The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effect of Ventilator Mode on Sleep Quality in Critically Ill Patients
Abstract
To determine whether sleep quality is influenced by the mode of mechanical ventilation, we performed polysomnography on 11 critically ill patients. Because pressure support predisposes to central apneas in healthy subjects, we examined whether the presence of a backup rate on assist-control ventilation would decrease apnea-related arousals and improve sleep quality. Sleep fragmentation, measured as the number of arousals and awakenings, was greater during pressure support than during assist-control ventilation: 79 +/- 7 versus 54 +/- 7 events per hour (p = 0.02). Central apneas occurred during pressure support in six patients; heart failure was more common in these six patients than in the five patients without apneas: 83 versus 20% (p = 0.04). Among patients with central apneas, adding dead space decreased sleep fragmentation: 44 +/- 6 versus 83 +/- 12 arousals and awakenings per hour (p = 0.02). Changes in sleep-wakefulness state caused greater changes in breath components and end-tidal CO2 during pressure support than during assist-control ventilation. In conclusion, inspiratory assistance from pressure support causes hypocapnia, which combined with the lack of a backup rate and wakefulness drive can lead to central apneas and sleep fragmentation, especially in patients with heart failure.
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Cites
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Cited by
Weaning from mechanical ventilation
Boles, J.-M., Bion, J., Connors, A., Herridge, M., Marsh, B., Melot, C., Pearl, R., Silverman, H., Stanchina, M., Vieillard-Baron, A., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00010206 · Cited by 2,064
Mechanical Ventilation: State of the Art
Pham, T., Brochard, L. J., & Slutsky, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.004 · Cited by 377
Sleep in the Intensive Care Unit
Pisani, M. A., Friese, R. S., Gehlbach, B. K., Schwab, R. J., Weinhouse, G. L., & Jones, S. F. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201411-2099ci · Cited by 366
Sleep in the intensive care unit
Parthasarathy, S., & Tobin, M. J. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2030-6 · Cited by 349
Self-citationBosma, K., Ferreyra, G., Ambrogio, C., Pasero, D., Mirabella, L., Braghiroli, A., Appendini, L., Mascia, L., & Ranieri, V. M. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000260055.64235.7c · Cited by 300
Metadata
- Authors
- Parthasarathy, S., & Tobin, M. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 166
- Issue
- 11
- Pages
- 1423-1429
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2073196382
- Cited by
- 324
- References
- 45
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
