The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Macrophages, Inflammation, and Lung Cancer
Abstract
Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, it has one of the lowest 5-year survival rates of all malignancies. With its highly complex mutational landscape, treatment strategies against lung cancer have proved largely ineffective. However with the recent success of immunotherapy trials in lung cancer, there is renewed enthusiasm in targeting the immune component of tumors. Macrophages make up the majority of the immune infiltrate in tumors and are a key cell type linking inflammation and cancer. Although the mechanisms through which inflammation promotes cancer are not fully understood, two connected hypotheses have emerged: an intrinsic pathway, driven by genetic alterations that lead to neoplasia and inflammation, and an extrinsic pathway, driven by inflammatory conditions that increase cancer risk. Here, we discuss the contribution of macrophages to these pathways and subsequently their roles in established tumors. We highlight studies investigating the association of macrophages with lung cancer prognosis and discuss emerging therapeutic strategies for targeting macrophages in the tumor microenvironment.
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Cites
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Cited by
Xu, F., Cui, W.-Q., Wei, Y., Cui, J., Qiu, J., Hu, L.-L., Gong, W.-Y., Dong, J.-C., & Liu, B.-J. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0878-0 · Cited by 331
Kim, W., Lee, E. J., Bae, I., Myoung, K., Kim, S. T., Park, P. J., Lee, K., Pham, A. V. Q., Ko, J., Oh, S. H., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1793514 · Cited by 232
Asbestos, Smoking and Lung Cancer: An Update
Klebe, S., Leigh, J., Henderson, D. W., & Nurminen, M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17010258 · Cited by 170
The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy
(2021) · doi:10.3389/fonc.2021.720842 · Cited by 136
Healy, C., Munoz-Wolf, N., Strydom, J., Faherty, L., Williams, N. C., Kenny, S., Donnelly, S. C., & Cloonan, S. M. (2021) · Respiratory Research · doi:10.1186/s12931-021-01722-y · Cited by 78
Metadata
- Authors
- Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S., Lam, W. L., & Bennewith, K. L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-15
- Volume
- 193
- Issue
- 2
- Pages
- 116-130
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2173603370
- Cited by
- 286
- References
- 126
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S., Lam, W. L., & Bennewith, K. L. (2016). Macrophages, Inflammation, and Lung Cancer. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201508-1545ci
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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