The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Cytokines IL-1 β, IL-6, and TNF- α Enhance In Vitro Growth of Bacteria
Abstract
We have previously reported that in acute respiratory distress syndrome (ARDS), nonsurvivors have persistent elevation in pulmonary and circulating proinflammatory cytokine levels over time and a high rate of nosocomial infections antemortem. In these patients, none of the proven or suspected nosocomial infections caused a transient or sustained increase in plasma proinflammatory cytokine levels above preinfection values. We hypothesized that cytokines secreted by the host during ARDS may favor the growth of bacteria. We conducted an in vitro study of the growth of three bacteria clinically relevant in nosocomial infections, evaluating their in vitro response to various concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6. We found that all three bacterial species showed concentration-dependent growth enhancement when incubated with one or more tested cytokines and that blockade by specific neutralizing cytokine MoAb significantly inhibited cytokine-induced growth. When compared with control, the 6-h growth response (cfu/ml) was maximal with IL-1beta at 1,000 pg for Staphylococcus aureus (36 +/- 16 versus 377 +/- 16; p = 0.0001) and Acinetobacter spp. (317 +/- 1,147 versus 1,124 +/- 147; p = 0.002) and with IL-6 at 1,000 pg for Pseudomonas aeruginosa (99 +/- 50 versus 509 +/- 50; p = 0.009). The effects of cytokines were seen only with fresh isolates and were lost with passage in vitro on bacteriologic medium without added cytokines. In this study we provide additional evidence for a newly described pathogenetic mechanism for bacterial proliferation in the presence of exaggerated and protracted inflammation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Almost every common clinical intervention used in intensive care (eg, enteral feeding,43 proton-pump inhibitors,38,39 systemic catecholamines,22,23 and systemic antibiotics65,66) changes environmental growth conditions for intestinal bacteria”
From The microbiome and critical illness (2016) · cites this paper as [23]
In the citing paper
“The normally nutrient-poor environment of the alveolus is flooded with nutrient-rich oedema,55 pockets of oxygen and heterogeneous temperature gradients are established,48,49 and the signalling molecules of the host stress response selectively promote the growth of potential pathogens.”
From The microbiome and critical illness (2016) · cites this paper as [23]
In the citing paper
“as well as catecholamines, growth promotion is seen with TNFα, interleukins 1, 6, and 8, and glucocorticoids.”
From The microbiome and critical illness (2016) · cites this paper as [23]
Citations
Cites
Baumann, H., & Gauldie, J. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90137-6 · Cited by 2,907
Persistent Elevation of Inflammatory Cytokines Predicts a Poor Outcome in ARDS
Meduri, G. U., Headley, S., Kohler, G., Stentz, F. B., Tolley, E. A., Umberger, R. A., & Leeper, K. V. (1995) · CHEST Journal · doi:10.1378/chest.107.4.1062 · Cited by 788
Inflammatory Cytokines in the BAL of Patients With ARDS
Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., & Postlethwaite, A. (1995) · Chest · doi:10.1378/chest.108.5.1303 · Cited by 695
Self-citationGrowth characteristics of group A streptococci in a new chemically defined medium
Rijn, I. V. D., & KESSLER, R. E. (1980) · Infection and Immunity · doi:10.1128/iai.27.2.444-448.1980 · Cited by 484
Evaluation of Bronchoscopic Techniques for the Diagnosis of Nosocomial Pneumonia
Chastre, J. E., Fagon, J.-Y., Lecsö‐Bornet, M., Calvat, S., Dombret, M.-C., Khani, R., Basset, F., & Gibert, C. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.1.7599829 · Cited by 362
Broug-Holub, E., Toews, G. B., van Iwaarden, J. F., Strieter, R. M., Kunkel, S. L., Paine, R., & Standiford, T. J. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1139-1146.1997 · Cited by 263
Infections and the Inflammatory Response in Acute Respiratory Distress Syndrome
Headley, A. S., Meduri, G. U., & Tolley, E. A. (1997) · CHEST Journal · doi:10.1378/chest.111.5.1306 · Cited by 259
Krafft, P., Fridrich, P., Pernerstorfer, T., Fitzgerald, R. D., Koç, D., Schneider, B., Hammerle, A. F., & Steltzer, H. (1996) · Intensive Care Medicine · doi:10.1007/bf01708091 · Cited by 244
Interactions Between Neutrophils and Cytokines in Blood and Alveolar Spaces During ARDS
Chollet‐Martin, S., Jourdain, B., Gibert, C., Elbim, C., Chastre, J. E., & Gougerot‐Pocidalo, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.3.8810592 · Cited by 240
Cerami, A. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90035-m · Cited by 199
Research works printed but not linked: 1
- Porat, 1992, IL-1β and Escherichia coli [Letter]., Science, 258, 1562, 10.1126/science.258.5088.1562.b · DOI
Cited by
Sorted by citations
Novel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 774
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460
Acute Lower Respiratory Tract Infection
Mizgerd, J. P. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074111 · Cited by 455
Held, H., BOETTCHER, S., Hamann, L., & Uhlig, S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.3.2003001 · Cited by 258
Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications
Jawa, R. S., Anillo, S., Huntoon, K. M., Baumann, H., & Kulaylat, M. N. (2010) · Journal of Intensive Care Medicine · doi:10.1177/0885066610384188 · Cited by 233
Seki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 227
Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature.
