Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 240

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Common Mechanisms of Dyspnea in Chronic Interstitial and Obstructive Lung Disorders

Faisal, Azmy, Alghamdi, Bader J., Ciavaglia, Casey E., Elbehairy, Amany F., Webb, Katherine A., Ora, Josuel, Neder, J. Alberto, O’Donnell, Denis E.·2016·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201504-0841oc
Open this paper in CoChat — free account

Abstract

Rationale: The mechanisms underlying dyspnea in interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are unknown. Objectives: To examine whether the relationship between inspiratory neural drive to the diaphragm and exertional dyspnea intensity is different in ILD and COPD, given the marked differences in static respiratory mechanics between these conditions. Methods: We compared sensory–mechanical relationships in patients with ILD, patients with COPD, and healthy control subjects (n = 16 each) during incremental cycle exercise with diaphragmatic electromyography (EMGdi) and respiratory pressure measurements. Measurements and Main Results: In patients with mild to moderate ILD or COPD with similarly reduced inspiratory capacity, the peak oxygen uptake, work rate, and ventilation were lower (P < 0.05) than in healthy control subjects. EMGdi expressed as a percentage of the maximum (EMGdi/EMGdi,max), respiratory effort (esophageal pressure expressed as percentage of the maximum), and ventilation were higher (P < 0.05) at rest and during exercise in both patients with ILD and patients with COPD than in control subjects. Each of these measurements was similar in the ILD and COPD groups. A Vt inflection and critically reduced inspiratory reserve volume occurred at a lower (P < 0.05) ventilation in the ILD and COPD groups than in control subjects. Patients with ILD had greater diaphragmatic activity, whereas patients with COPD had greater expiratory muscle activity. The relationship between dyspnea intensity and EMGdi/EMGdi,max during exercise was similar in all three groups. In ILD and COPD, descriptors alluding to inspiratory difficulty were selected more frequently, with a greater disparity between EMGdi/EMGdi,max and Vt. Conclusions: Disease-specific differences in mechanics and respiratory muscle activity did not influence the key association between dyspnea intensity and inspiratory neural drive to the diaphragm.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1164/rccm.201504-0841oc

