35
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Memi, E., Pavli, P., Papagianni, M., Vrachnis, N., & Mastorakos, G. P. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09882-0 · Cited by 39
Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up
van Santen, H. M., van den Heuvel‐Eibrink, M. M., van de Wetering, M. D., & Wallace, W. H. (2019) · Hormone Research in Paediatrics · doi:10.1159/000495943 · Cited by 37
Self-citation
Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female DahlS.Z- Lepr fa /Lepr fa Rats as a New Animal Model of Metabolic Syndrome
Murase, T., Hattori, T., Ohtake, M., Nakashima, C., Takatsu, M., Murohara, T., & Nagata, K. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.180976 · Cited by 34
Hormone replacement therapy after treatment for a gynaecological malignancy
O'Donnell, R. L., Clement, K. M., & Edmondson, R. J. (2015) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000238 · Cited by 31
Hypertension in menopausal women: the effect and role of estrogen
Srivaratharajah, K., & Abramson, B. L. (2019) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001304 · Cited by 30
Aortic dissection in children and adolescents with Turner syndrome: risk factors and management recommendations
Turtle, E. J., Sule, A. A., Webb, D. J., & Bath, L. (2015) · Archives of Disease in Childhood · doi:10.1136/archdischild-2014-307080 · Cited by 29
Self-citation
Turner syndrome-issues to consider for transition to adulthood
Lucaccioni, L., Wong, S. C., Smyth, A. R., Lyall, H., Dominiczak, A. F., Ahmed, S. F., & Mason, A. (2014) · British Medical Bulletin · doi:10.1093/bmb/ldu038 · Cited by 28
Estrogen Replacement in Young Hypogonadal Women—Transferrable Lessons From the Literature Related to the Care of Young Women With Premature Ovarian Failure and Transgender Women
Swee, D. S., Javaid, U., & Quinton, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00685 · Cited by 28
Cardiovascular Disease and Primary Ovarian Insufficiency
Wellons, M. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1280918 · Cited by 28
Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis
Gonçalves, C. R., de Vasconcellos, A. S., Rodrigues, T. R., Comin, F. V., & dos Reis, F. M. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.02.006 · Cited by 27
Review of Hormone Replacement Therapy in Girls and Adolescents with Hypogonadism
Klein, K. O., & Phillips, S. A. (2019) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2019.04.010 · Cited by 27
Ovarian Damage during Chemotherapy in Autoimmune Diseases: Broad Health Implications beyond Fertility
Marder, W., Fisseha, S., Ganser, M. A., & Somers, E. C. (2012) · Clinical Medicine Insights Reproductive Health · doi:10.4137/cmrh.s10415 · Cited by 27
Care of the adult woman with Turner syndrome
Shah, S. S., Nguyen, H. H., & Vincent, A. J. (2018) · Climacteric · doi:10.1080/13697137.2018.1476969 · Cited by 27
Diagnosis and management of premature ovarian failure
Arora, P. K., & POLSON, D. W. (2011) · The Obstetrician & Gynaecologist · doi:10.1576/toag.13.2.67.27648 · Cited by 26
Relationships between central arterial stiffness, lean body mass, and absolute and relative strength in young and older men and women
Fahs, C. A., Thiebaud, R. S., Rossow, L. M., Loenneke, J. P., Bemben, D. A., & Bemben, M. G. (2017) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12467 · Cited by 26
Peri- and postmenopause—diagnosis and interventions interdisciplinary S3 guideline of the association of the scientific medical societies in Germany (AWMF 015/062): short version
Ortmann, O., Beckermann, M. J., Inwald, E. C., Strowitzki, T., Windler, E. E. T., Tempfer, C. M., & For the guideline group (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05682-4 · Cited by 28
Metabolic Changes in Patients with Premature Ovarian Insufficiency: Adipose Tissue Focus—A Narrative Review
Sanchez-García, M. L., León-Wu, K. S., Miguel-Ibáñez, R. D., López-Juárez, N., Ramírez‐Rentería, C., Espinosa-Cárdenas, E., Sosa, E., & García-Sáenz, M. R. (2025) · Metabolites · doi:10.3390/metabo15040242 · Cited by 28
Tailored hormonal approach in women with premature ovarian insufficiency
Fruzzetti, F., Palla, G., Gambacciani, M., & Simoncini, T. (2019) · Climacteric · doi:10.1080/13697137.2019.1632284 · Cited by 24
Turner Syndrome: transition from childhood to adolescence
Kosteria, I., & Kanaka‐Gantenbein, C. (2018) · Metabolism · doi:10.1016/j.metabol.2017.12.016 · Cited by 23
Primary ovarian insufficiency: Relation to changes in body composition and adiposity
Michalakis, K. G., & Coppack, S. W. (2012) · Maturitas · doi:10.1016/j.maturitas.2011.12.023 · Cited by 23
Effectiveness of exercise training on arterial stiffness and blood pressure among postmenopausal women: a systematic review and meta-analysis
Yang, D., Tao, S., Shao, M., Huang, L., Xiao, X., Zhang, J., Yao, R., & Sun, Z. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02589-y · Cited by 25
Cardiovascular health in patients with premature ovarian insufficiency. Management of long-term consequences
Podfigurna, A., & Męczekalski, B. (2018) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2018.78551 · Cited by 22
The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?”