Halbertsma, F. J. J., Vaneker, M., Scheffer, G. J., & van der Hoeven, J. G. (2005) · PubMed · Cited by 176
Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia
Yende, S. P., TUOMANEN, E. I., Wunderink, R. G., Kanaya, A. M., Newman, A. B., Harris, T. B., de Rekeneire, N., & Kritchevsky, S. B. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-888oc · Cited by 155
Calabrese, E. J. (2005) · Critical Reviews in Toxicology · doi:10.1080/10408440590917044 · Cited by 154
Roux, D., Gaudry, S., Dreyfuss, D., El-Benna, J., de Prost, N., Denamur, E., Saumon, G., & Ricard, J.-D. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819629d2 · Cited by 129
Asehnoune, K., Séguin, P., Allary, J., Feuillet, F., Lasocki, S., Cook, F., Floch, H. L., Chabanne, R., Geeraerts, T., Roger, C., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70144-4 · Cited by 129
Airway epithelial cell inflammatory signalling in cystic fibrosis
Jacquot, J. P., Tabary, O., Rouzic, P. L., & Clément, A. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.002 · Cited by 120
Effects of cytokines and endotoxin on the intracellular growth of bacteria
Kanangat, S., Meduri, G. U., Tolley, E. A., Patterson, D. R., Meduri, C. U., Pak, C., Griffin, J. P., Bronze, M. S., & Schaberg, D. R. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2834-2840.1999 · Cited by 110
Self-citationStéphan, F., Yang, K., Tankovic, J., Soussy, C., Dhonneur, G., Duvaldestin, P., Brochard, L. J., Brun‐Buisson, C., HARF, A., & Delclaux, C. (2002) · Critical Care Medicine · doi:10.1097/00003246-200202000-00009 · Cited by 101
Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong
Yam, L. Y.-C., Lau, A. C.-W., Lai, F. Y.-L., Shung, E., Chan, J., & Wong, V. C. W. (2006) · Journal of Infection · doi:10.1016/j.jinf.2006.01.005 · Cited by 100
Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis
Domenico, E. G. D., Cavallo, I., Capitanio, B., Ascenzioni, F., Pimpinelli, F., Morrone, A., & Ensoli, F. (2019) · Microorganisms · doi:10.3390/microorganisms7090301 · Cited by 101
Agouridakis, P., Kyriakou, D., Alexandrakis, M. G., Prekates, A. A., Perisinakis, K., Karkavitsas, N. S., & Bouros, D. E. (2002) · Respiratory Research · doi:10.1186/rr193 · Cited by 98
Lung Microbiome in Asthma: Current Perspectives
Loverdos, K., Bellos, G., Kokolatou, L., Vasileiadis, I., Giamarellos‐Bourboulis, E. J., Pecchiari, M., Koulouris, N. G., Koutsoukou, A., & Rovina, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111967 · Cited by 91
Domenico, E. G. D., Cavallo, I., Bordignon, V., Prignano, G., Sperduti, I., Gurtner, A., Trento, E., Toma, L., Pimpinelli, F., Capitanio, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27421-1 · Cited by 87
Wood, G. C., Boucher, B. A., Croce, M. A., Hanes, S. D., Herring, V. L., & Fabian, T. C. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.12.972.33596 · Cited by 86
Protective Effects of Steroids in Cardiac Surgery: A Meta-Analysis of Randomized Double-Blind Trials
Cappabianca, G., Rotunno, C., Schinosa, L. D. L. T., Ranieri, V. M., & Paparella, D. (2010) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2010.03.015 · Cited by 84
Production of Modified C-Reactive Protein in U937-Derived Macrophages
Ciubotaru, I., Potempa, L. A., & Wander, R. C. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523001010 · Cited by 80
Hijacking of immune defences by biofilms: a multifront strategy
Campoccia, D., Mirzaei, R., Montanaro, L., & Arciola, C. R. (2019) · Biofouling · doi:10.1080/08927014.2019.1689964 · Cited by 81
Meduri, G. U. (2002) · Critical Care · doi:10.1186/cc1450 · Cited by 76
Bouros, D. E., Alexandrakis, M. G., Antoniou, K. M., Agouridakis, P., Pneumatikos, I. A., Anevlavis, S., Pataka, A., Patlakas, G., Karkavitsas, N. S., & Kyriakou, D. (2004) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-4-6 · Cited by 75
