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Cited by 373

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Airway Inflammation and Bronchial Bacterial Colonization in Chronic Obstructive Pulmonary Disease

Open access
Sethi, Sanjay, Maloney, Jane, Grove, Lori, Wrona, Catherine, Berenson, Charles S.·2006·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200509-1525oc
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Abstract

RATIONALE: Inflammation is now recognized as an integral part of the pathogenesis of chronic obstructive pulmonary disease (COPD). In contrast to the sterile airways of normal lungs, bacterial pathogens are often isolated from the airways in stable COPD. This "colonization" of the tracheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, independent of current tobacco smoke exposure. OBJECTIVE: To test the hypothesis that bacterial colonization is associated with airway inflammation in stable COPD. METHODS: Bronchoscopy with bronchoalveolar lavage (BAL) was performed in three groups of subjects: 26 ex-smokers with stable COPD (COPD), 20 ex-smokers without COPD (ex-smokers), and 15 healthy nonsmokers (nonsmokers). Quantitative bacterial cultures, cell counts, chemokine, cytokine, proteinase/antiproteinase, and endotoxin levels in the BAL fluid were compared. RESULTS: Potentially pathogenic bacteria were recovered at > or = 100 cfu/ml in 34.6% of COPD, 0% of ex-smokers, and in 6.7% of nonsmokers (p = 0.003). All values are expressed as median (interquartile range). Subjects with colonized COPD had significantly greater relative (12.0 [28.4] vs. 3.0 [7.8]%, p = 0.03) and absolute (4.98 [5.26] x 10(4)/ml vs. 3.04 [2.82] x 10(4)/ml, p = 0.02) neutrophil counts, interleukin 8 (33.8 [189.8] vs. 16.9 [20.1] pg/ml, p = 0.005), active matrix metalloproteinase-9 (2.16 [4.30] vs. 0.84 [0.99] U/ml, p = 0.03), and endotoxin (36.0 [72.6] vs. 3.55 [7.17] mEU/ml, p = 0.004) levels in the BAL than the subjects with noncolonized COPD. These inflammatory constituents of BAL were also significantly elevated in subjects with colonized COPD when compared with ex-smokers and nonsmokers. CONCLUSIONS: Bacterial colonization is associated with neutrophilic airway lumen inflammation in ex-smokers with COPD and could contribute to progression of airway disease in COPD.

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Metadata

Authors
Sethi, S., Maloney, J., Grove, L., Wrona, C., & Berenson, C. S.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2006-05-01
Volume
173
Issue
9
Pages
991-998
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200509-1525oc
OpenAlex
W2099627512
Cited by
373
References
34
FWCI
18.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Airway Inflammation and Bronchial Bacterial Colonization in Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/rccm.200509-1525oc
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Sethi, S., Maloney, J., Grove, L., Wrona, C., & Berenson, C. S. (2006). Airway Inflammation and Bronchial Bacterial Colonization in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200509-1525oc

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.