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 36

  1. Van Meerhaeghe, 1981, Respiratory drive and ventilatory pattern during exercise in interstitial lung disease, Bull Eur Physiopathol Respir, 17, 15
  2. Leblanc, 1986, Breathlessness and exercise in patients with cardiorespiratory disease, Am Rev Respir Dis, 133, 21, 10.1164/arrd.1986.133.1.21 · DOI
  3. Mahler, 1995, Changes in dyspnea, health status, and lung function in chronic airway disease, Am J Respir Crit Care Med, 151, 61, 10.1164/ajrccm.151.1.7812573 · DOI
  4. O’Donnell, 1998, Qualitative aspects of exertional dyspnea in patients with interstitial lung disease, J Appl Physiol (1985), 84, 2000, 10.1152/jappl.1998.84.6.2000 · DOI
  5. Guz, 1966, The effect of bilateral block of vagus and glossopharyngeal nerves on the ventilatory response to CO2 of conscious man, Respir Physiol, 1, 206, 10.1016/0034-5687(66)90017-X · DOI
  6. Means, 1924, Dyspnoea, medicine monographs 3., 309
  7. Gandevia, 1988, Neural mechanisms underlying the sensation of breathlessness: kinesthetic parallels between respiratory and limb muscles, Aust N Z J Med, 18, 83, 10.1111/j.1445-5994.1988.tb02252.x · DOI · Paper page
  8. Rampulla, 1992, Dyspnea on exercise: pathophysiologic mechanisms, Chest, 101, 248S
  9. O’Donnell, 1997, Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms, Am J Respir Crit Care Med, 155, 109, 10.1164/ajrccm.155.1.9001298 · DOI
  10. Smith, 2009, Qualitative aspects of breathlessness in health and disease, Thorax, 64, 713, 10.1136/thx.2008.104869 · DOI
  11. Luo, 2008, Diaphragm electromyography using an oesophageal catheter: current concepts, Clin Sci (Lond), 115, 233, 10.1042/CS20070348 · DOI
  12. Jolley, 2009, Neural respiratory drive in healthy subjects and in COPD, Eur Respir J, 33, 289, 10.1183/09031936.00093408 · DOI
  13. Guenette, 2014, Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD, Eur Respir J, 44, 1177, 10.1183/09031936.00034714 · DOI · Paper page
  14. Jolley, 2015, Neural respiratory drive and breathlessness in COPD, Eur Respir J, 45, 355, 10.1183/09031936.00063014 · DOI · Paper page
  15. Alghamdi, 2014, Intensity and quality of exertional dyspnea are similar in patients with restrictive and obstructive lung diseases when resting inspiratory capacity is matched [abstract], Am J Respir Crit Care Med, 189, A6273
  16. Borg, 1982, Psychophysical bases of perceived exertion, Med Sci Sports Exerc, 14, 377, 10.1249/00005768-198205000-00012 · DOI · Paper page
  17. O’Donnell, 2000, Respiratory sensation during chest wall restriction and dead space loading in exercising men, J Appl Physiol (1985), 88, 1859, 10.1152/jappl.2000.88.5.1859 · DOI
  18. Ciavaglia, 2014, Differences in respiratory muscle activity during cycling and walking do not influence dyspnea perception in obese patients with COPD, J Appl Physiol (1985), 117, 1292, 10.1152/japplphysiol.00502.2014 · DOI · Paper page
  19. Sinderby, 1998, Voluntary activation of the human diaphragm in health and disease, J Appl Physiol (1985), 85, 2146, 10.1152/jappl.1998.85.6.2146 · DOI
  20. Wagner, 1976, Distribution of ventilation-perfusion ratios in patients with interstitial lung disease, Chest, 69, 256, 10.1378/chest.69.2_Supplement.256-a · DOI
  21. Wagner, 1977, Ventilation-perfusion inequality in chronic obstructive pulmonary disease, J Clin Invest, 59, 203, 10.1172/JCI108630 · DOI
  22. Killian, 1992, Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation, Am Rev Respir Dis, 146, 935, 10.1164/ajrccm/146.4.935 · DOI
  23. Elbehairy, 2015, Pulmonary gas exchange abnormalities in mild chronic obstructive pulmonary disease: implications for dyspnea and exercise intolerance, Am J Respir Crit Care Med, 191, 1384, 10.1164/rccm.201501-0157OC · DOI · Paper page
  24. Gandevia, 1982, The perception of motor commands or effort during muscular paralysis, Brain, 105, 151, 10.1093/brain/105.1.151 · DOI
  25. Killian, 1984, Effect of increased lung volume on perception of breathlessness, effort, and tension, J Appl Physiol, 57, 686, 10.1152/jappl.1984.57.3.686 · DOI
  26. Chen, 1992, Respiratory-associated thalamic activity is related to level of respiratory drive, Respir Physiol, 90, 99, 10.1016/0034-5687(92)90137-L · DOI
  27. Wright, 1954, The origin of the sensations of dyspnea, Trans Am Clin Climatol Assoc, 66, 116
  28. Manning, 1992, Reduced tidal volume increases ‘air hunger’ at fixed PCO2 in ventilated quadriplegics, Respir Physiol, 90, 19, 10.1016/0034-5687(92)90131-F · DOI
  29. Harty, 1999, External thoracic restriction, respiratory sensation, and ventilation during exercise in men, J Appl Physiol (1985), 86, 1142, 10.1152/jappl.1999.86.4.1142 · DOI
  30. Sibuya, 1994, Effect of chest wall vibration on dyspnea in patients with chronic respiratory disease, Am J Respir Crit Care Med, 149, 1235, 10.1164/ajrccm.149.5.8173764 · DOI
  31. Cristiano, 1997, Effect of chest wall vibration on dyspnea during hypercapnia and exercise in chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 155, 1552, 10.1164/ajrccm.155.5.9154856 · DOI
  32. Scano, 2010, Do obstructive and restrictive lung diseases share common underlying mechanisms of breathlessness?, Respir Med, 104, 925, 10.1016/j.rmed.2010.02.019 · DOI
  33. de Troyer, 1980, Inspiratory muscle force in normal subjects and patients with interstitial lung disease, Thorax, 35, 92, 10.1136/thx.35.2.92 · DOI
  34. Kyroussis, 2000, Respiratory muscle activity in patients with COPD walking to exhaustion with and without pressure support, Eur Respir J, 15, 649, 10.1034/j.1399-3003.2000.15d05.x · DOI
  35. Laveneziana, 2014, Does expiratory muscle activity influence dynamic hyperinflation and exertional dyspnea in COPD?, Respir Physiol Neurobiol, 199, 24, 10.1016/j.resp.2014.04.005 · DOI · Paper page
  36. Villafranca, 1998, Effect of inspiratory muscle training with an intermediate load on inspiratory power output in COPD, Eur Respir J, 11, 28, 10.1183/09031936.98.11010028 · DOI

Cited by

See all 240

Metadata

Authors
Faisal, A., Alghamdi, B. J., Ciavaglia, C. E., Elbehairy, A. F., Webb, K. A., Ora, J., Neder, J. A., & O’Donnell, D. E.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2016-02-01
Volume
193
Issue
3
Pages
299-309
ISSN
  • 1073-449X
  • 1535-4970
DOI
10.1164/rccm.201504-0841oc
Cited by
240
References
7
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Funders
Queen’s University

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.