Task-Induced Deactivation from Rest Extends beyond the Default Mode Brain Network
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Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
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Functional deactivations may be as equally informative for understanding the neural substrates of complex mental activities, including emotion processing, as activations.
“As is now broadly recognized in the neuroimaging field, functional deactivations may be as equally informative for understanding the neural substrates of complex mental activities, [8][9][10] including emotion processing.8,11,12”
From Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies (2016) · cites this paper as [8]
The vmPFC and PCC are recognized as a characteristic functional signature of the human default mode network, a large-scale brain system that exhibits consistent functional decreases in activity in fMRI studies when goal-directed task performance is compared with low task demand such as passive resting states.
“vmPFC and PCC, in particular, has become recognized as a characteristic functional signature of the human 'default mode network'-a large-scale brain system that exhibits consistent functional decreases in activity in fMRI studies when conditions of goal-directed task performance are compared with conditions of low task demand, such as passive resting states.8,9”
From Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies (2016) · cites this paper as [8]
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A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326 · see citing works
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997 · see citing works
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892 · see citing works
Self-referential processing in our brain—A meta-analysis of imaging studies on the self
Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., & Panksepp, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.002 · Cited by 2,792 · see citing works
Wandering minds: the default network and stimulus-independent thought
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792 · see citing works
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556 · see citing works
Common blood flow changes across visual tasks: II. Decreases in cerebral cortex
Shulman, G. L., Fiez, J. A., Corbetta, M., Buckner, R. L., Miezin, F. M., Raichle, M. E., & Petersen, S. E. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.5.648 · Cited by 1,890 · see citing works
Intrinsic functional architecture in the anaesthetized monkey brain
Vincent, J. L., Patel, G. H., Fox, M. D., Snyder, A. Z., Baker, J. T., Van Essen, D. C., Zempel, J. M., Snyder, L. H., Corbetta, M., & Raichle, M. E. (2007) · Nature · doi:10.1038/nature05758 · Cited by 1,786 · see citing works
Christoff, K., Gordon, A. M., Smallwood, J., Smith, R., & Schooler, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900234106 · Cited by 1,769 · see citing works
The neural bases of momentary lapses in attention
Weissman, D. H., Roberts, K. C., Visscher, K. M., & Woldorff, M. G. (2006) · Nature Neuroscience · doi:10.1038/nn1727 · Cited by 1,566 · see citing works
Competition between functional brain networks mediates behavioral variability
Kelly, A. M. C., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.008 · Cited by 1,287 · see citing works
Modulating emotional responses: effects of a neocortical network on the limbic system
Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000) · NeuroReport · doi:10.1097/00001756-200001170-00009 · Cited by 1,277 · see citing works
A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
Van Essen, D. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.058 · Cited by 1,151 · see citing works
A Parametric Manipulation of Factors Affecting Task-induced Deactivation in Functional Neuroimaging
McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J., & Binder, J. R. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321593117 · Cited by 1,080 · see citing works
My body in the brain: A neurocognitive model of body-ownership.
Tsakiris, M. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.034 · Cited by 1,069 · see citing works
Spreng, R. N., & Grady, C. L. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21282 · Cited by 985 · see citing works
Mazoyer, B., Zago, L., Mellet, E., Bricogne, S., Etard, O., Houdé, O., Crivello, F., Joliot, M., Petit, L., & Tzourio-Mazoyer, N. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00437-8 · Cited by 906 · see citing works
Imaging how attention modulates pain in humans using functional MRI
Bantick, S. J., Wise, R. G., Ploghaus, A., Clare, S., Smith, S. M., & Tracey, I. (2002) · Brain · doi:10.1093/brain/awf022 · Cited by 888 · see citing works
Functional connectivity of the insula in the resting brain
Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., & Vercelli, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.049 · Cited by 793 · see citing works
Evidence for the Default Network's Role in Spontaneous Cognition
Andrews-Hanna, J. R., Reidler, J. S., Huang, C., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00830.2009 · Cited by 685 · see citing works
Two systems of resting state connectivity between the insula and cingulate cortex
Taylor, K. S., Seminowicz, D. A., & Davis, K. D. (2009) · Human Brain Mapping · doi:10.1002/hbm.20705 · Cited by 665 · see citing works
Schilbach, L., Eickhoff, S. B., Rotarska-Jagiela, A., Fink, G. R., & Vogeley, K. (2008) · Consciousness and Cognition · doi:10.1016/j.concog.2008.03.013 · Cited by 615 · see citing works
Craig, A. D. (. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0248-y · Cited by 600 · see citing works
Bornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., & Büchel, C. (2002) · Brain · doi:10.1093/brain/awf137 · Cited by 584 · see citing works
Friston, K. J., Penny, W. D., & Glaser, D. E. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.013 · Cited by 578 · see citing works
Laird, A. R., Eickhoff, S. B., Li, K., Robin, D. A., Glahn, D. C., & Fox, P. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4004-09.2009 · Cited by 550 · see citing works
Age-related alterations in default mode network: Impact on working memory performance
Sambataro, F., Murty, V. P., Callicott, J. H., Tan, H.-Y., Das, S., Weinberger, D. R., & Mattay, V. S. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.022 · Cited by 517 · see citing works
Prediction of human errors by maladaptive changes in event-related brain networks
Eichele, T., Debener, S., Calhoun, V. D., Specht, K., Engel, A. K., Hugdahl, K., von Cramon, D. Y., & Ullsperger, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708965105 · Cited by 456 · see citing works
The Human Parietal Operculum. II. Stereotaxic Maps and Correlation with Functional Imaging Results
Eickhoff, S. B., Amunts, K., Mohlberg, H., & Zilles, K. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi106 · Cited by 411 · see citing works
Consistency and functional specialization in the default mode brain network
Harrison, B. J., Pujol, J., López-Solà, M., Hernández-Ribas, R., Deus, J., Ortiz, H., Soriano-Mas, C., Yücel, M., Pantelis, C., & Cardoner, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711791105 · Cited by 363 · see citing works
Self-citationAge Differences in Deactivation: A Link to Cognitive Control?
