The DOI matches its Crossref record.
Distribution, Translocation and Accumulation of Silver Nanoparticles in Rats
Abstract
Silver nanoparticles (SNPs) are widely used in the field of biomedicine, but a comprehensive understanding of how SNPs distribute in the body and the induced toxicity remains largely unknown. The present study was designed to investigate the distribution and accumulation of SNPs in rats with subcutaneous injection. Rats were injected with either SNPs or silver microparticles (SMPs) at 62.8 mg/kg, and then sacrificed at predetermined time points. The main organs of the experimental animals were harvested for ultrastructural analysis by transmission electron microscopy (TEM) and for silver content analysis by inductively coupled plasma mass spectrometry (ICP-MS). Results indicated that SNPs translocated to the blood circulation and distributed throughout the main organs, especially in the kidney, liver, spleen, brain and lung in the form of particles. SMPs, however, could not invade the blood stream, or organ tissues. Ultrastructural observations indicate that those SNPs that had accumulated in organs could enter different kinds of cells, such as renal tubular epithelial cells and hepatic cells. Moreover, SNPs also induced blood-brain barrier (BBB) destruction and astrocyte swelling, and caused neuronal degeneration. The results suggest more cautions needed in biomedical applications of SNPs, in particular, the long-term uses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ferdous, Z., & Nemmar, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072375 · Cited by 1,019
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559
Trickler, W. J., Lantz, S. M., Murdock, R. C., Schrand, A. M., Robinson, B. L., Newport, G. D., Schlager, J. J., Oldenburg, S. J., Paule, M. G., Slikker, W., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq244 · Cited by 346
You, C., Li, Q., Wang, X., Wu, P., Ho, J. K., Jin, R., Zhang, L., Shao, H., & Han, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-10481-0 · Cited by 304
Engineered nanoparticles, How brain friendly is this new guest?
Cupaioli, F. A., Zucca, F. A., Boraschi, D., & Zecca, L. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.05.002 · Cited by 139
Metadata
- Authors
- Tang, J., Xiong, L., Wang, S., Wang, J., Liu, L., Li, J., Yuan, F., & Xi, T.
- Venue
- Journal of Nanoscience and Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2009-08-01
- Volume
- 9
- Issue
- 8
- Pages
- 4924-4932
- ISSN
- 1533-4880 (ISSN-L)
- OpenAlex
- W1972502322
- Cited by
- 414
- References
- 0
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Distribution, Translocation and Accumulation of Silver Nanoparticles in Rats. https://app.cochat.ai/papers/10.1166/jnn.2009.1269
- The paper
- Tang, J., Xiong, L., Wang, S., Wang, J., Liu, L., Li, J., Yuan, F., & Xi, T. (2009). Distribution, Translocation and Accumulation of Silver Nanoparticles in Rats. Journal of Nanoscience and Nanotechnology. https://doi.org/10.1166/jnn.2009.1269
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
