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Cited by 367

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Selective Loss of Inner Retinal Layer Thickness in Type 1 Diabetic Patients with Minimal Diabetic Retinopathy

Open access
van Dijk, Hille W., Kok, Pauline H. B., Garvin, Mona, Sonka, Milan, DeVries, J. Hans, Michels, Robert P. J., van Velthoven, Mirjam E. J., Schlingemann, Reinier O., Verbraak, Frank D., Abra`moff, Michael D.·2009·Investigative Opthalmology & Visual Science
DOI 10.1167/iovs.08-3143
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Abstract

PURPOSE: To determine whether type 1 diabetes preferentially affects the inner retinal layers by comparing the thickness of six retinal layers in type 1 diabetic patients who have no or minimal diabetic retinopathy (DR) with those of age- and sex-matched healthy controls. METHODS: Fifty-seven patients with type 1 diabetes with no (n = 32) or minimal (n = 25) DR underwent full ophthalmic examination, stereoscopic fundus photography, and optical coherence tomography (OCT). After automated segmentation of intraretinal layers of the OCT images, mean thickness was calculated for six layers of the retina in the fovea, the pericentral area, and the peripheral area of the central macula and were compared with those of an age- and sex-matched control group. RESULTS: In patients with minimal DR, the mean ganglion cell/inner plexiform layer was 2.7 microm thinner (95% confidence interval [CI], 2.1-4.3 microm) and the mean inner nuclear layer was 1.1 microm thinner (95% CI, 0.1-2.1 microm) in the pericentral area of the central macula compared to those of age-matched controls. In the peripheral area, the mean ganglion cell/inner plexiform layer remained significantly thinner. No other layers showed a significant difference. CONCLUSIONS: Thinning of the total retina in type 1 diabetic patients with minimal retinopathy compared with healthy controls is attributed to a selective thinning of inner retinal layers and supports the concept that early DR includes a neurodegenerative component.

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Metadata

Authors
van Dijk, H. W., Kok, P. H. B., Garvin, M., Sonka, M., DeVries, J. H., Michels, R. P. J., van Velthoven, M. E. J., Schlingemann, R. O., Verbraak, F. D., & Abra`moff, M. D.
Venue
Investigative Opthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Published
2009-07-01
Volume
50
Issue
7
Pages
3404
ISSN
  • 0146-0404 (ISSN-L)
  • 1552-5783
DOI
10.1167/iovs.08-3143
OpenAlex
W2108833891
Cited by
367
References
1
FWCI
15.52
Type
journal article
Language
en
Open access
green

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