Neuropeptide Y Promoter Polymorphism Modifies Effects of a Weight-Loss Diet on 2-Year Changes of Blood Pressure: The Preventing Overweight Using Novel Dietary Strategies Trial
Open accessAbstract
Neuropeptide Y (NPY) is implicated in the regulation of blood pressure (BP), and NPY pathways in the hypothalamus are sensitive to dietary fat. We evaluated the potential effect of a functional variant rs16147 located in the NPY gene promoter region on the association between 2-year diet intervention and change in multiple BP measures in the randomized Preventing Overweight Using Novel Dietary Strategies Trial. The NPY rs16147 was genotyped in 723 obese adults who were randomly assigned to 1 of 4 diets differing in the target percentages of energy derived from fat, protein, and carbohydrate. The changes of 4 BP phenotypes, including systolic BP, diastolic BP, pulse pressure, and mean arterial pressure, during 2-year diet intervention were analyzed. In the total participants and participants with hypertension, we observed significant and consistent interactions between rs16147 genotype and dietary fat intake on changes in multiple BP phenotypes at 2 years (all P for interactions <0.05). The risk allele (C allele) was associated with a greater reduction of BP phenotypes in response to low-fat diet, whereas an opposite genetic effect was observed in response to high-fat diet. In addition, the C allele was related to greater changes in 4 BP phenotypes in hypertensive compared with nonhypertensive participants. Our data suggest that NPY rs16147 may modulate the association between dietary fat intake and changes in BP phenotypes, and the C allele exerts a long-term beneficial effect on lowering BP in response to low-fat diet in obese and hypertensive subjects.
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Patients carrying certain polymorphisms related to obesity and hypertension seem more likely to benefit from dietary interventions for weight loss and blood pressure control.
“This is based on the observation that patients carrying certain polymorphisms related to obesity and hypertension seems more likely to benefit from dietary interventions for weight loss and blood pressure control (12;13).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [12]
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Cites
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039 · cited 2× · see citing works
“The hypothesis suggests that vulnerability genes or risk alleles may function more like plasticity genes, thereby rendering some individuals more responsive to environmental influences than others where genetic risk is either attenuated by a favorable environment or amplified by an adverse environment.(18,33) Consiste…”
BackgroundResultComparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804748 · Cited by 1,966 · cited 3× · see citing works
“Dietary intake was assessed in a random sample of 50% of the participants by a review of the 5-day diet record at baseline and by 24-hour recall during a telephone interview on 3 nonconsecutive days at 6 months and 2 years.(24) Biomarkers of nutrient intake were used to validate selfreported adherence to macronutrient…”
MethodSelf-citationVulnerability genes or plasticity genes?
Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.44 · Cited by 1,017 · cited 2× · see citing works
“Several previous studies have demonstrated that NPY pathways in the hypothalamus were responsive to the amounts of fat present in the ingested diet.(33,34) In animal studies, longterm feeding of high-fat diets led to decreased NPY levels in hypothalamus,(16,17) whereas feeding of low-fat diets led to an increased NPY…”
ResultDickinson, H. O., Mason, J. M., Nicolson, D. J., Campbell, F., Beyer, F. R., Cook, J. V., Williams, B., & Ford, G. A. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000199800.72563.26 · Cited by 759 · see citing works
Neuropeptide Y distribution in human brain
Adrian, T. E., Allen, J. M., Bloom, S. R., Ghatei, M. A., Rossor, M. N., Roberts, G. W., Crow, T. J., Tatemoto, K., & Polak, J. M. (1983) · Nature · doi:10.1038/306584a0 · Cited by 701 · see citing works
