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Cited by 30Blood Pressure and Hypertension StudiesGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesWilliams Syndrome Research

Pilot Study of Blood Pressure in Girls With Turner Syndrome: An Awareness Gap, Clinical Associations, and New Hypotheses

Los, Evan, Quezada, Emilio, Chen, Zunqiu, Lapidus, Jodi, Silberbach, Michael·2016·Hypertension
DOI 10.1161/hypertensionaha.115.07065
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Abstract

Cardiovascular disease is the major factor that reduces lifespan in Turner syndrome. High blood pressure (BP) is common in Turner syndrome and is the most easily treatable cardiovascular risk factor. We studied the prevalence of elevated screening systemic BP, awareness of the problem, and its clinical associations in a large group of girls attending the annual meeting of the Turner Syndrome Society of the United States. Among 168 girls aged 2 to 17 years, 42% had elevated screening BP (systolic and diastolic), yet only 8% reported a previous diagnosis of hypertension. History of aortic coarctation repair (17%) was positively associated with elevated systolic BP (52% versus 32%; P<0.05). Elevated systolic BP was positively associated with obesity (56% versus 31%; P<0.05). Because the prevalence of obesity in the studied population was similar to Center for Disease Control published data for obesity in all girls and the prevalence of increased BP is approximately twice that of the general population, the Turner syndrome phenotype/genotype probably includes an intrinsic risk for hypertension. Obesity and repaired aortic coarctation increase this risk further. There seems to be a BP awareness gap in girls with Turner syndrome. Because girls living with Turner syndrome are a sensitized population for hypertension, further study may provide clues to genetic factors leading to a better understanding of essential hypertension in the general population.

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Crossref · 10.1161/hypertensionaha.115.07065

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34 of 34 references verified0 citation errors · 0 not checkable

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  • The most frequently used indexing methods are the Z-score, the aortic height index (AHI), and the aortic size index (ASI).

    “The most frequently used indexing methods are the Z-score (Z, dimensionless unit indicating the number of standard deviations from the population mean), the aortic height index (AHI, aortic diameter in millimeters divided by body length in meters), and the aortic size index (ASI, aortic diameter in centimeters divided by body surface area (BSA) per square meters) (Table 12).232,233,441-443”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [441]

  • The prevalence of hypertension is as high as 20%-40% in children and up to 60% in adults with TS.

    “The prevalence of hypertension is as high as 20%-40% in children441,453 and up to 60% in adults with TS.357,452,454-456”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [441]

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Authors
Los, E., Quezada, E., Chen, Z., Lapidus, J., & Silberbach, M.
Affiliations
Oregon Health & Science University (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-07
Volume
68
Issue
1
Pages
133-136
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.115.07065
OpenAlex
W2407371908
Cited by
30
References
34
Citations by year
2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 2
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords
Turner syndrome, blood pressure screening, girls, aortic coarctation repair, obesity, essential hypertension, cardiovascular risk, hypertension awareness, prevalence
MeSH terms
Adolescent, Blood Pressure Determination, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Hypertension, Mass Screening, Obesity, Pilot Projects, Surveys and Questionnaires, Turner Syndrome, United States, Comorbidity, Body Mass Index, Prevalence, Confidence Intervals, Odds Ratio, Age Distribution, Risk Assessment

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