Cited by 307Clinical Nutrition and GastroenterologyHyperglycemia and glycemic control in critically ill and hospitalized patientsEnhanced Recovery After Surgery

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial

Open access

Casaer, Michael P., Wilmer, Alexander, Hermans, Greet, Wouters, Pieter J., Mesotten, Dieter, Van den Berghe, Greet·2013·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201206-0999oc

Open this paper in CoChat — free account Open PDF

Abstract

Rationale: Early parenteral nutrition to supplement insufficient enteral feeding during intensive care (early PN) delays recovery as compared with withholding parenteral nutrition for 1 week (late PN). Objectives: To assess whether deleterious effects of early PN relate to severity of illness or to the dose or type of macronutrients. Methods: Secondary analyses of a randomized controlled trial (EPaNIC; n = 4,640) performed in seven intensive care units from three departments in two Belgian hospitals. In part 1, all patients were included to assess the effect of the randomized allocation to early PN or late PN in subgroups of patients with increasing-on-admission severity of illness. In part 2, observationally, the association of the amount and type of macronutrients with recovery was documented in those patient cohorts still present in intensive care on Days 3, 5, 7, 10, and 14. Measurements and Main Results: The primary end point was time to live discharge from the intensive care unit. For part 1, a secondary end point, acquisition of new infections, was also analyzed. All statistical analyses were performed by univariable and adjusted multivariable methods. In none of the subgroups defined by type or severity of illness was a beneficial effect of early PN observed. The lowest dose of macronutrients was associated with the fastest recovery and any higher dose, administered parenterally or enterally, was associated with progressively more delayed recovery. The amount of proteins/amino acids rather than of glucose appeared to explain delayed recovery with early feeding. Conclusions: Early combined parenteral/enteral nutrition delayed recovery irrespective of severity of critical illness. No dose or type of macronutrient was found to be associated with improved outcome. Clinical trial registered with www.clinicaltrials.gov (NCT00512122).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1164/rccm.201206-0999oc

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
ESPEN Guidelines for Nutrition Screening 2002
Kondrup, J. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00098-0 · Cited by 3,159
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696
Self-citation
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
ESPEN guidelines on enteral nutrition: intensive care
Kreymann, K. G., Berger, M. M., Deutz, N. E. P., Hiesmayr, M., Jolliet, P., Kazandjiev, G., Nitenberg, G., van den Berghe, G., Wernerman, J., Ebner, C., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.021 · Cited by 1,366
Autophagy is required to maintain muscle mass.
Masiero, E., Agatea, L., Mammucari, C., Blaauw, B., Loro, E., Komatsu, M., Metzger, D., Reggiani, C., Schiaffino, S., & Sandri, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.008 · Cited by 1,282
Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients
Villet, S., Chiolero, R. L., Bollmann, M. D., Revelly, J.-P., Cayeux RN, M.-C., Delarue, J., & Berger, M. M. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.03.006 · Cited by 995
The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975

Show all 46 references

Research works printed but not linked: 2

Felbinger, 2011, Early or late parenteral nutrition in critically ill adults [letter], N Engl J Med, 365, 1839, 10.1056/NEJMc1110994 · DOI
Bistrian, 2011, Early or late parenteral nutrition in critically ill adults, N Engl J Med, 365, 1840

Sorted by citations

Items 101–200 of 301

The Metabolic Response to Stress and Infection in Critically Ill Children: The Opportunity of an Individualized Approach
Cosmi, V. D., Milani, G. P., Mazzocchi, A., D’Oria, V., Silano, M., Calderini, E., & Agostoni, C. V. (2017) · Nutrients · doi:10.3390/nu9091032 · Cited by 28
The Association Between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients
Lew, C. C. H., Lee, Z., Day, A. G., Jiang, X., Bear, D. E., Jensen, G. L., Ng, P. Y., Tweel, L. E., Parillo, A., Heyland, D. K., et al. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.02.008 · Cited by 28
Does artificial nutrition improve outcome of critical illness? An alternative viewpoint!
