Cited by 346Muscle Physiology and DisordersChronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in Aging

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

Agustí, Alvar G. N., Sauleda, Jaume, Miralles, Cristina, Gomez, Cristina, Togores, Bernat, Sala, Ernest, Batle, Santiago, Busquets, Xavier·2002·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.2108013

Open this paper in CoChat — free account

Abstract

Patients with chronic obstructive pulmonary disease (COPD) often lose weight during the course of their disease. We hypothesized that this may be due to skeletal muscle apoptosis. To investigate this possibility, we obtained quadriceps femoris biopsies in 15 patients with COPD (8 with normal body mass index [BMI] and 7 with low [< 20 kg/m(2)] BMI), 8 healthy volunteers, and 6 sedentary subjects undergoing orthopedic surgery (both groups with normal BMI). Skeletal muscle apoptosis was assessed by the transferase-mediated dUTP nick end labeling (TUNEL) technique and the immunodetection of poly-(ADP-ribose)-polymerase proteolytic fragments. Exercise tolerance on a cycloergometer was also determined in patients with COPD. We found that skeletal muscle apoptosis (by both techniques) was increased in patients with COPD and low BMI as compared with the other three groups (p < 0.005). In patients with COPD, BMI was inversely related to skeletal muscle apoptosis (TUNEL, p = 0.009), and it was better correlated with exercise capacity (p = 0.006) than with the degree of airflow obstruction present (p = 0.02). Markers of skeletal muscle apoptosis were not related to any of the measured lung function variables. This study shows that skeletal muscle apoptosis (1) is increased in patients with COPD having low BMI; and (2) is associated with a lower exercise tolerance despite a similar degree of lung function impairment.

Integrity signals

Registry

Crossref · 10.1164/rccm.2108013

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715
Chronic Obstructive Pulmonary Disease
Flavin, K., Morkane, C. M., & Marsh, S. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108233712.025 · Cited by 2,687
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., & Earnshaw, W. C. (1994) · Nature · doi:10.1038/371346a0 · Cited by 2,563
Oxidative stress as a mediator of apoptosis
Buttke, T. M., & Sandstrom, P. A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90018-3 · Cited by 2,149
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Apoptosis in Myocytes in End-Stage Heart Failure
Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 5

1999, Am J Respir Crit Care Med, 159, S1
1986, Bull Eur Physiopathol Respir, 22, 217
1985, Am Rev Respir Dis, 131, 700
1986, Lancet, 1, 307
1998, Curr Top Dev Biol, 36, 259