Neuropeptide Y: Anatomical distribution and possible function in mammalian nervous system
Gray, T. S., & Morley, J. E. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90061-5 · Cited by 501 · see citing works
Genetic variation in human NPY expression affects stress response and emotion
Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., et al. (2008) · Nature · doi:10.1038/nature06858 · Cited by 455 · cited 2× · see citing works
“Recently, a functional single nucleotide polymorphism (SNP) in the promoter region of NPY, rs16147 (C-399T), was found to be related to risks for early onset atherosclerosis(19) and ischemic stroke(20) and showed allele-specific effects on NPY gene expression and NPY peptide level.(19,21) However, no study has examine…”
BackgroundStudy, L. C., Wain, L. V., CardioGram, Verwoert, G. C., O’Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.922 · Cited by 427 · see citing works
DOMANSKI, M. J., Mitchell, G. F., Norman, J. E., Exner, D. V., Pitt, B., & Pfeffer, M. A. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00679-2 · Cited by 259 · cited 4× · see citing works
“Both PP and MAP are predictive of hypertension and cardiovascular disease.(22,23)”
BackgroundMethodInfluentialAucott, L., Poobalan, A., Smith, W. C. S., Avenell, A., Jung, R., & Broom, J. (2005) · Hypertension · doi:10.1161/01.hyp.0000165680.59733.d4 · Cited by 241 · see citing works
Obesity and hypertension: epidemiological and clinical issues
Macmohan, S., Cutler, J. A., Brittain, E., & HIGGINS, M. W. (1987) · European Heart Journal · doi:10.1093/eurheartj/8.suppl_b.57 · Cited by 237 · cited 1× · see citing works
“1169 Obesity frequently coexists with hypertension, and both are important risk factors for cardiovascular disease.(1) Many studies have shown that dietary intervention on weight loss resulted in lower blood pressure (BP), and weight reduction is recommended in major guidelines as primary intervention in the treatment…”
Backgroundde Souza, R. J., Bray, G. A., Carey, V. J., Hall, K. D., LeBoff, M. S., Loria, C. M., Laranjo, N. M., Sacks, F. M., & Smith, S. R. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.026328 · Cited by 192 · cited 1× · see citing works
“Biomarkers of nutrient intake were used to validate selfreported adherence to macronutrient targets as follows: high-density lipoprotein cholesterol for carbohydrate, urinary nitrogen excretion for protein, and respiratory quotient for fat.(24,25) Blood pressure was measured on 2 days at baseline and at 6, 12, and 24…”
MethodSelf-citationZheng, L., Sun, Z., Li, J., Zhang, R., Zhang, X., Liu, S., Li, J., Xu, Z., Hu, D., & Sun, Y. (2008) · Stroke · doi:10.1161/strokeaha.107.510677 · Cited by 161 · cited 1× · see citing works
“Both PP and MAP are predictive of hypertension and cardiovascular disease.(22,23)”
BackgroundSelf-citationHorvath, K. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.6.571 · Cited by 141 · see citing works
Qi, Q., Bray, G. A., Smith, S. R., Hu, F. B., Sacks, F. M., & Qi, L. (2011) · Circulation · doi:10.1161/circulationaha.111.025767 · Cited by 139 · cited 1× · see citing works
“Replicated quality control samples (10%) were included in every genotyping plate with >99% concordance.(26)”
MethodSelf-citationVelkoska, E., Cole, T. J., & Morris, M. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00505.2004 · Cited by 122 · see citing works
Long-term effects of weight-reducing diets in hypertensive patients
Siebenhofer, A., Jeitler, K., Berghold, A., Waltering, A., Hemkens, L. G., Semlitsch, T., Pachler, C., Strametz, R., & Horvath, K. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008274.pub2 · Cited by 121 · see citing works
Sommer, W. H., Lidström, J., Sun, H., Passer, D., Eskay, R. L., Parker, S. C. J., Witt, S. H., Zimmermann, U. S., Nieratschker, V., Rietschel, M., et al. (2010) · Human Mutation · doi:10.1002/humu.21299 · Cited by 104 · cited 1× · see citing works
“Additive genetic models were analyzed for genotype, following the previous reports.(27,28) Because the majority of the study population were white (80%), similar analyses were repeated in white participants.”
MethodNeuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
Shah, S. H., Freedman, N. J., Zhang, L., Crosslin, D. R., Stone, D. H., Haynes, C. S., Johnson, J., Nelson, S. C., Wang, L., Connelly, J. J., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000318 · Cited by 101 · cited 3× · see citing works
“Recently, a functional single nucleotide polymorphism (SNP) in the promoter region of NPY, rs16147 (C-399T), was found to be related to risks for early onset atherosclerosis(19) and ischemic stroke(20) and showed allele-specific effects on NPY gene expression and NPY peptide level.(19,21) However, no study has examine…”
BackgroundResultKarvonen, M. K., Valkonen, V.-P., Lakka, T. A., Salonen, R. M., Koulu, M., Pesonen, U., Tuomainen, T., Kauhanen, J., Nyyssönen, K., Lakka, H., et al. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00468-3 · Cited by 97 · cited 1× · see citing works
“Thus, we did not include low-frequency SNPs such as rs16139, which has also been previously reported.(35) In addition, although our study is thus far the largest and longest diet intervention trial on changes in BP, the size may be relatively small to detect small genetic effects or gene-diet interactions.”
ResultNeuropeptide Y: a possible role in hypertension?
Michel, M. C., & Rascher, W. (1995) · PubMed · Cited by 87 · see citing works
Buckland, P. R., Hoogendoorn, B., Guy, C., Coleman, S. L., Smith, S. K., Buxbaum, J. D., Haroutunian, V. H., & O’Donovan, M. C. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.023 · Cited by 74 · see citing works
Michel, M. C., & Rascher, W. (1995) · Journal of Hypertension · doi:10.1097/00004872-199504000-00003 · Cited by 69 · cited 8× · see citing works
“In contrast, when consuming a high-fat diet, carriers of the C allele with hypertension had a more unfavorable effect on BP.”
ResultInfluentialWitt, S. H., Buchmann, A. F., Blomeyer, D., Nieratschker, V., Treutlein, J., Esser, G., Schmidt, M. H., Bidlingmaier, M., Wiedemann, K., Rietschel, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.015 · Cited by 54 · cited 1× · see citing works
“Additive genetic models were analyzed for genotype, following the previous reports.(27,28) Because the majority of the study population were white (80%), similar analyses were repeated in white participants.”
MethodHypothalamic neuropeptide Y and plasma leptin after long-term high-fat feeding in the rat
Stricker‐Krongrad, A., Cumin, F., Burlet, C. R., & Beck, B. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00678-8 · Cited by 53 · see citing works
Baltatzi, M. S., Hatzitolios, A. I., Τζιόμαλος, Κ., Iliadis, F., & Zamboulis, C. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01823.x · Cited by 49 · cited 9× · see citing works
“In contrast, when consuming a high-fat diet, carriers of the C allele with hypertension had a more unfavorable effect on BP.”
BackgroundResultInfluentialNeuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases.
Pons, J., Lee, E. W., Li, L., & Kitlinska, J. B. (2004) · PubMed · Cited by 45 · see citing works
Dufficy, L., Naumovski, N., Ng, X., Blades, B. L., Yates, Z. R., Travers, C., Lewis, P., Sturm, J., Veysey, M. J., Roach, P. D., et al. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.009 · Cited by 41 · see citing works
Baltazi, M., Katsiki, N., Savopoulos, C. G., Iliadis, F. S., Koliakos, G., & Hatzitolios, A. I. (2011) · Europe PMC (PubMed Central) · Cited by 39 · see citing works
Plasma Neuropeptide Y and Catecholamines in Women and Men with Essential Hypertension
Wocial, B., Ignatowska-Switalska, H., Pruszczyk, P., Jędrusik, P., Januszewicz, A., Łapiński, M., Januszewicź, W., & Żukowska-Grójec, Z. (1995) · Blood Pressure · doi:10.3109/08037059509077586 · Cited by 34 · cited 1× · see citing works
“Previous studies showed that plasma NPY levels correlated with the BP levels(14) and were elevated in hypertensive patients.(15) In addition, NPY levels are modulated by dietary factors, especially dietary fat.”
