Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241 · see citing works

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979 · see citing works

EDHF: bringing the concepts together

Busse, R., Edwards, G., Félétou, M., Fleming, I., Vanhoutte, P. M., & Weston, A. H. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02050-3 · Cited by 822 · see citing works

Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)

Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818 · cited 1× · see citing works

Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721 · see citing works

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

Matoba, T., Shimokawa, H., Nakashima, M., Hirakawa, Y., Mukai, Y., Hirano, K., Kanaide, H., & Takeshita, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10506 · Cited by 721 · see citing works

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622 · see citing works

Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences

Cai, H. “. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.06.021 · Cited by 568 · see citing works

Measurement of Reactive Oxygen Species in Cardiovascular Studies

Dikalov, S., Griendling, K. K., & Harrison, D. G. (2007) · Hypertension · doi:10.1161/01.hyp.0000258594.87211.6b · Cited by 532 · see citing works

Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation

Burgoyne, J. R., Madhani, M., Cuello, F., Charles, R. L., Brennan, J. P., Schröder, E., Browning, D. D., & Eaton, P. (2007) · Science · doi:10.1126/science.1144318 · Cited by 457 · see citing works

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

Heitzer, T., Krohn, K., Albers, S., & Meinertz, T. (2000) · Diabetologia · doi:10.1007/s001250051551 · Cited by 427 · see citing works

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h815 · Cited by 376 · see citing works

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

Ray, R., Murdoch, C. E., Wang, M., Santos, C. X. C., Zhang, M., Alom-Ruiz, S. P., Anilkumar, N. P., Ouattara, A., Cave, A. C., Walker, S. J., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219238 · Cited by 325 · see citing works

Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 321 · see citing works

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

Crabtree, M. J., Tatham, A. L., Hale, A. B., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041483 · Cited by 210 · see citing works

Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo

Bendall, J. K., Alp, N. J., Warrick, N., Cai, S., Adlam, D., Rockett, K. A., Yokoyama, M., Kawashima, S., & Channon, K. M. (2005) · Circulation Research · doi:10.1161/01.res.0000187447.03525.72 · Cited by 209 · see citing works

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805403200 · Cited by 200 · see citing works

Tetrahydrobiopterin

Channon, K. M. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.10.003 · Cited by 196 · see citing works

Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice

Alp, N. J., McAteer, M. A., Khoo, J., Choudhury, R. P., & Channon, K. M. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000115637.48689.77 · Cited by 194 · see citing works

Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes

Bitar, M. S., Wahid, S., Mustafa, S., Al‐Saleh, E., Dhaunsi, G. S., & Al‐Mulla, F. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.014 · Cited by 174 · see citing works

Reactive Oxygen Species Mediate Endothelium-Dependent Relaxations in Tetrahydrobiopterin-Deficient Mice

Cosentino, F., Barker, J. E., Brand, M. P., Heales, S., Werner, E. R., Tippins, J. R., West, N. E. J., Channon, K. M., Volpe, M., & Lüscher, T. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.496 · Cited by 171 · see citing works

Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice

Bendall, J. K., Rinze, R., Adlam, D., Tatham, A. L., de Bono, J., & Channon, K. M. (2007) · Circulation Research · doi:10.1161/01.res.0000263381.83835.7b · Cited by 157 · see citing works

Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension

Khoo, J. P., Zhao, L., Alp, N. J., Bendall, J. K., Nicoli, T., Rockett, K. A., Wilkins, M. R., & Channon, K. M. (2005) · Circulation · doi:10.1161/01.cir.0000162470.26840.89 · Cited by 153 · see citing works

Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase

Wolin, M. S., & Burke, T. M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90623-1 · Cited by 63 · see citing works

GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

Tatham, A. L., Crabtree, M. J., Warrick, N., Cai, S., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807959200 · Cited by 61 · see citing works

Induction of vascular relaxation by hydroperoxides

Thomas, G. R., & Ramwell, P. W. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80085-7 · Cited by 58 · see citing works

Inhibition of Tetrahydrobiopterin Synthesis Reducesin VivoNitric Oxide Production in Experimental Endotoxic Shock

Bune, A. J., Brand, M. P., Heales, S., Shergill, J. K., Cammack, R., & Cook, H. T. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0348 · Cited by 44 · see citing works

Tetrahydrobiopterin deficiency and brain nitric oxide synthase in thehph1 mouse

Brand, M. P., Heales, S., Land, J. M., & Clark, J. B. (1994) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00711370 · Cited by 41 · see citing works

