Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine
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Splanchnic venous pooling is a major hemodynamic determinant of orthostatic hypotension, but is not specifically targeted by pressor agents, the mainstay of treatment. We developed an automated inflatable abdominal binder that provides sustained servo-controlled venous compression (40 mm Hg) and can be activated only on standing. We tested the efficacy of this device against placebo and compared it to midodrine in 19 autonomic failure patients randomized to receive either placebo, midodrine (2.5–10 mg), or placebo combined with binder on separate days in a single-blind, crossover study. Systolic blood pressure (SBP) was measured seated and standing before and 1-hour post medication; the binder was inflated immediately before standing. Only midodrine increased seated SBP (31±5 versus 9±4 placebo and 7±5 binder, P =0.003), whereas orthostatic tolerance (defined as area under the curve of upright SBP [AUC SBP ]) improved similarly with binder and midodrine (AUC SBP , 195±35 and 197±41 versus 19±38 mm Hg×minute for placebo; P =0.003). Orthostatic symptom burden decreased with the binder (from 21.9±3.6 to 16.3±3.1, P =0.032) and midodrine (from 25.6±3.4 to 14.2±3.3, P <0.001), but not with placebo (from 19.6±3.5 to 20.1±3.3, P =0.756). We also compared the combination of midodrine and binder with midodrine alone. The combination produced a greater increase in orthostatic tolerance (AUC SBP , 326±65 versus 140±53 mm Hg×minute for midodrine alone; P =0.028, n=21) and decreased orthostatic symptoms (from 21.8±3.2 to 12.9±2.9, P <0.001). In conclusion, servo-controlled abdominal venous compression with an automated inflatable binder is as effective as midodrine, the standard of care, in the management of orthostatic hypotension. Combining both therapies produces greater improvement in orthostatic tolerance. Clinical Trial Registration—: URL: https://www.clinicaltrials.gov . Unique identifier: NCT00223691.
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In a study of patients with autonomic failure, abdominal compression of 40 mmHg was as effective as midodrine.
“In a study of patients with autonomic failure, abdominal compression of 40 mmHg was as effective as midodrine (53).”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [53]
Graded compression garments and abdominal binders have improved symptoms of orthostatic intolerance in conditions associated with excessive blood pooling.
“Graded compression garments and abdominal binders have improved symptoms of orthostatic intolerance in conditions associated with excessive blood pooling (52, 53).”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [53]
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MDS clinical diagnostic criteria for Parkinson’s disease
Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., et al. (2015) · Movement Disorders · doi:10.1002/mds.26424 · Cited by 7,653 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Second consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140 · see citing works
Self-citationFreeman, R., Wieling, W., Axelrod, F. B., Benditt, D. G., Benarroch, E., Biaggioni, I., Cheshire, W. P., Chelimsky, T., Cortelli, P., Gibbons, C. H., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.02.004 · Cited by 1,243 · see citing works
Self-citationVenous Function and Central Venous Pressure
Gelman, S., Warner, D. S., & Warner, M. A. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181672607 · Cited by 573 · see citing works
Kaufmann, H. (1996) · Clinical Autonomic Research · doi:10.1007/bf02291236 · Cited by 376 · see citing works
The association between orthostatic hypotension and recurrent falls in nursing home residents
Ooi, W. L., Hossain, M., & Lipsitz, L. A. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00425-8 · Cited by 276 · see citing works
Prevalence of orthostatic hypotension
Low, P. A. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-007-1001-3 · Cited by 271 · see citing works
Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.
