Cited by 346Muscle Physiology and DisordersChronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in Aging

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Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

Agustí, Alvar G. N., Sauleda, Jaume, Miralles, Cristina, Gomez, Cristina, Togores, Bernat, Sala, Ernest, Batle, Santiago, Busquets, Xavier·2002·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.2108013

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Abstract

Patients with chronic obstructive pulmonary disease (COPD) often lose weight during the course of their disease. We hypothesized that this may be due to skeletal muscle apoptosis. To investigate this possibility, we obtained quadriceps femoris biopsies in 15 patients with COPD (8 with normal body mass index [BMI] and 7 with low [< 20 kg/m(2)] BMI), 8 healthy volunteers, and 6 sedentary subjects undergoing orthopedic surgery (both groups with normal BMI). Skeletal muscle apoptosis was assessed by the transferase-mediated dUTP nick end labeling (TUNEL) technique and the immunodetection of poly-(ADP-ribose)-polymerase proteolytic fragments. Exercise tolerance on a cycloergometer was also determined in patients with COPD. We found that skeletal muscle apoptosis (by both techniques) was increased in patients with COPD and low BMI as compared with the other three groups (p < 0.005). In patients with COPD, BMI was inversely related to skeletal muscle apoptosis (TUNEL, p = 0.009), and it was better correlated with exercise capacity (p = 0.006) than with the degree of airflow obstruction present (p = 0.02). Markers of skeletal muscle apoptosis were not related to any of the measured lung function variables. This study shows that skeletal muscle apoptosis (1) is increased in patients with COPD having low BMI; and (2) is associated with a lower exercise tolerance despite a similar degree of lung function impairment.

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Authors: Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X.
Affiliations: Hospital Universitario Son Dureta (ES)
ORCID: Agustí, Alvar G. N.
Sauleda, Jaume
Miralles, Cristina
Sala, Ernest
Busquets, Xavier
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2002-08
Volume: 166
Issue: 4
Pages: 485-489
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.2108013
OpenAlex: W2140886594
Cited by: 343
References: 35
Citations by year: 2026: 3 · 2025: 5 · 2023: 8 · 2022: 12 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 16 · 2013: 13 · 2012: 21
FWCI: 6.74
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: chronic obstructive pulmonary disease, skeletal muscle apoptosis, weight loss, body mass index, quadriceps, exercise tolerance, poly(ADP-ribose) polymerase, TUNEL, muscle atrophy, lung function
MeSH terms: Aged, Biopsy, Blood Gas Analysis, Forced Expiratory Volume, Humans, Immunohistochemistry, Middle Aged, Muscular Atrophy, Poly(ADP-ribose) Polymerases, Severity of Illness Index, Blotting, Western, Weight Loss, Exercise, Body Mass Index, Case-Control Studies, Exercise Tolerance, Apoptosis, Muscle, Skeletal, In Situ Nick-End Labeling, Pulmonary Disease, Chronic Obstructive

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Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

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