Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions

Jones, Lily; Blair, Joanne; Hawcutt, Daniel B.; Lip, Gregory Y.H.; Shantsila, Alena

doi:10.1097/hjh.0000000000003321

Cited by 13Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesBlood Pressure and Hypertension StudiesHormonal Regulation and Hypertension

The DOI matches its Crossref record; 115 of the 116 references it cites were found in a registry or an index.

Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions

Jones, Lily, Blair, Joanne, Hawcutt, Daniel B., Lip, Gregory Y.H., Shantsila, Alena·2023·Journal of Hypertension

DOI 10.1097/hjh.0000000000003321

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Abstract

Acquired cardiovascular diseases account for much of the increased risk of premature death in patients with Turner syndrome (TS). Hypertension is a major modifiable cardiovascular risk factor. It has a high prevalence in TS developing at an early age and thus leading to prolonged exposure to high blood pressure. The aetiology for hypertension in TS is largely unknown. It is likely multifactorial, and recent hypotheses include altered sympathetic tone, vasculopathy and endocrine factors. In this review article we aim to provide a comprehensive review of data on mechanisms of hypertension in TS and their implication for diagnostics and optimal choice of antihypertensive treatments. Ultimately this knowledge should help prevent hypertension-related complications, and improve quality of life and life expectancy for patients with TS.

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While hypertension is correlated with the presence of aortic dilation in TS, no studies have demonstrated that antihypertensive therapies slow or prevent aortic dilation.
“While hypertension is correlated with the presence of aortic dilation in TS, no studies have demonstrated that antihypertensive therapies slow or prevent aortic dilation.447,456,458”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [458]
Two systematic reviews of hypertension in pediatric and primarily adult TS case series were published in 2022.
“Two systematic reviews of hypertension in pediatric (127 full texts) and primarily adult (63 full texts) TS case series were published in 2022.453,458”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [458]

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Authors: Jones, L., Blair, J., Hawcutt, D. B., Lip, G. Y. H., & Shantsila, A.
Affiliations: University of Liverpool (GB)
Alder Hey Children's NHS Foundation Trust (GB)
Corresponding author: Shantsila, Alena
ORCID: Jones, Lily
Blair, Joanne
Hawcutt, Daniel B.
Lip, Gregory Y.H.
Shantsila, Alena
Venue: Journal of Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-11-02
Volume: 41
Issue: 2
Pages: 203-211
ISSN: 0263-6352 (ISSN-L)
1473-5598
DOI: 10.1097/hjh.0000000000003321
OpenAlex: W4313296101
Cited by: 13
References: 116
Citations by year: 2025: 5 · 2024: 8
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Locations: Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: Turner syndrome, hypertension, sympathetic nervous system, vasculopathy, hormonal factors, antihypertensive therapy, cardiovascular risk, premature mortality
MeSH terms: Antihypertensive Agents, Heart, Humans, Hypertension, Quality of Life, Turner Syndrome

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Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions

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