Goldstein, D. S., Eisenhofer, G., Stull, R., Folio, C. J., Keiser, H. R., & Kopin, I. J. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113298 · Cited by 245 · see citing works
The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
Kaufmann, H., Malamut, R. I., Norcliffe‐Kaufmann, L., Rosa, K., & Freeman, R. L. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0146-2 · Cited by 245 · see citing works
Continuous Invasive Blood Pressure and Cardiac Output Monitoring during Cesarean Delivery
Langesæter, E., Rosseland, L. A., & Stubhaug, A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31818a401f · Cited by 220 · see citing works
Mineralocorticoid-Induced Hypertension in Patients with Orthostatic Hypotension
Chobanian, A. V., Volicer, L., Tifft, C. P., Gavras, H. P., Liang, C., & Faxon, D. P. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907123010202 · Cited by 218 · see citing works
Importance of the splanchnic vascular bed in human blood pressure regulation
Rowell, L. B., Detry, J. M., Blackmon, J. R., & WYSS, C. R. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.2.213 · Cited by 176 · see citing works
Smit, A. J., Wieling, W., Fujimura, J., Denq, J., Opfer-Gehrking, T., Akarriou, M., Karemaker, J., & Low, P. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-0187-x · Cited by 153 · see citing works
Biaggioni, I., Freeman, R. L., Mathias, C. J., Low, P. A., Hewitt, L. A., & Kaufmann, H. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04035 · Cited by 145 · see citing works
Self-citationEfficacy of compression of different capacitance beds in the amelioration of orthostatic hypotension
Denq, J.-C., Opfer-Gehrking, T. L., Giuliani, M., Felten, J., Convertino, V. A., & Low, P. A. (1997) · Clinical Autonomic Research · doi:10.1007/bf02267725 · Cited by 138 · see citing works
Orthostatic hypotension and mortality risk: a meta-analysis of cohort studies
Xin, W., Lin, Z., & Mi, S. (2014) · Heart · doi:10.1136/heartjnl-2013-304121 · Cited by 114 · see citing works
Arnold, A. C., Okamoto, L. E., Gamboa, A. C., Shibao, C. A., Raj, S. R., Robertson, D., & Biaggioni, I. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00377 · Cited by 93 · see citing works
Self-citationPreservation of autoregulation of cerebral blood flow in autonomic failure
Thomas, D. J., & Bannister, R. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90127-6 · Cited by 81 · see citing works
Orthostatic Hypotension and Incident Chronic Kidney Disease
Franceschini, N., Rose, K. M., Astor, B. C., Couper, D. J., & Vupputuri, S. X. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156380 · Cited by 74 · see citing works
Segmental orthostatic fluid shifts
Diedrich, A., & Biaggioni, I. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-0188-9 · Cited by 70 · see citing works
Self-citationCampbell, I. W., Ewing, D. J., & Clarke, B. F. (1975) · Diabetes · doi:10.2337/diab.24.4.381 · Cited by 70 · see citing works
Treatment of Hypotension after Hyperbaric Tetracaine Spinal Anesthesia
Brooker, R. F., Butterworth, J. F. I., Kitzman, D. W., Berman, J. M., Kashtan, H. I., & McKinley, A. C. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00009 · Cited by 55 · see citing works
Okamoto, L. E., Shibao, C. A., Gamboa, A. C., Choi, L., Diedrich, A., Raj, S. R., Black, B. K., Robertson, D., & Biaggioni, I. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.184812 · Cited by 54 · see citing works
Self-citationAre Compression Stockings an Effective Treatment for Orthostatic Presyncope?
Protheroe, C. L., Dikareva, A., Menon, C., & Claydon, V. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028193 · Cited by 50 · see citing works
Wilkins, R. W., Culbertson, J. W., & Ingelfinger, F. J. (1951) · Journal of Clinical Investigation · doi:10.1172/jci102446 · Cited by 49 · see citing works
Figueroa, J. J., Singer, W., Sandroni, P., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. A., & Basford, J. R. (2014) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2014.10.012 · Cited by 48 · see citing works
Thulesius, O., Gj�res, J. E., & Berlin, E. (1979) · European Journal of Clinical Pharmacology · doi:10.1007/bf00568204 · Cited by 46 · see citing works
Orthostatic Hypotension and Cardiovascular Risk
Shibao, C. A., & Biaggioni, I. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.162768 · Cited by 46 · see citing works
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Sieker, H. O. (1956) · JAMA · doi:10.1001/jama.1956.02970020012003 · Cited by 35 · see citing works
Sharrock, N. E., Go, G., Mineo, R., & Harpel, P. C. (1992) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646293 · Cited by 35 · see citing works
Use of an Air Force Antigravity Suit in a Case of Severe Postural Hypotension
Stanford, W. L. (1961) · Annals of Internal Medicine · doi:10.7326/0003-4819-55-5-843 · Cited by 13 · see citing works
Aortic bloof low during sequential MAST inflation
Hauswald, M., & Greene, E. R. (1986) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(86)80613-8 · Cited by 12 · see citing works
9‐Alpha‐fluorohydrocortisone in the Treatment of Postural Hypotension
Frick, M. H. (1966) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1966.tb05461.x · Cited by 12 · see citing works
Calf venous compliance in multiple system atrophy
Lipp, A., Sandroni, P., Ahlskog, J. E., Maraganore, D. M., Shults, C. W., & Low, P. A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01208.2006 · Cited by 11 · see citing works
Application of USAF G-suit technology for clinical orthostatic hypotension: a case study.