Pulmonary infection in Wegener granulomatosis and idiopathic pulmonary fibrosis
Richter, A. G., STOCKLEY, R. A., Harper, L., & THICKETT, D. R. (2009) · Thorax · doi:10.1136/thx.2008.110445 · Cited by 75
Induction of human β‐defensin‐2 expression in human astrocytes by lipopolysaccharide and cytokines
Hao, H., Zhao, J., Lotoczky, G. A., Grever, W. E., & Lyman, W. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00305.x · Cited by 75
Ahn, J., Song, J., Yun, Y., Jeong, G., & Choi, I. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2005.00021.x · Cited by 74
Gram-Negative Bacterial Sensors for Eukaryotic Signal Molecules
Lesouhaitier, O., Véron, W., Chapalain, A., Madi, A., Blier, A.-S., Dagorn, A., Connil, N., Chevalier, S., Orange, N., & Feuilloley, M. G. J. (2009) · Sensors · doi:10.3390/s90906967 · Cited by 72
Mechanical ventilation may increase susceptibility to the development of bacteremia
Lin, C.-Y., Zhang, H., Cheng, K.-C., & Slutsky, A. S. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000063449.58029.81 · Cited by 70
Aerosolised antibiotics: a critical appraisal of their use
Hagerman, J., Hancock, K., & Klepser, M. E. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.1.71 · Cited by 70
IMMUNOMODULATION AND SEPSIS: IMPACT OF THE PATHOGEN
Moine, P., & Abraham, E. H. (2004) · Shock · doi:10.1097/01.shk.0000140663.80530.73 · Cited by 66
Preoperative C-Reactive Protein Predicts Mid-Term Outcome After Cardiac Surgery
Cappabianca, G., Paparella, D., Visicchio, G., Capone, G., Lionetti, G., Numis, F., Ferrara, P., d’Agostino, C., & Schinosa, L. D. L. T. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.06.039 · Cited by 66
Modulation of Bacterial Growth by Tumor Necrosis Factor-α In Vitro and In Vivo
Lee, J. H., Sorbo, L. D., Khine, A. A., de Azavedo, J., Low, D. E., Bell, D., Uhlig, S., Slutsky, A. S., & Zhang, H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200302-303oc · Cited by 63
Lin, W., Lin, C., Chen, C., Chen, C.-W., & Lin, Y.-S. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2009.009256 · Cited by 62
Meduri, G. U. (1999) · Sepsis · doi:10.1023/a:1009870524359 · Cited by 59
Wu, Q., Yu, L.-J., Qiu, J., Shen, B., Wang, D., Soromou, L. W., & Feng, H. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.05.030 · Cited by 59
Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S. B., Seo, B., Rich, A. M., & Hussaini, H. M. (2021) · International Endodontic Journal · doi:10.1111/iej.13524 · Cited by 62
Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
Kapétanovic, R., Jouvion, G., Fitting, C., Parlato, M., Blanchet, C., Huerre, M., Cavaillon, J., & Adib‐Conquy, M. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.05.003 · Cited by 57
Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application
Hajishengallis, G., Hajishengallis, E., Kajikawa, T., Wang, B., Yancopoulou, D., Ricklin, D., & Lambris, J. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.006 · Cited by 57
Wasielewski, H., Alcock, J., & Aktipis, A. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13118 · Cited by 58
Chang, R. Y. K., Chow, M. Y. T., Wang, Y., Liu, C., Hong, Q., Morales, S., McLachlan, A. J., Kutter, E. M., Li, J., & Chan, H. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.01.006 · Cited by 53
McLaughlin, R. A., & Hoogewerf, A. J. (2006) · Microbial Pathogenesis · doi:10.1016/j.micpath.2006.04.005 · Cited by 53
Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis
Ziaka, M., & Exadaktylos, A. K. (2024) · Critical Care · doi:10.1186/s13054-024-04855-w · Cited by 54
Mechanisms of Epithelial Immunity Evasion by Respiratory Bacterial Pathogens
