The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction: Relationship to Clinical Outcome
Open accessAbstract
Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR). In this study, spiral artery remodeling and extravillous-cytotrophoblast were examined in placental bed biopsies from normal pregnancy (n=25), preeclampsia (n=22), and severe FGR (n=10) and then compared with clinical parameters. Biopsies were immunostained to determine vessel wall integrity, extravillous-cytotrophoblast location/density, periarterial fibrinoid, and endothelium. Muscle disruption was reduced in myometrial spiral arteries in preeclampsia ( P =0.0001) and FGR ( P =0.0001) compared with controls. Myometrial vessels from cases with birth weight <5th percentile ( P <0.001), abnormal uterine Doppler ( P <0.01), abnormal umbilical artery Doppler ( P <0.001), and preterm delivery ( P <0.001) had less muscle destruction compared with >5th percentile. Fewer extravillous-cytotrophoblast surrounded both decidual and myometrial vessels in the normal group and preeclampsia group compared with the FGR group ( P =0.001). For myometrial vessels, the normal group contained more intramural extravillous-cytotrophoblast than in preeclampsia ( P =0.015). Decidual vessels in the FGR group had less fibrinoid deposition compared with controls ( P =0.013). For myometrial vessels, less fibrinoid was deposited in both the preeclampsia group ( P =0.0001) and the FGR group ( P =0.01) when compared with controls, and less fibrinoid was deposited in the preeclampsia group when compared with FGR group ( P <0.001). Myometrial vessels obtained from birth weights <5th percentile had less periarterial fibrinoid than those with >5th percentile ( P <0.02). A major defect in myometrial spiral artery remodeling occurs in preeclampsia and FGR that is linked to clinical parameters. Interstitial extravillous-cytotrophoblast is not reduced in preeclampsia but is increased in FGR.
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Latest Advances in Understanding Preeclampsia
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The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies
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Cited by
Pre-eclampsia: pathophysiology and clinical implications
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250
Pathophysiology of placental-derived fetal growth restriction
Burton, G. J., & Jauniaux, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.577 · Cited by 1,070
Dimitriadis, E., Rolnik, D. L., Zhou, W., Estrada-Gutierrez, G., Koga, K., Francisco, R. P. V., Whitehead, C., Hyett, J., da Silva Costa, F., Nicolaides, K., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00417-6 · Cited by 866
Why is placentation abnormal in preeclampsia?
Fisher, S. J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.042 · Cited by 630
Garovic, V. D., Dechend, R., Easterling, T., Karumanchi, S. A., McMurtry Baird, S., Magee, L. A., Rana, S., Vermunt, J. V., August, P., & on behalf of the American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, K. I. H. D. S. C. C. O. A. (2022) · Hypertension · doi:10.1161/hyp.0000000000000208 · Cited by 598
Metadata
- Authors
- Lyall, F., Robson, S. C., & Bulmer, J. N.
- Venue
- Hypertension
- Published
- 2013-12
- Volume
- 62
- Issue
- 6
- Pages
- 1046-1054
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2141003443
- Cited by
- 502
- References
- 40
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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