EPR quantification of vascular nitric oxide production in genetically modified mouse models

Khoo, J. P., Alp, N. J., Bendall, J. K., Kawashima, S., Yokoyama, M., Zhang, Y. H., Casadei, B., & Channon, K. M. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.04.003 · Cited by 33 · see citing works

Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension

Youn, J. Y., Wang, T., Blair, J., Laude, K. M., Oak, J., McCann, L. A., Harrison, D. G., & Cai, H. “. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00835.2011 · Cited by 32 · see citing works

Radiochemical HPLC detection of arginine metabolism: Measurement of nitric oxide synthesis and arginase activity in vascular tissue

de Bono, J. P., Warrick, N., Bendall, J. K., Channon, K. M., & Alp, N. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.008 · Cited by 32 · see citing works

Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta

Fujimoto, S., Mori, M., & Tsushima, H. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02825-x · Cited by 30 · see citing works

Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine

Pickert, G., Myrczek, T., Rückert, S., Weigert, A., Häußler, A., Ferreirós, N., Brüne, B., Lötsch, J., & Tegeder, I. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0927-7 · Cited by 21 · see citing works

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

Adlam, D., Herring, N., Douglas, G., de Bono, J. P., Li, D., Danson, E., Tatham, A. L., Lu, C.-J., Jennings, K. A., Cragg, S. J., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs005 · Cited by 17 · see citing works

Dihydrofolate reductase and biopterin recycling in cardiovascular disease

Crabtree, M. J., & Channon, K. M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.09.011 · Cited by 11 · see citing works

Endothelial dysfunction and vascular disease - a 30th anniversary update

Vanhoutte, P. M., Shimokawa, H., Feletou, M., & Tang, E. H. C. (2017) · Acta Physiologica · doi:10.1111/apha.12646 · Cited by 937 · see citing works

Endothelial Cell Metabolism in Normal and Diseased Vasculature

Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.302855 · Cited by 619 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update

Roumeliotis, S. K., Mallamaci, F., & Zoccali, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082359 · Cited by 295 · see citing works

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., et al. (2018) · Nature · doi:10.1038/s41586-018-0701-2 · Cited by 285 · see citing works

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Bailey, J. D., Diotallevi, M., NICOL, T., McNeill, E., Shaw, A., Chuaiphichai, S., Hale, A., Starr, A., Nandi, M., Stylianou, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.018 · Cited by 266 · see citing works

Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I

Zhou, Z., Mahdi, A., Tratsiakovich, Y., Zahorán, S., Kövamees, O., Nordin, F., Gonzalez, A. E. U., Alvarsson, M., Östenson, C., Andersson, D. C., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.052 · Cited by 184 · see citing works

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

McNeill, E., Crabtree, M. J., Sahgal, N., Patel, J., Chuaiphichai, S., Iqbal, A. J., Hale, A., Greaves, D. R., & Channon, K. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.575 · Cited by 150 · see citing works

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Latrémolière, A., Latini, A., Andrews, N., Cronin, S. J. F., Fujita, M., Gorska, K. I., Hovius, R., Romero, C., Chuaiphichai, S., Painter, M. W., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.033 · Cited by 117 · see citing works

Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification

Liu, Z., Dong, N., Hui, H., Wang, Y., Liu, F., Xu, L., Liu, M., Rao, Z., Yuan, Z., Shang, Y., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac037 · Cited by 78 · see citing works

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

Bailey, J. D., Shaw, A., McNeill, E., NICOL, T., Diotallevi, M., Chuaiphichai, S., Patel, J., Hale, A., Channon, K. M., & Crabtree, M. J. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.04.005 · Cited by 74 · see citing works

Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia

Sorop, O., van den Heuvel, M., van Ditzhuijzen, N. S., de Beer, V. J., HEINONEN, I. H. A., van Duin, R. W. B., Zhou, Z., Koopmans, S. J., Merkus, D., van der Giessen, W. J., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00458.2015 · Cited by 69 · see citing works

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice

Chuaiphichai, S., Crabtree, M. J., McNeill, E., Hale, A., Trelfa, L., Channon, K. M., & Douglas, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13728 · Cited by 52 · see citing works

Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice

Santhanam, A. V. R., d’Uscio, L. V., He, T., Das, P., Younkin, S. G., & Katušić, Z. S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13205 · Cited by 51 · see citing works

