Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

Massively parallel digital transcriptional profiling of single cells

Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353

Pancreatic Cancer

Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202

Super-enhancers in the control of cell identity and disease

Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

The Molecular Landscape and Utility of Multiomic Analyses in Triple-Negative Breast Cancer: Further Subtyping and Exploring Novel Biomarkers and Therapeutic Targets

Juan, C., & Peng, Y. S. (2025) · Cancers · doi:10.3390/cancers17244003 · Cited by 8

Intercellular cross-talk through lineage-specific gap junction of cancer-associated fibroblasts related to stromal fibrosis and prognosis

Cho, S. J., Oh, J., Baek, J., Shin, Y., Kim, W., Ko, J., Jun, E., Lee, D., Kim, S., Sohn, I., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-40957-1 · Cited by 8

Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy

Sun, W., Xie, S., Liu, S., Hu, X., & Xing, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s453265 · Cited by 8

The application of single-cell sequencing in pancreatic neoplasm: analysis, diagnosis and treatment

Lv, G., Zhang, L., Gao, L., Cui, J., Liu, Z., Sun, B., Wang, G., & Tang, Q. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02023-x · Cited by 8

Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials

Mejia, I., Bodapati, S., Chen, K. T., & Díaz, B. (2020) · Biomedicines · doi:10.3390/biomedicines8100401 · Cited by 9

Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-CulturePreprint

Kinny‐Köster, B., Guinn, S. R., Tandurella, J. A., Mitchell, J. T., Sidiropoulos, D. N., Loth, M., Lyman, M. R., Pucsek, A. B., Seppälä, T. T., Cherry, C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.14.500096 · Cited by 10

CFTR represses a PDX1 axis to govern pancreatic ductal cell fate

Rotti, P. G., Yi, Y., Gasser, G. N., Yuan, F., Sun, X., Evans, I. A., Wu, P., Liu, G., Choi, S. H., Reeves, R. E., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111393 · Cited by 7

Stromal Cells in Early Inflammation-Related Pancreatic Carcinogenesis—Biology and Its Potential Role in Therapeutic Targeting

Seidel, T., Ohri, N., Glaß, M., Sunami, Y., Müller, L. P., & Kleeff, J. H. (2025) · Cancers · doi:10.3390/cancers17091541 · Cited by 7

Transgelin defines pro-tumorigenic cancer-associated fibroblasts in pancreatic cancer

Wang, X., Shinjo, K., Kumegawa, K., Maruyama, R., Mii, S., Shiraki, Y., Nishimura, T., Murofushi, Y., Suzuki, M., Kabasawa, T., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03299-5 · Cited by 7

A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer

Ngodup, T., Elson, B. E., Mello, A. M., Hannifin, S., Liu, M., Zhang, Y., Shi, J., Shah, Y. M., Lawrence, D. A., di Magliano, M. P., et al. (2026) · Science Advances · doi:10.1126/sciadv.aea6734 · Cited by 7

ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human

Tang, Y., Zhang, S., Li, J., Wu, C., & Fan, Q. (2022) · Scientific Reports · doi:10.1038/s41598-022-17827-3 · Cited by 7

Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts

Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472433 · Cited by 7

Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis

Castro-Pando, S., Howell, R. M., Li, L., Mascaró, M., Faraoni, E. Y., Roux, O. L., Romanin, D., Tahan, V., Riquelme, E. M., Zhang, Y., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0527 · Cited by 7

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic CancerPreprint

Halbrook, C. J., Thurston, G., McCarthy, A., Nelson, B. S., Sajjakulnukit, P., Krall, A. S., Mullen, P. J., Zhang, L., Batra, S., Viale, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.15.098368 · Cited by 7

Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer

Caronni, N., Montaldo, E., Mezzanzanica, L., Cilenti, F., Genua, M., & Ostuni, R. (2021) · Immunological Reviews · doi:10.1111/imr.12944 · Cited by 6

