Cited by 9Blood Pressure and Hypertension StudiesGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and Disorders

The prevalence of hypertension in paediatric Turner syndrome: a systematic review and meta-analysis

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McCarrison, Sarah, Carr, Aoife, Wong, Sze Choong, Mason, Avril·2022·Journal of Human Hypertension

Abstract

Cardiovascular related deaths account for over 40% of the excess mortality in Turner syndrome (TS). Hypertension, a modifiable risk factor for both aortic dilatation and dissection, is more commonly encountered in TS during childhood and adolescence. Treatment of hypertension is currently recommended beyond the age of 16 years in TS to help reduce the risk of aortic dissection. This study aims to determine the prevalence of hypertension in paediatric patients with TS and explore the associated methodologies of blood pressure evaluation reported in these studies. Three online databases were searched (Medline, Embase and Web of Science) for literature which reported a prevalence, or allowed calculation of prevalence, of hypertension in patients with TS who were 18 years of age or younger. Seventeen studies which met the primary eligibility criteria, with a total of 1948 patients, were included. The estimated pooled prevalence of hypertension in children and adolescents with TS was 16% (95% CI: 8.9-24.6%). There was significant heterogeneity detected between the studies. The prevalence of hypertension in those studies which assessed 24-h Ambulatory Blood Pressure Monitoring (ABPM) was 21.1% (95% CI: 15.2-27.6%) compared those which used another method of blood pressure measurement which was 13.5% (95% CI: 5.2-24.4%). Given the impact of hypertension with long-term health outcomes and the reversibility of these same outcomes by addressing abnormal blood pressure, prompt and early diagnosis of hypertension in young girls with TS should be prioritised. We recommend the use of 24-h ABPM in screening for hypertension in the paediatric TS population.

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Authors
McCarrison, S., Carr, A., Wong, S. C., & Mason, A.
Affiliations
  • Royal Hospital for Children (GB)
  • University of Glasgow (GB)
Corresponding author
Mason, Avril
Venue
Journal of Human Hypertension
Published
2022-12-05
Volume
37
Issue
8
Pages
675-688
ISSN
  • 0950-9240 (ISSN-L)
  • 1476-5527
OpenAlex
W4310675947
Cited by
9
References
56
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3
FWCI
0.41
Type
journal article
Language
en
Open access
Locations
  • Journal of Human Hypertension (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
Turner syndrome, hypertension, pediatric hypertension, prevalence, ambulatory blood pressure monitoring, blood pressure measurement methods, aortic dissection, aortic dilatation, cardiovascular risk, hypertension screening, children and adolescents
MeSH terms
Adolescent, Blood Pressure, Child, Female, Humans, Hypertension, Turner Syndrome, Prevalence, Blood Pressure Monitoring, Ambulatory

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