Physiological Correlates of Prolonged Sleep Deprivation in Rats
Abstract
The issue of whether sleep is physiologically necessary has been unresolved because experiments that reported deleterious effects of sleep deprivation did not control for the stimuli used to prevent sleep. In this experiment, however, experimental and control rats received the same relatively mild physical stimuli, but stimulus presentations were timed to reduce sleep severely in experimental rats but not in controls. Experimental rats suffered severe pathology and death; control rats did not.
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Sleep deprivation of rats is lethal after approximately 2-3 weeks.
“Later studies using more controlled approaches found that sleep deprivation of rats is lethal after ~2–3 wk (459)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [459]
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Self-citation
- Authors
- Rechtschaffen, A., Gilliland, M. A., Bergmann, B. M., & Winter, J. B.
- Affiliations
- University of Chicago (US)
- Venue
- Science
- Published
- 1983-07-08
- Volume
- 221
- Issue
- 4606
- Pages
- 182-184
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073264303
- Cited by
- 487
- References
- 16
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 14 · 2023: 15 · 2022: 11 · 2021: 12 · 2020: 13 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 14 · 2013: 19 · 2012: 24
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, physical stimuli, sleep pathology
- MeSH terms
- Adrenal Glands, Animals, Body Weight, Electroencephalography, Male, Organ Size, Rats, Inbred Strains, Sleep Deprivation, Time Factors, Rats
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