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Evidence for Sympathetic Origins of Hypertension in Juvenile Offspring of Obese Rats
Open accessAbstract
Maternal obesity in rodents is associated with increased adiposity, impaired glucose tolerance, and hypertension in adult offspring. In this study we investigated the influence of maternal obesity in the rat on blood pressure and blood pressure regulatory pathways in juvenile and adult offspring. Obesity was induced before pregnancy in female Sprague-Dawley rats by feeding a highly palatable energy-dense diet. In juvenile animals (30 days of age), before the onset of obesity and hyperleptinemia, basal nighttime mean arterial pressure was significantly raised in the offspring of obese dams (OffOb) relative to offspring of controls (OffCon; mean arterial pressure, males: OffOb, 121.8±0.6 mm Hg versus OffCon, 115.0±0.5 mm Hg, n=6, P <0.01; females: OffOb, 125.4±0.4 mm Hg versus OffCon, 114.4±0.5 mm Hg, n=6, P <0.001), as was the mean arterial pressure response to restraint stress ( P <0.01). The pressor response to a leptin challenge was enhanced in OffOb rats (Δmean arterial pressure: OffOb, 9.7±0.8 mm Hg versus OffCon, 5.3±1.3 mm Hg; n=8; P <0.05). Renal tissue norepinephrine content ( P <0.001) and renin expression ( P <0.05) were markedly raised. Analysis of heart rate variability revealed an increased low:high frequency ratio in OffOb versus OffCon rats ( P <0.05). At 90 days, hypertension in OffOb rats persisted and was abolished by α1- and β-adrenergic blockade, and cardiovascular responses to phenylephrine or sodium nitroprusside indicated altered baroreceptor function. The exaggerated pressor response to leptin in OffOb rats was maintained. Hypertension in the offspring of obese rats may arise from persistent sympathoexcitatory hyperresponsiveness acquired in early stages of development.
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“This suggests that cardiac afterload-dependent effects could be influencing the development of cardiac hypertrophy in adult offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Samuelsson et al. [129] identified an enhanced response to sodium nitroprusside, an enhanced pressor response to phenylephrine and reduced baroreflex sensitivity in the 30- and 90-day-old offspring of obese dams.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
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“Beyond the vasculature, the activity of the sodium-potassium ATPase [130] was significantly reduced, and the expression of renin [129] was increased in the kidneys from offspring of obese dams, which could also influence blood pressure.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
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“Notably, hypertension could be abolished with α- and β-adrenergic blockade.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [129]
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Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
Samuelsson, A.-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101477 · Cited by 923
Self-citationRegion-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737
Bouret, S. G., Draper, S. J., & Simerly, R. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-03.2004 · Cited by 584
Maternal obesity at conception programs obesity in the offspring
Shankar, K., Harrell, A., Liu, X., Gilchrist, J. M., Ronis, M. J. J., & Badger, T. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2007 · Cited by 385
Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers
Japundžić, N., Grichois, M. L., Zitoun, P., Laude, D., & Elghozi, J. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90132-3 · Cited by 384
Kirk, S. L., Samuelsson, A., Argenton, M., Dhonye, H., Κalamatianos, T., Poston, L., Taylor, P. D., & Coen, C. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005870 · Cited by 381
Self-citationKhan, I. Y., Dekou, V., Douglas, G., Jensen, R., Hanson, M. A., Poston, L., & Taylor, P. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00354.2004 · Cited by 357
Self-citationRole of Selective Leptin Resistance in Diet-Induced Obesity Hypertension
Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319
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Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Reynolds, R. M., Allan, K. M., Raja, E. A., Bhattacharya, S., McNeill, G., Hannaford, P. C., Sarwar, N., Lee, A. J., Bhattacharya, S., & Norman, J. E. (2013) · BMJ · doi:10.1136/bmj.f4539 · Cited by 571
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Drake, A. J., & Reynolds, R. M. (2010) · Reproduction · doi:10.1530/rep-10-0077 · Cited by 507
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Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 234
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Poston, L. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.010 · Cited by 219
Self-citationLi, M., Sloboda, D. M., & Vickers, M. H. (2011) · Experimental Diabetes Research · doi:10.1155/2011/592408 · Cited by 217
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Alexander, B. T., Dasinger, J. H., & Intapad, S. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140036 · Cited by 224
Entringer, S., Buß, C., Swanson, J. M., Cooper, D. M., Wing, D. A., Waffarn, F., & Wadhwa, P. D. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/632548 · Cited by 176
Hasan, W. (2013) · Organogenesis · doi:10.4161/org.24892 · Cited by 152
Franco, J. G., Fernandes, T. P., Dias-Rocha, C. P., Calviño, C., Pazos-Moura, C. C., Lisboa, P. C., de Moura, E. G., & Trevenzoli, I. H. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240655 · Cited by 149
Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Obesity · doi:10.1002/oby.21165 · Cited by 128
Blackmore, H. L., Niu, Y., Fernandez-Twinn, D. S., Tarry-Adkins, J. L., Giussani, D. A., & Ozanne, S. E. (2014) · Endocrinology · doi:10.1210/en.2014-1383 · Cited by 127
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Stanford, K. I., Takahashi, H., So, K., Alves-Wagner, A. B., Prince, N. B., Lehnig, A. C., Getchell, K. M., Lee, M.-Y., Hirshman, M. F., & Goodyear, L. J. (2017) · Diabetes · doi:10.2337/db17-0098 · Cited by 114
Leptin in pregnancy and development: a contributor to adulthood disease?
