The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Visualizing the Neural Bases of a Disconnection Syndrome with Diffusion Tensor Imaging
Abstract
Disconnection syndromes are often conceptualized exclusively within cognitive box-and-arrow diagrams unrelated to brain anatomy. In a patient with alexia in his left visual field resulting from a posterior callosal lesion, we illustrate how diffusion tensor imaging can reveal the anatomical bases of a disconnection syndrome by tracking the degeneration of neural pathways and relating it to impaired fMRI activations and behavior. Compared to controls, an abnormal pattern of brain activity was observed in the patient during word reading, with a lack of activation of the left visual word form area (VWFA) by left hemifield words. Statistical analyses of diffusion images revealed a damaged fiber tract linking the left ventral occipito-temporal region to its right homolog across the lesioned area of corpus callosum and stopping close to the areas found active in fMRI. The behavioral disconnection syndrome could, thus, be related functionally to abnormal fMRI activations and anatomically to the absence of a connection between those activations. The present approach, based on the "negative tracking" of degenerated bundles, provides new perspectives on the understanding of human brain connections and disconnections.
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In the citing paper
“Callosal lesions of fibers connecting the right-hemispheric visual regions to the VWFA provoke a subtype of PA restricted to words displayed in the left half of the visual field [9,50].”
From The visual word form area: expertise for reading in the fusiform gyrus (2003) · cites this paper as [50]
In the citing paper
“In such cases, we observed reduced activations of the VWFA for words presented in the left hemifield (Cohen et al., 2000; Molko et al., 2002).”
From Specialization within the ventral stream: the case for the visual word form area (2004) · cites this paper as Molko et al., 2002
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Cites
DISCONNEXION SYNDROMES IN ANIMALS AND MAN
Geschwind, N. (1965) · Brain · doi:10.1093/brain/88.2.237 · Cited by 3,419
Toward a quantitative assessment of diffusion anisotropy
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Cohen, L., Dehaene, S., Naccache, L., Lehéricy, S., Dehaene-Lambertz, G., Hénaff, M.-A., & Michel, F. (2000) · Brain · doi:10.1093/brain/123.2.291 · Cited by 1,954
DISCONNEXION SYNDROMES IN ANIMALS AND MAN
Geschwind, N. (1965) · Brain · doi:10.1093/brain/88.3.585 · Cited by 1,840
Tracking neuronal fiber pathways in the living human brain
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., McKinstry, R. C., Burton, H., & Raichle, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10422 · Cited by 1,774
The visual word form area: expertise for reading in the fusiform gyrus
McCandliss, B. D., Cohen, L., & Dehaene, S. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(03)00134-7 · Cited by 1,489
Self-citationCerebral mechanisms of word masking and unconscious repetition priming
Dehaene, S., Naccache, L., Cohen, L., Bihan, D. L., Mangin, J.-F., Poline, J.-B., & Rivière, D. (2001) · Nature Neuroscience · doi:10.1038/89551 · Cited by 1,305
Puce, A., Allison, T., Asgari, M., Gore, J. C., & McCarthy, G. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05205.1996 · Cited by 987 · cited 1×
“Within this extensive network, converging evidence suggests that a subregion of the left fusiform gyrus, whose Talairach coordinates are approximately x = � 43, y = � 54, z = � 12, contributes crucially to the cerebral basis of the VWF (Cohen et al., 2000; Beauregard et al., 1997; Puce, Allison, Asgari, Gore, & McCart…”
BackgroundMicrostructure of Temporo-Parietal White Matter as a Basis for Reading Ability
Klingberg, T., Hedehus, M., Temple, E., Salz, T., Gabrieli, J. D. E., Moseley, M. E., & Poldrack, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)80911-3 · Cited by 729
Neuroimaging studies of word reading
Fiez, J. A., & Petersen, S. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.914 · Cited by 727
Research works printed but not linked: 1
- Dejerine J., 1892, Mémoires de la Sociétéde Biologie, 4, 61
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Sorted by citations
Looking into the functional architecture of the brain with diffusion MRI.
Le Bihan, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1119 · Cited by 1,571
The visual word form area: expertise for reading in the fusiform gyrus
McCandliss, B. D., Cohen, L., & Dehaene, S. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(03)00134-7 · Cited by 1,489
Self-citationThe unique role of the visual word form area in reading
Dehaene, S., & Cohen, L. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.04.003 · Cited by 1,488
Specialization within the ventral stream: the case for the visual word form area
Cohen, L., & Dehaene, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.049 · Cited by 776
Self-citationUpdate of Neuropathology and Neurological Recovery After Traumatic Brain Injury
Povlishock, J. T., & Katz, D. I. (2005) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200501000-00008 · Cited by 676
Metadata
- Authors
- Molko, N., Cohen, L., Mangin, J. F., Chochon, F., Lehéricy, S., Bihan, D. L., & Dehaene, S.
- Affiliations
- Inserm (FR)
- UNAF, Service Hospitalier Frédéric Joliot, Commisariat à l'Energie Atanique
- Pitié-Salpêtrière Hospital (FR)
- Human Brain Research Center, Graduate School of Medicine, Kyoto University (JP)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2002-05
- Volume
- 14
- Issue
- 4
- Pages
- 629-636
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2098520947
- Cited by
- 144
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2022: 4 · 2021: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- disconnection syndrome, alexia, corpus callosum lesions, posterior corpus callosum, visual word form area, interhemispheric connectivity, word reading, fMRI activation, diffusion tensor imaging
- MeSH terms
- Adult, Brain, Brain Mapping, Dominance, Cerebral, Dyslexia, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Reading, Verbal Behavior, Anisotropy
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