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

Douglas, G., Hale, A., Patel, J., Chuaiphichai, S., Zen, A. A. H., Rashbrook, V. S., Trelfa, L., Crabtree, M. J., McNeill, E., & Channon, K. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy078 · Cited by 49 · see citing works

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

Cronin, S. J. F., Rao, S., Tejada, M. A., Turnes, B. L., Licht‐Mayer, S., Omura, T., Brenneis, C., Jacobs, E., Barrett, L. B., Latrémolière, A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj1531 · Cited by 48 · see citing works

Tissue‐specific up‐regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus

Pernow, J., Kiss, A., Tratsiakovich, Y., & Climent, B. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13242 · Cited by 42 · see citing works

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

McNeill, E., Stylianou, E., Crabtree, M. J., Harrington-Kandt, R., Kolb, A.-L., Diotallevi, M., Hale, A., Bettencourt, P. J. G., Tanner, R., O’Shea, M. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07714-9 · Cited by 35 · see citing works

Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy

Silva, M., Martins, D., Charrua, A., Piscitelli, F., Tavares, I., Morgado, C., & Marzo, V. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.007 · Cited by 31 · see citing works

CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

Wang, C., Chao, Y., Xu, W., Liang, M., Deng, S., Zhang, D., & Huang, K. (2019) · Diabetes · doi:10.2337/db19-0635 · Cited by 30 · see citing works

Redox regulation of vascular remodeling

Galougahi, K. K., Ashley, E. A., & Ali, Z. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2068-y · Cited by 29 · see citing works

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

Chuaiphichai, S., Rashbrook, V. S., Hale, A., Trelfa, L., Patel, J., McNeill, E., Lygate, C. A., Channon, K. M., & Douglas, G. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11144 · Cited by 28 · see citing works

Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways

Lin, L., Jang, S., Zhu, J., Qin, Q., Sun, L., & Sun, J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103056 · Cited by 26 · see citing works

l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex

Heikal, L., Starr, A., Hussein, D. A., Prieto‐Lloret, J., Aaronson, P. I., Dailey, L. A., & Nandi, M. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.01.015 · Cited by 26 · see citing works

Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers

Channon, K. M. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_390 · Cited by 24 · see citing works

Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury

Feng, Y., Feng, Y., Gu, L., Mo, W., Wang, X., Song, B., Hong, M., Geng, F., Huang, P., Yang, H., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01208-z · Cited by 23 · see citing works

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Chuaiphichai, S., Starr, A., Nandi, M., Channon, K. M., & McNeill, E. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.08.009 · Cited by 22 · see citing works

Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients

Hübschmann, O. K., Mohr, A., Friedman, J., Manti, F., Horvath, G. A., Cortès‐Saladelafont, E., Mercimek‐Andrews, S., Yıldız, Y., Pons, R. M., Kulhánek, J., et al. (2021) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12360 · Cited by 19 · see citing works

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth

Chuaiphichai, S., Yu, G. Z., Tan, C., Whiteman, C. A. R., Douglas, G., Dickinson, Y., Drydale, E. N., Appari, M., Zhang, W., Crabtree, M. J., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.17646 · Cited by 19 · see citing works

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

Liu, Y., Baumgardt, S. L., Fang, J., Shi, Y., Qiao, S., Bosnjak, Z. J., Vasquez-Vivar, J. M., Xia, Z., Warltier, D. C., Kersten, J. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03234-6 · Cited by 19 · see citing works

Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain

Starkl, P. M., Jonsson, G., Artner, T., Turnes, B. L., Gail, L. M., Oliveira, T., Jain, A., Serhan, N., Stejskal, K., Lakovits, K., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adh0545 · Cited by 23 · see citing works

A novel and reliable method for tetrahydrobiopterin quantification: Benzoyl chloride derivatization coupled with liquid chromatography-tandem mass spectrometry analysis

Yuan, T.-F., Huang, H.-Q., Gao, L., Wang, S., & Li, Y. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.035 · Cited by 16 · see citing works

Development of an Adverse Outcome Pathway for the Onset of Hypertension by Oxidative Stress-Mediated Perturbation of Endothelial Nitric Oxide Bioavailability

Lowe, F., Luettich, K., Talikka, M., Hoang, V., Haswell, L. E., Hoeng, J., & Gaça, M. (2017) · Applied In Vitro Toxicology · doi:10.1089/aivt.2016.0031 · Cited by 17 · see citing works

