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Cited by 326

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Airway Wall Thickening and Emphysema Show Independent Familial Aggregation in Chronic Obstructive Pulmonary Disease

Patel, Bipen D., Coxson, Harvey O., Pillai, Sreekumar G., Agustí, Alvar G. N., Calverley, Peter M. A., Donner, Claudio F., Make, Barry J., Müller, Nestor L., Rennard, Stephen I., Vestbo, Jørgen, Wouters, Emiel F. M., Hiorns, Melanie P., Nakano, Yasutaka, Camp, Patricia G., Nasute Fauerbach, Paola V., Screaton, Nicholas J., Campbell, Edward J., Anderson, Wayne H., Paré, Peter D., Levy, Robert D., Lake, Stephen L., Silverman, Edwin K., Lomas, David A.·2008·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200801-059oc
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Abstract

Rationale: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families. Objectives: To determine whether airway wall thickening and emphysema (1) make independent contributions to the severity of COPD and (2) show independent aggregation in families of individuals with COPD. Methods: Index cases with COPD and their smoking siblings underwent spirometry and were offered high-resolution computed tomography scans of the thorax to assess the severity of airway wall thickening and emphysema. Measurements and Main Results: A total of 3,096 individuals were recruited to the study, of whom 1,159 (519 probands and 640 siblings) had technically adequate high-resolution computed tomography scans without significant non–COPD-related thoracic disease. Airway wall thickness correlated with pack-years smoked (P ≤ 0.001) and symptoms of chronic bronchitis (P < 0.001). FEV1 (expressed as % predicted) was independently associated with airway wall thickness at a lumen perimeter of 10 mm (P = 0.0001) and 20 mm (P = 0.0013) and emphysema at −950 Hounsfield units (P < 0.0001). There was independent familial aggregation of both the emphysema (adjusted odds ratio, 2.1; 95% confidence interval, 1.1–4.0; P ≤ 0.02) and airway disease phenotypes (P < 0.0001) of COPD. Conclusions: Airway wall thickening and emphysema make independent contributions to airflow obstruction in COPD. These phenotypes show independent aggregation within families of individuals with COPD, suggesting that different genetic factors influence these disease processes.

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Cited by

Metadata

Authors
Patel, B. D., Coxson, H. O., Pillai, S. G., Agustí, A. G. N., Calverley, P. M. A., Donner, C. F., Make, B. J., Müller, N. L., Rennard, S. I., Vestbo, J., Wouters, E. F. M., Hiorns, M. P., Nakano, Y., Camp, P. G., Nasute Fauerbach, P. V., Screaton, N. J., Campbell, E. J., Anderson, W. H., Paré, P. D., Levy, R. D., Lake, S. L., Silverman, E. K., & Lomas, D. A.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2008-09-01
Volume
178
Issue
5
Pages
500-505
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200801-059oc
OpenAlex
W2112662842
Cited by
326
References
2
FWCI
27.27
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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