One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke
Abstract
Background and Purpose— We sought to evaluate the long-term effects of bone marrow stromal cell (BMSC) treatment on retired breeder rats with stroke. Methods— Female retired breeder rats were subjected to 2-hour middle cerebral artery occlusion (MCAO) followed by an injection of 2×10 6 male BMSCs (n=8) or phosphate-buffered saline (n=11) into the ipsilateral internal carotid artery at 1 day after stroke. The rats were humanely killed 1 year later. Functional tests, in situ hybridization, and histochemical and immunohistochemical staining were performed. Results— Significant recovery of neurological deficits was found in BMSC-treated rats beginning 2 weeks after cell injection compared with control animals. The beneficial effects of cell transplantation persisted for at least 1 year ( P <0.01). In situ hybridization for the Y chromosome showed that donor cells survived in the brains of recipient rats, among which 22.3±1.95% of cells expressed the astrocyte marker glial fibrillary acidic protein, 16.8±2.13% expressed the neuronal marker microtubule-associated protein 2, and 5.5±0.42% and <1% of cells colocalized with the microglial marker IB4 and the endothelial cell marker von Willebrand factor, respectively. Only very few BMSCs, however, were found in peripheral organs such as the heart, lung, liver, spleen, and kidney in recipient rats. BMSCs significantly reduced axonal loss ( P <0.01), the thickness of the lesion scar wall ( P <0.01), and the number of Nogo-A–positive cells ( P <0.05) along the scar border; meanwhile, synaptophysin expression ( P <0.05) was significantly increased in BMSC-treated ischemic brains compared with control untreated brains. Conclusions— The beneficial effects of BMSCs on ischemic brain tissue persisted for at least 1 year. Most surviving BMSCs were present in the ischemic brain, but very few were found in other organs. The long-term improvement in functional outcome may be related to the structural and molecular changes induced by BMSCs.
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In rodents, survival of ischaemic pyramidal tract axons can be improved by pharmacological and cell-based treatments.
“In rodents, the survival of ischaemic pyramidal tract axons can be improved by pharmacological and cell-based treatments.26–28”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
Enhanced plasticity and neurological recovery after stroke were evident in both young and older animals.
“Enhanced plasticity and neurological recovery after stroke were evident not only in young but also in older animals.17,26,33”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
After treatment with bone-marrow-derived stromal cells, structural effects on preservation of corticospinal axons persisted for up to 1 year.
“After treatment with bone-marrow-derived stromal cells, structural effects on the preservation of corticospinal axons persisted for up to 1 year.26”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
In aged rats with ischaemia, treatment with anti-NogoA antibodies, pharmacological compounds, or bone-marrow-derived stromal cells improved neurological recovery and was linked to preservation of ipsilateral pyramidal tract axons and enhanced contralateral pyramidal tract sprouting.
“Improved neurological recovery associated with preservation of pyramidal tract axons ipsilateral to the stroke and enhanced pyramidal tract sprouting contralateral to the stroke was identified in 25-month-old or 12-month-old rats with ischaemia treated with neutralising anti-NogoA antibodies,17 pharmacological compounds, 76 or bone-marrow-derived stromal cells.26”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
Aged rats can respond to plasticity-promoting treatments, though age may influence some processes that neurorestorative interventions target.
“Aged rats respond to plasticity-promoting therapies, but age might have an effect on some of the processes targeted by neurorestorative interventions.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
With bone-marrow-derived stromal cell treatment, neurological improvements in middle-aged rats (12 months) lasted at least 1 year.
“In the case of treatment with bone-marrow-derived stromal cells, neurological improvements persisted in middle-aged rats (12 months of age) for at least 1 year.26”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
Although restorative treatments can promote neurological recovery in old animals, specific findings in ageing animals and in animals with vascular risk factors suggest that efficacy of new therapeutics might be compromised in elderly patients with risk factors.
“Although restorative treat ments can promote neurological recovery in old ani mals,17,26,72,76–79 specific findings in ageing animals72,77–79 and in animals with vascular risk factors80,82,86,87 suggest that the efficacy of new therapeutics might be compromised in elderly patients with risk factors.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
Although evidence is limited, preserved neurological recovery in old animals argues against specific age limits for neurorestorative treatments.
“Although evidence is limited to a rather small number of studies, the preserved neurological recovery in old animals argues against specific age limits for neurorestorative treatments.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [26]
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Self-citation
- Authors
- Shen, L. H., Li, Y., Chen, J., Cui, Y., Zhang, C., Kapke, A., Lu, M., Savant-Bhonsale, S., & Chopp, M.
- Affiliations
- Henry Ford Health (US)
- From the Departments of Neurology (L.H.S., Y.L., J.C., Y.C., C.Z., M.C.) and of Biostatistics and Research Epidemiology (A.K., M.L.), Henry Ford Hospital, Detroit, Mich; Theradigm Inc (S.S.-B.), Baltimore, Md; and the Department of Physics (M.C.), Oakland University, Rochester, Mich.
- Venue
- Stroke
- Published
- 2007-07
- Volume
- 38
- Issue
- 7
- Pages
- 2150-2156
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2048416790
- Cited by
- 208
- References
- 35
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 18 · 2015: 13 · 2014: 12 · 2013: 17 · 2012: 19
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (P01NS23393, R01NS045041, P01NS023393, P01NS042345, R01 NS45041)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- mesenchymal stem cells, cell transplantation, ischemic stroke, middle cerebral artery occlusion, long-term functional recovery, donor cell survival, axonal loss, Nogo-A, synaptophysin, glial fibrillary acidic protein, microglia, astrocytes, middle-aged female rats
- MeSH terms
- Age Factors, Animals, Behavior, Animal, Bone Marrow Cells, Female, Follow-Up Studies, Humans, Male, Random Allocation, Sex Factors, Bone Marrow Transplantation, Treatment Outcome, Stromal Cells, Rats, Wistar, In Situ Hybridization, Infarction, Middle Cerebral Artery, Stroke, Rats
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