BackgroundKim, N. S., Oh, S.-M., Ko, M. M., Ho, M., Kang, B. K., & Bang, O. S. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.07.012 · Cited by 32 · cited 1× · see citing works
“The NPY SNP has been previously related to several BP-related conditions, such as early onset atherosclerosis(19) and ischemic stroke.(20,31) Findings from the present study provide further support the significant association between the -6.”
ResultSchorr, U., Beige, J., Ringel, J., Turan, S., Kreutz, R. H., Distler, A., & Sharma, A. M. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715070-00002 · Cited by 32 · see citing works
Is neuropeptide Y a contributor to volume-induced hypertension?
Odar‐Cederlöf, I., ERICSSON, F., Theodorsson, E., & Kjellstrand, C. M. (1998) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(98)70049-6 · Cited by 27 · see citing works
Neuropeptide Y polymorphisms and ischemic stroke in Chinese population
Yu, J., Yu, N., Gao, S.-S., Song, J., Ma, T., Wang, N., Tang, Y.-C., Zhang, N., & Tan, L. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.11.011 · Cited by 26 · cited 1× · see citing works
“The NPY SNP has been previously related to several BP-related conditions, such as early onset atherosclerosis(19) and ischemic stroke.(20,31) Findings from the present study provide further support the significant association between the -6.”
ResultCoelho, E. F., Ferrari, M., Maximino, J. R., & Fior-Chadi, D. R. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.03.001 · Cited by 24 · see citing works
Kelly, T. N., Rice, T., Gu, D., Hixson, J. E., Chen, J., Liu, D., Jaquish, C. E., Bazzano, L., Hu, D., Ma, J., et al. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.118 · Cited by 23 · see citing works
Effects of Obesity Phenotype on Coronary Heart Disease Risk Factors in Response to Weight Loss
Okura, T., Tanaka, K., Nakanishi, T., Lee, D. J., Nakata, Y., Wee, S. W., & Shimokata, H. (2002) · Obesity Research · doi:10.1038/oby.2002.103 · Cited by 23 · see citing works
Michalkiewicz, M., Zhao, G., Jia, Z., Michalkiewicz, T., & Racadio, M. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000153953.69799.f2 · Cited by 19 · see citing works
Long-term effects of weight-reducing diets in hypertensive patients
Siebenhofer, A., Jeitler, K., Berghold, A., Hemkens, L. G., Waltering, A., & Horvath, K. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008274 · Cited by 12 · see citing works
Ilveskoski, E., Viiri, L. E., Mikkelsson, J., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.10.021 · Cited by 10 · see citing works
Generation of a subtraction mask for digital angiography based on the movement of the coronary
Haaker, P., Klotz, E., Koppe, R., & Linde, R. (1987) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a062160 · Cited by 7 · see citing works
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- [30]Appel LJ Sacks FM Carey VJ Obarzanek E Swain JF Miller ER 3rd Conlin PR Erlinger TP Rosner BA Laranjo NM Charleston J McCarron P Bishop LM Effects of protein, monounsaturated fat, carbohydrate intake on blood pressure and serum lipids: Results of the omniheart randomized trial JAMA 2005 294 2455 2464 16287956
- [38]Ronald L Simons MKL Steven R. H. Beach Gene H. Brody Robert A Philibert and Frederick X. Gibbons. Social environment, genes, and aggression: Evidence supporting the differential susceptibility perspective American Sociological Review 2011 76 883 912 PMC3244082 22199399
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Heianza, Y., & Qi, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040787 · Cited by 209 · see citing works
Self-citationObesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis
Rahmouni, K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.00920 · Cited by 150 · see citing works
Huang, T., Qi, Q., Li, Y., Hu, F. B., Bray, G. A., Sacks, F. M., Williamson, D. A., & Qi, L. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.082164 · Cited by 88 · see citing works
“This observation was similar to findings in our previous analyses on other phenotypes such as blood pressure (18) and insulin resistance (9).”
