The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis
Open accessAbstract
RATIONALE: A hallmark of pulmonary tuberculosis (TB) is the formation of granulomas. However, the immune factors that drive the formation of a protective granuloma during latent TB, and the factors that drive the formation of inflammatory granulomas during active TB, are not well defined. OBJECTIVES: The objective of this study was to identify the underlying immune mechanisms involved in formation of inflammatory granulomas seen during active TB. METHODS: The immune mediators involved in inflammatory granuloma formation during TB were assessed using human samples and experimental models of Mycobacterium tuberculosis infection, using molecular and immunologic techniques. MEASUREMENTS AND MAIN RESULTS: We demonstrate that in human patients with active TB and in nonhuman primate models of M. tuberculosis infection, neutrophils producing S100 proteins are dominant within the inflammatory lung granulomas seen during active TB. Using the mouse model of TB, we demonstrate that the exacerbated lung inflammation seen as a result of neutrophilic accumulation is dependent on S100A8/A9 proteins. S100A8/A9 proteins promote neutrophil accumulation by inducing production of proinflammatory chemokines and cytokines, and influencing leukocyte trafficking. Importantly, serum levels of S100A8/A9 proteins along with neutrophil-associated chemokines, such as keratinocyte chemoattractant, can be used as potential surrogate biomarkers to assess lung inflammation and disease severity in human TB. CONCLUSIONS: Our results thus show a major pathologic role for S100A8/A9 proteins in mediating neutrophil accumulation and inflammation associated with TB. Thus, targeting specific molecules, such as S100A8/A9 proteins, has the potential to decrease lung tissue damage without impacting protective immunity against TB.
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Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel-Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,439
Self-citationVogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×
“S100A8/A9 protein levels were measured in mouse lung homogenates and culture supernatants (15) and in human serum (16) by ELISA as described before.”
BackgroundMethodSelf-citationRyckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 858
Self-citationEum, S.-Y., Kong, J.-H., Hong, M.-S., Lee, Y.-J., Kim, J.-H., Hwang, S.-H., Cho, S.-N., Via, L. E., & Barry, C. E. (2010) · Chest · doi:10.1378/chest.09-0903 · Cited by 548
Edgeworth, J., Gorman, M., Bennett, R., Freemont, P., & Hogg, N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89506-4 · Cited by 479
High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
Svenson, K. L., Gatti, D. M., Valdar, W., Welsh, C. E., Cheng, R., Chesler, E. J., Palmer, A. A., McMillan, L., & Churchill, G. A. (2012) · Genetics · doi:10.1534/genetics.111.132597 · Cited by 464
Macrophages and control of granulomatous inflammation in tuberculosis
Flynn, J. L., Chan, J., & Lin, P. L. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.14 · Cited by 417
Scriba, T. J., Kalsdorf, B., Abrahams, D.-A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S. J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1962 · Cited by 410
Cited by
Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450
Innate immunity in tuberculosis: host defense vs pathogen evasion
Liu, C. H., Liu, H., & Ge, B. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2017.88 · Cited by 532
Tuberculosis and lung damage: from epidemiology to pathophysiology
Ravimohan, S., Kornfeld, H., Weissman, D., & Bisson, G. P. (2018) · European Respiratory Review · doi:10.1183/16000617.0077-2017 · Cited by 531
Calprotectin: from biomarker to biological function
Jukic, A., Bakiri, L., Wagner, E. F., Tilg, H., & Adolph, T. E. (2021) · Gut · doi:10.1136/gutjnl-2021-324855 · Cited by 500
Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?
Porto, B. N., & Stein, R. T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00311 · Cited by 317
Metadata
- Authors
- Gopal, R., Monin, L., Torres, D., Slight, S., Mehra, S., McKenna, K. C., Fallert Junecko, B. A., Reinhart, T. A., Kolls, J., Báez-Saldaña, R., Cruz-Lagunas, A., Rodríguez-Reyna, T. S., Kumar, N. P., Tessier, P., Roth, J., Selman, M., Becerril-Villanueva, E., Baquera-Heredia, J., Cumming, B., Kasprowicz, V. O., Steyn, A. J. C., Babu, S., Kaushal, D., Zúñiga, J., Vogl, T., Rangel-Moreno, J., & Khader, S. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-01
- Volume
- 188
- Issue
- 9
- Pages
- 1137-1146
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2141361194
- Cited by
- 255
- References
- 46
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Gopal, R., Monin, L., Torres, D., Slight, S., Mehra, S., McKenna, K. C., Fallert Junecko, B. A., Reinhart, T. A., Kolls, J., Báez-Saldaña, R., Cruz-Lagunas, A., Rodríguez-Reyna, T. S., Kumar, N. P., Tessier, P., Roth, J., Selman, M., Becerril-Villanueva, E., Baquera-Heredia, J., Cumming, B., . . . Khader, S. A. (2013). S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201304-0803oc
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
