Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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Epigenetic programming by maternal behavior

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Developmental Plasticity and Evolution

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Epigenetic differences arise during the lifetime of monozygotic twins

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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

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Persistent epigenetic differences associated with prenatal exposure to famine in humans

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The Wellcome Trust Case Control Consortium, U.K.

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Genome-scale DNA methylation maps of pluripotent and differentiated cells

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Epigenetics: A landscape takes shape

Goldberg, A. D., Allis, C. D., & Bernstein, E. (2007) · Cell · doi:10.1016/j.cell.2007.02.006 · Cited by 2,466 · see citing works

Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus

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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

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Stability and flexibility of epigenetic gene regulation in mammalian development

Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · cited 1× · see citing works

The Strategy of the Genes: A Discussion of Some Aspects of Theoretical Biology

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Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring

Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139 · see citing works

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

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Early life events and their consequences for later disease: a life history and evolutionary perspective

Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · American Journal of Human Biology · doi:10.1002/ajhb.20590 · Cited by 1,006 · see citing works

Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

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Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from Obesity by Modifying the Fetal Epigenome

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RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

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Early growth and death from cardiovascular disease in women.

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DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status

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Prenatal exposure to the Dutch famine and disease in later life: An overview

Painter, R. C., Roseboom, T. J., & Bleker, O. P. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.04.005 · Cited by 784 · see citing works

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases

Waterland, R. A., & Jirtle, R. L. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.011 · Cited by 783 · see citing works

Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study

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Genotype score in addition to common risk factors for prediction of type 2 diabetes

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Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

Hales, C., & Barker, D. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt133 · Cited by 711 · see citing works

Neonatal anthropometry: the thin–fat Indian baby. The Pune Maternal Nutrition Study

Yajnik, C. S., Fall, C. H. D., Coyaji, K., Hirve, S. S., Rao, S. R., Barker, D. J. P., Joglekar, C. V., & Kellingray, S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.802219 · Cited by 709 · see citing works

Transgenerational inheritance of epigenetic states at the murine Axin Fu allele occurs after maternal and paternal transmission

Rakyan, V. K., Chong, S., Blewitt, M. E., Cuthbert, P. C., Morgan, H. D., Luu, K. V. K., & Whitelaw, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436776100 · Cited by 642 · see citing works

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

Park, J. H., Stoffers, D. A., Nicholls, R. D., & Simmons, R. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33655 · Cited by 640 · see citing works

Neonatal Leptin Treatment Reverses Developmental Programming

Vickers, M. H., Gluckman, P. D., Coveny, A. H., Hofman, P. L., Cutfield, W. S., Gertler, A., Breier, B. H., & Harris, M. A. (2005) · Endocrinology · doi:10.1210/en.2005-0581 · Cited by 616 · see citing works

Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

Lillycrop, K. A., Slater-Jefferies, J. L., Hanson, M. A., Godfrey, K. M., Jackson, A. A., & Burdge, G. C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450769196x · Cited by 563 · see citing works

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Böttinger, E. P., Reid, S. P., Levy, D. E., & Bromberg, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.259 · Cited by 559 · see citing works

Early Life Origins of Insulin Resistance and Type 2 Diabetes in India and Other Asian Countries

Yajnik, C. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.205 · Cited by 491 · see citing works

Maternal methyl supplements increase offspring DNA methylation at <i>Axin fused</i>

Waterland, R. A., Dolinoy, D. C., Lin, J., Smith, C. A., Shi, X., & Tahiliani, K. G. (2006) · genesis · doi:10.1002/dvg.20230 · Cited by 480 · see citing works

Noncoding RNA in development

Amaral, P., & Mattick, J. S. (2008) · Mammalian Genome · doi:10.1007/s00335-008-9136-7 · Cited by 479 · see citing works

Epigenetic Modification of the Renin-Angiotensin System in the Fetal Programming of Hypertension

Bogdarina, I. G., Welham, S. J. M., King, P., BURNS, S. P., & Clark, A. J. L. (2007) · Circulation Research · doi:10.1161/01.res.0000258855.60637.58 · Cited by 478 · see citing works

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

Lillycrop, K. A., Phillips, E. S., Torrens, C., Hanson, M. A., Jackson, A. A., & Burdge, G. C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507894438 · Cited by 461 · see citing works

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

Aagaard-Tillery, K. M., Grove, K. L., Bishop, J. M., Ke, X., Fu, Q., McKnight, R. A., & Lane, R. H. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0025 · Cited by 433 · see citing works

Dietary protein restriction of pregnant rats in the F 0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F 1 and F 2 generations

Burdge, G. C., Slater-Jefferies, J. L., Torrens, C., Phillips, E. S., Hanson, M. A., & Lillycrop, K. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507352392 · Cited by 418 · see citing works

Methyl donor supplementation prevents transgenerational amplification of obesity

Waterland, R. A., Travisano, M., Tahiliani, K. G., Rached, M.-T., & Mirza, S. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.100 · Cited by 414 · see citing works