ResultSelf-citationAging and cardiovascular diseases: the role of gene-diet interactions
Corella, D., & Ordovás, J. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.08.002 · Cited by 83 · see citing works
Mansour, S., Alkhaaldi, S. M. I., Sammanasunathan, A. F., Ibrahim, S. M., Farhat, J., & Al‐Omari, B. (2024) · Nutrients · doi:10.3390/nu16050581 · Cited by 58 · see citing works
Kokubo, Y., Padmanabhan, S., Iwashima, Y., Yamagishi, K., & Goto, A. (2019) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-019-0771-2 · Cited by 56 · see citing works
“A 2-year-randomized intervention trial revealed significant interactions between the Neuropeptide Y (NPY) rs16147 SNP and dietary fat intake in relation to changes in SBP and DBP (Table 3) [26].”
BackgroundGene–diet interaction and weight loss
Qi, L. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000037 · Cited by 51 · see citing works
Self-citationThe role of neuropeptide Y in the pathophysiology of atherosclerotic cardiovascular disease
Zhu, P., Sun, W., Zhang, C.-L., Song, Z.-Y., & Lin, S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.138 · Cited by 45 · see citing works
Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial
Lin, X., Qi, Q., Zheng, Y., Huang, T., Lathrop, M. G., Zélénika, D., Bray, G. A., Sacks, F. M., Liang, L., & Qi, L. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.107276 · Cited by 43 · see citing works
Self-citationHuang, T., Huang, J., Qi, Q., Li, Y., Bray, G. A., Rood, J. C., Sacks, F. M., & Qi, L. (2014) · Diabetes Care · doi:10.2337/dc14-0473 · Cited by 41 · see citing works
“As we observed previously, the genotype effects on insulin resistance (14), blood pressure (18), and body weight (19) showed “reversion” patterns during weight regain in the POUNDS LOST trial.”
BackgroundSelf-citationEffect of Dipeptidyl Peptidase 4 Inhibition on Arterial Blood Pressure Is Context Dependent
Jackson, E. K., Mi, Z., Tofovic, S. P., & Gillespie, D. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04631 · Cited by 41 · see citing works
Bray, G. A., Krauss, R. M., Sacks, F. M., & Qi, L. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00353-1 · Cited by 41 · see citing works
Self-citationCorella, D., Coltell, Ó., Mattingley, G., Sorlí, J. V., & Ordovás, J. M. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1311208 · Cited by 40 · see citing works
Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children
Olza, J., Gil‐Campos, M., Leis, R., Rupérez, A. I., Tojo, R., Cañete, R., Gil, Á., & Aguilera, C. M. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.007 · Cited by 34 · see citing works
Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome
Louca, P., Menni, C., & Padmanabhan, S. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa022 · Cited by 32 · see citing works
Qi, Q., Xu, M., Wu, H., Liang, L., Champagne, C. M., Bray, G. A., Sacks, F. M., & Qi, L. (2013) · Diabetes Care · doi:10.2337/dc13-0018 · Cited by 31 · see citing works
Self-citationBray, G. A., Ryan, D. H., Johnson, W. D., Champagne, C. M., Johnson, C. M., Rood, J. C., Williamson, D. A., & Sacks, F. M. (2017) · Clinical Obesity · doi:10.1111/cob.12188 · Cited by 30 · see citing works
Self-citationNutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study
Franzago, M., Nicola, M. D., Fraticelli, F., Marchioni, M., Stuppia, L., & Vitacolonna, E. (2021) · Acta Diabetologica · doi:10.1007/s00592-021-01787-7 · Cited by 28 · see citing works
Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review
Bayer, S., Winkler, V., Hauner, H., & Holzapfel, C. (2020) · Nutrients · doi:10.3390/nu12092891 · Cited by 26 · see citing works
“Interaction of Genotype and Protein Intake on Weight Loss In total, seven publications assessed the interaction of genotype and protein intake on weight loss [39,40,42,43,46,49,51] (Table 4).”