Persson, J., Lustig, C., Nelson, J. K., & Reuter‐Lorenz, P. A. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.6.1021 · Cited by 314 · see citing works
Singh, K. D., & Fawcett, I. P. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.051 · Cited by 312 · see citing works
Ebisch, S. J. H., D, V. G. M., Willems, R. M., Mantini, D., Groen, W. B., Romani, G. L., Buitelaar, J. K., & Harold Bekkering, A. (2010) · Human Brain Mapping · doi:10.1002/hbm.21085 · Cited by 278 · see citing works
Anticevic, A., Repovš, G., Shulman, G. L., & Barch, D. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.008 · Cited by 271 · see citing works
Differential Coding of Pain Intensity in the Human Primary and Secondary Somatosensory Cortex
Timmermann, L., Ploner, M., Haucke, K., Schmitz, F., Baltissen, R., & Schnitzler, A. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1499 · Cited by 270 · see citing works
Cytoarchitecture and Probabilistic Maps of the Human Posterior Insular Cortex
Kurth, F., Eickhoff, S. B., Schleicher, A., Hömke, L., Zilles, K., & Amunts, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp208 · Cited by 241 · see citing works
Human SII and Posterior Insula Differently Encode Thermal Laser Stimuli
Frot, M., Magnin, M., Mauguı̀ere, F., & Garcı́a-Larrea, L. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk007 · Cited by 205 · see citing works
Tomasi, D. G., Ernst, T., Caparelli, E. C., & Chang, L. (2006) · Human Brain Mapping · doi:10.1002/hbm.20211 · Cited by 201 · see citing works
Interactions of Pain Intensity and Cognitive Load: The Brain Stays on Task
Seminowicz, D. A., & Davis, K. D. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl052 · Cited by 194 · see citing works
Mayer, J. S., Roebroeck, A. F., Maurer, K., & Linden, D. E. J. (2009) · Human Brain Mapping · doi:10.1002/hbm.20850 · Cited by 187 · see citing works
Gentili, C., Ricciardi, E., Gobbini, M. I., Santarelli, M. F., Haxby, J. V., Pietrini, P., & Guazzelli, M. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.02.002 · Cited by 186 · see citing works
Cortical and thalamic afferent connections of the insular and adjacent cortex of the rat
Guldin, W. O., & Markowitsch, H. J. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902150203 · Cited by 181 · see citing works
Task-induced deactivation of midline cortical regions in schizophrenia assessed with fMRI
Harrison, B. J., Yücel, M., Pujol, J., & Pantelis, C. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.12.027 · Cited by 166 · see citing works
Self-citationMüller, J. (2009) · doi:10.1037/11919-047 · Cited by 144 · see citing works
Pujol, J., Harrison, B. J., Ortiz, H., Deus, J., Soriano‐Mas, C., López‐Solà, M., Yücel, M., Perich, X., & Cardoner, N. (2009) · Psychological Medicine · doi:10.1017/s003329170800500x · Cited by 76 · see citing works
Self-citationTask-specific deactivation patterns in functional magnetic resonance imaging
Hutchinson, M., Schiffer, W. K., Joseffer, S. S., Liu, A., Schlösser, R. G. M., Dikshit, S., Goldberg, E., & Brodie, J. D. (1999) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(99)00093-4 · Cited by 71 · see citing works
Cardoner, N., Harrison, B. J., Pujol, J., Soriano‐Mas, C., Hernández‐Ribas, R., López‐Solà, M., Real, E., Deus, J., Ortiz, H., Alonso, P., et al. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.559268 · Cited by 65 · see citing works
Self-citationCortical and thalamic afferent connections of the insular and adjacent cortex of the cat
Guldin, W. O., & Markowitsch, H. J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902290309 · Cited by 56 · see citing works
Posterior cingulate activation during moral dilemma in adolescents
Pujol, J., Reixach, J., Harrison, B., Timoneda-Gallart, C., Vilanova, J., & Pérez-Álvarez, F. (2008) · Human Brain Mapping · doi:10.1002/hbm.20436 · Cited by 46 · see citing works
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Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies
Fullana, M. A., Harrison, B. J., Soriano-Mas, C., Vervliet, B., Cardoner, N., Àvila-Parcet, A., & Radua, J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.88 · Cited by 702 · see citing works
Self-citationMapping the self in the brain's default mode network
Davey, C. G., Pujol, J., & Harrison, B. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.022 · Cited by 559 · see citing works
“Such DMN-associated regions include the retrosplenial–temporal cortical system, which supports episodic memory, and areas of the mid and anterior cingulate cortex (Buckner et al., 2008; Harrison et al., 2008; Harrison et al., 2011).”
Self-citationFear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants
Fullana, M. A., Albajes-Eizagirre, A., Soriano-Mas, C., Vervliet, B., Cardoner, N., Benet, O., Radua, J., & Harrison, B. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.002 · Cited by 308 · see citing works
Self-citationArmbruster, D. J. N., Ueltzhöffer, K., Basten, U., & Fiebach, C. J. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00286 · Cited by 202 · see citing works
“There is, however, also evidence that the SFG is part of a task-negative network (or “default mode network”) that is typically deactivated during task performance (Shirer, Ryali, Rykhlevskaia, Menon, & Greicius, 2012; Harrison et al., 2011; Laird et al., 2011; Raichle et al., 2001).”
BackgroundLarge-scale brain network dynamics supporting adolescent cognitive control
Dwyer, D. B., Harrison, B. J., Yücel, M., Whittle, S., Zalesky, A., Pantelis, C., Allen, N. B., & Fornito, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1634-14.2014 · Cited by 143 · see citing works
Self-citationResting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder
Crowther, A., Smoski, M. J., Minkel, J. D., Moore, T. M., Gibbs, D. E., Petty, C., Bizzell, J., Schiller, C. E., Sideris, J. H., Carl, H., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.12 · Cited by 137 · see citing works
“The DMN supports internal mental activity, (Greicius et al, 2003; Mason et al, 2007) and deactivation of the DMN is associated with goaldirected behaviors (Harrison et al, 2011).”
BackgroundStress Impact on Resting State Brain Networks
Soares, J. M., Sampaio, A., Ferreira, L. M., Santos, N. C., Marques, P., Marques, F., Palha, J. A., Cerqueira, J., & Sousa, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066500 · Cited by 134 · see citing works
“There is also evidence that task-induced deactivations of the DMN have been functionally associated with goal-directed behavior [18].”
BackgroundPujol, J., Macià, D., Garcia‐Fontanals, A., Blanco‐Hinojo, L., López‐Solà, M., Garcia-Blanco, S., Poca‐Dias, V., Harrison, B. J., Contreras‐Rodríguez, O., Monfort, J., et al. (2014) · Pain · doi:10.1016/j.pain.2014.04.028 · Cited by 122 · see citing works
Self-citationConnectomic Intermediate Phenotypes for Psychiatric Disorders
Fornito, A., & Bullmore, E. T. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00032 · Cited by 116 · see citing works
Default mode network interference in mild traumatic brain injury – A pilot resting state study
Sours, C., Zhuo, J., Janowich, J. R., Aarabi, B., Shanmuganathan, K., & Gullapalli, R. P. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.034 · Cited by 110 · see citing works
Pujol, J., Blanco‐Hinojo, L., Batalla, A., López‐Solà, M., Harrison, B. J., Soriano‐Mas, C., Crippa, J. A. S., Fagundo, A. B., Deus, J., de la Torre, R., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.008 · Cited by 107 · see citing works
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Functional Heterogeneity within the Default Network during Semantic Processing and Speech Production
Seghier, M. L., & Price, C. J. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00281 · Cited by 104 · see citing works
Human ventromedial prefrontal cortex and the positive affective processing of safety signals
Harrison, B. J., Fullana, M. A., Via, E., Soriano‐Mas, C., Vervliet, B., Martínez‐Zalacaín, I., Pujol, J., Davey, C. G., Kircher, T. T. J., Straube, B., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.080 · Cited by 91 · see citing works
Self-citationPalaniyappan, L., White, T., & Liddle, P. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612805289881 · Cited by 81 · see citing works
Duan, X., Liao, W., Liang, D., Qiu, L., Gao, Q. C., Liu, C.-Y., Gong, Q., & Chen, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032532 · Cited by 73 · see citing works
Default mode network deactivation during emotion processing predicts early antidepressant response
Spies, M., Kraus, C., Geissberger, N., Auer, B., Klöbl, M., Tik, M., Stürkat, I.-L., Hahn, A., Woletz, M., Pfabigan, D. M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.265 · Cited by 68 · see citing works
Language comprehension and brain function in individuals with an optimal outcome from autism
Eigsti, I., Stevens, M. C. G., Schultz, R. T., Barton, M. L., Kelley, E. A., Naigles, L., Orinstein, A. J., Troyb, E., & FEIN, D. A. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.11.014 · Cited by 68 · see citing works
Does “Task Difficulty” Explain “Task-Induced Deactivation?”
Gilbert, S. J., Bird, G., Frith, C., & Burgess, P. W. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00125 · Cited by 67 · see citing works
“…al. (2003) suggests that diverse cognitive demands cause relatively consistent patterns of deactivation, other recent studies have suggested that a single measure of cognitive demand is inadequate to explain task-induced deactivation across all regions (Mayer et al., 2010; Harrison et al., 2011).”
ResultArviv, O., Goldstein, A., & Shriki, O. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0477-15.2015 · Cited by 60 · see citing works
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Gonçalves, Ó. F., Soares, J. M., Carvalho, S., Leite, J., Ganho-Ávila, A., Fernandes-Gonçalves, A., Pocinho, F., Carracedo, A., & Sampaio, A. (2017) · Scientific Reports · doi:10.1038/srep44468 · Cited by 57 · see citing works
Pujol, J., Macià, D., Blanco‐Hinojo, L., Martínez‐Vilavella, G., Sunyer, J., de la Torre, R., Caixàs, A., Martín‐Santos, R., Deus, J., & Harrison, B. J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.065 · Cited by 57 · see citing works
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BackgroundSelf-citationRey, G., Desseilles, M., Favre, S., Dayer, A. G., Piguet, C., Aubry, J., & Vuilleumier, P. O. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.04.016 · Cited by 57 · see citing works
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Steffener, J., Habeck, C. G., & Stern, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044421 · Cited by 56 · see citing works
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BackgroundJang, G., Yoon, S.-A., Lee, S., Park, H., Kim, J., Ko, J. H., & Park, H. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.027 · Cited by 55 · see citing works
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Dumais, K. M., Chernyak, S. V., Nickerson, L. D. H., & Janes, A. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199049 · Cited by 50 · see citing works
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BackgroundDavey, C. G., Yücel, M., Allen, N. B., & Harrison, B. J. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00014 · Cited by 50 · see citing works
Self-citationRance, M., Ruttorf, M., Nees, F., Schad, L. R., & Flor, H. (2014) · Human Brain Mapping · doi:10.1002/hbm.22585 · Cited by 48 · see citing works
Age-related differences in brain activation during working memory updating: An fMRI study
Qin, S., & Basak, C. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107335 · Cited by 46 · see citing works
“Although the insula and the inferior frontal gyrus are not typically considered to be a part of the DMN, suppressions of these two regions have been in cognitively challenging tasks, including tasks of executive functions (Harrison et al., 2011; Prakash et al., 2012).”
BackgroundJamieson, A. J., Harrison, B. J., Razi, A., & Davey, C. G. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01214-z · Cited by 41 · see citing works
Self-citationContextual reinstatement promotes extinction generalization in healthy adults but not PTSD
Hennings, A. C., McClay, M., Lewis‐Peacock, J. A., & Dunsmoor, J. E. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107573 · Cited by 41 · see citing works
Zabik, N. L., Iadipaolo, A. S., Marusak, H. A., Peters, C., Burghardt, K. J., & Rabinak, C. A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24860 · Cited by 41 · see citing works
“Null findings in the vmPFC may relate to increased resting- state “default mode network” activity— as the vmPFC resides within the default mode network (Fullana et al., 2018; Harrison et al., 2008, 2011; Raichle et al., 2001).”
BackgroundThe association between stress and mood across the adult lifespan on default mode network
Soares, J. M., Marques, P., Magalhães, R. J. D. S., Santos, N. C., & Sousa, N. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1203-3 · Cited by 37 · see citing works
“Additionally, task-induced deactivation studies have also reported impaired DMN deactivation in older adults (Grady et al. 2006; Harrison et al. 2011; Hafkemeijer et al. 2012).”
BackgroundAlterations in working memory networks in amnestic mild cognitive impairment
Migo, E. M., Mitterschiffthaler, M. T., O’Daly, O., Dawson, G. R., Dourish, C. T., Craig, K. J., Simmons, A., Wilcock, G. K., McCulloch, E., Jackson, S. H., et al. (2014) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2014.894958 · Cited by 36 · see citing works
“Although not usually considered to be part of the DMN, there has been some evidence that task-induced deactivation can extend more widely, including in the posterior insula (Harrison et al., 2011), albeit when tasks are demanding.”
BackgroundHumphreys, G. F., & Tibon, R. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02510-0 · Cited by 37 · see citing works
“Specifically, dLPC (IPS) shows a positive correlation with task difficulty across cognitive domains, whereas vLPC, which is commonly associated with the DMN, shows the inverse pattern—stronger deactivation for harder tasks (Gilbert et al. 2012; Harrison et al. 2011; Humphreys and Lambon Ralph 2017b).”
BackgroundBinelli, C., Muñiz, A., Subirà, S., Navinés, R., Blanco‐Hinojo, L., Pérez-García, D., Crippa, J. A. S., Farré, M., Jurado, L. A. P., Pujol, J., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140384 · Cited by 29 · see citing works
Self-citationThe convergence and divergence of episodic and semantic functions across lateral parietal cortex
Humphreys, G. F., Jung, J., & Ralph, M. A. L. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac044 · Cited by 30 · see citing works
“Regressor analyses: It has been previously shown that LPC activity is modulated by task difficulty, with dorsal LPC showing a positive correlation with difficulty and ventral parietal cortex showing a negative correlation with difficulty (Harrison et al. 2011; Gilbert et al. 2012; Humphreys and Lambon Ralph 2017), thi…”
BackgroundInfluentialAttention and Working Memory in Adolescents with Autism Spectrum Disorder: A Functional MRI Study
Rahko, J. S., Vuontela, V., Carlson, S., Nikkinen, J., Hurtig, T. M., Kuusikko‐Gauffin, S., Mattila, M., Jussila, K. K., Remes, J. J., Jansson-Verkasalo, E. M., et al. (2015) · Child Psychiatry & Human Development · doi:10.1007/s10578-015-0583-6 · Cited by 31 · see citing works
Spatial Dependencies between Large-Scale Brain Networks
Leech, R., Scott, G., Carhart-Harris, R. L., Turkheimer, F., Taylor-Robinson, S. D., & Sharp, D. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098500 · Cited by 28 · see citing works
Rance, M., Ruttorf, M., Nees, F., Schad, L. R., & Flor, H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00357 · Cited by 26 · see citing works
fMRI investigation of working memory in adolescents with surgically treated congenital heart disease
King, T. Z., Smith, K. M., Burns, T. G., Sun, B., Shin, J., Jones, R. A., Drossner, D., & Mahle, W. T. (2017) · Applied Neuropsychology: Child · doi:10.1080/21622965.2015.1065185 · Cited by 25 · see citing works
“More recent studies have shown that areas of the brain displaying TID from rest are also found outside the default mode network (Harrison et al., 2011; Hutchinson et al., 1999; Mason et al., 2007; Mayer, Roebroeck, Maurer, & Linden, 2010; Persson, Lustig, Nelson, & Reuter-Lorenz, 2007), especially…”
BackgroundContributive sources analysis: A measure of neural networks' contribution to brain activations
Beldzik, E., Domagalik, A., Daselaar, S. M., Fąfrowicz, M., Froncisz, W., Ogińska, H., & Marek, T. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.014 · Cited by 24 · see citing works
“Further studies demonstrated that additional TIDs appear outside of the DMN (Harrison et al., 2011; Mayer et al., 2010; Pelphrey et al., 2003).”
A thalamo-centric neural signature for restructuring negative self-beliefs
Steward, T., Kung, P., Davey, C. G., Moffat, B. A., Glarin, R. K., Jamieson, A. J., Felmingham, K. L., & Harrison, B. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01402-9 · Cited by 26 · see citing works
“An alternative explanation is that this pathway reflects individual differences in the perceived difficulty of challenging negative beliefs [39, 47], as we did observe an interaction between the choice to challenge or repeat beliefs that were more strongly endorsed.”
BackgroundSelf-citationJamieson, A. J., Davey, C. G., & Harrison, B. J. (2021) · eNeuro · doi:10.1523/eneuro.0380-20.2021 · Cited by 24 · see citing works
Self-citationModulation of the brain's core-self network by self-appraisal processes
Delahoy, R., Davey, C. G., Jamieson, A. J., Finlayson-Short, L., Savage, H. S., Steward, T., & Harrison, B. J. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118980 · Cited by 22 · see citing works
“…view has emerged from euroimaging studies over the past two decades, particularly those hat associate DMN activity with self-related processes ( Raichle et al., 001 ; D’Argembeau et al., 2005 ; Harrison et al., 2008 a; Qin and orthoff, 2011 ; Whitfield-Gabrieli et al., 2011 ; Amft et al., 2015 ).”
BackgroundResultSelf-citationSuppressed activity of the rostral anterior cingulate cortex as a biomarker for depression remission
Davey, C. G., Cearns, M., Jamieson, A. J., & Harrison, B. J. (2021) · Psychological Medicine · doi:10.1017/s0033291721004323 · Cited by 21 · see citing works
“Our contrast of interest was shapes > faces, which captures the suppression of activity that occurs routinely in rACC during engagement with face-matching tasks (Harrison et al., 2011).”
BackgroundMethodInfluentialSelf-citationGreenwood, P. M., Blumberg, E. J., & Scheldrup, M. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.006 · Cited by 21 · see citing works
Effects of Expressive Writing on Neural Processing During Learning
DiMenichi, B. C., Ceceli, A. O., Bhanji, J. P., & Tricomi, E. M. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00389 · Cited by 20 · see citing works
“Because the MCC is typically deactivated during task engagement (Harrison et al., 2011), while increases in activation are typically associated with processing of negative emotion (Maddock et al., 2003; Shackman et al., 2011), we also examined how individual differences in MCC activation correlated…”
BackgroundInfluentialNeurodevelopmental correlates of the emerging adult self
Davey, C. G., Fornito, A., Pujol, J., Breakspear, M. J., Schmaal, L., & Harrison, B. J. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100626 · Cited by 21 · see citing works
Self-citationMadjar, C., Gauthier, C. J., Bellec, P., Birn, R. M., Brooks, J. C. W., & Hoge, R. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.080 · Cited by 21 · see citing works
“Increased task the BOLD signal during spontaneous breathing (A) and when controlling PETCO2 (B). difficulty is known to modulate the amplitude of measured negative responses (Harrison et al., 2011).”
BackgroundBehavioral and neural responses to infant and adult tears: The impact of maternal love withdrawal.
Riem, M. M. E., van IJzendoorn, M. H., Carli, P. D., Vingerhoets, A. J. J. M., & Bakermans‐Kranenburg, M. J. (2017) · Emotion · doi:10.1037/emo0000288 · Cited by 19 · see citing works
“Insula deactivation during the perception of adult faces has been found in previous research and may reflect vigilance, concentration on the environment and social signals, and reduced self-awareness (Harrison et al., 2011).”
ResultLongitudinal task-negative network analyses in preclinical Huntington’s disease
Wolf, R. C., Sambataro, F., Vasić, N., Wolf, N. D., Thomann, P. A., Landwehrmeyer, G. B., & Orth, M. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0447-7 · Cited by 18 · see citing works
The role of vision in the neural representation of unique entities
Wang, X., Peelen, M. V., Han, Z., Caramazza, A., & Bi, Y. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.05.007 · Cited by 18 · see citing works
“…Buckner et al., 2008; Raichle, 2015), which has been shown to be deactivated during explicit tasks compared to rest, with the extent of deactivation being correlated with task dif fi culty (Buckner et al., 2008; Fox et al., 2005; Gilbert et al., 2012; Harrison et al., 2011; Humphreys et al., 2015).”
ResultDysregulation, Catastrophic Reactions, and the Anxiety Disorders
Walkup, J. T., Friedland, S. J., Peris, T. S., & Strawn, J. R. (2021) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.10.011 · Cited by 19 · see citing works
A new window to understanding individual differences in reward sensitivity from attentional networks
Costumero, V., Barrós‐Loscertales, A., Bustamante, J. C., Fuentes‐Claramonte, P., Rosell‐Negre, P., Ventura‐Campos, N., & Ávila, C. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0760-6 · Cited by 17 · see citing works
“Previous research has repeatedly shown that, during cognitive tasks, the higher the task demands, the stronger DMN deactivation is (Harrison et al. 2011).”
BackgroundLee, S. W., Cha, H., Chung, Y., Kim, E., Song, H., Chang, Y., & Lee, S. J. (2019) · Depression and Anxiety · doi:10.1002/da.22933 · Cited by 17 · see citing works
“…is involved in self‐referential processing, which is activated during focus on one's own feelings, thoughts, and memories (Whitfield‐Gabrieli & Ford, 2012) and is deactivated during cognitive tasks compared with the resting state (Harrison et al., 2011; Mayer, Roebroeck, Maurer, & Linden, 2010).”
BackgroundAmaoui, S., Martín-Pérez, C., Marín‐Morales, A., Bueso‐Izquierdo, N., García‐León, M. Á., Pérez-Garcı́a, M., & Verdejo‐Román, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-14181-2 · Cited by 16 · see citing works
Leonards, C. A., Harrison, B. J., Jamieson, A. J., Steward, T., Lux, S., Philipsen, A., & Davey, C. G. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac361 · Cited by 15 · see citing works
“Distinct from the other core DMN regions, suppression of the MPFC has been consistently observed in most cognitive tasks (Shulman et al. 1997; Binder et al. 1999; Mazoyer et al. 2001) and levels of difficulty (McKiernan et al. 2003; McKiernan et al. 2006; Mayer et al. 2010; Harrison et al. 2011).”
BackgroundMethodResultInfluentialSelf-citationProper and common names in the semantic system
Desai, R. H., Tadimeti, U., & Riccardi, N. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02593-9 · Cited by 16 · see citing works
“It is commonly observed that relative to rest, AG is deactivated less for less demanding conditions regardless of the nature of task or stimulus materials (Gilbert et al. 2012; Harrison et al. 2011; Humphreys and Lambon Ralph 2017).”
Galazzo, I. B., Magrinelli, F., Pizzini, F. B., Storti, S. F., Agosta, F., Filippi, M., Marotta, A., Mansueto, G., Menegaz, G., & Tinazzi, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69514-w · Cited by 16 · see citing works
Exploring spatiotemporal network transitions in task functional MRI
Scott, G., Hellyer, P. J., Hampshire, A., & Leech, R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22706 · Cited by 15 · see citing works
“n-stationary and may adapt to cognitive demands (Leech et al, 2014). For example, the spatial pattern of relative DMN deactivation evoked by even quite similar cognitive tasks can vary substantially (Harrison et al., 2011; Leech et al., 2011; Leech et al., 2013; Seghier and Price, 2012b). Equally, individual brain net…”
BackgroundMomentary lapses of attention in multisensory environment
Su, W. Q., Guo, Q., Li, Y., Zhang, K., Zhang, Y., & Chen, Q. (2020) · Cortex · doi:10.1016/j.cortex.2020.07.014 · Cited by 11 · see citing works
Differential activation of the default mode network in jet lagged individuals
Coutinho, J. F. P., Gonçalves, Ó. F., Maia, L., Vasconcelos, C., Perrone, K. M., Simon-Dack, S. L., Hernandez, K. O., Oliveira‐Silva, P., Mesquita, A. R., & Sampaio, A. (2014) · Chronobiology International · doi:10.3109/07420528.2014.955187 · Cited by 12 · see citing works
“Importantly, the DMN, in particular its pattern of deactivation during the transition to goaloriented or attention-demanding tasks (Arbabshirani et al., 2013; Harrison et al., 2011), has also been related to the performance in attention demanding tasks.”
BackgroundThe influence of sex steroid treatment on insular connectivity in gender dysphoria
Reed, M. B., Handschuh, P. A., Klöbl, M., Konadu, M. E., Kaufmann, U., Hahn, A., Kranz, G. S., Spies, M., & Lanzenberger, R. R. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106336 · Cited by 10 · see citing works
de Bézenac, C. E., Sluming, V., Gouws, A. D., & Corcoran, R. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.07.003 · Cited by 9 · see citing works
Humphreys, G. F., Halai, A. D., Branzi, F. M., & Ralph, M. A. L. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00116 · Cited by 8 · see citing works
Amnesia in healthy people via hippocampal inhibition: A new forgetting mechanism
Anderson, M. C., & Subbulakshmi, S. (2023) · Quarterly Journal of Experimental Psychology · doi:10.1177/17470218231202728 · Cited by 7 · see citing works
“…internal cues to external tasks (Anticevic et al., 2012; Binder et al., 1999; Buckner et al., 2008; Buckner & DiNicola, 2019; Fakhraei et al., 2021; Harrison et al., 2011; Mazoyer et al., 2001; McKiernan et al., 2006; Raichle, 2015; Shulman et al., 1997; Singh & Fawcett, 2008; Smallwood et al.,…”
BackgroundMisaki, M., Young, K. D., Tsuchiyagaito, A., Savitz, J. B., & Guinjoan, S. M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02880-3 · Cited by 7 · see citing works
Altered task-related decoupling of the rostral anterior cingulate cortex in depression
Leonards, C. A., Harrison, B. J., Jamieson, A. J., Agathos, J. A., Steward, T., & Davey, C. G. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103564 · Cited by 6 · see citing works
“This contrast was the most appropriate for our analysis as this captures the relative suppression of activity that routinely occurs in the rACC during demanding conditions (Davey et al., 2023; Harrison et al., 2011; Leonards et al., 2023).”
BackgroundMethodSelf-citationAltered effective connectivity among face-processing systems in major depressive disorder
Sheng, F., Wang, Y., Li, R., Li, X., Chen, X., Zhang, Z., Liu, R., Zhang, L., Zhou, Y., & Wang, G. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230123 · Cited by 5 · see citing works
“38 We believe that the discrepancy between our findings and those of this previous study can be attributed to the difference in the specific cognitive processes J Psychiatry Neurosci 2024;49(3) under investigation.”
BackgroundMethodResultInfluentialSingle neuron responses to perceptual difficulty in the mouse auditory cortex
Haimson, B., Gilday, O. D., Lavi-Rudel, A., Sagi, H., Lottem, E., & Mizrahi, A. (2024) · Science Advances · doi:10.1126/sciadv.adp9816 · Cited by 6 · see citing works
Lu, L., Li, H., Mills, J. A., Schroeder, H. K., Mossman, S. A., Varney, S. T., Cecil, K. M., Huang, X., Gong, Q., Levine, A. A., et al. (2020) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2020.0024 · Cited by 5 · see citing works
“2013), the default mode network processes selfreferential cognition (Harrison et al. 2011) and generates mental representations of one’s self and future actions, thoughts, and feelings in addition to assigning significance to thoughts about oneself (Andrews-Hanna et al.”
BackgroundYakunina, N., Tae, W., Lee, K. U., Kim, S. S., & Nam, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066424 · Cited by 4 · see citing works
Yoo, J. H., Park, Y. W., Kim, D., Park, H., & Jeong, B. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.22.1019 · Cited by 5 · see citing works
Agency performance modulates resting-state variation in prefrontal brain regions
de Bézenac, C. E., Sluming, V., Alhazmi, F. H., & Corcoran, R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.12.035 · Cited by 4 · see citing works
Barreiros, A. R., Breukelaar, I. A., Mayur, P. M., Andepalli, J., Tomimatsu, Y., Funayama, K., Foster, S., Harris, A. W. F., & Korgaonkar, M. S. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03600-3 · Cited by 4 · see citing works
“This reduction in activity, or ‘ deactivation, ’ is believed to indicate a shift from internal processing to increased attention on external tasks [10, 11].”
Investigation of Prefrontal Hemodynamics of PTSD Patients While Performing Stroop Task Using fNIRS
Yennu, A. S., Tian, F., Smith‐Osborne, A., & Liu, H. (2014) · Biomedical optics · doi:10.1364/biomed.2014.bw2b.7 · Cited by 3 · see citing works
Elwér, Å., & Andin, J. (2024) · Brain and Language · doi:10.1016/j.bandl.2024.105416 · Cited by 2 · see citing works
“Similar findings of deactivation in the IPL have also been found for non-mathematical tasks, for example, face matching and Stroop color-word interference tasks (Harrison et al., 2011).”
ResultMemory Recognition Performance in Women Survivors of Intimate Partner Violence: An fMRI Study
Pérez-González, M. Á., Daugherty, J. C., Hidalgo-Ruzzante, N. A., Pérez-Garcı́a, M., & Verdejo‐Román, J. (2025) · Journal of Interpersonal Violence · doi:10.1177/08862605251350109 · Cited by 2 · see citing works
“Moreover, greater brain deactivation may reflect a greater effort to achieve similar results (Harrison et al., 2011).”
Mapping brain neural networks in stress brain connectivity
Wadan, A. S., Ahmed, M. A., & Moradikor, N. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.014 · Cited by 1 · see citing works
Functional and Structural MRI in Alzheimer’s Disease: A Multimodal Approach
Grothe, M. J., Bokde, A. L. W., & Teipel, S. J. (2014) · Springer eBooks · doi:10.1007/978-3-642-54542-9_20 · Cited by 1 · see citing works
Rodríguez, C., & Oren (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Jackson, R. L. (2014) · Research Explorer (The University of Manchester)
Structural and functional connectivity in multiple sclerosis
Sampaio, A. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/9atj-na03
Disconnection, network dysfunction and cognitive impairment after traumatic brain injury
Bonnelle, V. (2012) · Spiral (Imperial College London) · doi:10.25560/9782
Exploring spatiotemporal network transitions in task functional MRIPreprint
Scott, G., Hellyer, P. J., Hampshire, A., & Leech, R. (2014) · arXiv (Cornell University) · doi:10.48550/arxiv.1408.5371
“n-stationary and may adapt to cognitive demands (Leech et al, 2014). For example, the spatial pattern of relative DMN deactivation evoked by even quite similar cognitive tasks can vary substantially (Harrison et al., 2011; Leech et al., 2011; Leech et al., 2013; Seghier and Price, 2012b). Equally, individual brain net…”
BackgroundAso, T., & Fukuyama, H. (2021) · Creative economy · doi:10.1007/978-981-16-4457-3_18
Lee, M., Lori, A., Langford, N. A., & Rilling, J. K. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114144 · Cited by 1 · see citing works
Zhao, M., Law, A. J. J., Su, C., Jennings, S. A., Bourgon, A., Jia, W., Larose, M.-H., Bowness, D., & Zeng, Y. (2025) · Frontiers in Neuroergonomics · doi:10.3389/fnrgo.2025.1472693
“Our findings align with previous research demonstrating that excessive activation or inefficient suppression of the DMN is associated with poorer task performance across various domains (Anticevic et al., 2012; Duan et al., 2012; Harrison et al., 2011).”
Youngkin, A. E., Snetkov, G., Grady, C., Puglia, M. H., Frazier, K. F., Pelphrey, K. A., Fairchild, K. D., Goodkin, H. P., & Evans, T. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.24.661281 · Cited by 1 · see citing works
He, L., He, X., Li, X., Wang, S., Ji, C., Yin, F., Yang, X., He, Y., Zuo, P., & Gao, J. (2026) · Brain and Behavior · doi:10.1002/brb3.71398
“These results support a compensatory but inefficient neural strategy underlying preserved accuracy but prolonged reaction time in MCI (Harrison et al. 2011 ).”
Prefrontal hemodynamic responses during video learning across academic disciplines: An fNIRS study
Liang, D., Xie, H., Yang, H., He, J., Jia, C., Yang, Y., Zhang, L., Ren, Z., Jiang, M., Yang, D., et al. (2026) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545826400122
- Authors
- Harrison, B. J., Pujol, J., Contreras-Rodríguez, O., Soriano-Mas, C., López-Solà, M., Deus, J., Ortiz, H., Blanco-Hinojo, L., Alonso, P., Hernández-Ribas, R., Cardoner, N., & Menchón, J. M.
- Affiliations
- The University of Melbourne (AU)
- Universitat Autònoma de Barcelona (ES)
- Barcelona Biomedical Research Park (ES)
- Bellvitge University Hospital (ES)
- Corresponding author
- Harrison, Ben J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-07-29
- Volume
- 6
- Issue
- 7
- Pages
- e22964
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3146521
- OpenAlex
- W2020498763
- Cited by
- 92
- References
- 53
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 16 · 2013: 7 · 2012: 10
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council (628509)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- task-induced deactivation, default mode network, resting state, task demands, posterior insular cortex, task difficulty, interoception, sensory integration
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Nerve Net, Neural Pathways, Rest, Task Performance and Analysis, Young Adult, Functional Neuroimaging
About these checks
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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