Briffa, J. F., McAinch, A. J., Romano, T., Wlodek, M. E., & Hryciw, D. H. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2014 · Cited by 116
Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies
Zambrano, E., & Nathanielsz, P. W. (2013) · Nutrition Reviews · doi:10.1111/nure.12068 · Cited by 114
Maternal obesity and the developmental programming of hypertension: a role for leptin
Taylor, P. D., Samuelsson, A., & Poston, L. (2014) · Acta Physiologica · doi:10.1111/apha.12223 · Cited by 103
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Intapad, S., Tull, F. L., Brown, A. D., Dasinger, J. H., Ojeda, N. B., Fahling, J. M., & Alexander, B. T. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00645 · Cited by 94
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Ojeda, N. B., Grigore, D., & Alexander, B. T. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.092890 · Cited by 93
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Intapad, S., Ojeda, N. B., Dasinger, J. H., & Alexander, B. T. (2014) · Physiology · doi:10.1152/physiol.00045.2013 · Cited by 83
A common cause for a common phenotype: The gatekeeper hypothesis in fetal programming
McMullen, S., Langley‐Evans, S. C., Gambling, L., Lang, C., Swali, A., & McArdle, H. J. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.047 · Cited by 84
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Johnson, A. K., & Xue, B. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0068-5 · Cited by 80
Samuelsson, A., Matthews, P. A., Jansen, E., Taylor, P. D., & Poston, L. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00014 · Cited by 77
Self-citationPrior, L. J., Davern, P. J., Burke, S. L., Lim, K., Armitage, J. A., & Head, G. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02498 · Cited by 72
Beeson, J. H., Blackmore, H. L., Carr, S. K., Dearden, L., Duque-Guimarães, D. E., Kusinski, L. C., Pantaleão, L. C., Pinnock, A. G., Aiken, C. E., Giussani, D. A., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.06.009 · Cited by 73
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Kane, A. D., Herrera, E. A., Camm, E. J., & Giussani, D. A. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0311 · Cited by 69
Menting, M. D., Mintjens, S., van de Beek, C., Frick, C., Ozanne, S. E., Limpens, J., Roseboom, T. J., Hooijmans, C. R., van Deutekom, A. W., & Painter, R. C. (2019) · Obesity Reviews · doi:10.1111/obr.12817 · Cited by 75
Programming of cardiovascular disease across the life-course
Blackmore, H. L., & Ozanne, S. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.006 · Cited by 71
Maternal Exercise Improves the Metabolic Health of Adult Offspring
Harris, J. E., Baer, L. A., & Stanford, K. I. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.01.003 · Cited by 65
Penfold, N., & Ozanne, S. E. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.015 · Cited by 62
Jackson, C. M., Alexander, B. T., Roach, L. A., Haggerty, D., Marbury, D. C., Hutchens, Z. M., Flynn, E. R., & Maric‐Bilkan, C. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00491.2011 · Cited by 61
Developmental origins of obesity‐related hypertension
Henry, S. L., Barzel, B., Wood‐Bradley, R. J., Burke, S. L., Head, G. A., & Armitage, J. A. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05579.x · Cited by 60
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Oben, J. A., Patel, T., Mouralidarane, A., Samuelsson, A., Matthews, P. A., Pombo, J., Morgan, M. L., McKee, C. M., Soeda, J., Novelli, M. R., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.057 · Cited by 58
Self-citationGademan, M. G. J., van Eijsden, M., Roseboom, T. J., van der Post, J., Stronks, K., & Vrijkotte, T. G. M. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01511 · Cited by 58
Remacle, C., Bieswal, F., Bol, V., & Reusens, B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001651 · Cited by 55
Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood
Matthews, P. A., Samuelsson, A., Seed, P. T., Pombo, J., Oben, J. A., Poston, L., & Taylor, P. D. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212324 · Cited by 51
Self-citationChowdhury, S., Lecomte, V., Erlich, J., Maloney, C., & Morris, M. J. (2016) · Nutrients · doi:10.3390/nu8090521 · Cited by 54
Samuelsson, A., Clark, J., Rudyk, O., Shattock, M. J., Bae, S., South, T., Pombo, J., Redington, K. L., Uppal, E., Coen, C. W., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00691 · Cited by 49
