The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Serial Testing of Health Care Workers for Tuberculosis Using Interferon-γ Assay
Open accessAbstract
RATIONALE: Although interferon-gamma (IFN-gamma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing performance is unknown. OBJECTIVE: To compare TST and IFN-gamma conversions and reversions in healthcare workers. METHODS: We prospectively followed-up 216 medical and nursing students in India who underwent baseline and repeat testing (after 18 mo) with TST and QuantiFERON-TB Gold In-Tube (QFT). TST conversions were defined as reactions greater than or equal to 10 mm, with increments of 6 or 10 mm over baseline. QFT conversions were defined as baseline IFN-gamma less than 0.35 and follow-up IFN-gamma greater than or equal to 0.35 or 0.70 IU/ml. QFT reversions were defined as baseline IFN-gamma greater than or equal to 0.35 and follow-up IFN-gamma less than 0.35 IU/ml. RESULTS: Of the 216 participants, 48 (22%) were TST-positive, and 38 (18%) were QFT-positive at baseline. Among 147 participants with concordant baseline negative results, TST conversions occurred in 14 (9.5%; 95% confidence interval [CI] = 5.3-15.5) using the 6 mm increment definition, and 6 (4.1%; 95% CI = 1.5-8.7) using the 10 mm increment definition. QFT conversions occurred in 17/147 participants (11.6%; 95% CI = 6.9-17.9) using the definition of IFN-gamma greater than or equal to 0.35 IU/ml, and 11/147 participants (7.5%; 95% CI = 3.8-13.0) using IFN-gamma greater than or equal to 0.70 IU/ml. Agreement between TST (10 mm increment) and QFT conversions (>or= 0.70 IU/ml) was 96% (kappa = 0.70). QFT reversions occurred in 2/28 participants (7%) with baseline concordant positive results, as compared with 7/10 participants (70%) with baseline discordant results (p < 0.001). CONCLUSIONS: IFN-gamma assay shows promise for serial testing, but repeat results need to be interpreted carefully. To meaningfully interpret serial results, the optimal thresholds to distinguish new infections from nonspecific variations must be determined.
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Cites
The Growing Burden of Tuberculosis: Global Trends and Interactions With the HIV Epidemic
Corbett, E. L., Watt, C. J., Walker, N., Maher, D., Williams, B. G., Raviglione, M. C., & Dye, C. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1009 · Cited by 2,553
(2005) · PsycEXTRA Dataset · doi:10.1037/e545842006-001 · Cited by 1,274
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.supplement_3.ats600 · Cited by 1,241
Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
Pai, M., Riley, L. W., & Colford, J. M. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01206-x · Cited by 913
Self-citation(2005) · PsycEXTRA Dataset · doi:10.1037/e548692006-002 · Cited by 691
Specific Detection of Tuberculosis Infection: An Interferon-γ–based Assay Using New Antigens
Mori, T., Sakatani, M., Yamagishi, F., Takashima, T., Kawabe, Y., Nagao, K., Shigeto, E., Harada, N., Mitarai, S., Okada, M., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-179oc · Cited by 657
Interpretation of Repeated Tuberculin Tests: Boosting, Conversion, and Reversion
MENZIES, D. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.1.9801120 · Cited by 488
Self-citationTuberculosis among Health Care Workers
Menzies, D., Fanning, A., Yuan, L., & Fitzgerald, M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501123320206 · Cited by 378
Self-citationTuberculosis; a comprehensive international approach
(1994) · International Journal of Biochemistry · doi:10.1016/0020-711x(94)90047-7 · Cited by 344
Comparison of Tuberculin Skin Test and New Specific Blood Test in Tuberculosis Contacts
Brock, I., Weldingh, K., Lillebaek, T., Follmann, F., & Andersen, P. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-232oc · Cited by 333
Cited by
Lewinsohn, D. M., Leonard, M. K., LoBue, P. A., Cohn, D. L., Daley, C. L., Desmond, E., Keane, J., Lewinsohn, D. A., Loeffler, A. M., Mazurek, G. H., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw694 · Cited by 992
Self-citationMenzies, D., Pai, M., & Comstock, G. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00006 · Cited by 984
Self-citationGamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection
Pai, M., Denkinger, C. M., Kik, S. V., Rangaka, M. X., Zwerling, A., Oxlade, O., Metcalfe, J. Z., Cattamanchi, A., Dowdy, D. W., Dheda, K., et al. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-13 · Cited by 886
Self-citationComparison of Two Interferon-γ Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts
Arend, S. M., Thijsen, S. F. T., Leyten, E. M. S., Bouwman, J. J. M., Franken, W. P. J., Koster, B. F. P. J., Cobelens, F. G. J., van Houte, A.-J., & Bossink, A. W. J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1099oc · Cited by 255
Metadata
- Authors
- Pai, M., Joshi, R., Dogra, S., Mendiratta, D. K., Narang, P., Kalantri, S., Reingold, A. L., Colford, J. M., Riley, L. W., & Menzies, D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-08-01
- Volume
- 174
- Issue
- 3
- Pages
- 349-355
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2028144733
- Cited by
- 275
- References
- 21
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- green
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