Heyland, D. K., & Wischmeyer, P. E. (2013) · Critical Care · doi:10.1186/cc12701 · Cited by 26
Medical Nutrition Therapy in Critically Ill Patients Treated on Intensive and Intermediate Care Units: A Literature Review
Lugli, A. K., de Watteville, A., Hollinger, A., Goetz, N., & Heidegger, C. P. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091395 · Cited by 27
The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity
Lew, C. C. H., Wong, G. J. Y., Cheung, K. P., Fraser, R. J., Chua, A. P., Chong, S. C., & Miller, M. (2019) · Critical Care · doi:10.1186/s13054-019-2500-z · Cited by 25
Impact of early high protein intake in critically ill patients: a randomized controlled trial
Wang, Y., Ye, Y., Xuan, L., Xu, L., Wang, P., Ma, J., Wang, Y., Chen, Y., Miao, J., Wang, W., et al. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00818-8 · Cited by 28
When timing and dose of nutrition support were examined, the modified Nutrition Risk in Critically Ill (mNUTRIC) score did not differentiate high-risk patients who would derive the most benefit from nutrition support: a prospective cohort study
Lew, C. C. H., Wong, G. J. Y., Cheung, K. P., Fraser, R. J., Chua, A. P., Chong, M. F., & Miller, M. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0443-1 · Cited by 25
Nutrition and autophagy deficiency in critical illness
Vanhorebeek, I., Casaer, M. P., & Gunst, J. (2023) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001056 · Cited by 25
Self-citation
Autophagy flux in critical illness, a translational approach
Tardif, N., Polia, F., Tjäder, I., Gustafsson, T., & Rooyackers, O. (2019) · Scientific Reports · doi:10.1038/s41598-019-45500-9 · Cited by 24
Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China
Guan, X., Chen, D., & Xu, Y. (2024) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2023.12.002 · Cited by 23
Should We Aim for Full Enteral Feeding in the First Week of Critical Illness?
McClave, S. A., Codner, P. A., Patel, J. J., Hurt, R. T., Allen, K. S., & Martindale, R. G. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653809 · Cited by 24
How soon should we start interventional feeding in the ICU?
Fremont, R. D., & Rice, T. W. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000047 · Cited by 24
Achieving protein targets without energy overfeeding in critically ill patients: A prospective feasibility study
Looijaard, W. G. P. M., Denneman, N., Broens, B., Girbes, A. R. J., Weijs, P. J. M., & Straaten, H. M. O. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.012 · Cited by 22
High protein intake without concerns?
Rooyackers, O., Rehal, M. S., Liebau, F., Norberg, Å., & Wernerman, J. (2017) · Critical Care · doi:10.1186/s13054-017-1699-9 · Cited by 22
Assessment of Energy and Protein Requirements in Relation to Nitrogen Kinetics, Nutrition, and Clinical Outcomes in Infants Receiving Early Enteral Nutrition Following Cardiopulmonary Bypass
Zhang, J., Cui, Y., Luo, Y., Chen, X., & Li, J. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1863 · Cited by 22
Low Glutamine Levels during Critical Illness — Adaptive or Maladaptive?
den Berghe, G. V. (2013) · New England Journal of Medicine · doi:10.1056/nejme1302301 · Cited by 23
Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research
Téblick, A., Gunst, J., Langouche, L., & den Berghe, G. V. (2022) · Clinical Science · doi:10.1042/cs20211003 · Cited by 21
Impact of Energy and Protein Delivery to Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nakanishi, N., Matsushima, S., Tatsuno, J., Liu, K., Tamura, T., Yonekura, H., Yamamoto, N., Unoki, T., Kondo, Y., & Nakamura, K. (2022) · Nutrients · doi:10.3390/nu14224849 · Cited by 23
Enteral feeding strategies in patients with acute gastrointestinal injury: From limited to progressive to open feeding
Wang, Y., Li, Y., Li, Y., Li, H., & Zhang, D. (2023) · Nutrition · doi:10.1016/j.nut.2023.112255 · Cited by 22
Controversies and Misconceptions in Intensive Care Unit Nutrition
Hooper, M. H., & Marik, P. E. (2015) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2015.05.013 · Cited by 21
What factors influence protein synthesis and degradation in critical illness?