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Dasinger, J. H., Davis, G. K., Newsome, A. D., & Alexander, B. T. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06603 · Cited by 51
Xue, B., Zhang, Y., & Johnson, A. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00650 · Cited by 47
Maternal diet-induced obesity and offspring cardiovascular health
Blackmore, H. L., & Ozanne, S. E. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000761 · Cited by 46
Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring
Inzani, I., & Ozanne, S. E. (2022) · Proceedings of The Nutrition Society · doi:10.1017/s0029665122001914 · Cited by 45
Maternal Obesity and the Fetal Origins of the Metabolic Syndrome
Rkhzay-Jaf, J., O’Dowd, J. F., & Stocker, C. J. (2012) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-012-0257-x · Cited by 45
Early life stress sensitizes the renal and systemic sympathetic system in rats
Loria, A. S., Brands, M. W., Pollock, D. M., & Pollock, J. S. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00008.2013 · Cited by 43
Richter, V., Briffa, J. F., Moritz, K. M., Wlodek, M. E., & Hryciw, D. H. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12505 · Cited by 42
Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity
Samuelsson, A., Mullier, A., Maicas, N., Oosterhuis, N. R., Bae, S., Novoselova, T. V., Chan, L. F., Pombo, J., Taylor, P. D., Joles, J. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607464113 · Cited by 40
Self-citationDalrymple, K. V., Tydeman, F. A. S., Taylor, P. D., Flynn, A. C., O'Keeffe, M. M., Briley, A. L., Santosh, P., Hayes, L., Robson, S. C., Nelson, S. M., et al. (2020) · Pediatric Obesity · doi:10.1111/ijpo.12725 · Cited by 40
Self-citationHiramatsu, L., Kay, J., Thompson, Z., Singleton, J. M., Claghorn, G. C., de Albuquerque, R. L., Ho, B. N., Ho, B., Sánchez, G., & Garland, T. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.06.008 · Cited by 38
Fardin, N. M., Oyama, L. M., & Campos, R. R. (2012) · Obesity · doi:10.1038/oby.2012.4 · Cited by 38
Gray, C. L., Harrison, C. J., Segovia, S. A., Reynolds, C. M., & Vickers, M. H. (2015) · Scientific Reports · doi:10.1038/srep09753 · Cited by 37
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Eitmann, S., Mátrai, P., Németh, D., Hegyi, P., Lukács, A., Bérczi, B., Czumbel, L. M., Kiss, I., Gyöngyi, Z., Varga, G., et al. (2022) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12859 · Cited by 35
Kereliuk, S. M., & Dolinsky, V. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084467 · Cited by 34
“Beyond the vasculature, the activity of the sodium-potassium ATPase [130] was significantly reduced, and the expression of renin [129] was increased in the kidneys from offspring of obese dams, which could also influence blood pressure.”
BackgroundPregnancy in obese women and mechanisms of increased cardiovascular risk in offspring
Cochrane, A. L. K., Murphy, M. P., Ozanne, S. E., & Giussani, D. A. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae671 · Cited by 33
Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0374-4 · Cited by 32
Influence of Maternal Nutritional Status on Vascular Function in the Offspring
Poston, L. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00086.x · Cited by 33
Self-citationZhang, Y., Huo, Y.-L., Fang, Z., Wang, X.-F., Li, J., Wang, H., Peng, W., Johnson, A. K., & Xue, B. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00698.2017 · Cited by 32
Early nutrition, epigenetics, and cardiovascular disease
Loche, E., & Ozanne, S. E. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000338 · Cited by 34
Flynn, E. R., Alexander, B. T., Lee, J., Hutchens, Z. M., & Maric‐Bilkan, C. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00433.2012 · Cited by 26
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Garland, T., Cadney, M. D., & Waterland, R. A. (2016) · Physiological and Biochemical Zoology · doi:10.1086/689775 · Cited by 27
Jawerbaum, A., & White, V. (2017) · Placenta · doi:10.1016/j.placenta.2017.02.009 · Cited by 26
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Gauda, E. B., Conde, S. V., Bassi, M., Zoccal, D. B., Colombari, D. S. A., Colombari, E., & Despotovic, N. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190031 · Cited by 32
Early nutrition, epigenetics, and cardiovascular disease.
Loche, E., & Ozanne, S. E. (2016) · Apollo (University of Cambridge) · doi:10.17863/cam.1243 · Cited by 24
Maragkoudaki, X., Naylor, M., Papacleovoulou, G., Stolarczyk, É., Rees, D., Pombo, J., Abu‐Hayyeh, S., Czajka, A., Howard, J. K., Malik, A. N., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00682-5 · Cited by 21
Self-citationCadney, M. D., Hiramatsu, L., Thompson, Z., Zhao, M., Kay, J., Singleton, J. M., de Albuquerque, R. L., Schmill, M. P., Wendy Saltzman, A., & Garland, T. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113389 · Cited by 23
Chen, K., Sun, D., Qu, S., Chen, Y., Wang, J., Zhou, L., José, P. A., Yang, Y., & Zeng, C. (2019) · Clinical Science · doi:10.1042/cs20190254 · Cited by 21
Ambrosetti, V., Guerra, M., Ramirez, L., Reyes, A., Álvarez, D., Olguín, S., Gonzalez‐Mañán, D., Fernandois, D., Sotomayor‐Zárate, R., & Cruz, G. (2016) · Endocrine · doi:10.1007/s12020-016-0858-0 · Cited by 20
Long, N., Nathanielsz, P. W., & Ford, S. P. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2011.12.002 · Cited by 20
Maternal obesity: focus on offspring cardiometabolic outcomes
Gambineri, A., Conforti, A., Nisio, A. D., Laudisio, D., Muscogiuri, G., Barrea, L., Savastano, S., & Colao, A. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0016-2 · Cited by 23
New Approaches to Quantifying Sympathetic Nerve Activity
Burke, S. L., Lambert, É., & Head, G. A. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0196-9 · Cited by 19
Rudyk, O., Makra, P., Jansen, E. H. J. M., Shattock, M. J., Poston, L., & Taylor, P. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025250 · Cited by 19
Self-citationNew perspectives on the origin of hypertension; the role of the hypothalamic melanocortin system
Samuelsson, A. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.080374 · Cited by 18
Self-citationWood‐Bradley, R. J., Henry, S. L., Vrselja, A., Newman, V., & Armitage, J. A. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0352 · Cited by 19
Yim, H. E., Ha, K. S., Bae, I. S., Yoo, K. H., Hong, Y. S., & Lee, J. W. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.04.020 · Cited by 18
Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review
Ludwig‐Walz, H., Schmidt, M., Günther, A. L. B., & Kroke, A. (2017) · Maternal and Child Nutrition · doi:10.1111/mcn.12561 · Cited by 16
Animal Foetal Models of Obesity and Diabetes – From Laboratory to Clinical Settings
Grzęda, E., Matuszewska, J., Ziarniak, K., Gertig-Kolasa, A., Krzyśko-Pieczka, I., Skowrońska, B., & Sliwowska, J. H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.785674 · Cited by 19
Taylor, P. D., Gu, H., Saunders, H., Fiori, F., Dalrymple, K. V., Sethupathi, P., Yamanouchi, L., Miller, F. A., Jones, B., Vieira, M. C., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01210-3 · Cited by 16
Self-citationMatuszak, O., Banach, W., Pogorzały, B., Muszyński, J., Mengesha, S. H., Bogdański, P., & Skrypnik, D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102062 · Cited by 16
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Raipuria, M., Hardy, G., Bahari, H., & Morris, M. J. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.05.011 · Cited by 16
Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3 · Cited by 23
Kelly, A. C., Rosario, F. J., Chan, J., Cox, L. A., Powell, T. L., & Jansson, T. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00263.2021 · Cited by 14
Schenewerk, A. L., Ramirez‐Perez, F. I., Foote, C. A., Ji, T., Martinez‐Lemus, L. A., & Rivera, R. M. (2013) · Reproduction · doi:10.1530/rep-13-0354 · Cited by 15
Paulino-Silva, K. M., & Costa‐Silva, J. H. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12628 · Cited by 14
Developmental programming of cardiovascular function: a translational perspective
Bourque, S. L., & Davidge, S. T. (2020) · Clinical Science · doi:10.1042/cs20191210 · Cited by 14
Granado, M., Fernández, N., Monge, L., Figueras, J. C., Carreño‐Tarragona, G., Amor, S., & Garcı́a-Villalón, Á. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054984 · Cited by 14
Ramirez‐Perez, F. I., Schenewerk, A. L., Coffman, K. L., Foote, C. A., Ji, T., Rivera, R. M., & Martinez‐Lemus, L. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112651 · Cited by 11
Li, L., Xue, J., Li, H., Ding, J. H., Wang, Y., & Wang, X. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0419-7 · Cited by 11
The Molecular Mechanisms of Offspring Effects from Obese Pregnancy
Dowling, D., & McAuliffe, F. M. (2013) · Obesity Facts · doi:10.1159/000350706 · Cited by 11
Metabolic control of ovarian function through the sympathetic nervous system: role of leptin
Astudillo-Guerrero, C., Paredes, A. H., Escobar, J., Fernandois, D., Barra, R., & Cruz, G. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1484939 · Cited by 10
Prenatal metformin treatment improves ovarian function in offspring of obese rats
Álvarez, D., Ceballo, K., Olguín, S., Martínez-Pinto, J., Maliqueo, M. A., Fernandois, D., Sotomayor‐Zárate, R., & Cruz, G. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0352 · Cited by 9
Hao, X., Long, X., Fan, L., Gou, J., Liu, Y., Fu, Y., Zhao, H., Xie, X., Wang, D., Liang, G., et al. (2024) · Hypertension Research · doi:10.1038/s41440-024-01754-z · Cited by 8
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Kelly, A. C., Chan, J., Powell, T. L., Cox, L. A., Jansson, T., & Rosario, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1178533 · Cited by 10
Cardiovascular Disease Risk Among Young Urban Women
Giardina, E. V., Paul, T. K., Hayes, D., & Sciacca, R. R. (2016) · Journal of Women s Health · doi:10.1089/jwh.2015.5697 · Cited by 7
Ahiante, B. O., Smith, W. T., Lammertyn, L., & Schutte, A. E. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-122236 · Cited by 7
Kett, M. M., & Denton, K. M. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01650 · Cited by 7
Maternal exercise and its beneficial effects on glucose metabolism in offspring
Zheng, J., Zhou, L.-Y., & Xiao, X.-H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000731 · Cited by 5
Karlen‐Amarante, M., Bassi, M., Barbosa, R. M., Sá, J. M., Menani, J. V., Colombari, E., Zoccal, D. B., & Colombari, D. S. A. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00013.2023 · Cited by 6
de Araújo, E. V., dos Santos, L. A. C., Speretta, G. F. F., Ferreira, G. D. A. H., Freire, M. O. D. L., de Santana, D. F., Carvalho‐Galvão, A., Cruz, J. C., Costa‐Silva, J. H., Braga, V. A., et al. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13174 · Cited by 6
Tamura, K., Ohki, K., Kobayashi, R., Uneda, K., Azushima, K., Ohsawa, M., Wakui, H., & Umemura, S. (2014) · Hypertension Research · doi:10.1038/hr.2014.105 · Cited by 4
Wang, A., Han, T.-L., Chen, Z., Zhou, X., Yu, X., Qi, H., Baker, P. N., & Zhang, H. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.05.001 · Cited by 4
Rahmouni, K. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.140764 · Cited by 4
Metadata
- Authors
- Samuelsson, A.-M., Morris, A., Igosheva, N., Kirk, S. L., Pombo, J. M. C., Coen, C. W., Poston, L., & Taylor, P. D.
- Affiliations
- King's College London (GB)
- Venue
- Hypertension
- Published
- 2010-01
- Volume
- 55
- Issue
- 1
- Pages
- 76-82
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2154990899
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 22 · 2012: 9
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation (PG/06/067, FS/10/003/28163)
- Biotechnology and Biological Sciences Research Council (BB/H008845/1, BB/D523186/1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal obesity, offspring hypertension, sympathetic nervous system, leptin, norepinephrine, renin-angiotensin system, baroreceptor function, heart rate variability, restraint stress, alpha-1 adrenergic blockade, beta-adrenergic blockade, developmental programming, energy-dense diet
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Blood Pressure, Body Weight, Dietary Fats, Female, Hypertension, Kidney, Peptidyl-Dipeptidase A, Male, Norepinephrine, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Renin, RNA, Messenger, Sex Factors, Sympathetic Nervous System, Time Factors, Weaning, Rats, Sprague-Dawley, Baroreflex, Rats
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