Sorted by citations

American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966
Systemic manifestations and comorbidities of COPD
Barnes, P. J., & Celli, B. R. (2009) · European Respiratory Journal · doi:10.1183/09031936.00128008 · Cited by 1,863
An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
Maltais, F., Decramer, M., Casaburi, R. H., Barreiro, E., Burelle, Y., Debigaré, R., Dekhuijzen, P. N. R., Franssen, F. M. E., Gayan‐Ramirez, G., Gea, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0373st · Cited by 1,165
Systemic effects of chronic obstructive pulmonary disease
Agustí, A. G. N., Noguera, A., Sauleda, J., Sala, E., Pons, J., & Busquets, X. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00405703 · Cited by 1,058
Self-citation
Disorders of the Respiratory Muscles
Laghi, F. A., & Tobin, M. J. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2206020 · Cited by 689
Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Troosters, T., Casaburi, R. H., Gosselink, R., & Decramer, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1109so · Cited by 656
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Chung, K. F., & Adcock, I. M. (2008) · European Respiratory Journal · doi:10.1183/09031936.00018908 · Cited by 613
Body Mass, Fat-Free Body Mass, and Prognosis in Patients with Chronic Obstructive Pulmonary Disease from a Random Population Sample
Vestbo, J., Prescott, E., Almdal, T., Dahl, M., Nordestgaard, B. G., Andersen, T., Sørensen, T. I. A., & Lange, P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-969oc · Cited by 654
C-reactive Protein as a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease
Dahl, M., Vestbo, J., Lange, P., Bojesen, S. E., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-713oc · Cited by 544
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
Demedts, I., Demoor, T., Bracke, K. R., Joos, G., & Brusselle, G. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-53 · Cited by 543
Burying the Dead
Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450
Pathogenesis of chronic obstructive pulmonary disease
Tuder, R. M., & Petrache, I. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60324 · Cited by 445
Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting
Song, Y., Li, Y., Du, J., Mitch, W. E., Rosenthal, N. A., & Delafontaine, P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22324 · Cited by 352
The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
Hatzelmann, A., Morcillo, E. J., Lungarella, G., Adnot, S., Sanjar, S., Beume, R., Schudt, C., & Tenor, H. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.03.011 · Cited by 324
COPD as a Lung Disease with Systemic Consequences – Clinical Impact, Mechanisms, and Potential for Early Intervention
Decramer, M., Rennard, S. I., Troosters, T., Mapel, D. W., Giardino, N. D., Mannino, D. M., Wouters, E. F. �., Sethi, S., & Cooper, C. B. (2008) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550802237531 · Cited by 296
Systemic Effects of Chronic Obstructive Pulmonary Disease
Agustí, A. G. N. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-026sr · Cited by 297
Self-citation
COPD as a Systemic Disease
Agustí, A. G. N., & Soriano, J. B. (2008) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550801941349 · Cited by 288
Self-citation
Pulmonary Rehabilitation for Management of Chronic Obstructive Pulmonary Disease
Casaburi, R., & ZuWallack, R. (2009) · New England Journal of Medicine · doi:10.1056/nejmct0804632 · Cited by 270
Systemic Effects of Chronic Obstructive Pulmonary Disease: What We Know and What We Don't Know (but Should)
Agustí, A. G. N. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200701-004fm · Cited by 270
Self-citation
Improvement in Quadriceps Strength and Dyspnea in Daily Tasks After 1 Month of Electrical Stimulation in Severely Deconditioned and Malnourished COPD
Vivodtzev, I., Pépin, J., Vottero, G., Mayer, V., Porsin, B., Levy, P. A., & Wuyam, B. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1540 · Cited by 271
Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease
Couillard, A., Maltais, F., Saey, D., Debigaré, R., Michaud, A., Koechlin‐Ramonatxo, C., Leblanc, P., & PREFAUT, C. G. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1028oc · Cited by 262
COPD: current therapeutic interventions and future approaches
Barnes, P. J., & Stockley, R. A. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00139104 · Cited by 262
Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7
He, W. A., Calore, F., Londhe, P., Canella, A., Guttridge, D. C., & Croce, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402714111 · Cited by 235
Outcomes and markers in the assessment of chronic obstructive pulmonary disease
Jones, P., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00145104 · Cited by 248
Self-citation
Pathophysiology of muscle dysfunction in COPD
Gea, J., Agustí, A. G. N., & Roca, J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00981.2012 · Cited by 250
Self-citation
Oxidative Stress in Pathogenesis of Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms
Rahman, I. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:1:167 · Cited by 237
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
Hussain, S., Cheol, K., & Mofarrahi, M. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s4480 · Cited by 224
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
Ábrigo, J., Elorza, Á. A., Riedel, C. A., Vilos, C., Simón, F., Cabrera, D., Estrada, L. D., & Cabello‐Verrugio, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2063179 · Cited by 225
From Seminars in Respiratory and Critical Care Medicine
Spurzem, J. R., & Rennard, S. I. (2011) · Cited by 215
Sarcopenia and cardiovascular diseases: A systematic review and meta‐analysis
Zuo, X., Li, X., Tang, K., Zhao, R., Wu, M., Wang, Y., & Li, T. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13221 · Cited by 221
NF- B activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight
Agustí, A. G. N. (2004) · Thorax · doi:10.1136/thx.2003.017640 · Cited by 205
Self-citation
COPD, a multicomponent disease: implications for management
Agustí, A. G. N. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2004.11.006 · Cited by 198
Self-citation
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Couillard, A., & Prefaut, C. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00139904 · Cited by 194
Circulating haemopoietic and endothelial progenitor cells are decreased in COPD
Palange, P., Testa, U., Huertas, A., Calabrò, L., Antonucci, R., Petrucci, E., Pelosi, E., Pasquini, L., Satta, A., Morici, G., et al. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00120604 · Cited by 196
Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
Dirks, A. J., & Leeuwenburgh, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.003 · Cited by 190
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies
Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00425.2021 · Cited by 194
The mechanisms of cachexia underlying muscle dysfunction in COPD
Remels, A. H. V., Gosker, H. R., LANGEN, R. C. J., & Schols, A. M. W. J. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00790.2012 · Cited by 181
Factors contributing to muscle wasting and dysfunction in COPD patients.
Wüst, R. C. I., & Degens, H. (2007) · PubMed Central · Cited by 175
Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY)
Mannino, D. M., Mott, J. A., Ferdinands, J. M., Camargo, C. A., Friedman, M., Greves, H. M., & Redd, S. C. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803145 · Cited by 178
The 6-min walking distance: long-term follow up in patients with COPD
Casanova, C., Côté, C., Marín, J. M., de-Torres, J. P., Aguirre‐Jaime, A., Mendez, R., Dordelly, L. J., & Celli, B. R. (2006) · European Respiratory Journal · doi:10.1183/09031936.00071506 · Cited by 181
Abnormal Mitochondrial Function in Locomotor and Respiratory Muscles of COPD Patients
Puente-Maestu, L., Pérez-Parra, J., Godoy, R., Moreno, N., Tejedor, A., González-Aragoneses, F., Bravo, J.-L., Villar Álvarez, F., Camaño, S., & Agustí, A. (2009) · European Respiratory Journal · doi:10.1183/09031936.00112408 · Cited by 172
Self-citation
Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings.
Gea, J., Pascual-Guàrdia, S., Casadevall, C., Orozco‐Levi, M., & Barreiro, E. (2015) · PubMed Central · doi:10.3978/j.issn.2072-1439.2015.08.04 · Cited by 185
The Role of Oxidative Stress in the Pathogenesis??of COPD
Rahman, I. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504030-00003 · Cited by 171
Body Mass and Fat-Free Mass Indices in COPD
Ischaki, E., Papatheodorou, G., Gaki, Ε., Papa, I., Koulouris, N. G., & Loukides, S. (2007) · CHEST Journal · doi:10.1378/chest.06-2789 · Cited by 173
Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease
LANGEN, R. C. J., Gosker, H. R., Remels, A. H. V., & Schols, A. M. W. J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.015 · Cited by 167
Diaphragm adaptations in patients with COPD
Ottenheijm, C. A. C., Heunks, L. M. A., & Dekhuijzen, R. P. N. (2008) · Respiratory Research · doi:10.1186/1465-9921-9-12 · Cited by 163
The Role of Oxidative Stress in Chronic Obstructive Pulmonary Disease
Bowler, R. P., Barnes, P. J., & Crapo, J. D. (2004) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200027031 · Cited by 153
Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective
Sanders, K. J. C., Kneppers, A. E. M., van de Bool, C., LANGEN, R. C. J., & Schols, A. M. W. J. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12062 · Cited by 153
BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials
Sun, Y., Milne, S. B., Jaw, J. E., Yang, C., Xu, F., Li, X., Obeidat, M., & Sin, D. D. (2019) · Respiratory Research · doi:10.1186/s12931-019-1209-5 · Cited by 138
Chronic Obstructive Pulmonary Disease: A Chronic Systemic Inflammatory Disease
van Eeden, S. F., & Sin, D. D. (2007) · Respiration · doi:10.1159/000111820 · Cited by 138
Phenotypes of Chronic Obstructive Pulmonary Disease
Friedlander, A. L., Lynch, D. A., Dyar, L. A., & Bowler, R. P. (2007) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550701629663 · Cited by 139
Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Jagoe, R. T., & Engelen, M. P. K. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004608 · Cited by 134
Update on the Management of COPD
Celli, B. R. (2008) · CHEST Journal · doi:10.1378/chest.07-2061 · Cited by 133
Sleep-Disordered Breathing and COPD: The Overlap Syndrome
Owens, R. L., & Malhotra, A. (2010) · Respiratory Care · doi:10.4187/respcare.10551333 · Cited by 135
Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review
Hurst, J. R., Han, M. K., Singh, B., Sharma, S., Kaur, G., Nigris, E. D., Holmgren, U., & Siddiqui, M. K. (2022) · Respiratory Research · doi:10.1186/s12931-022-02123-5 · Cited by 131
Diaphragm Muscle Fiber Dysfunction in Chronic Obstructive Pulmonary Disease
Ottenheijm, C. A. C., Heunks, L. M. A., & Dekhuijzen, P. N. R. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-020pp · Cited by 130
Constitutive activation of MAPK cascade in acute quadriplegic myopathy
Giovanni, S. D., Molon, A., Broccolini, A., Melcon, G., Massimiliano Mirabella, A., Hoffman, E. P., & Servidei, S. (2003) · Annals of Neurology · doi:10.1002/ana.10811 · Cited by 130
Prevalence of malnutrition in COPD and its relationship with the parameters related to disease severity
Mete, B., Pehlivan, E., Gülbaş, G., & Günen, H. (2018) · International Journal of COPD · doi:10.2147/copd.s179609 · Cited by 114
Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
Hornikx, M., Remoortel, H. V., Lehouck, A., Mathieu, C., Maes, K., Gayan‐Ramirez, G., Decramer, M., Troosters, T., & Janssens, W. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-84 · Cited by 113
Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD
Sugawara, K., Takahashi, H., Kashiwagura, T., Yamada, K., Yanagida, S., Homma, M., Dairiki, K., Sasaki, H., Kawagoshi, A., Satake, M., et al. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.07.001 · Cited by 111
Cigarette Smoke Extract Induces DNA Damage but Not Apoptosis in Human Bronchial Epithelial Cells
Liu, X., Conner, H., Kobayashi, T., Kim, H., Wen, F., Abe, S., Fang, Q., Wang, X., Hashimoto, M., Bitterman, P. B., et al. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0341oc · Cited by 112
Skeletal muscle weakness, reduced exercise tolerance, and COPD: is systemic inflammation the missing link?
Sin, D. D. (2005) · Thorax · doi:10.1136/thx.2005.044941 · Cited by 105
Apoptosis in lung injury and remodeling
Li, X., Shu, R., Filippatos, G. S., & Uhal, B. D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00519.2004 · Cited by 101
Chianina beef tenderness investigated through integrated Omics
D’Alessandro, A., Marrocco, C., Rinalducci, S., Mirasole, C., Failla, S., & Zolla, L. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.052 · Cited by 102
Chronic obstructive pulmonary disease
Vijayan, V. K. (2019) · Dental Abstracts · doi:10.1016/j.denabs.2018.11.040 · Cited by 102
Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study
Miniati, M., Monti, S., Basta, G., Cocci, F., Fornai, E., & Bottai, M. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-37 · Cited by 100
The Mitochondrial Phenotype of Peripheral Muscle in Chronic Obstructive Pulmonary Disease
Picard, M., Godin, R., Sinnreich, M., Baril, J., Bourbeau, J., Perrault, H., Taivassalo, T., & Burelle, Y. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1005oc · Cited by 95
The Study to Understand Mortality and Morbidity in COPD (SUMMIT) study protocol
Vestbo, J., Anderson, J. A., Brook, R. D., Calverley, P. M. A., Celli, B. R., Crim, C. C., Haumann, B., Martínez, F. J., Yates, J., & Newby, D. E. (2012) · European Respiratory Journal · doi:10.1183/09031936.00087312 · Cited by 91
Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients
Rabinovich, R., & Vilaró, J. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328336438d · Cited by 93
Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks
Wing, S. S., Lecker, S. H., & Jagoe, R. T. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.586171 · Cited by 93
Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome
Ioachimescu, O. C., & Teodorescu, M. (2013) · Respirology · doi:10.1111/resp.12062 · Cited by 89
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
Abrigo, J., Simon, F., Cabrera, D., Vilos, C., & Cabello-Verrugio, C. (2019) · Current Protein & Peptide Science · doi:10.2174/1389203720666190402100902 · Cited by 88
Genome-Wide MRNA Expression Profiling in Vastus Lateralis of COPD Patients with Low and Normal Fat Free Mass Index and Healthy Controls
Rabinovich, R. A., Drost, E., Manning, J. R., Dunbar, D. R., Díaz-Ramos, M., Lakhdar, R., Bastos, R., & MacNee, W. (2015) · Respiratory Research · doi:10.1186/s12931-014-0139-5 · Cited by 88
Molecular and Biological Pathways of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
Barreiro, E., & Gea, J. (2016) · Chronic Respiratory Disease · doi:10.1177/1479972316642366 · Cited by 87
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Rehn, T. A., Munkvik, M., Lunde, P., Sjaastad, I., & Sejersted, O. M. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9289-4 · Cited by 86
The metabolomics of airway diseases, including COPD, asthma and cystic fibrosis
Gh, B. F. N. M., Aliannejad, R., Rezaei–Tavirani, M., Taheri, S., & Oskouie, A. A. (2014) · Biomarkers · doi:10.3109/1354750x.2014.983167 · Cited by 86
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85
“Since the early reports of Agusti and colleagues and Gosker and colleagues, who observed, respectively, an increased and unchanged myonuclear fragmentation in muscle cells [111,112], only one study reported increased terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL)-positive cells in quadri…”
Result
Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease
Pons, J., Sauleda, J., Regueiro, V., Santos, C., López, M., Ferrer, J. M., Agustí, A. G. N., & Bengoechea, J. A. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-64 · Cited by 85
Self-citation
Elevated Levels of IL-18 in Plasma and Skeletal Muscle in Chronic Obstructive Pulmonary Disease
Petersen, A. M. W., Penkowa, M., Iversen, M., Frydelund-Larsen, L., Andersen, J. L., Mortensen, J., Lange, P., & Pedersen, B. K. (2007) · Lung · doi:10.1007/s00408-007-9000-7 · Cited by 83
Apoptotic mechanisms in the pathogenesis of COPD
Plataki, M. E., Tzortzaki, E. G., Rytilä, P. H., Demosthenes, M., Koutsopoulos, A. V., & Siafakas, N. M. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.2.161 · Cited by 81
Mechanisms underlying the anti-wasting effect of l-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies
Ringseis, R., Keller, J., & Eder, K. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0511-0 · Cited by 83
The clinical management in extremely severe COPD
Ambrosino, N., & Simonds, A. K. (2007) · Respiratory Medicine · doi:10.1016/j.rmed.2007.02.011 · Cited by 80
Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005–2008 National Health and Nutrition Examination Survey
Du, W., Liu, J., Zhou, J., Ye, D., OuYang, Y., & Deng, Q. (2018) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s148735 · Cited by 77
Skeletal Muscle Mitochondrial Dysfunction during Chronic Obstructive Pulmonary Disease: Central Actor and Therapeutic Target
Meyer, A., Zoll, J., Charles, A. L., Charloux, A., de Blay, F., Diemunsch, P., Sibilia, J., Piquard, F., & Geny, B. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2012.069468 · Cited by 90
Structural alterations of skeletal muscle in copd
Mathur, S., Brooks, D., & Carvalho, C. R. F. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00104 · Cited by 87