Girolamo, F. G. D., Situlin, R., & Biolo, G. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000347 · Cited by 21
Bioimpedance-assessed muscle wasting and its relation to nutritional intake during the first week of ICU: a pre-planned secondary analysis of Nutriti Study
Deana, C., Gunst, J., Rosa, S. D., Umbrello, M., Danielis, M., Biasucci, D. G., Piani, T., Cotoia, A., Molfino, A., & Vetrugno, L. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01262-w · Cited by 20
Initial Nutritional Status and Clinical Outcomes in Patients with Deep Neck Infection
Park, M. J., Kim, J. W., Kim, Y., Lee, Y. S., Roh, J., Choi, S.-H., Kim, S. Y., & Nam, S. Y. (2018) · Clinical and Experimental Otorhinolaryngology · doi:10.21053/ceo.2018.00108 · Cited by 20
Protein supplementation in critical illness: why, when and how?
Bels, J. L. M., Abdelhamid, Y. A., & van de Poll, M. C. G. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000912 · Cited by 20
Assessing nutrition in the critically ill elderly patient: A comparison of two screening tools
Mishra, J. (2015) · Indian Journal of Critical Care Medicine · doi:10.4103/0972-5229.164798 · Cited by 20
Gluttony in the Intensive Care Unit
Rice, T. W. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201212-2228ed · Cited by 19
Parenteral nutrition in the critically ill
Gunst, J., & den Berghe, G. V. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000385 · Cited by 19
Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
Xiong, W., & Qian, K. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s296296 · Cited by 18
Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
Hajimohammadebrahim‐Ketabforoush, M., Shariatpanahi, Z. V., Shariatpanahi, M. V., Shahbazi, E., & Shahbazi, S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.708271 · Cited by 20
Feeding During Phases of Altered Mitochondrial Activity: A Theory
McKeever, L., Bonini, M. G., & Braunschweig, C. L. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1010 · Cited by 18
Impact of early low-calorie low-protein versus standard-calorie standard-protein feeding on outcomes of ventilated adults with shock: design and conduct of a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)
Reignier, J., Le Gouge, A., Lascarrou, J.-B., Annane, D., Argaud, L., Hourmant, Y., Asfar, P., Badie, J., Nay, M.-A., Botoc, N.-V., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-045041 · Cited by 17
Personalized Nutrition in the Pediatric ICU: Steering the Shift from Acute Stress to Metabolic Recovery and Rehabilitation
Briassoulis, G. C., Ilia, S., & Briassouli, E. (2024) · Nutrients · doi:10.3390/nu16203523 · Cited by 19
Appropriate Use of Parenteral Nutrition Through the Perioperative Period
McClave, S. A., Martindale, R. G., Taylor, B. E., & Gramlich, L. M. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113495570 · Cited by 17
Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: A pilot randomized controlled trial (REPLENISH pilot trial)
Arabi, Y. M., Al‐Dorzi, H. M., Tamim, H., Sadat, M., Al-Hameed, F. M., Alghamdi, A., Mekhlafi, G. A. A., Rasool, G., Afesh, L. Y., Sakkijha, M. H., et al. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.05.008 · Cited by 17
Pros and Cons of Feeding the Septic Intensive Care Unit Patient
Fremont, R. D., & Rice, T. W. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615578457 · Cited by 17
Effect of calories delivered on clinical outcomes in critically ill patients: Systemic review and meta-analysis
Chelkeba, L., Mojtahedzadeh, M., & Mekonnen, Z. (2017) · Indian Journal of Critical Care Medicine · doi:10.4103/ijccm.ijccm_453_16 · Cited by 18
The impact of high versus standard enteral protein provision on functional recovery following intensive care admission: A pre-planned Bayesian analysis of the PRECISe trial
Schouteden, E., Heuts, S., Bels, J. L. M., Thiessen, S., van Gassel, R. J. J., Lee, Z., Stoppe, C., Beishuizen, A., Dekker, A. D. B., Fraipont, V., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.03.022 · Cited by 16
Self-citation
Considerations When Using Predictive Equations to Estimate Energy Needs Among Older, Hospitalized Patients: A Narrative Review
Parker, E. A. D., Feinberg, T., Wappel, S. R., & Verceles, A. C. (2017) · Current Nutrition Reports · doi:10.1007/s13668-017-0196-8 · Cited by 17
Role of glucagon in protein catabolism
Thiessen, S., Gunst, J., & den Berghe, G. V. (2018) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000509 · Cited by 17
Proceedings of the 2016 Clinical Nutrition Week Research Workshop—The Optimal Dose of Protein Provided to Critically Ill Patients
Heyland, D. K., Rooyackers, O., Mourtzakis, M., & Stapleton, R. D. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607116682003 · Cited by 15
Association between nutrition support and acute gastrointestinal injury in critically ill patients during the first 72 hours
Li, H., Lu, J., Li, H., Duan, A., Wang, Y., & Zhang, D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.011 · Cited by 15
Nutrition in the critically ill surgical patient
Puzio, T. J., & Kozar, R. A. (2020) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000764 · Cited by 16
The Loss of Temporal Muscle Volume is Associated with Poor Outcome in Patients with Subarachnoid Hemorrhage: An Observational Cohort Study
Kofler, M., Reitmeir, P., Glodny, B., Rass, V., Lindner, A., Ianosi, B., Gaasch, M., Schiefecker, A. J., Putnina, L., Beer, R., et al. (2023) · Neurocritical Care · doi:10.1007/s12028-023-01751-z · Cited by 15
Replacing protein via enteral nutrition in a stepwise approach in critically ill patients: the REPLENISH randomized clinical trial protocol
Arabi, Y. M., Al‐Dorzi, H. M., Sadat, M., Muharib, D., Algethamy, H. M., Al-Hameed, F. M., Mady, A. M., Alghamdi, A., Almekhlafi, G. A., Al-Fares, A. A., et al. (2023) · Trials · doi:10.1186/s13063-023-07507-6 · Cited by 15
Early phosphate changes as potential indicator of unreadiness for artificial feeding: a secondary analysis of the EPaNIC RCT
Lauwers, C., Langouche, L., Wouters, P. J., Wilmer, A. P., den Berghe, G. V., Casaer, M. P., & Gunst, J. (2025) · Critical Care · doi:10.1186/s13054-025-05273-2 · Cited by 14
Self-citation
Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial
Veldsman, L., Richards, G. A., Nel, D. G., Kohn, T. A., & Blaauw, R. (2025) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.70041 · Cited by 14
Combination of High-Calorie Delivery and Organ Failure Increases Mortality Among Patients With Acute Respiratory Distress Syndrome
Peterson, S. J., McKeever, L., Lateef, O., Freels, S. A., Fantuzzi, G., & Braunschweig, C. A. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003476 · Cited by 16
C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery
Ingels, C., Langouche, L., Dubois, J., Derese, I., Perre, S. V., Wouters, P. J., Gunst, J., Casaer, M. P., Güiza, F., Vanhorebeek, I., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06565-1 · Cited by 14
Self-citation
Adequacy of enteral nutritional support in intensive care units does not affect the short- and long-term prognosis of mechanically ventilated patients: a pilot study
Couto, C. F. L., Dariano, Â., Texeira, C., da Silva, C. H., Torbes, A. B., & Friedman, G. (2019) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20190004 · Cited by 14
Intensive Care Nutrition and Post–Intensive Care Recovery
Gunst, J., & den Berghe, G. V. (2018) · Critical Care Clinics · doi:10.1016/j.ccc.2018.06.004 · Cited by 15
Quick Fix for Hospital‐Acquired Malnutrition?
Ochoa, J. B. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115581376 · Cited by 14
On how to feed critically ill children in intensive care: A slowly shifting paradigm
Gunst, J., Vanhorebeek, I., Verbruggen, S. C. A. T., Dulfer, K., Joosten, K. F. M., & den Berghe, G. V. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.02.003 · Cited by 13
Protein delivery in mechanically ventilated adults in Australia and New Zealand: current practice
Murthy, T. A., Bellomo, R., Chapman, M. J., Deane, A. M., Ferrie, S., Finnis, M., Hurford, S., O’Connor, S. N., Peake, S., Summers, M. J., et al. (2021) · Critical Care and Resuscitation · doi:10.51893/2021.4.oa3 · Cited by 13
Macronutrient intake and outcomes of ICU patients with refeeding hypophosphatemia
Slingerland-Boot, R., Rooijakkers, E. P. E. M., Koekkoek, K. W. A. C., van Blokland, D. A., Arbous, M. S., & van Zanten, A. R. H. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.03.003 · Cited by 14
Do We Have Clinical Equipoise (or Uncertainty) About How Much Protein to Provide to Critically Ill Patients?
Patel, J. J., Rice, T. W., Compher, C. W., & Heyland, D. K. (2019) · Nutrition in Clinical Practice · doi:10.1002/ncp.10320 · Cited by 14
Early Achievement of Enteral Nutrition Protein Goals by Intensive Care Unit Day 4 is Associated With Fewer Complications in Critically Injured Adults
Hartwell, J. L., Cotton, A. B., Wenos, C. D., Timsina, L., Zarzaur, B. L., & Rozycki, G. S. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003708 · Cited by 13
Relation between nutrition therapy in the acute phase and outcomes of ventilated patients with COVID-19 infection: a multicenter prospective observational study
Nakamura, K., Hatakeyama, J., Liu, K., Kanda, N., Yamakawa, K., Nishida, T., Ohshimo, S., Inoue, S., Hashimoto, S., Maruyama, S., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac014 · Cited by 12
The association of intravenous insulin and glucose infusion with intensive care unit and hospital mortality: a retrospective study
van Steen, S. C. J., Rijkenberg, S., van der Voort, P. H. J., & DeVries, J. H. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0507-x · Cited by 12
A New Perspective on Overfeeding in the Intensive Care Unit (ICU): Challenges, Dangers and Prevention Methods
Cehan, V.-D., Cehan, A.-R., Pui, M. C., & Lazăr, A. E. (2025) · Life · doi:10.3390/life15050828 · Cited by 12
The nutritional energy to clinical outcome relation revisited
Casaer, M. P. (2014) · Critical Care · doi:10.1186/cc13861 · Cited by 11
Self-citation
Early Enteral Nutrition in Trauma: Is There Still Any Doubt?
Miller, K. R., Smith, J. W., Harbrecht, B. G., & Benns, M. V. (2016) · Current Trauma Reports · doi:10.1007/s40719-016-0045-z · Cited by 11
Experimental and Outcome‐Based Approaches to Protein Requirements in the Intensive Care Unit
Weijs, P. J. M., Dickerson, R. N., Heyland, D. K., Moore, F. A., Rugéles, S., & McClave, S. A. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617692774 · Cited by 11
Trophic or full nutritional support?
Arabi, Y. M., & Al‐Dorzi, H. M. (2018) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000508 · Cited by 11
Supplemental parenteral nutrition in critically ill patients
Marik, P. E., & Hooper, M. H. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61071-5 · Cited by 11
Protein Delivery in Critical Care- What Have Recent Trials Shown Us?