BackgroundBerberine for Appetite Suppressant and Prevention of Obesity
Park, H.-J., Jung, E.-Y., & Shim, I. (2020) · BioMed Research International · doi:10.1155/2020/3891806 · Cited by 24 · see citing works
“Neuropeptide Y is a key peptide affecting adiposity and has been related to obesity risk such as food intake [26] and cardiovascular regulation [27, 28].”
BackgroundTang, H.-N., Xiao, F., Chen, Y., Zhuang, S.-Q., Guo, Y., Wu, H.-X., & Zhou, H.-D. (2020) · Mediators of Inflammation · doi:10.1155/2020/7903140 · Cited by 18 · see citing works
“Several studies also showed [23, 33] that the NPY rs16147 genotype could influence changes in abdominal adiposity in overweight or obese participants with dietary interventions.”
ResultParizadeh, S. A., Jamialahmadi, K., Rooki, H., Zaim-Kohan, H., Mirhafez, S. R., Hosseini, N., Mohiti-Ardakani, J., Moohebati, M., Masoudi-Kazemabad, A., Ferns, G. A., et al. (2014) · Annals of Human Biology · doi:10.3109/03014460.2014.916750 · Cited by 17 · see citing works
“The neuropeptide Y gene is highly polymorphic and several polymorphisms of the gene have been found to be associated with adiposity or obesity phenotypes, such as high body mass index (Patel et al., 2006; Sitticharoon et al., 2013; Zhang et al., 2012).”
BackgroundInterplay between diet and genetic susceptibility in obesity and related traits
Wang, T., Xu, M., Bi, Y., & Ning, G. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0648-6 · Cited by 17 · see citing works
de Luis, D. A., Izaola, O., de la Fuente, B., Primo, D., & Aller, R. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12406 · Cited by 13 · see citing works
de Luis, D. A., Izaola, O., de la Fuente, B., Primo, D., & Aller, R. (2016) · Lifestyle Genomics · doi:10.1159/000452131 · Cited by 13 · see citing works
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O'Connor, S. E., & Rudkowska, I. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2018.07.004 · Cited by 11 · see citing works
de Luis, D. A., Izaola, O., Primo, D., & Aller, R. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107825 · Cited by 10 · see citing works
de Luis, D. A., Izaola, O., Primo, D., & Aller, R. (2017) · Lifestyle Genomics · doi:10.1159/000478528 · Cited by 9 · see citing works
Guirette, M., Lan, J., Mckeown, N., Brown, M. R., Chen, H., de Vries, P. D., Kim, H., Rebholz, C., Morrison, A., Bartz, T., et al. (2024) · HYPERTENSION · doi:10.1161/hypertensionaha.123.22334 · Cited by 3 · see citing works
“9 Gene-diet interaction has also been examined in other general populations 10–13 ; however, these studies are limited to investigating specific dietary components such as sodium intake, 10 different types of dietary fat, 11,12 or caloric intake.”
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Jennings, G. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00863 · Cited by 10 · see citing works
Aller, R., Gómez, J. J. L., Izaola, O., Primo, D., & de Luis, D. A. (2019) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2018.10.007 · Cited by 7 · see citing works
Pacheco, D., Izaola, O., Primo, D., & de Luis, D. A. (2021) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2021.02.003 · Cited by 5 · see citing works
Černelič-Bizjak, M., Kenig, S., Petelin, A., Pražnikar, Z. J., & Mohorko, N. (2023) · Nutrition and Health · doi:10.1177/02601060231154464 · Cited by 5 · see citing works
“Peripheral NPY (pNPY) acts directly on fat tissue and mediates stress-induced obesity and metabolic syndrome (Kuo et al., 2007) and is important in immune (Wheway et al., 2005) and cardiovascular function (Pedrazzini et al., 1993; Zhang et al., 2012).”
Parizadeh, S. A., Jamialahmadi, K., Rooki, H., Mirhafez, S. R., Moohebati, M., Hosseini, N., Zaim-Kohan, H., Mohiti-Ardakani, J., Masoudi, A., Ferns, G. A., et al. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000367854 · Cited by 4 · see citing works
Genetics of Central Obesity and Body Fat
Heianza, Y., & Qi, L. (2019) · Nutrition in the Prevention and Treatment of Abdominal Obesity · doi:10.1016/b978-0-12-816093-0.00014-8 · Cited by 1 · see citing works
Self-citationRole of nutrigenomics in obesity, hypertension, and cardiovascular diseases
Lao-Polestico, R. R., Lim, M. V. B., Roy, M., Sankaralingam, P., Mariadoss, C. A., Sivaraj, A., & Mahankali, M. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824412-8.00013-8 · Cited by 2 · see citing works
The Challenging Chase for Nutrigenetic Predictors of Metabolic Responses to Dietary Interventions
Sarzynski, M. A., & Bouchard, C. (2013) · Diabetes Care · doi:10.2337/dc13-1399 · Cited by 1 · see citing works
de Luis, D. A., Primo, D., Izaola, O., Gómez, J. J. L., Hoyos, E. G., Ortolá, A., Delgado, E., & Díaz, G. (2020) · Nutrición Hospitalaria · doi:10.20960/nh.02941 · Cited by 1 · see citing works
Aller, R., Gómez, J. J. L., Izaola, O., Primo, D., & de Luis, D. A. (2019) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2019.04.002 · Cited by 1 · see citing works
Cano, R., & Iris, A. (2014) · Institutional Repository of the University of Granada (University of Granada)
Weber, C. I. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5637
Gene and Metabolic Environment Interactions in Obesity and Diabetes
Liang, J., & Teng, F. (2014)
Self-citationSong, Y., Choi, J., Park, J. M., Kwon, Y., Hong, K., & Lee, J. (2024) · Nutrients · doi:10.3390/nu16234147
“A few more studies were conducted regarding “healthy diets” such as the DASH diet score [30,31], dietary fat [32] or fatty acid intake [33,34], and dietary protein [35] or high energy intake [36].”
Kumari, B. (2025) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20253744
- Authors
- Zhang, X., Qi, Q., Liang, J., Hu, F. B., Sacks, F. M., & Qi, L.
- Affiliations
- Brigham and Women's Hospital (US)
- From the Departments of Nutrition (X.Z., Q.Q., J.L., F.B.H., F.M.S., L.Q.) and Epidemiology (F.B.H.), Harvard School of Public Health, Boston, MA; Department of Occupational and Environmental Health and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.Z.); Department of Endocrinology, Central Hospital of Xuzhou, Xuzhou, China (J.L.); and Channing Laboratory, Department of Medicine,...
- Venue
- Hypertension
- Published
- 2012-11
- Volume
- 60
- Issue
- 5
- Pages
- 1169-1175
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3869086
- OpenAlex
- W2141514407
- Cited by
- 44
- References
- 38
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 9 · 2013: 5
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- American Heart Association
- University of Southern California
- National Natural Science Foundation of China
- Program for New Century Excellent Talents in University
- National Heart, Lung, and Blood Institute (R01HL071981, HL-071981)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091718, DK091718, P30DK046200, DK46200.)
- National Center for Research Resources (M01RR002635)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- neuropeptide Y, blood pressure, dietary fat intake, low-fat diet, high-fat diet, obesity, gene-diet interaction, pulse pressure, mean arterial pressure, systolic and diastolic blood pressure, weight loss diet
- MeSH terms
- Adult, Alleles, Blood Pressure, Diet, Reducing, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Neuropeptide Y, Obesity, Promoter Regions, Genetic, Time Factors, Treatment Outcome, Polymorphism, Single Nucleotide, Overweight
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