The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps
Open accessAbstract
RATIONALE: Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) are associated with Th1 and Th2 cytokine polarization, respectively; however, the pathophysiology of CRS remains unclear. The importance of innate lymphoid cells in Th2-mediated inflammatory disease has not been clearly defined. OBJECTIVES: The objective of this study was to investigate the role of the epithelial cell-derived cytokine IL-33 and IL-33-responsive innate lymphoid cells in the pathophysiology of CRS. METHODS: Relative gene expression was evaluated using quantitative real-time polymerase chain reaction. Innate lymphoid cells in inflamed ethmoid sinus mucosa from patients with CRSsNP and CRSwNP were characterized using flow cytometry. Cytokine production from lymphoid cells isolated from inflamed mucosa of patients with CRS was examined using ELISA and intracellular cytokine staining. MEASUREMENTS AND MAIN RESULTS: Elevated expression of ST2, the ligand-binding chain of the IL-33 receptor, was observed in inflamed sinonasal mucosa from CRSwNP compared with CRSsNP and healthy control subjects. An increased percentage of innate lymphoid cells was observed in inflamed sinonasal mucosa from CRSwNP compared with CRSsNP. ST2(+) innate lymphoid cells are a consistent source of IL-13 in response to IL-33 stimulation. Significant induction of IL-33 was observed in epithelial cells derived from patients with CRSwNP compared with patients with CRSsNP in response to stimulation with Aspergillus fumigatus extract. CONCLUSIONS: These data suggest a role for sinonasal epithelial cell-derived IL-33 and an IL-33-responsive innate lymphoid cell population in the pathophysiology of CRSwNP demonstrating the functional importance of innate lymphoid cells in Th2-mediated inflammatory disease.
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Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
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The IL-1 family: regulators of immunity
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
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Cited by
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Orlandi, R. R., Kingdom, T. T., Smith, T. L., Bleier, B., DeConde, A., Luong, A. U., Poetker, D. M., Soler, Z., Welch, K. C., Wise, S. K., et al. (2021) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22741 · Cited by 959
Self-citationInternational Consensus Statement on Allergy and Rhinology: Rhinosinusitis
Orlandi, R. R., Kingdom, T. T., Hwang, P. H., Smith, T. L., Alt, J. A., Baroody, F. M., Batra, P. S., Bernal‐Sprekelsen, M., Bhattacharyya, N., Chandra, R. K., et al. (2016) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21695 · Cited by 892
Self-citationInterleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Enhanced innate type 2 immune response in peripheral blood from patients with asthma
Bartemes, K. R., Kephart, G. M., Fox, S. J., & Kita, H. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.024 · Cited by 390
Chronic rhinosinusitis pathogenesis
Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.009 · Cited by 388
Metadata
- Authors
- Shaw, J. L., Fakhri, S., Citardi, M. J., Porter, P. C., Corry, D. B., Kheradmand, F., Liu, Y.-J., & Luong, A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-15
- Volume
- 188
- Issue
- 4
- Pages
- 432-439
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2086914849
- Cited by
- 279
- References
- 33
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Shaw, J. L., Fakhri, S., Citardi, M. J., Porter, P. C., Corry, D. B., Kheradmand, F., Liu, Y.-J., & Luong, A. (2013). IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201212-2227oc
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