Colonnello, E., Graziani, A., Rossetti, R., Voltan, G., Masi, D., Lubrano, C., Mariani, S., Watanabe, M., Isidori, A. M., Ferlin, A., et al. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf013 · Cited by 24
Clinical care of adult Turner syndrome--new aspects.
Trolle, C., Mortensen, K. H., Hjerrild, B., Cleemann, L. H., & Gravholt, C. H. (2012) · PubMed · Cited by 20
Premature ovarian failure after childhood cancer and risk of metabolic syndrome: a cross-sectional analysis
Netterlid, A., Mörse, H., Giwercman, A., Hénic, E., Åkesson, K., Erfurth, E.-M., & Elfving, M. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1275 · Cited by 20
Ovariectomy Via 12/15-lipoxygenase Augments Angiotensin II-Induced Hypertension and Its Pathogenesis in Female Mice
Dutta, S. R., Singh, P., & Malik, K. U. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.20836 · Cited by 20
Primary gonadal failure
Ladjouze, A., & Donaldson, M. (2019) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2019.101295 · Cited by 21
Premature ovarian insufficiency: a toolkit for the primary care physician
Lambrinoudaki, I. V., Paschou, S. Α., Lumsden, M. A., Faubion, S. S., Makrakis, E., Kalantaridou, S., & Panay, N. (2021) · Climacteric · doi:10.1080/13697137.2020.1859246 · Cited by 18
Late effects of cancer treatment
Toogood, A. A. (2011) · doi:10.1093/med/9780199235292.003.7133 · Cited by 18
Natural history of hypertension in Turner syndrome during a 12-year pragmatic interventional study
Sandahl, K., Wen, J., Erlandsen, M., Andersen, N. H., & Gravholt, C. H. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15292 · Cited by 17
Premature ovarian insufficiency: the need for evidence on the effectiveness of hormonal therapy
Upton, C. E., DANIELS, J. P., & Davies, M. C. (2021) · Climacteric · doi:10.1080/13697137.2021.1902496 · Cited by 17
Primary Ovarian Insufficiency and Ovarian Aging
Verrilli, L. E. (2023) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2023.08.004 · Cited by 16
A randomised controlled trial comparing the effects of micronized progesterone to medroxyprogesterone acetate on cardiovascular health, lipid metabolism and the coagulation cascade in women with premature ovarian insufficiency: Study protocol and review of the literature
Mittal, M., Savvas, M., Arya, R., McEniery, C. M., Narvekar, N. N., Cardozo, L., Panay, N., & Hamoda, H. (2013) · Menopause international · doi:10.1177/1754045313503635 · Cited by 14
Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions
Jones, L., Blair, J., Hawcutt, D. B., Lip, G. Y. H., & Shantsila, A. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003321 · Cited by 13
Impact of micronised progesterone and medroxyprogesterone acetate in combination with transdermal oestradiol on cardiovascular markers in women diagnosed with premature ovarian insufficiency or an early menopause: a randomised pilot trial
Mittal, M., McEniery, C. M., Supramaniam, P. R., Cardozo, L., Savvas, M., Panay, N., & Hamoda, H. (2022) · Maturitas · doi:10.1016/j.maturitas.2022.01.012 · Cited by 13

Authors: Langrish, J. P., Mills, N. L., Bath, L. E., Warner, P., Webb, D. J., Kelnar, C. J., Critchley, H. O. D., Newby, D. E., & Wallace, W. H. B.
Affiliations: University of Edinburgh (GB)
ORCID: Mills, Nicholas L.
Warner, Pamela
Webb, David J.
Critchley, Hilary O.D.
Newby, David E.
Wallace, W. Hamish B.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-05
Volume: 53
Issue: 5
Pages: 805-811
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.108.126516
OpenAlex: W2161581155
Cited by: 207
References: 37
Citations by year: 2026: 12 · 2025: 7 · 2024: 16 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 16 · 2019: 20 · 2018: 16 · 2017: 15 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 9
FWCI: 7.02
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: British Heart Foundation (FS/07/048)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: premature ovarian failure, sex hormone replacement therapy, transdermal estradiol, vaginal progesterone, ethinyl estradiol, norethisterone, cardiovascular health, blood pressure, arterial stiffness, renin-angiotensin system, angiotensin II, aldosterone, renal function, luteinizing hormone suppression, follicle-stimulating hormone
MeSH terms: Adult, Arteries, Blood Pressure, Female, Humans, Estrogen Replacement Therapy, Primary Ovarian Insufficiency, Cross-Over Studies, Blood Pressure Monitoring, Ambulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cardiovascular Effects of Physiological and Standard Sex Steroid Replacement Regimens in Premature Ovarian Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks