Trait Antagonism and the Progression of Arterial Thickening: Women With Antagonistic Traits Have Similar Carotid Arterial Thickness as Men
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A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk factors, low agreeableness and, in particular, low straightforwardness and low compliance, were associated with greater carotid thickening, measured concurrently and prospectively, and with increases in intima-media thickness over 3 years. Indeed, those in the bottom 10% of agreeableness had a 40% increase in risk for elevated intima-media thickness. Although men have thicker arterial walls, women with antagonistic traits had similar carotid thickening as antagonistic men. Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors.
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The increasing inclusion of biomarkers in personality-longevity studies is beginning to illuminate biological pathways such as systemic inflammation and artery calcification.
“Second, the increasing inclusion of biomarkers in personality-longevity studies is beginning to illuminate biological pathways such as systemic inflammation [65, 66, 218, 219] and artery calcification [220, 221]”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [220]
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- Authors
- Sutin, A. R., Scuteri, A., Lakatta, E. G., Tarasov, K. V., Ferrucci, L., Costa, P. T., Schlessinger, D., Uda, M., & Terracciano, A.
- Affiliations
- National Institute on Aging (US)
- ORCID
- Venue
- Hypertension
- Published
- 2010-10
- Volume
- 56
- Issue
- 4
- Pages
- 617-622
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC2950971
- OpenAlex
- W2131004909
- Cited by
- 21
- References
- 40
- Citations by year
- 2024: 1 · 2022: 2 · 2018: 1 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (ZIAAG000180, ZIAAG000197, ZIAAG000183)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- agreeableness, carotid intima-media thickness, cardiovascular risk factors, compliance, manipulativeness, aggression, sex differences
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Carotid Arteries, Carotid Artery Diseases, Cholesterol, Female, Hostility, Humans, Italy, Male, Middle Aged, Stress, Psychological, Triglycerides, Logistic Models, Tunica Intima, Disease Progression, Young Adult
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