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Cited by 134

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Neural respiratory drive and breathlessness in COPD

Jolley, Caroline J., Luo, Yuanming M., Steier, Joerg, Rafferty, Gerrard F., Polkey, Michael I., Moxham, John·2015·European Respiratory Journal
DOI 10.1183/09031936.00063014
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Abstract

The aim of this study was to test the hypothesis that neural respiratory drive, measured using diaphragm electromyogram (EMG di ) activity expressed as a percentage of maximum (EMG di%max ), is closely related to breathlessness in chronic obstructive pulmonary disease. We also investigated whether neuroventilatory uncoupling contributes significantly to breathlessness intensity over an awareness of levels of neural respiratory drive alone. EMGdi and ventilation were measured continuously during incremental cycle and treadmill exercise in 12 chronic obstructive pulmonary disease patients (forced expiratory volume in 1 s± sd was 38.7±14.5 % pred). EMG di was expressed both as EMG di%max and relative to tidal volume expressed as a percentage of predicted vital capacity to quantify neuroventilatory uncoupling. EMG di%max was closely related to Borg breathlessness in both cycle (r=0.98, p=0.0001) and treadmill exercise (r=0.94, p=0.005), this relationship being similar to that between neuroventilatory uncoupling and breathlessness (cycling r=0.94, p=0.005; treadmill r=0.91, p=0.01). The relationship between breathlessness and ventilation was poor when expansion of tidal volume became limited. In chronic obstructive pulmonary disease the intensity of exertional breathlessness is closely related to EMG di%max . These data suggest that breathlessness in chronic obstructive pulmonary disease can be largely explained by an awareness of levels of neural respiratory drive, rather than the degree of neuroventilatory uncoupling. EMG di%max could provide a useful physiological biomarker for breathlessness in chronic obstructive pulmonary disease.

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Metadata

Authors
Jolley, C. J., Luo, Y. M., Steier, J., Rafferty, G. F., Polkey, M. I., & Moxham, J.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2014-10-16
Volume
45
Issue
2
Pages
355-364
ISSN
  • 0903-1936
  • 1399-3003
DOI
10.1183/09031936.00063014
Cited by
134
References
5
Language
en

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CoChat. (2026). Citation check: Neural respiratory drive and breathlessness in COPD. https://app.cochat.ai/papers/10.1183/09031936.00063014
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Jolley, C. J., Luo, Y. M., Steier, J., Rafferty, G. F., Polkey, M. I., & Moxham, J. (2015). Neural respiratory drive and breathlessness in COPD. European Respiratory Journal. https://doi.org/10.1183/09031936.00063014

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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