CoChat
Sign Up
Cited by 264Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyRespiratory Support and Mechanisms

Exercise Training Decreases Ventilatory Requirements and Exercise-Induced Hyperinflation at Submaximal Intensities in Patients With COPD

Porszasz, Janos, Emtner, Margareta, Goto, Shinichi, Somfay, Attila, Whipp, Brian J., Casaburi, Richard·2005·Chest
DOI 10.1378/chest.128.4.2025
Open this paper in CoChat — free account

Abstract

Study objectives We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance. Methods Twenty-four patients with COPD (mean FEV(1), 36.4 +/- 8.5% of predicted [+/- SD]) undertook a high-intensity cycle ergometer exercise training program for 45 min, three times a week for 7 weeks. Before and after training, the patients performed both an incremental exercise test to maximum and a constant work rate (CWR) test on a cycle ergometer at 75% of the peak work rate obtained in the pretraining incremental test. Ventilatory variables were measured breath-by-breath, and inspiratory capacity (IC) was measured every 2 min to assess changes in end-expiratory lung volume. Results After training, the increase in peak oxygen uptake was not statistically significant; however, the peak work rate increased by 12.9 +/- 10.3 W (p < 0.01). For the CWR test performed at the same work rate both before and after training, ventilation and breathing frequency (f) were lower after training (average, 1.97 L/min and 3.2 breaths/min, respectively; p < 0.01) and IC was greater (by an average of 133 mL, p < 0.05), signifying decreased hyperinflation. The increase in IC at the point of termination in the shortest CWR test for each individual (defined as isotime) correlated well with both the decreased f (r = 0.63, p = 0.001) and with the increase in CWR exercise endurance (average, 13.1 min, r = 0.46, p = 0.023). Conclusions Exercise training in patients with severe COPD dramatically improves submaximal exercise endurance. Decreased dynamic hyperinflation may, in part, mediate the improvement in exercise endurance by delaying the attainment of a critically high inspiratory lung volume.

Integrity signals

Registry

Crossref · 10.1378/chest.128.4.2025

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • It is generally accepted that exercise training, unlike bronchodilators, does not have an impact on resting pulmonary mechanics.

    “It is generally accepted that exercise training, unlike bronchodilators, does not have an impact on resting pulmonary mechanics.190”

    From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [190]

  • Similar to the acute effects of oxygen supplementation, exercise training reduces ventilatory needs for a given level of exertion.

    “Similar to the acute effects of oxygen supplementation, exercise training reduces ventilatory needs for a given level of exertion.170,190,191”

    From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [190]

Cites

Flagged first, then by citations

3 of the 34 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Porszasz, J., Emtner, M., Goto, S., Somfay, A., Whipp, B. J., & Casaburi, R.
Affiliations
  • Uppsala University (SE)
  • Tokyo Women's Medical University (JP)
  • University of Szeged (HU)
  • The Lundquist Institute (US)
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2005-10
Volume
128
Issue
4
Pages
2025-2034
ISSN
0012-3692 (ISSN-L)
DOI
10.1378/chest.128.4.2025
OpenAlex
W2129477026
Cited by
262
References
34
Citations by year
2026: 8 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 20 · 2014: 14 · 2013: 23 · 2012: 10
FWCI
13.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
chronic obstructive pulmonary disease, exercise training, inspiratory capacity, end-expiratory lung volume, peak work rate, respiratory rate, peak oxygen uptake
MeSH terms
Aged, Exercise Test, Female, Forced Expiratory Volume, Humans, Male, Oxygen Consumption, Physical Fitness, Residual Volume, Vital Capacity, Exercise, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review