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

Villeneuve, L. M., Reddy, M. A., Lanting, L. L., Wang, M., Li, M., & Natarajan, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803623105 · Cited by 412 · see citing works

Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children

Whincup, P. H. (2002) · BMJ · doi:10.1136/bmj.324.7338.635 · Cited by 410 · see citing works

Inheritance of a Cancer-Associated MLH1 Germ-Line Epimutation

Hitchins, M. P., Wong, J. J. L., Suthers, G., Suter, C. M., Martin, D. I. K., Hawkins, N. J., & Ward, R. L. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064522 · Cited by 409 · see citing works

Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats

Drake, A. J., Walker, B. R., & Seckl, J. R. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00106.2004 · Cited by 409 · see citing works

Non‐genomic transgenerational inheritance of disease risk

Gluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · BioEssays · doi:10.1002/bies.20522 · Cited by 381 · see citing works

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

Ng, R. K., Dean, W., Dawson, C., Lucifero, D., Madeja, Z. E., Reik, W., & Hemberger, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1786 · Cited by 367 · see citing works

Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

Farthing, C. R., Ficz, G., Ng, R. K., Chan, C.-F., Andrews, S., Dean, W., Hemberger, M., & Reik, W. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000116 · Cited by 348 · see citing works

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus

Waterland, R. A., Lin, J.-R., Smith, C. A., & Jirtle, R. L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi484 · Cited by 337 · see citing works

Maternal constraint of fetal growth and its consequences

Gluckman, P. D., & Hanson, M. A. (2004) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2004.03.001 · Cited by 336 · see citing works

Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome

Weksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 328 · see citing works

Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

Nightingale, K. P., O’Neill, L. P., & Turner, B. M. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.02.015 · Cited by 311 · see citing works

A review of known imprinting syndromes and their association with assisted reproduction technologies

Amor, D. J., & Halliday, J. L. (2008) · Human Reproduction · doi:10.1093/humrep/den310 · Cited by 311 · see citing works

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status

Gluckman, P. D., Lillycrop, K. A., Vickers, M. H., Pleasants, A. B., Phillips, E. S., Beedle, A. S., Burdge, G. C., & Hanson, M. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705667104 · Cited by 309 · see citing works

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

Jiménez‐Chillarón, J. C., ISGANAITIS, E. M., Charalambous, M., Gesta, S., Pentinat, T., Faucette, R., Otis, J. P., Chow, A., Díaz, R., Ferguson‐Smith, A. C., et al. (2008) · Diabetes · doi:10.2337/db08-0490 · Cited by 299 · see citing works

Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebrates

Matzke, M. A., Mette, M. F., & Matzke, A. J. M. (2000) · Plant Molecular Biology · doi:10.1023/a:1006484806925 · Cited by 290 · see citing works

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

Dhandapany, P. S., Sadayappan, S., Xue, Y., Powell, G. T., Rani, D. S., Nallari, P., Singh, T., Khullar, M., Soares, P. A., Bahl, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.309 · Cited by 285 · see citing works

Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes.

Lawlor, D., Smith, G., O'callaghan, M., Alati, R., Mamun, A. A., Williams, G., & Najman, J. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk030 · Cited by 280 · see citing works

Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney

Pham, T. D., MacLennan, N. K., Chiu, C. T., Laksana, G. S., Hsu, J. L., & Lane, R. H. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00201.2003 · Cited by 278 · see citing works

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

Raychaudhuri, N., Raychaudhuri, S., Thamotharan, M., & Devaskar, S. U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800128200 · Cited by 227 · see citing works

Metabolic reconfiguration is a regulated response to oxidative stress

Grant, C. M. (2008) · Journal of Biology · doi:10.1186/jbiol63 · Cited by 225 · see citing works

Review article: Epigenetic control of fetal gene expression

Nafee, T. M., Farrell, W., Carroll, W. D., Fryer, A. A., & Ismail, K. (2007) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01528.x · Cited by 220 · see citing works

Birth Weight and Parental BMI Predict Overweight in Children From Mothers With Gestational Diabetes

Schaefer-Graf, U. M., Pawliczak, J., Passow, D., Hartmann, R., Rossi, R., Bührer, C., Harder, T., Plagemann, A., Vetter, K., & Kordonouri, O. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1745 · Cited by 219 · see citing works

Developmental Origins of Health and Disease

Rass, E. (2017) · Routledge eBooks · doi:10.4324/9781315445564-6 · Cited by 200 · see citing works

Diet‐induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female

Waterland, R. A., Travisano, M., & Tahiliani, K. G. (2007) · The FASEB Journal · doi:10.1096/fj.07-8229com · Cited by 193 · see citing works

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

Ling, C., Poulsen, P., Simonsson, S., Rönn, T., Holmkvist, J., Almgren, P., Hagert, P., Nilsson, E., Mabey, A. G., Nilsson, P. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30938 · Cited by 191 · see citing works

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring

Watkins, A. J., Wilkins, A., Cunningham, C. M., Perry, V. H., Seet, M. J., Osmond, C., Eckert, J. J., Torrens, C., Cagampang, F. R. A., Cleal, J. K., et al. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.149229 · Cited by 190 · see citing works

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Rönn, T., Poulsen, P., Hansson, O., Holmkvist, J., Almgren, P., Nilsson, P., Tuomi, T., Isomaa, B., Groop, L., Vaag, A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1018-8 · Cited by 175 · see citing works

Impact of educational attainment on the quality of young women's diets

Robinson, S. M., Crozier, S., Borland, S. E., Hammond, J., Barker, D. J. P., & Inskip, H. M. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601946 · Cited by 174 · see citing works

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

Park, H., Georgescu, S. P., Du, C., Madias, C. A., Aronovitz, M. J., Welzig, C. M., Wang, B., Begley, U., Zhang, Y., Blaustein, R. O., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32011 · Cited by 171 · see citing works

DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expressionPreprint

Yagi, S., Hirabayashi, K., Sato, S., Li, W., Takahashi, Y., Hirakawa, T., Wu, G., Hattori, N., Hattori, N., Ohgane, J., et al. (2008) · Genome Research · doi:10.1101/gr.074070.107 · Cited by 163 · see citing works

Developmental Origins of Health and Disease: List of contributors

Gluckman, P., & Hanson, M. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544699 · Cited by 142 · see citing works

Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age

Ibáñez, L. (2003) · Human Reproduction · doi:10.1093/humrep/deg351 · Cited by 128 · see citing works

Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development

Song, F., Mahmood, S., Ghosh, S., Liang, P., Smiraglia, D. J., Nagase, H., & Held, W. A. (2008) · Genomics · doi:10.1016/j.ygeno.2008.09.003 · Cited by 126 · see citing works

Lipid profiles in adolescent Filipinos: relation to birth weight and maternal energy status during pregnancy

Kuzawa, C. W., & Adair, L. S. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.960 · Cited by 126 · see citing works

Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet

Kwong, W. Y., Miller, D. J., Ursell, E., Wild, A. E., Wilkins, A., Osmond, C., Anthony, F. W., & Fleming, T. P. (2006) · Reproduction · doi:10.1530/rep.1.01038 · Cited by 123 · see citing works

Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver

Fu, Q., McKnight, R. A., Yu, X., Wang, L., Callaway, C. W., & Lane, R. H. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00175.2004 · Cited by 114 · see citing works

Intrauterine Growth Retardation and Development of Endocrine Pancreas in the Experimental Rat

Prins, F. A. D., & Assche, F. A. V. (2009) · Biology of the Neonate · doi:10.1159/000241511 · Cited by 98 · see citing works

Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential

Jiang, M., Fei, J., Lan, M. S., Lu, Z., Liu, M., Fan, W., Gao, X., & Lu, D. (2008) · Diabetologia · doi:10.1007/s00125-008-1034-8 · Cited by 87 · see citing works

The ‘developmental origins’ hypothesis: epidemiology

Godfrey, K. M. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544699.003 · Cited by 86 · see citing works

Differential methylation of the X‐chromosome is a possible source of discordance for bipolar disorder female monozygotic twins

Rosa, A., Picchioni, M., Kalidindi, S., Loat, C. S., Knight, J., Toulopoulou, T., Vonk, R., van der Schot, A. C., Nolen, W. A., Kahn, R. S., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30616 · Cited by 85 · see citing works

Analysis of Histones in Xenopus laevis

Shechter, D., Nicklay, J. J., Chitta, R. K., Shabanowitz, J., Hunt, D. F., & Allis, C. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807273200 · Cited by 80 · see citing works

Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis: Figure 1.Preprint

Branco, M. R., Oda, M., & Reik, W. (2008) · Genes & Development · doi:10.1101/gad.1690508 · Cited by 72 · see citing works

Early Nutrition and Long-Term Cardiovascular Health

Singhal, A. (2006) · Nutrition Reviews · doi:10.1301/nr.2006.may.s44-s49 · Cited by 70 · see citing works

Origins of differentiation via phenotypic plasticity

Schlichting, C. D. (2002) · Evolution & Development · doi:10.1046/j.1525-142x.2003.03015.x · Cited by 69 · see citing works

Genomic imprinting in marsupial placentation

Renfree, M. B., Ager, E. I., Shaw, G., & Pask, A. J. (2008) · Reproduction · doi:10.1530/rep-08-0264 · Cited by 63 · see citing works

Maternal regulation of estrogen receptor α methylation

Champagne, F. A., & Curley, J. P. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.06.018 · Cited by 63 · see citing works

Metabolic Consequences of Obesity and Body Fat Pattern: Lessons from Migrant Studies

McKeigue, P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514962.ch4 · Cited by 62 · see citing works

X-chromosome inactivation: the molecular basis of silencing

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