Fat-Free Mass Index for Evaluating the Nutritional Status and Disease Severity in COPD
Luo, Y., Zhou, L., Li, Y., Guo, S., Li, X., Zheng, J., Zhu, Z., Chen, Y., Huang, Y., Chen, R., et al. (2016) · Respiratory Care · doi:10.4187/respcare.04358 · Cited by 87
Management of severe COPD
Wouters, E. F. �. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16984-5 · Cited by 80
Gene Expression Profiling in Vastus Lateralis Muscle During an Acute Exacerbation of COPD
Crul, T., Testelmans, D., Spruit, M., Troosters, T., Gosselink, R., Geeraerts, I., Decramer, M., & Gayan-Ramirez, G. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000303054 · Cited by 79
Inflammatory Cells and Apoptosis in Respiratory and Limb Muscles of Patients with COPD
Barreiro, E., Ferrer, D., Sanchez, F., Minguella, J., Marin-Corral, J., Martinez-Llorens, J., Lloreta, J., & Gea, J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01017.2010 · Cited by 79
Factors Limiting Exercise Tolerance in Chronic Lung Diseases
Vogiatzis, I., & Zakynthinos, S. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110015 · Cited by 77
Network medicine, multimorbidity and the lung in the elderly
Faner, R., Cruz, T., López-Giraldo, A., & Agustí, A. G. N. (2014) · European Respiratory Journal · doi:10.1183/09031936.00078714 · Cited by 74
Self-citation
Elevation of IL-6 and IL-33 Levels in Serum Associated with Lung Fibrosis and Skeletal Muscle Wasting in a Bleomycin-Induced Lung Injury Mouse Model
Shieh, J., Tseng, H., Jung, F., Yang, S., & Lin, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/7947596 · Cited by 74
Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss
Siu, P. M. (2009) · Frontiers in bioscience · doi:10.2741/3253 · Cited by 73
Nutritional Status is Related to Fat-Free Mass, Exercise Capacity and Inspiratory Strength in Severe Chronic Obstructive Pulmonary Disease Patients
Sabino, P. G., Silva, B. M., & Brunetto, A. F. (2010) · Clinics · doi:10.1590/s1807-59322010000600007 · Cited by 72
Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases
Schmidt, E. P., & Tuder, R. M. (2010) · Journal of Cell Death · doi:10.4137/jcd.s5375 · Cited by 70
Phenotyping COPD by 1H NMR metabolomics of exhaled breath condensate
Bertini, I., Luchinat, C., Miniati, M., Monti, S., & Tenori, L. (2013) · Metabolomics · doi:10.1007/s11306-013-0572-3 · Cited by 70
Mechanisms of Physical Activity Limitation in Chronic Lung Diseases
Vogiatzis, I., Zakynthinos, G. Ε., & Andrianopoulos, V. (2012) · Pulmonary Medicine · doi:10.1155/2012/634761 · Cited by 77
Chronic Obstructive Pulmonary Disease
Nazir, S. A., & Erbland, M. L. (2009) · Drugs & Aging · doi:10.2165/11316760-000000000-00000 · Cited by 71
Comparative assessment of the quadriceps and the diaphragm in patients with COPD
Caron, M., Debigaré, R., Dekhuijzen, P. N. R., & Maltais, F. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00194.2009 · Cited by 69
Predicting survival of patients with idiopathic pulmonary fibrosis using GAP score: a nationwide cohort study
Lee, S. H., Kim, S. Y., Kim, D. S., Kim, Y. W., Chung, M. P., Uh, S. T., Park, C., Jeong, S. H., Park, Y. B., Lee, H. L., et al. (2016) · Respiratory Research · doi:10.1186/s12931-016-0454-0 · Cited by 68

Authors: Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X.
Affiliations: Hospital Universitario Son Dureta (ES)
ORCID: Agustí, Alvar G. N.
Sauleda, Jaume
Miralles, Cristina
Sala, Ernest
Busquets, Xavier
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2002-08
Volume: 166
Issue: 4
Pages: 485-489
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.2108013
OpenAlex: W2140886594
Cited by: 343
References: 35
Citations by year: 2026: 3 · 2025: 5 · 2023: 8 · 2022: 12 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 16 · 2013: 13 · 2012: 21
FWCI: 6.74
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: chronic obstructive pulmonary disease, skeletal muscle apoptosis, weight loss, body mass index, quadriceps, exercise tolerance, poly(ADP-ribose) polymerase, TUNEL, muscle atrophy, lung function
MeSH terms: Aged, Biopsy, Blood Gas Analysis, Forced Expiratory Volume, Humans, Immunohistochemistry, Middle Aged, Muscular Atrophy, Poly(ADP-ribose) Polymerases, Severity of Illness Index, Blotting, Western, Weight Loss, Exercise, Body Mass Index, Case-Control Studies, Exercise Tolerance, Apoptosis, Muscle, Skeletal, In Situ Nick-End Labeling, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks