Exercise Systolic Blood Pressure at Moderate Workload Is Linearly Associated With Coronary Disease Risk in Healthy Men
Open accessAbstract
There is no consensus on the definition of an exaggerated increase in systolic blood pressure (SBP) during exercise. The aim was to explore a potential threshold for exercise SBP associated with increased risk of coronary heart disease in healthy men using repeated exercise testing. Two thousand fourteen healthy white male employees were recruited into the Oslo Ischemia Study during early 1970s. At follow-up 7 years later, 1392 men were still considered healthy. A bicycle exercise test at 100 W workload was performed at both visits. Cox regression analyses were performed with increasing cutoff levels of peak exercise SBP at 100 W workload (SBP100W) from 160 mm Hg to 200 mm Hg, adjusted for cardiovascular risk factors and physical fitness. Participants with SBP100W below cutoff level at both baseline and first follow-up were compared with participants with SBP100W equal to or above cutoff level at both visits. Compared with participants with SBP100W below all cutoff levels between 165 and 195 mm Hg, coronary heart disease risk was increased among participants with SBP100W equal to or above cutoff at all levels. There was no evidence of a distinct threshold level for coronary heart disease risk, and the relation between SBP100W and coronary heart disease appears linear. When investigating exercise SBP at moderate workload measured at 2 exercise tests in healthy middle-aged white men, there is increasing risk of coronary heart disease with increasing exercise SBP independent of SBP at rest. The association is linear from the low range of exercise SBP, and there is no sign of a distinct threshold level for increased coronary disease risk.
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Exaggerated exercise blood pressure (EEBP) recorded during clinical exercise testing is independently associated with blood pressure-related cardiovascular disease (CVD) outcomes.
“Exaggerated exercise blood pressure recorded during clinical exercise testing is independently associated with blood pressure -related cardiovascular disease outcomes”
From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [7]
Subsequent meta-analysis and other longitudinal studies have confirmed the association between submaximal exercise systolic blood pressure and cardiovascular events and death.
“A subsequent meta-analysis (10), and other longitudinal studies (7,8), have since confirmed these results.”
From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [7]
Mariampillai et al. described a linear association between submaximal exercise systolic BP (recorded at 100 watts) and coronary artery disease risk beyond a systolic BP value of 165 mmHg.
“Mariampillai et al [7] recently described a linear association between submaximal exercise systolic BP (recorded at a workload of 100 watts) and coronary artery disease risk beyond a systolic BP value of 165 mmHg.”
From The Identification and Management of High Blood Pressure Using Exercise Blood Pressure: Current Evidence and Practical Guidance (2022) · cites this paper as [7]
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- Authors
- Mariampillai, J. E., Liestøl, K., Kjeldsen, S. E., Prestgaard, E. E., Engeseth, K., Bodegard, J., Berge, E., Gjesdal, K., Erikssen, J., Grundvold, I., & Skretteberg, P. T.
- Affiliations
- Oslo University Hospital (NO)
- University of Oslo (NO)
- From the Department of Cardiology, Oslo University Hospital, Ullevaal, Norway (J.E.M., S.E.K., E.E.P., K.E., J.B., E.B., I.G., P.T.S.)
- ORCID
- Venue
- Hypertension
- Published
- 2020-01
- Volume
- 75
- Issue
- 1
- Pages
- 44-50
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2984461912
- Cited by
- 45
- References
- 35
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- coronary heart disease risk, linear association, blood pressure thresholds, cardiovascular risk factors, physical fitness
- MeSH terms
- Adult, Blood Pressure, Coronary Disease, Exercise Test, Humans, Male, Middle Aged, Risk Factors, Exercise
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