Paulus, M. C., & van Zanten, A. R. H. (2024) · Critical Care Clinics · doi:10.1016/j.ccc.2024.09.003 · Cited by 9
Early Feeding in Critical Care - Where Are We Now?
Berger, M. M., Blaser, A. R., Raphaeli, O., & Singer, P. (2024) · Critical Care Clinics · doi:10.1016/j.ccc.2024.09.002 · Cited by 9
Small peptide formulas versus standard polymeric formulas in critically ill patients with acute gastrointestinal injury: a systematic review and meta-analysis
Wang, Y., Li, Y., Li, H., Li, Y., Li, X., & Zhang, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-47422-z · Cited by 9
A Narrative Review of Nutrition Therapy in Patients Receiving Extracorporeal Membrane Oxygenation
Karpasiti, T. (2021) · ASAIO Journal · doi:10.1097/mat.0000000000001540 · Cited by 11
Effect of Early Parenteral Nutrition on the HPA Axis and on Treatment With Corticosteroids in Intensive Care Patients
Meersseman, P., Boonen, E., Peeters, B., Perre, S. V., Wouters, P. J., Langouche, L., & den Berghe, G. V. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1846 · Cited by 9
Self-citation
Editorial: Personalized nutrition therapy in critical illness and convalescence: moving beyond one-size-fits-all to phenotyping and endotyping
van Zanten, A. R. H. (2023) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001060 · Cited by 9
Reply to: Adequacy of enteral nutrition support in intensive care units does not affect the short- and long-term prognosis of mechanically ventilated patients: a pilot study
Couto, C. F. L., Dariano, Â., Texeira, C., da Silva, C. H., Torbes, A. B., & Friedman, G. (2020) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20200101 · Cited by 8
Nutrition therapy for physical impairment in critically ill patients: A narrative review of the latest evidence
Yoshida, M., Yamamoto, R., Izumino, H., Matsushima, S., Takatani, Y., Hatakeyama, J., Nakanishi, N., Watanabe, S., Taguchi, A., Kano, K., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.07.021 · Cited by 8
Enteral versus parental nutrition after pancreaticoduodenectomy under enhanced recovery after surgery protocol: study protocol for a multicenter, open-label randomized controlled trial (ENE-PAN trial)
Takeda, Y., Mise, Y., Kishi, Y., Sugo, H., Kyoden, Y., Hasegawa, K., Takahashi, Y., & Saiura, A. (2022) · Trials · doi:10.1186/s13063-022-06856-y · Cited by 7
Assessing calorie and protein recommendations for survivors of critical illness weaning from prolonged mechanical ventilation – can we find a proper balance?
Balasubramanian, S., Tran, D. H., Serra, M. C., Parker, E. A. D., Diaz‐Abad, M., Deepak, J., McCurdy, M. T., & Verceles, A. C. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.001 · Cited by 7
Nutrition priorities in obese critically ill patients
Al‐Dorzi, H. M., Stapleton, R. D., & Arabi, Y. M. (2021) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000803 · Cited by 7
Changing paradigms in metabolic support and nutrition therapy during critical illness
van Zanten, A. R. H. (2018) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000519 · Cited by 7
Trophic Nutrition in ICU Patients Undergoing High-Flow Oxygen Therapy and/or Noninvasive Mechanical Ventilation: The Nutri-Trophic Study
Reta-Pérez, O., Colmenero, M., Hernández-Socorro, C. R., Saavedra, P., Maichle, S., Portugal-Rodríguez, E., Cerezo-Arias, M., Sanchez-Ales, L., Martínez-Carmona, J. F., Mateu‐Campos, L., et al. (2024) · Nutrients · doi:10.3390/nu16091366 · Cited by 7
Protective nutrition strategy in the acute phase of critical illness: why, what and how to protect
Wang, Y., Li, Y., Li, N., Li, Y., Li, H., & Zhang, D. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1555311 · Cited by 8
The 2016 ESPEN Sir David Cuthbertson lecture: Interfering with neuroendocrine and metabolic responses to critical illness: From acute to long-term consequences
den Berghe, G. V. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.10.011 · Cited by 6
Parenteral nutrition in intensive care patients
Berger, M. M., Achamrah, N., & Pichard, C. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000454 · Cited by 6
Significant Publications for Pharmacy Nutrition Support Practice in 2013
Dickerson, R. N., Kumpf, V. J., Rollins, C. J., Frankel, E. H., Kraft, M. D., Canada, T. W., & Crill, C. M. (2014) · Hospital Pharmacy · doi:10.1310/hpj4908-717 · Cited by 6
The intensity of organ support: Restrictive or aggressive therapy for critically ill patients
Li, H., Li, Y., Fu, Y., Zhang, X., & Zhang, D. (2023) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2023.04.002 · Cited by 5
The impact of high versus standard enteral protein provision on functional recovery following intensive care admission: Protocol for a pre-planned secondary Bayesian analysis of the PRECISe trial
Heuts, S., de Heer, P., Gabrio, A., Bels, J. L. M., Lee, Z., Stoppe, C., van Kuijk, S. M. J., Beishuizen, A., de Bie-Dekker, A., Fraipont, V., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.10.040 · Cited by 5
Self-citation
Development and validation of a nomogram for predicting 28-day mortality in critically ill patients with acute gastrointestinal injury: prospective observational study
Wang, Y., Li, Y., Zhang, Y., Wang, H., Li, Y., Zhang, L., Zhang, C., Gao, M. Q., Li, H., & Zhang, D. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1469870 · Cited by 5
Association Between Energy Delivery and Outcomes in Adult Critically Ill Patients Diagnosed With or At Risk of Malnutrition: A Systematic Review and Meta-analysis With Trial Sequential Analysis
Chong, S. H., Huang, Y., Heng, M. S., Chong, E. S. T., Lim, C. D. Q., Wong, K. W., Chan, H. N., Heyland, D. K., Stoppe, C., Compher, C. W., et al. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf042 · Cited by 5
The Influence of Timing in Critical Care Nutrition
McKeever, L., Peterson, S. J., Lateef, O., & Braunschweig, C. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-114108 · Cited by 5
Quality improvement initiative to reduce adverse effects associated with parenteral nutrition overfeeding
Franck, A. J. (2018) · Frontline Gastroenterology · doi:10.1136/flgastro-2018-100995 · Cited by 5
The goldilocks problem: Nutrition and its impact on glycaemic control
Knopp, J. L., Chase, J. G., & Shaw, G. M. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.002 · Cited by 5
Nutrition in Critical Care Hepatology
Mehtani, R., Premkumar, M., & Kulkarni, A. V. (2022) · Current Hepatology Reports · doi:10.1007/s11901-022-00586-0 · Cited by 5
Features of energy and protein supply in patients with sepsis: a retrospective observational study
Матвеевич, Л. В., Shlyapnikov, S. A., Demko, A. E., Викторович, Л. А., Batyrshin, I. M., Pichugina, G. A., Dubikaytis, P. A., & Zolotukhin, A. I. (2022) · Annals of critical care · doi:10.21320/1818-474x-2022-4-101-110 · Cited by 5
Early low-energy versus high-energy enteral nutrition support in patients with traumatic intracerebral haemorrhage: protocol for a randomised controlled trial
Shen, Y., Cheng, X., Ying, M., Zhang, W., Jiang, X., & Du, K. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-019199 · Cited by 5
Safety of increasing protein delivery with an enteral nutrition formula containing very high protein (VHP) and lower carbohydrate concentrations compared to conventional standard (SF) and high protein (HP) formulas
Ochoa, J. B., Berger, A. L., Hussein, R., & Huhmann, M. B. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.10.020 · Cited by 7
How to achieve nutrition goals by actual nutrition guidelines
Stoppe, C., Preiser, J., & Heyland, D. K. (2019) · Critical Care · doi:10.1186/s13054-019-2502-x · Cited by 5
Supplemental parenteral nutrition in critically ill patients
Shime, N., & MacLaren, G. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61069-7 · Cited by 5
Potential Benefits of Medical Nutrition Therapy for Timely Ventilator Weaning in the Critically Ill
Rosa, S. D., Rauseo, M., Umbrello, M., Lassola, S., & Battaglini, D. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005557 · Cited by 6
Current concepts on feeding the critically ill patient: a narrative review
Adolph, M., van Zanten, A. R. H., Berger, M. M., Petros, S., Hiesmayr, M., Weimann, A., Martignoni, M. E., Feil, K., Hirschberger, S., Haller, V., et al. (2026) · Critical Care · doi:10.1186/s13054-026-06123-5 · Cited by 4
Rationale for and Design of the Study of Early Enteral Dextrose in Sepsis: A Pilot Placebo‐Controlled Randomized Clinical Trial
Shah, F. A., Kitsios, G. D., Zhang, Y., Morris, A., Yende, S. P., Huang, D. T., O'Donnell, C. P., & McVerry, B. J. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1608 · Cited by 4
Intravenous amino acids may mediate the adverse effect of early parenteral nutrition on mortality in critically ill patients requiring mechanical ventilation: A post hoc analysis of the NEED trial
Lin, J., Liu, M., Huang, M., Ye, X., Xu, Y., Lv, C., Liu, Z., Liu, Y., Tong, Z., Li, W., et al. (2022) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2455 · Cited by 5
Advances in nutrition for the surgical patient
Yeh, D. D., Martin, M. J., Sakran, J. V., Meier, K., Mendoza, A. E., Grant, A. A., Parks, J. J., Byerly, S. E., Lee, E. E., McKinley, W. I., et al. (2019) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2019.04.003 · Cited by 4
Association between enteral nutrition support and neurological outcome in patients with acute intracranial haemorrhage: A retrospective cohort study
Cheng, X., Ru, W., Du, K., Jiang, X., Hu, Y., Zhang, W., Xu, Y., & Shen, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-53100-w · Cited by 4

Authors: Casaer, M. P., Wilmer, A., Hermans, G., Wouters, P. J., Mesotten, D., & Van den Berghe, G.
Affiliations: Universitair Ziekenhuis Leuven (BE)
KU Leuven (BE)
Laboratory and Department of Intensive Care Medicine and
Corresponding author: Casaer, Michael P.
ORCID: Casaer, Michael P.
Wilmer, Alexander
Hermans, Greet
Mesotten, Dieter
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2013-02-01
Volume: 187
Issue: 3
Pages: 247-255
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201206-0999oc
OpenAlex: W1840057839
Semantic Scholar: 37a3fd62d1564a467a4fe20b913801329a33e0e8
Cited by: 307
References: 46
Citations by year: 2026: 15 · 2025: 20 · 2024: 26 · 2023: 22 · 2022: 24 · 2021: 28 · 2020: 18 · 2019: 23 · 2018: 33 · 2017: 27 · 2016: 12 · 2015: 27 · 2014: 23 · 2013: 9
FWCI: 17.54
Type: journal article
Language: en
Open access: green
lirias.kuleuven.be
Licence: other-oa
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Lirias (KU Leuven) (submittedVersion, other-oa)
Funders: European Commission
Vlaamse regering
FP7 Ideas: European Research Council (321670)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords: early parenteral nutrition, critical illness, glucose supplementation, enteral nutrition, intensive care unit discharge, infection acquisition, disease severity
MeSH terms: Aged, Belgium, Energy Intake, Critical Care, Cross Infection, Dietary Carbohydrates, Dietary Proteins, Enteral Nutrition, Female, Humans, Intensive Care Units, Length of Stay, Lipids, Male, Middle Aged, Parenteral Nutrition, Severity of Illness Index, Time Factors, Cohort Studies, Causality, Odds Ratio, Critical Illness, Dietary Supplements, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks