The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Evidence for Sympathetic Origins of Hypertension in Juvenile Offspring of Obese Rats
Open accessAbstract
Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, males: OffOb, 121.8±0.6 mm Hg versus OffCon, 115.0±0.5 mm Hg, n=6, P <0.01; females: OffOb, 125.4±0.4 mm Hg versus OffCon, 114.4±0.5 mm Hg, n=6, P <0.001), as was the mean arterial pressure response to restraint stress ( P <0.01). The pressor response to a leptin challenge was enhanced in OffOb rats (Δmean arterial pressure: OffOb, 9.7±0.8 mm Hg versus OffCon, 5.3±1.3 mm Hg; n=8; P <0.05). Renal tissue norepinephrine content ( P <0.001) and renin expression ( P <0.05) were markedly raised. Analysis of heart rate variability revealed an increased low:high frequency ratio in OffOb versus OffCon rats ( P <0.05). At 90 days, hypertension in OffOb rats persisted and was abolished by α1- and β-adrenergic blockade, and cardiovascular responses to phenylephrine or sodium nitroprusside indicated altered baroreceptor function. The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This suggests that cardiac afterload-dependent effects could be influencing the development of cardiac hypertrophy in adult offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Beyond the vasculature, the activity of the sodium-potassium ATPase [130] was significantly reduced, and the expression of renin [129] was increased in the kidneys from offspring of obese dams, which could also influence blood pressure.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
The cited source says what the claim attributes to it.
In the citing paper
“Notably, hypertension could be abolished with α- and β-adrenergic blockade.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
Samuelsson, A.-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101477 · Cited by 923
Self-citationRegion-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Bouret, S. G., Draper, S. J., & Simerly, R. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-03.2004 · Cited by 584
Maternal obesity at conception programs obesity in the offspring
Shankar, K., Harrell, A., Liu, X., Gilchrist, J. M., Ronis, M. J. J., & Badger, T. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2007 · Cited by 385
Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers
Japundžić, N., Grichois, M. L., Zitoun, P., Laude, D., & Elghozi, J. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90132-3 · Cited by 384
Kirk, S. L., Samuelsson, A., Argenton, M., Dhonye, H., Κalamatianos, T., Poston, L., Taylor, P. D., & Coen, C. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005870 · Cited by 381
Self-citationKhan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00354.2004 · Cited by 357
Self-citationRole of Selective Leptin Resistance in Diet-Induced Obesity Hypertension
Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319
Cited by
Sorted by citations
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Reynolds, R. M., Allan, K. M., Raja, E. A., Bhattacharya, S., McNeill, G., Hannaford, P. C., Sarwar, N., Lee, A. J., Bhattacharya, S., & Norman, J. E. (2013) · BMJ · doi:10.1136/bmj.f4539 · Cited by 571
Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
Drake, A. J., & Reynolds, R. M. (2010) · Reproduction · doi:10.1530/rep-10-0077 · Cited by 507
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 234
Maternal obesity, gestational weight gain and diet as determinants of offspring long term health
Poston, L. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.010 · Cited by 219
Self-citation
Metadata
- Authors
- Samuelsson, A.-M., Morris, A., Igosheva, N., Kirk, S. L., Pombo, J. M. C., Coen, C. W., Poston, L., & Taylor, P. D.
- Affiliations
- King's College London (GB)
- Venue
- Hypertension
- Published
- 2010-01
- Volume
- 55
- Issue
- 1
- Pages
- 76-82
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2154990899
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 22 · 2012: 9
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation (PG/06/067, FS/10/003/28163)
- Biotechnology and Biological Sciences Research Council (BB/H008845/1, BB/D523186/1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal obesity, offspring hypertension, sympathetic nervous system, leptin, norepinephrine, renin-angiotensin system, baroreceptor function, heart rate variability, restraint stress, alpha-1 adrenergic blockade, beta-adrenergic blockade, developmental programming, energy-dense diet
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Blood Pressure, Body Weight, Dietary Fats, Female, Hypertension, Kidney, Peptidyl-Dipeptidase A, Male, Norepinephrine, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Renin, RNA, Messenger, Sex Factors, Sympathetic Nervous System, Time Factors, Weaning, Rats, Sprague-Dawley, Baroreflex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
