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Office, Home, and Ambulatory Blood Pressures as Predictors of Cardiovascular Risk

Niiranen, Teemu J., Mäki, Juhani, Puukka, Pauli, Karanko, Hannu, Jula, Antti M.·2014·Hypertension

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Abstract

Ambulatory blood pressure (BP) is considered as the gold standard of BP measurement although it has not been shown to be more strongly associated with cardiovascular risk than is home BP. Our objective was to compare the prognostic value of office, home, and ambulatory BP for cardiovascular risk in 502 participants examined in 1992 to 1996. The end point was a composite of cardiovascular mortality, myocardial infarction, stroke, heart failure hospitalization, and coronary intervention. We assessed the prognostic value of each BP in multivariable-adjusted Cox models. The likelihood χ2 ratio value was used to test whether the addition of a BP variable improved the model’s goodness of fit. After a follow-up of 16.1±3.9 years, 70 participants (13.9%) had experienced ≥1 cardiovascular event. Office (systolic/diastolic hazard ratio per 1/1 mm Hg increase in BP, 1.024/1.018; systolic/diastolic 95% confidence interval, 1.009–1.040/0.994–1.043), home (hazard ratio, 1.029/1.028; 95% confidence interval, 1.013–1.045/1.005–1.052), and 24-hour ambulatory BP (hazard ratio, 1.033/1.049; 95% confidence interval, 1.019–1.047/1.023–1.077) were predictive of cardiovascular events. When all 3 BP variables were included in the model simultaneously, only systolic/diastolic ambulatory BP was a significant predictor of cardiovascular events (P=0.002/<0.001). Home systolic/diastolic BP improved the fit of the model only marginally when added to a model including office BP (χ2=3.0/4.0, P=0.09/0.047). Ambulatory BP, however, improved the fit of model more clearly when added to office and home BP (χ2=9.0/12.3, P=0.001/<0.001). Our findings suggest that ambulatory BP is prognostically superior to office and home BP.

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Authors: Niiranen, T. J., Mäki, J., Puukka, P., Karanko, H., & Jula, A. M.
Affiliations: Turku University Hospital (FI)
ORCID: Niiranen, Teemu J.
Jula, Antti M.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-08
Volume: 64
Issue: 2
Pages: 281-286
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.114.03292
OpenAlex: W2129391087
Cited by: 143
References: 31
Citations by year: 2026: 6 · 2025: 8 · 2024: 15 · 2023: 9 · 2022: 16 · 2021: 8 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 9 · 2016: 17 · 2015: 14 · 2014: 5
FWCI: 10.36
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords: home blood pressure, office blood pressure, cardiovascular risk, cardiovascular events, prognostic value, cardiovascular mortality, myocardial infarction, stroke, heart failure hospitalization, coronary intervention
MeSH terms: Adult, Blood Pressure, Blood Pressure Determination, Cardiovascular Diseases, Female, Humans, Hypertension, Male, Middle Aged, Risk Factors, Blood Pressure Monitoring, Ambulatory

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Office, Home, and Ambulatory Blood Pressures as Predictors of Cardiovascular Risk

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