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury

Chuaiphichai, S., Chu, S. M., Carnicer, R., Kelly, M., Bendall, J. K., Simon, J. N., Douglas, G., Crabtree, M. J., Casadei, B., & Channon, K. M. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00562.2022 · Cited by 16 · see citing works

Sepiapterin reductase gene‐disrupted mice suffer from hypertension with fluctuation and bradycardia

Sumi‐Ichinose, C., Suganuma, Y., Kano, T., Ihira, N., Nomura, H., Ikemoto, K., Hata, T., Katoh, S., Ichinose, H., & Kondo, K. (2017) · Physiological Reports · doi:10.14814/phy2.13196 · Cited by 16 · see citing works

The Inhibitory Effect of Ojeoksan on Early and Advanced Atherosclerosis

Han, B. H., Seo, C., Yoon, J. J., Kim, H. Y., Ahn, Y. M., Eun, S. Y., Hong, M. H., Lee, J., Shin, H., Lee, H. S., et al. (2018) · Nutrients · doi:10.3390/nu10091256 · Cited by 14 · see citing works

PHACTR1modulates vascular compliance but not endothelial function: a translational study

Wood, A., Antonopoulos, A. S., Chuaiphichai, S., Kyriakou, T., Diaz, R., Al-Hussaini, A., Marsh, A.-M., Sian, M., Meisuria, M., McCann, G. P., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac092 · Cited by 13 · see citing works

Parkinson’s disease-associated genetic variants synergistically shape brain networksPreprint

Chen, Z., Wu, B., Li, G., Zhou, L., Zhang, L., & Liu, J. (2022) · medRxiv · doi:10.1101/2022.12.25.22283938 · Cited by 10 · see citing works

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

Bailey, J. D., Davis, S. A., Shaw, A., Diotallevi, M., Fischer, R., Benson, M. A., Zhu, H., Brown, J., Bhattacharya, S., Kessler, B. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32481-4 · Cited by 9 · see citing works

Possible vasculoprotective role of linagliptin against sodium arsenite-induced vascular endothelial dysfunction

Jyoti, U., Kansal, S. K., Kumar, P., & Goyal, S. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1184-4 · Cited by 9 · see citing works

Validating the GTP ‐cyclohydrolase 1‐feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

Hussein, D. A., STARR, A. M., Heikal, L., McNeill, E., Channon, K. M., Brown, P. R., Sutton, B. J., McDonnell, J. M., & Nandi, M. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13202 · Cited by 9 · see citing works

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice

Chuaiphichai, S., Dickinson, Y., Whiteman, C. A. R., Au-Yeung, D., McNeill, E., Channon, K. M., & Douglas, G. (2023) · Vascular Pharmacology · doi:10.1016/j.vph.2023.107168 · Cited by 7 · see citing works

GTP Cyclohydrolase I as a Potential Drug Target: New Insights into Its Allosteric Modulation via Normal Mode Analysis

Khairallah, A., Ross, C. J., & Bishop, Ö. T. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00898 · Cited by 7 · see citing works

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neuronsPreprint

Cronin, S. J. F., Yu, W., Hale, A., Licht‐Mayer, S., Crabtree, M. J., Korecka, J. A., Tretiakov, E. O., Sealey‐Cardona, M., Somlyay, M., Onji, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539795 · Cited by 7 · see citing works

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria

Diotallevi, M., Outeiral, C., Patel, P., Purvis, G. S. D., Chuaiphichai, S., Nicol, T., Ayaz, F., Nissley, D. A., Krasnoselska, G. O., Hester, S., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01492-1 · Cited by 6 · see citing works

Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension

Dickinson, Y., Boehni, R., Obeid, R., Knapp, J.-P., Moser, R., Lewandowski, A. J., Douglas, G., Leeson, P., Channon, K. M., & Chuaiphichai, S. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.22838 · Cited by 6 · see citing works

Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward

Xia, W., Zhang, M., Liu, C., Wang, S., Xu, A., Xia, Z., Pang, L., & Cai, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122594 · Cited by 6 · see citing works

Erythropoietin Prevents Endothelial Dysfunction in GTP-cyclohydrolase I–deficient hph1 Mice

d’Uscio, L. V., Santhanam, A. V. R., & Katušić, Z. S. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000145 · Cited by 6 · see citing works

Does endothelial tetrahydrobiopterin control the endothelial NO synthase coupling state in arterial resistance arteries?