Sharma, L., Feng, J., Britto, C. J., & Cruz, C. S. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00091 · Cited by 51
Effects of Methylprednisolone on Intracellular Bacterial Growth
Meduri, G. U., Kanangat, S., Bronze, M. S., Patterson, D. R., Meduri, C., Pak, C., Tolley, E. A., & Schaberg, D. R. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.6.1156-1163.2001 · Cited by 50
Kanangat, S., Bronze, M. S., Meduri, G. U., Postlethwaite, A. E., Stentz, F. B., Tolley, E. A., & Schaberg, D. R. (2001) · The Journal of Infectious Diseases · doi:10.1086/317645 · Cited by 50
The local inflammatory environment and microorganisms in “aseptic” loosening of hip prostheses
Hoenders, C. S. M., Harmsen, M. C., & van Luyn, M. J. A. (2007) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30992 · Cited by 49
Deramaudt, T. B., Ali, M., Vinit, S., & Bonay, M. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4563 · Cited by 50
Environmental Stimuli Shape Biofilm Formation and the Virulence of Periodontal Pathogens
Pöllänen, M., Paino, A., & Ihalin, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140817221 · Cited by 48
Evaluation of Non-Resolving and Progressive Pneumonia
Menéndez, R., & Torres, A. (2003) · Springer eBooks · doi:10.1007/978-1-4757-5548-0_17 · Cited by 48
Helenalin reduces Staphylococcus aureus infection in vitro and in vivo
Boulanger, D. S. M., Brouillette, É., Jaspar, F., Malouin, F., Mainil, J. G., Bureau, F., & Lekeux, P. M. (2006) · Veterinary Microbiology · doi:10.1016/j.vetmic.2006.08.020 · Cited by 46
Betulin protects mice from bacterial pneumonia and acute lung injury
Wu, Q., Li, H., Qiu, J., & Feng, H. (2014) · Microbial Pathogenesis · doi:10.1016/j.micpath.2014.08.005 · Cited by 45
Host Defence against Bacterial Biofilms: “Mission Impossible”?
Hänsch, G. M. (2012) · ISRN Immunology · doi:10.5402/2012/853123 · Cited by 46
A cooperativity between virus and bacteria during respiratory infections
Lalbiaktluangi, C., Yadav, M., Singh, P. K., Singh, A., Iyer, M., Vellingiri, B., Zomuansangi, R., Zothanpuia, Z., & Ram, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1279159 · Cited by 43
Mizgerd, J. P., Lupa, M. M., Hjoberg, J., Vallone, J., Warren, H. B., Butler, J. P., & Silverman, E. S. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00353.2003 · Cited by 42
The Human Respiratory Microbiome: Implications and Impact
Mitchell, A. B., & Glanville, A. R. (2018) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0037-1617441 · Cited by 38
Demoule, A., Decailliot, F., Jonson, B., Christov, C., Maître, B., Touqui, L., Brochard, L. J., & Delclaux, C. (2006) · Intensive Care Medicine · doi:10.1007/s00134-005-0043-z · Cited by 38
Intestinal Microbiota: Facts and Fiction
Kverka, M., & Tlaskalová-Hogenová, H. (2017) · Digestive Diseases · doi:10.1159/000449095 · Cited by 37
Mittal, R., Sharma, S., Chhibber, S., & Harjai, K. (2006) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2005.11.002 · Cited by 37
Kaza, S. K., McClean, S., & Callaghan, M. (2011) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.06.005 · Cited by 36
Nguyen, M. T., Sharma, A., Wu, W., Gomi, R., Sung, B., Hospodsky, D., Angenent, L. T., & Worgall, S. (2016) · The ISME Journal · doi:10.1038/ismej.2016.76 · Cited by 36
Leid, J. G., Costerton, J. W., Shirtliff, M. E., Gilmore, M. S., & Engelbert, M. (2002) · DNA and Cell Biology · doi:10.1089/10445490260099692 · Cited by 36
Endothelial Perturbation in Cystic Fibrosis
Romano, M., Collura, M., Iapichino, L., Pardo, F., Falco, A., Chiesa, P. L., Caimi, G., & Davı̀, G. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616736 · Cited by 36
Hyperinflammation in airways of cystic fibrosis patients: what’s new?
Jacquot, J. P., Tabary, O., & Clément, A. (2008) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.8.4.359 · Cited by 35
Hasibeder, W. R. (2003) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-200304000-00006 · Cited by 34
Wu, C., Lee, Y.-L., Chang, K.-M., Chang, G., King, S.-L., Chiang, C., & Niederman, M. S. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000054865.47068.58 · Cited by 33
Lau, A. C. W., So, L. K.-Y., Miu, F. P. L., Yung, R. W., Poon, E., CHEUNG, T. M., & Yam, L. Y.-C. (2004) · Respirology · doi:10.1111/j.1440-1843.2004.00588.x · Cited by 32
Serum biomarkers in Acute Respiratory Distress Syndrome an ailing prognosticator
Τzouvelekis, Α., Pneumatikos, I. A., & Bouros, D. E. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-62 · Cited by 32
Karzai, W., Cui, X., Mehlhorn, B., Straube, E., Härtung, T., Gerstenberger, E. P., Banks, S. M., Natanson, C., Reinhart, K., & Eichacker, P. Q. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00016 · Cited by 31
Kaya, E., Grassi, L. C., Benedetti, A., Maisetta, G., Pileggi, C., Luca, M. D., Batoni, G., & Esin, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00187 · Cited by 29
Pseudomonas aeruginosa Protease IV Exacerbates Pneumococcal Pneumonia and Systemic Disease
Bradshaw, J. L., Caballero, A. R., Bierdeman, M. A., Adams, K. V., Pipkins, H. R., Tang, A., O’Callaghan, R. J., & McDaniel, L. S. (2018) · mSphere · doi:10.1128/msphere.00212-18 · Cited by 30
Candida colonization in ventilated ICU patients: no longer a bystander!
Ricard, J.-D., & Roux, D. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2587-z · Cited by 30
Fosfomycin nebulizer therapy to chronic sinusitis
Kamijyo, A., Matsuzaki, Z., Kikushima, K., Ogino, J., Nozawa, I., Matsuoka, T., Endo, S., & Okamoto, Y. (2001) · Auris Nasus Larynx · doi:10.1016/s0385-8146(01)00049-9 · Cited by 27
Inflammatory Bowel Disease — Live Transmission
Hecht, G. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmcibr0707718 · Cited by 27
Ashry, H. S. A., Mansour, G., Kalil, A. C., Walters, R. W., & Vivekanandan, R. (2016) · Burns · doi:10.1016/j.burns.2016.02.024 · Cited by 26
Chen, Y., Rong, L., & Qiao, J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2328 · Cited by 25
Paino, A., Tuominen, H. K., Jääskeläinen, M., Alanko, J., Nuutila, J., Asikainen, S. E., Pelliniemi, L. J., Pöllänen, M. T., Chen, C., & Ihalin, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018929 · Cited by 25
Subversion of interleukin‐1‐mediated host defence by a nasal carrier strain of Staphylococcus aureus
Quinn, G. A., Tarwater, P. M., & Cole, A. M. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02952.x · Cited by 24
Staats, K., Kolbitsch, P., Sigmund, I. K., Hobusch, G. M., Holinka, J., & Windhager, R. H. (2016) · The Journal of Arthroplasty · doi:10.1016/j.arth.2016.11.016 · Cited by 24
Xu, J., Wang, K.-Q., Xu, W., Li, Y., Yang, Q., Wu, H.-Y., Li, J.-Z., He, Z.-G., Hu, H., Wang, Y., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw445 · Cited by 23
Wang, S., Xiang, D., Tian, F., & Ni, M. (2021) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001352 · Cited by 25
Meduri, G. U., Bell, W., Sinclair, S. E., & Annane, D. (2011) · La Presse Médicale · doi:10.1016/j.lpm.2011.04.023 · Cited by 23
Microbial adaptive pathogenicity strategies to the host inflammatory environment
Hitzler, S. U. J., Fernández-Fernández, C., Montaño, D. E., Dietschmann, A., & Gresnigt, M. S. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae032 · Cited by 24
Biomarkers and Bacterial Pneumonia Risk in Patients with Treated HIV Infection: A Case-Control Study
Bjerk, S., Baker, J. V., Emery, S., Neuhaus, J., Angus, B., Gordin, F. M., Pett, S. L., Stephan, C., Kunisaki, K. M., & for the INSIGHT SMART Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0056249 · Cited by 21
Proinflammatory Cytokines as Regulators of Vaginal Microbiota
Александровна, К. Е., & Av, S. (2016) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-016-3549-1 · Cited by 21
Solís-Soto, J. M., Quintanilla-Rodriguez, L. E., Meester, I., Segoviano-Ramírez, J. C., Vázquez-Juárez, J., & Salinas-Carmona, M. C. (2008) · PubMed · doi:10.14670/hh-23.573 · Cited by 21
Dyakov, I. N., Мавлетова, Д. А., Chernyshova, I. N., Snegireva, N. A., Gavrilova, M. V., Константиновна, Б. К., Dyachkova, M. S., Алексеева, М. Г., & Даниленко, В. Н. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102247 · Cited by 23
Meduri, G. U., Marik, P. E., & Annane, D. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819d2b43 · Cited by 21
Kaya, E., Batoni, G., Luca, M. D., Apolloni, E., Mazzoni, A., Maisetta, G., & Esin, S. (2021) · Microorganisms · doi:10.3390/microorganisms9091846 · Cited by 19
Lee, J. S., Chowdhury, N., Roberts, J. S., & Yilmaz, Ö. (2020) · Virulence · doi:10.1080/21505594.2020.1763061 · Cited by 19
Bacterial strategies for immune systems — Role of the type VI secretion system
Wang, Y., Zeng, M., Lin, X., Olovo, C. V., Su, Z., & Zhang, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109550 · Cited by 19
Functional and structural characteristics of bacterial proteins that bind host cytokines
Högbom, M., & Ihalin, R. (2017) · Virulence · doi:10.1080/21505594.2017.1363140 · Cited by 18
Topical p38 MAPK inhibition reduces bacterial growth in an in vivo burn wound model
Ipaktchi, K. R., Mattar, A., Niederbichler, A. D., Hoesel, L. M., Vollmannshauser, S., Hemmila, M. R., Minter, R. M., Su, G. L., Wang, S. C., & Arbabi, S. (2007) · Surgery · doi:10.1016/j.surg.2007.02.007 · Cited by 18
Teramoto, S., & Ishii, T. (2001) · CHEST Journal · doi:10.1378/chest.119.1.315 · Cited by 18
Udovičić, I., Stanojević, I., Djordjevic, D., Zeba, S., Rondović, G., Abazovic, T., Lazic, S., Vojvodić, D., To, K., Abazović, D., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245815 · Cited by 19
Zerouti, K., Khemili, D., Laraba‐Djebari, F., & Hammoudi-Triki, D. (2019) · Toxin Reviews · doi:10.1080/15569543.2019.1614064 · Cited by 16
Ahlstrand, T., Torittu, A., Elovaara, H., Välimaa, H., Pöllänen, M. T., Kasvandik, S., Högbom, M., & Ihalin, R. (2018) · Virulence · doi:10.1080/21505594.2018.1499378 · Cited by 15
Effects of Anti-Cytokine Antibodies on Gut Barrier Function
Liu, F., Lee, S. A., Riordan, S. M., Zhang, L., & Zhu, L. (2019) · Mediators of Inflammation · doi:10.1155/2019/7028253 · Cited by 15
Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture
Gopinath, V. K., Mohammad, M. G., & Sheela, S. (2022) · International Endodontic Journal · doi:10.1111/iej.13839 · Cited by 14
Metadata
- Authors
- MEDURI, G. U., KANANGAT, S., STEFAN, J., TOLLEY, E., & SCHABERG, D.
- Affiliations
- Memphis VA Medical Center (US)
- ORCID
- TOLLEY, ELIZABETH
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 160
- Issue
- 3
- Pages
- 961-967
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2064610856
- Cited by
- 155
- References
- 26
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IL-1β, interleukin-6, TNF-α, inflammatory cytokines, bacterial growth enhancement, nosocomial infections, acute respiratory distress syndrome, Staphylococcus aureus, Acinetobacter, Pseudomonas aeruginosa
- MeSH terms
- Acinetobacter, Analysis of Variance, Antibodies, Monoclonal, Culture Media, Dose-Response Relationship, Drug, Interleukin-1, Pseudomonas aeruginosa, Staphylococcus aureus, Tumor Necrosis Factor-alpha, Interleukin-6, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review