Outcome After Mobilization Within 24 Hours of Acute Stroke: A Randomized Controlled Trial
Open accessAbstract
Background and Purpose—: Very early mobilization (VEM) is considered to contribute to the beneficial effects of stroke units, but there are uncertainties regarding the optimal time to start mobilization. We hypothesized that VEM within 24 hours after admittance to the hospital would reduce poor outcome 3 months poststroke compared with mobilization between 24 and 48 hours. Methods—: We conducted a prospective, randomized, controlled trial with blinded assessment at follow-up. Patients admitted to the stroke unit within 24 hours after stroke were assigned to either VEM within 24 hours of admittance or mobilization between 24 and 48 hours (control group). Primary outcome was the proportion of poor outcome (modified Rankin scale score, 3–6), whereas secondary outcomes were death rate, change in neurological impairment (National Institutes of Health Stroke Scale score), and dependency (Barthel Index 0–17). Results—: Fifty-six patients were included (mean age±SD, 76.9±9.4 years), 27 were in the VEM group and 29 were in the control group. VEM patients had nonsignificant higher odds (adjusted for age and National Institutes of Health Stroke Scale score on admission) of poor outcome (OR, 2.70; 95% CI, 0.78–9.34; P =0.12), death (OR, 5.26; 95% CI, 0.84–32.88; P =0.08), and dependency (OR, 1.25; 95% CI, 0.36–4.34; P =0.73). The control group, having milder strokes (National Institutes of Health Stroke Scale score±SD: control group, 7.5±4.2; VEM, 9.2±6.5; P =0.26), had better neurological improvement ( P =0.02). Conclusions—: We identified a trend toward increased poor outcome, death rate, and dependency among patients mobilized within 24 hours after hospitalization, and an improvement in neurological functioning in favor of patients mobilized between 24 and 48 hours. Very early or delayed mobilization after acute stroke is still undergoing debate, and results from ongoing larger trials are required.
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- Authors
- Sundseth, A., Thommessen, B., & Rønning, O. M.
- Affiliations
- University of Oslo (NO)
- Venue
- Stroke
- Published
- 2012-09
- Volume
- 43
- Issue
- 9
- Pages
- 2389-2394
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1984210675
- Cited by
- 113
- References
- 41
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 15 · 2013: 6 · 2012: 1
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Keywords
- acute stroke, stroke unit, functional outcome, mortality, dependency, neurological deficit, modified Rankin Scale, Barthel Index, NIHSS
- MeSH terms
- Stroke Rehabilitation, Aged, Data Interpretation, Statistical, Early Ambulation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nervous System Diseases, Neurologic Examination, Neuropsychological Tests, Prospective Studies, Risk Factors, Treatment Outcome, Sample Size, Stroke, Physical Therapy Modalities
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