Elizondo, L., Doerr, D., Sims, M., Hoffler, G. W., & Convertino, V. A. (1996) · PubMed · Cited by 5 · see citing works
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McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298 · see citing works
Gibbons, C. H., Schmidt, P., Biaggioni, I., Frazier-Mills, C., Freeman, R., Isaacson, S., Karabin, B., Kuritzky, L., Lew, M., Low, P., et al. (2017) · Journal of Neurology · doi:10.1007/s00415-016-8375-x · Cited by 455 · see citing works
Self-citationKaufmann, H., Norcliffe‐Kaufmann, L., & Palma, J. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1509723 · Cited by 271 · see citing works
Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
Palma, J., & Kaufmann, H. (2018) · Movement Disorders · doi:10.1002/mds.27344 · Cited by 246 · see citing works
Diagnosis and treatment of orthostatic hypotension
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Postural orthostatic tachycardia syndrome: mechanisms and new therapies
Mar, P. L., & Raj, S. R. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-041818-011630 · Cited by 122 · see citing works
Self-citationPhillips, A. A., Squair, J. W., Sayenko, D. G., Edgerton, V. R., Gerasimenko, Y., & Krassioukov, A. V. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5082 · Cited by 118 · see citing works
Orthostatic Hypotension in Parkinson Disease
Palma, J., & Kaufmann, H. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.09.002 · Cited by 109 · see citing works
Orthostatic hypotension: A review
Joseph, A., Wanono, R., Flamant, M., & Vidal‐Petiot, E. (2017) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2017.01.003 · Cited by 109 · see citing works
Management of Orthostatic Hypotension in Parkinson’s Disease
Fanciulli, A., Leys, F., Falup‐Pecurariu, C., Thijs, R. D., & Wenning, G. K. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202036 · Cited by 108 · see citing works
Orthostatic hypotension in older people: considerations, diagnosis and management
Dani, M., Dirksen, A., Taraborrelli, P., Panagopolous, D., Torocastro, M., Sutton, R., & Lim, P. B. (2021) · Clinical Medicine · doi:10.7861/clinmed.2020-1044 · Cited by 111 · see citing works
Magkas, N., Tsioufis, C. P., Thomopoulos, C., Dilaveris, P., Georgiopoulos, G. A., Sanidas, E. A., Papademetriou, V., & Tousoulis, D. M. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13521 · Cited by 95 · see citing works
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Palma, J., & Kaufmann, H. (2017) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12478 · Cited by 90 · see citing works
Magkas, N., Tsioufis, C. P., Thomopoulos, C., Dilaveris, P., Georgiopoulos, G. A., Doumas, M. N., Papadopoulos, D. P., & Tousoulis, D. M. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13491 · Cited by 89 · see citing works
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Juraschek, S. P., Cortez, M. M., Flack, J. M., Ghazi, L., Kenny, R. A., Rahman, M., Spikes, T. A., Shibao, C. A., & Biaggioni, I. (2024) · Hypertension · doi:10.1161/hyp.0000000000000236 · Cited by 80 · see citing works
Self-citationBourne, K. M., Sheldon, R. S., Hall, J., Lloyd, M., Kogut, K., Sheikh, N., Jorge, J., Ng, J., Exner, D. V., Tyberg, J. V., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.040 · Cited by 76 · see citing works
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Raber, I., Belanger, M. J., Farahmand, R., Aggarwal, R., Chiu, N., Rifai, M. A., Jacobsen, A. P., Lipsitz, L. A., & Juraschek, S. P. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.18557 · Cited by 39 · see citing works
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Self-citationToma, M., Jose, R., Syed, F., & Devine, T. J. (2024) · Clinics and Practice · doi:10.3390/clinpract14050138 · Cited by 1 · see citing works
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Emani, V. S., Escher, A., Juraschek, S. P., & Roche, E. T. (2026) · Annals of Biomedical Engineering · doi:10.1007/s10439-025-03941-6
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- Authors
- Okamoto, L. E., Diedrich, A., Baudenbacher, F. J., Harder, R., Whitfield, J. S., Iqbal, F., Gamboa, A., Shibao, C. A., Black, B. K., Raj, S. R., Robertson, D., & Biaggioni, I.
- Affiliations
- Vanderbilt University (US)
- ORCID
- Venue
- Hypertension
- Published
- 2016-08
- Volume
- 68
- Issue
- 2
- Pages
- 418-426
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4945429
- OpenAlex
- W2411962200
- Cited by
- 79
- References
- 37
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 11 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 2
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000445)
- National Heart, Lung, and Blood Institute (P01HL056693, R01HL122847)
- National Institute of Neurological Disorders and Stroke (U54NS065736)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- midodrine, autonomic failure, orthostatic tolerance, orthostatic symptoms, pressor agents, combination therapy, placebo-controlled crossover trial, orthostatic hypotension
- MeSH terms
- Aged, Autonomic Nervous System, Blood Pressure, Blood Pressure Determination, Female, Humans, Hypotension, Orthostatic, Male, Midodrine, Monitoring, Physiologic, Splanchnic Circulation, Vasoconstrictor Agents, Treatment Outcome, Intermittent Pneumatic Compression Devices
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