Münzel, T. F., & Daiber, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13827 · Cited by 5 · see citing works

Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk

Zhao, W., Yao, M., Zhang, Y., Xiong, D., Dai, G., Zhang, J., Cao, Y., & Li, H. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104348 · Cited by 5 · see citing works

eNOS Uncoupling: A Therapeutic Target For Ischemic Foot of Diabetic Rat

Gao, L., Yu, A., Liu, J., Ma, L., & Li, J. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-124763 · Cited by 5 · see citing works

Mast cell-derived BH4 is a critical mediator of postoperative painPreprint

Starkl, P. M., Jonsson, G., Artner, T., Turnes, B. L., Serhan, N., Oliveira, T., Gail, L. M., Stejskal, K., Channon, K. M., Köcher, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.24.525378 · Cited by 4 · see citing works

Inducible Endothelial Gch1 Deletion Reveals Rapid, Sex-Specific Effects on Blood Pressure and Pregnancy Outcomes

Chuaiphichai, S., Au-Yeung, D., Whiteman, C. A. R., Cook, S. L., McNeill, E., Douglas, G., & Channon, K. M. (2025) · Hypertension · doi:10.1161/hypertensionaha.125.25058 · Cited by 2 · see citing works

Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies

Cheng, C., Zhang, L., Lu, J., Tan, F., Huang, Y., Gao, S., Li, S., Qiu, Y., Hao, W., Zhou, Y., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.01.030 · Cited by 2 · see citing works

A Putative Guanosine Triphosphate Cyclohydrolase I Named CaGCH1 Is Involved in Hyphal Branching and Fruiting Development in Cyclocybe aegerita

Tao, N., Cheng, B., Chai, H., Cui, X., Ma, Y., Yan, J., Zhao, Y., & Chen, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.870658 · Cited by 1 · see citing works

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury

Chu, S. M., Heather, L. C., Chuaiphichai, S., NICOL, T., Wright, B., Miossec, M. J., Bendall, J. K., Douglas, G., Crabtree, M. J., Channon, K. M., et al. (2023) · Experimental Physiology · doi:10.1113/ep090795

Nutrients Intake and Hypertension

Fantin, F. (2020) · MDPI eBooks · doi:10.3390/books978-3-03928-663-8

Full Issue PDF

(2018) · JACC Basic to Translational Science · doi:10.1016/s2452-302x(18)30124-4

Faculty Opinions recommendation of Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Netea, M. G., & Domínguez‐Andrés, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736126018.793562936

Faculty Opinions recommendation of The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Ichinose, M., & Yamada, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734378603.793555631

Faculty Opinions recommendation of The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Chandel, N. S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734378603.793554283

Cardiomyocyte Tetrahydrobiopterin Synthesis Regulates Fatty Acid Metabolism and Susceptibility to Ischemia Reperfusion InjuryPreprint

Chu, S. M., Heather, L. C., Chuaiphichai, S., Nicol, T., Wright, B., Miossec, M. J., Lockstone, H. E., Bendall, J. K., Douglas, G., Crabtree, M. J., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4151379

FTO/m6A Regulate Prenatal Nicotine-Induced eNOS Uncoupling and BP Susceptibility

Liu, B., He, E., Li, N., Ye, Y., Li, Y., Yu, W., Liu, T., Shao, X. M., Zhang, L., Chen, Y., et al. (2026) · Hypertension · doi:10.1161/hypertensionaha.126.27374

Abstract 167: A Cell-Autonomous Role for Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Chuaiphichai, S., McNeill, E., Douglas, G., Crabtree, M. J., Bendall, J. K., Hale, A., Alp, N. J., & Channon, K. M. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.34.suppl_1.167

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation

Chuaiphichai, S., McNeill, E., Douglas, G., Crabtree, M. J., Bendall, J. K., Hale, A., Alp, N., & Channon, K. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu089.2

The requirement for endothelial cell tetrahydrobiopterin in health and disease

Chuaiphichai, S. (2014) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-qzkjnpkkb

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice

Chuaiphichai, S., Crabtree, M. J., McNeill, E., Hale, A., Trelfa, L., Channon, K. M., & Douglas, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13728 · Cited by 52 · see citing works

Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

Wang, S., Xu, J., Song, P., Wu, Y., Zhang, J., Choi, H. C., & Zou, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112094 · Cited by 110 · see citing works