The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A Parametric Manipulation of Factors Affecting Task-induced Deactivation in Functional Neuroimaging
Abstract
Task-induced deactivation (TID) refers to a regional decrease in blood flow during an active task relative to a “resting” or “passive” baseline. We tested the hypothesis that TID results from a reallocation of processing resources by parametrically manipulating task difficulty within three factors: target discriminability, stimulus presentation rate, and short-term memory load. Subjects performed an auditory target detection task during functional magnetic resonance imaging (fMRI), responding to a single target tone or, in the short-term memory load conditions, to target sequences. Seven task conditions (a common version and two additional levels for each of the three factors) were each alternated with “rest” in a block design. Analysis of covariance identified brain regions in which TID occurred. Analyses of variance identified seven regions (left anterior cingulate/superior frontal gyrus, left middle frontal gyrus, right anterior cingulate gyrus, left and right posterior cingulate gyrus, left posterior parieto-occipital cortex, and right precuneus) in which TID magnitude varied across task levels within a factor. Follow-up tests indicated that for each of the three factors, TID magnitude increased with task difficulty. These results suggest that TID represents reallocation of processing resources from areas in which TID occurs to areas involved in task performance. Short-term memory load and stimulus rate also predict suppression of spontaneous thought, and many of the brain areas showing TID have been linked with semantic processing, supporting claims that TID may be due in part to suspension of spontaneous semantic processes that occur during “rest” (Binder et al., 1999). The concept that the typical “resting state” is actually a condition characterized by rich cognitive activity has important implications for the design and analysis of neuroimaging studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, these drivers may suppress off-task and self-focused attention, buffering learners from these obstacles to optimal performance (McKiernan, Kaufman, Kucera-Thompson, & Binder, 2003).”
From Optimizing performance through intrinsic motivation and attention for learning: The OPTIMAL theory of motor learning (2016) · cites this paper as McKiernan, Kaufman, Kucera-Thompson, & Binder, 2003
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
James, W. (1891) · Personality Culture Society · doi:10.1037/11059-000 · Cited by 25,876
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371
Research works printed but not linked: 3
- 10.2466/pms.1966.23.2.399 · DOI · Paper page
- Ingvar D. H., 1985, Human Neurobiology, 4, 127
- McGuire P. K., 1996, NeuroReport, 7, 2095
Cited by
Sorted by citations
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
The precuneus: a review of its functional anatomy and behavioural correlates
Cavanna, A. E., & Trimble, M. R. (2006) · Brain · doi:10.1093/brain/awl004 · Cited by 5,128
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326
Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp055 · Cited by 4,060
Self-citation
Metadata
- Authors
- McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J., & Binder, J. R.
- Affiliations
- Medical College of Wisconsin (US)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press
- Published
- 2003-04-01
- Volume
- 15
- Issue
- 3
- Pages
- 394-408
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2169605136
- Cited by
- 1,080
- References
- 56
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 19 · 2023: 20 · 2022: 29 · 2021: 41 · 2020: 42 · 2019: 47 · 2018: 33 · 2017: 39 · 2016: 62 · 2015: 44 · 2014: 77 · 2013: 82 · 2012: 76
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P01MH051358, P0 MH51358)
- National Institute of Neurological Disorders and Stroke (R01NS033576)
- National Center for Research Resources (M01RR000058)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- task-induced deactivation, resting state, task difficulty, stimulus presentation rate, auditory target detection, posterior cingulate cortex, precuneus, anterior cingulate cortex, semantic processing
- MeSH terms
- Acoustic Stimulation, Adult, Auditory Perception, Brain, Brain Mapping, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Mental Processes, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
