The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Exercise Hypercapnia in Advanced Chronic Obstructive Pulmonary Disease: The Role of Lung Hyperinflation
Abstract
In severe chronic obstructive pulmonary disease (COPD), carbon dioxide retention during exercise is highly variable and is poorly predicted by resting pulmonary function and arterial blood gases or by tests of ventilatory control. We reasoned that in patients with compromised gas exchange capabilities, exercise hypercapnia could be explained, in part, by the restrictive consequences of dynamic lung hyperinflation. We studied 20 stable patients with COPD (FEV1 = 34 ± 3 percent predicted; mean ± SEM) with varying gas exchange abnormalities (PaO2 range, 35 to 84 mm Hg; PaCO2 range, 31 to 64 mm Hg). During symptom-limited maximum cycle exercise breathing room air, PaCO2 increased 7 ± 1 mm Hg (p < 0.05) from rest to peak exercise (range, −6 to 25 mm Hg). We measured the change in PaCO2 after hyperoxic breathing at rest as an indirect test of ventilation–perfusion abnormalities. The change in PaCO2 from rest to peak exercise correlated best with the acute change in PaCO2 during hyperoxia at rest (r2 = 0.62, p < 0.0005) and with resting arterial oxygen saturation (r2 = 0.30, p = 0.011). During exercise, the strongest correlates of serial changes in PaCO2 from rest included concurrent changes in end-expiratory lung volume expressed as a percentage of total lung capacity (partial correlation coefficient [r] = 0.562, p < 0.0005) and oxygen saturation (partial r = 0.816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities.
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“These collective derangements can predispose to critical inspiratory muscle functional weakness, fatigue or even overt respiratory insufficiency with carbon dioxide (CO 2 ) retention [21,67].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [67]
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“In advanced COPD, the ratio of respired effort (and presumably neural drive) to V T increases steeply from rest to peak exercise, reflecting progressive neuromechanical dissociation of the respiratory system [67].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [67]
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Cites
Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076
Self-citationO'DONNELL, D. E., D'ARSIGNY, C., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.2007026 · Cited by 332
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Cited by
ATS/ACCP statement on cardiopulmonary exercise testing
(2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.2.211 · Cited by 3,026
Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
O'Donnell, D. E., Flüge, T., Gerken, F., Hamilton, A., Webb, K., Aguilaniu, B., Make, B., & Magnussen, H. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00116004 · Cited by 859
Self-citationCasanova, C., Cote, C., de Torres, J. P., Aguirre-Jaime, A., Marin, J. M., Pinto-Plata, V., & Celli, B. R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-867oc · Cited by 597
Porszasz, J., Emtner, M., Goto, S., Somfay, A., Whipp, B. J., & Casaburi, R. (2005) · Chest · doi:10.1378/chest.128.4.2025 · Cited by 262
Physiology and consequences of lung hyperinflation in COPD
O'Donnell, D. E., & Laveneziana, P. (2006) · European Respiratory Review · doi:10.1183/09059180.00010002 · Cited by 234
Self-citationThe major limitation to exercise performance in COPD is dynamic hyperinflation
O'Donnell, D. E., & Webb, K. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90336.2008b · Cited by 221
Self-citationDyspnea and Activity Limitation in COPD: Mechanical Factors
O'Donnell, D. E., & Laveneziana, P. (2007) · COPD: Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550701480455 · Cited by 220
Self-citationInspiratory Capacity during Exercise: Measurement, Analysis, and Interpretation
Guenette, J. A., Chin, R. C., Cory, J. M., Webb, K. A., & O'Donnell, D. E. (2013) · Pulmonary Medicine · doi:10.1155/2013/956081 · Cited by 203
Self-citationLung hyperinflation in COPD: applying physiology to clinical practice
O’Donnell, D. E., Webb, K. A., & Neder, J. A. (2015) · COPD Research and Practice · doi:10.1186/s40749-015-0008-8 · Cited by 93
Self-citationMonitoring mast cell activation by prostaglandin D2 in vivo
Dahlen, S.-E. (2004) · Thorax · doi:10.1136/thx.2004.026641 · Cited by 77
Collins, E. G., Langbein, W. E., Fehr, L., O'Connell, S., Jelinek, C., Hagarty, E., Edwards, L., Reda, D., Tobin, M. J., & Laghi, F. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-477oc · Cited by 63
Exercise‐induced dynamic hyperinflation in chronic obstructive pulmonary disease
D'Cruz, R. F., Wilkins, D., & Jolley, C. J. (2026) · Experimental Physiology · doi:10.1113/ep091459 · Cited by 3
Metadata
- Authors
- O'Donnell, D. E., D'Arsigny, C., Fitzpatrick, M., & Webb, K. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09-01
- Volume
- 166
- Issue
- 5
- Pages
- 663-668
- ISSN
- 1073-449X
- 1535-4970
- Cited by
- 177
- References
- 2
- Language
- en
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