CAFomics: convergence to translation for precision stroma approaches

McCabe, I. C., Peng, X. L., Kearney, J. F., & Yeh, J. J. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae063 · Cited by 6

Type 2 diabetes alters quiescent pancreatic stellate cells to tumor-prone state

Hara, Y., Mizukami, H., Yamada, T., Shimoyama, S., Yamazaki, K., Sasaki, T., Wang, Z., Kushibiki, H., Ryuzaki, M., Ogasawara, S., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.187424 · Cited by 6

Role of MEX3A in tumorigenesis: Mechanisms, tumor‑specific effects and therapeutic implications (Review)

Tang, L., Zhang, L. R., Yao, S., Li, X., Wang, Y., Liu, Q., Li, J., Wen, G., An, J., Jin, H., et al. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5579 · Cited by 6

ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma

Xin, S., Zhang, Y., Zhang, Z., Li, Z., Sun, X., Liu, X., Jin, L., Li, W., Tang, C., Mei, W., et al. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00779-3 · Cited by 6

Multiphasic Heterogeneity of Fibroblasts in the Microenvironment of Pancreatic Ductal Adenocarcinoma: Dissection and the Sum of the Dynamics

Ijichi, H. (2022) · Cancers · doi:10.3390/cancers14194880 · Cited by 6

Geostatistical Modeling and Heterogeneity Analysis of Tumor Molecular Landscape

Hajihosseini, M., Amini, P., Voicu, D., Dinu, I. A., & Pyne, S. (2022) · Cancers · doi:10.3390/cancers14215235 · Cited by 6

Tracing the Origin of Fibroblasts in Pancreatic Cancer

Biffi, G. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.06.008 · Cited by 6

Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer

Hannifin, S., Mello, A. M., Ngodup, T., Kim, N. H., di Magliano, M. P., & Lee, K. E. (2026) · Cells · doi:10.3390/cells15080683 · Cited by 5

Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity

Amini, P., Hajihosseini, M., Pyne, S., & Dinu, I. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1065586 · Cited by 5

Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts

Chen, X., & Huang, H. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.04.001 · Cited by 5

Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization

Griffith, B. D., Kadiyala, P., McGue, J. J., Sun, L., Kumar, A., Espinoza, C. E., Donahue, K. L., Iyer, M. K., Speyer, C. B., Nelson, S., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0377 · Cited by 5

KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer

Wei, Y., Liu, M., Yen, E.-Y., Yao, J., Xun, Z., Nguyen, P. T.-M., Wang, X., Yang, Z., Yousef, A. M. G., Pan, D. N., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-2024 · Cited by 5

The influence of clinical risk factors on the classification of human cancer-associated fibroblasts in PDAC and pancreatitis patients

Boeker, V., Wilke, L., Mansourkiaei, A., Le, V. M. H., Church, K. A., Czigány, Z., Kong, B., Kugeratski, F. G., Kleeff, J. H., Weitz, J., et al. (2025) · BJC Reports · doi:10.1038/s44276-025-00150-5 · Cited by 4

Identification and characterization of MARCO-expressing tumor-associated macrophages in pancreatic ductal adenocarcinoma with pan-cancer relevance

Sun, H., Gao, M., Liu, Z., Zg, Z., Li, X., Huang, H., Li, T., Shi, J., Yan, J., Sun, M., et al. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01293-5 · Cited by 4

Reprogramming the pancreatic tumor microenvironment using smart stem cells: A new frontier in cancer therapy

Khan, T. B., Choudhary, N., Sharma, S., Kumar, D., Kaushik, U., Gupta, V., Gowri, S., Faiyazuddin, M., & Webster, T. J. (2026) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2026.100188 · Cited by 4

ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer

Roger, É., Mummey, H. M., Zimmer, E., Srinivasan, D., Härle, A., Moubri, L., Michels, A. K., Singh, R., Ekizce, M., Melzer, M. K., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-26-0138 · Cited by 4

Tumor-Fibroblast Interactions in Carcinomas

Dongre, H., & Costea, D. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_7 · Cited by 4

Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1

Chang, J., Lo, Z. H. Y., Alenizi, S., & Kovačević, Ž. (2023) · Cancers · doi:10.3390/cancers15102779 · Cited by 5

Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer

Sun, X., Yang, D., & Chen, Y. (2023) · Cells · doi:10.3390/cells12222614 · Cited by 4

Extracellular vesicles from cancer cell lines of different origins drive the phenotype of normal oral fibroblasts in a CAF-like direction

Søland, T. M., Lipka, A., Ruus, A., Molværsmyr, A.-K., Galtung, H. K., & Haug, T. M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1456346 · Cited by 4

A single-cell perspective on immunotherapy for pancreatic cancer: from microenvironment analysis to therapeutic strategy innovation

Wang, R., Liu, J., Jiang, B., Gao, B., Luo, H., Yang, F., Ye, Y., Chen, Z., Liu, H. S., Cui, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1454833 · Cited by 4

The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic Cancer

Bowman, C. L., Daniel, C. J., Carlson, E. J., Shah, V. M., Farrell, A. S., Kresse, K. M., Wang, X., Lindley, K. A., Kuhn, M. R., Hawthorne, K., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3437 · Cited by 6

Single-cell transcriptome analysis for cancer and biology of the pancreas: A review on recent progress

Tamaddon, M., Azimzadeh, M., Gifani, P., & Tavangar, S. M. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1029758 · Cited by 3

Single-cell transcriptome reveals the heterogeneity of malignant ductal cells and the prognostic value of REG4 and SPINK1 in primary pancreatic ductal adenocarcinoma

Ji, Y., Xu, Q., & Wang, W. (2024) · PeerJ · doi:10.7717/peerj.17350 · Cited by 3

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

Layeghi‐Ghalehsoukhteh, S., Choudhuri, S. P., Ocal, O., Zolghadri, Y., Pashkov, V., Niederstrasser, H., Posner, B. A., Kantheti, H. S., Azevedo‐Pouly, A. C. P., Huang, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77373-8 · Cited by 3

Significance of Tumor Microenvironment for Regulating Pancreatic Cancer

Ijichi, H. (2023) · Cancers · doi:10.3390/cancers15092482 · Cited by 3

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancerPreprint

Costa, D. B. V., Francescone, R., Franco‐Barraza, J., Luong, T., Graves, M., de Aquino, A. M., Steele, N. G., Gardiner, J. C., dos Santos, S. A. A., Ogier, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594354 · Cited by 3

Genomic landscapes and therapeutic perspectives of cancer stem cells in the tumor microenvironment

Shrestha, P., Lee, D., Giri, A., Thi, T.-H. L., & Yook, S. (2025) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-025-00794-y · Cited by 2

Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis

Lunina, N. A., Safina, D. R., & Kostrov, S. V. (2023) · Molecular Biology · doi:10.31857/s0026898423050105 · Cited by 2

Single-cell sequencing in pancreatic cancer research: A deeper understanding of heterogeneity and therapy

Liu, Z., Zhang, Y., & Wu, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115664 · Cited by 2

CMTM6 as a potential therapy target is associated with immunological tumor microenvironment and can promote migration and invasion in pancreatic adenocarcinoma

Gao, H., Yin, J., Guan, X., Zhang, S., Peng, S., Liu, X., & Xing, F. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01235-5 · Cited by 2

Phenotype-guided subpopulation identification from single-cell sequencing dataPreprint

Sun, D., Guan, X., Moran, A. E., Qian, D. Z., Schedin, P. S., Dai, M., Danilov, A., Alumkal, J., Adey, A., Spellman, P. T., et al. (2020) · Research Square · doi:10.1101/2020.06.05.137240 · Cited by 2

SpatioEv: Spatial evolution of protein and morphological features reveals development dynamics of cells and spatial neighbourhoodsPreprint

Wu, S., Amin, S., Lee, C., Richard, J.-B., Merali, N., Morrell, C., Overend, L., Gao, W., Tucci, F., Gordon-Weeks, A. N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.30.662328 · Cited by 2

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencing

Liu, H., Wang, T., Cui, Y., Zhang, B., Shang, D., & Song, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-03679-6 · Cited by 1

Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis

Lunina, N. A., Safina, D. R., & Kostrov, S. V. (2023) · Molecular Biology · doi:10.1134/s0026893323050096 · Cited by 1

Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma

Kantheti, H. S., Hale, M. A., Choudhuri, S. P., Huang, H., Wang, X., Zolghadri, Y., Innamorati, G., Manikonda, S. P. R., Reddy, N. R., Reddy, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126619 · Cited by 1

Suggested experimental design and computational modeling to infer single-cell lipid dynamics from a single destructive measurement

Jost, P. J., Weindl, D., Wunderling, K., Thiele, C., & Hasenauer, J. (2026) · iScience · doi:10.1016/j.isci.2026.115474 · Cited by 1

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Li, W., Jihad, M., Lloyd, E. G., Zaccaria, M., Mucciolo, G., Nsubuga, G., Koonan-Lonappan, A., Henríquez, J. A., Cheng, P. S. W., Harish, S., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02057-w · Cited by 1

Autophagy in cancer-associated fibroblasts: biology and targeting

Ly, T., Gaur, G., & Thomas, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00004-3 · Cited by 1

[Heterogeneity analysis of pancreatic cancer and identification of molecular subtypes of tumor cells based on CEACAM5, LGALS1 and CENPF gene expression].

Sun, J., Lu, P., Guan, S., & Liu, S. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.09.14 · Cited by 1

Vitamin D and pancreatic cancer

de Maturana, E. L., Zagorac, S., Malats, N., & Real, F. X. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91338-6.00042-2 · Cited by 1

Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers

NEVE, B. P., Jonckheere, N., Vincent, A., & SEUNINGEN, I. V. (2020) · RNA technologies · doi:10.1007/978-3-030-44743-4_9 · Cited by 1

Genetic landscape of prognostic value in pancreas ductal adenocarcinoma microenvironment—reply

Pu, N., Yu, J., & Wu, W. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.04.30 · Cited by 1

Single Cell Nuclear Sequencing of Healthy and Diseased Pancreas: The Coming-of-Age of Single Nucleus RNA Sequencing

Jacob, H. K. C., Lavania, S., & Saluja, A. K. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.028 · Cited by 1

The Prolyl Isomerase PIN1 Plays a Critical Role in Fibroblast Differentiation States to Support Pancreatic CancerPreprint

Langer, E. M., Farrell, A. S., Allen-Petersen, B. L., Daniel, C. J., Kresse, K., English, I., Shah, V. M., MacPherson, K. A., Wang, X., Pelz, C., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3800381

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironmentPreprint

Qiao, K., Yang, Q., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.15.688565 · Cited by 1

Local glucocorticoid signalling promotes pancreatic cancerPreprint

Veiga-Villauriz, C., Hussein, H. A. M., Ward, C. J., Saji, S. K., Chakraborty, S., Pramanik, J., Yamashita-Kanemaru, Y., Simpson, J. P., Laforest, S., Diez, F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.14.688472 · Cited by 1

The Japan Kibbutz Association.

Altman, A. A. (1970)

Tracing back to one of the origins of immune evasion in pancreatic cancer

Henríquez, J. A., & Biffi, G. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.05.002

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinomaPreprint

Krieger, T. G., Sudy, A., Schicktanz, F., Tosti, L., Liebig, J., Konukiewitz, B., Rouault, M., Niesnerova, A., Qian, X., Weichert, W., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.23.509133

Data from A Transcriptionally Distinct Subpopulation of Healthy Acinar Cells Exhibit Features of Pancreatic Progenitors and PDAC

Gopalan, V., Singh, A., Mehrabadi, F. R., Wang, L., Ruppin, E., Arda, H. E., & Hannenhalli, S. S. (2023) · doi:10.1158/0008-5472.c.6512943.v1

Data from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Carpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · doi:10.1158/2159-8290.c.6651113

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancerPreprint

Kishore, U., Varghese, P. M., Mangogna, A., Klein, L., Tu, M., Urbach, L., Qiu, M., Nicolle, R., Murugaiah, V., Beirag, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.28.564512

Single-Cell RNA Sequencing: A Deep Dive into The Cellular Landscape and Interactions in Osteosarcoma

Zheng, S. (2023) · Transactions on Materials Biotechnology and Life Sciences · doi:10.62051/91yqvp26

Additional file 2 of Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211339

Comparison of Different Approaches to Single Cell RNA Sequencing of Cancer Associated FibroblastsPreprint

Kung, H., Loycano, M., Zheng, L., Chen, S. Y., & Zimmerman, J. W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.29.591011

Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical StudyPreprint

Gupta, M., Choi, H., Furth, E. E., Shaffer, S. M., Pickup, S., Clendenin, C., Liu, F., Cao, Q., Song, H. K., Yong Fan, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.24.630138

Additional file 4 of Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211348

Additional file 5 of Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211351

Additional file 1 of Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211336

Additional file 3 of Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Zhang, A. M. Y., Chu, K., Daly, B. F., Ruiter, T. J. J., Dou, Y., Yang, J. C. C., de Winter, T. J. J., Chhuor, J., Wang, S., Flibotte, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19211345

A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancerPreprint

Kim, N. H., Song, Y. M., Kwon, S. S., Lee, S. H., Kim, E. N., Hong, J. J., Seok, S. H., & Na, Y. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.05.704114

Utilisation d’agents d’imagerie et de chimiothérapie conjugués à des peptides ciblant le récepteur aux LDL à des fins diagnostiques et thérapeutiques de l’adénocarcinome canalaire pancréatique

Acier, A. (2020) · theses.fr (ABES) · doi:10.70675/c986499cze490z42c8z802bzc8e87aa3134c

Impact du dialogue entre microenvironnement et cellules cancéreuses dans l'adénocarcinome canalaire pancréatique

Nigri, J. (2020) · theses.fr (ABES) · doi:10.70675/8e941da5z4553z4ca3zaf8az9ac2c39c788a

Stromal cells in mammary gland development and cancer

Benabid, A. (2020) · theses.fr (ABES) · doi:10.70675/8612698bz63e1z401eza0caz2b4d989c570f

Etude de l’influence du TGF-β sur les sous-populations de fibroblastes associés au cancer et leur implication pronostique dans les cancers du pancréas

Vienot, A. (2021) · theses.fr (ABES) · doi:10.70675/25d883b4z5eadz4f1bz93f0zcfa886c08e78

Role of the early stage stroma-immune interactions in the tumor microenvironment of pancreatic adenocarcinoma

Wu, Z. (2021) · theses.fr (ABES) · doi:10.70675/e97fe804z820dz4c4bz843az1f81f0b86c85

Identification et ciblage de dialogues tumeur-stroma impliqués dans l'agressivité de l'adénocarcinome canalaire pancréatique

Brunel, A. (2022) · theses.fr (ABES) · doi:10.70675/4f9e08fez29b2z4a0dzabf6z424c6decb590

Role of the stromal microenvironment in PDAC and resistance to therapies

Ode, A. (2024) · theses.fr (ABES) · doi:10.70675/0452e0e9z98e8z47d9za007zd4b472926aab

LyP vs advanced-stage CTCLs: single-cell profiling reveals markers of self-limited vs aggressive disease behavior

Meledathu, S., Chennareddy, S., Naidu, M. P., Meehan, S. A., Aðalsteinsson, J. A., Alkon, N., Cohenour, E. R., Christensen, G., Port, L. R., Fleischli, A., et al. (2026) · Blood Advances · doi:10.1182/bloodadvances.2025017533

The clinical ionizable lipid SM-102 enhances photochemical immunogenic cell death by verteporfin-conjugated liposomes and improves survival in vivo

Shah, N., Quaye, M. B., Sudula, B., Kulkarni, N., Upreti, A., Malkoochi, A., Aileni, T. R., Karambelkar, K., Peterson, A., Mahmoud, D., et al. (2026) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-026-00909-w

Integration of pathomics and single-cell omics in pancreatic ductal adenocarcinoma: Applications and clinical translation prospects

Yan, X., Xu, H.-Y., Liu, J.-W., Yang, Z.-Y., & Zhu, Q. (2026) · World Journal of Clinical Oncology · doi:10.5306/wjco.v17.i5.119864

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinomaPreprint

Hsu, J., Song, H., Ogawa, S., Kubota, C. S., Peck, K. L., Jacobs, E., Garcia-Rivera, L., Zhu, J., Sui, Y., Jung, W., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.727290

DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines

Zoi, I., Rajput, M., Holguín-Horcajo, A., Haidar, M., Brusa, D., Chu, K., Xie, J., Shields, M. A., Ferreira, S., Stanger, B. Z., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218666

RNA methyltransferase 3 drives pancreatic acinar cell carcinoma growth and is a therapeutic target

Tatekawa, S., Hara, T., Meng, S., Sato, T., Arai, T., Tamari, K., Arao, Y., Tsuji, Y., Konno, M., Ofusa, K., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02880-5

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions

Treffert, S. M., Heneka, Y. M., Martin, J., Gargano, A., Launhardt, L., Akilli‐Öztürk, Ö., Stanganello, E., Andrieux, G., Hoch, D., Sonnentag, S. J., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09155-5

SPP1-CD44-Mediated Crosstalk Between Endothelial and Macrophage Subpopulations Promotes Pancreatic Ductal Adenocarcinoma Progression Through S100A6 Upregulation

Zhou, Y., Guo, S., Zhou, W., & Wang, W. (2026) · Cells · doi:10.3390/cells15201844

Subtype or state? Rethinking the apCAF paradox and fibroblast plasticity in gastrointestinal cancers

Yu, Z., Hu, D., & An, Z. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.2000409

MUC16 drives macrophage-mediated immunosuppression in pancreatic cancer

Rajesh, C., Sagar, S., Huang, Y., Mundry, C. S., Chaitankar, V., Shah, O. S., Sumeet, C., Caffrey, T., O’Connell, K. A., Swanson, B., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218927

Dataset related to article "Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts"

Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.15005984

Immune cell metabolic reprogramming in pancreatic cancer: roles in tumor progression and therapeutic strategies

Gu, G., Du, Y., Zhang, H., Zheng, Y., Yanjun, Y., & Yan, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1968254

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysis

Byeon, S., du Toit‐Thompson, T., Gillson, J., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2023) · Cancer Medicine · doi:10.1002/cam4.6407 · Cited by 15

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321

Abstract 5353: Single cell RNA sequencing of pancreatic ductal adenocarcinoma reveals tumor heterogeneity

Noel, P., Lin, W., Borazanci, E. H., Amini, A., Muñoz, R. M., Rodela, E., Ng, S., Hoff, D. D. V., & Han, H. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-5353

Deciphering the heterogeneity of epithelial cells in pancreatic ductal adenocarcinoma: implications for metastasis and immune evasion

Liu, J., Li, H., Lin, X., Xiong, J., Wu, G., Ding, L., & Lin, B. (2025) · World Journal of Surgical Oncology · doi:10.1186/s12957-025-03793-3 · Cited by 1

Abstract C057: An integrative analysis of pancreatic cancer cells and cancer-associated fibroblasts using single cell transcriptomic analysis

Leem, G., Kim, S., Hwang, H. K., Jo, J. H., Lee, H. S., Chung, M. J., Park, J. Y., Park, S. W., Song, S. Y., Shin, E., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c057