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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Shaashua, L., Ben-Shmuel, A., Pevsner-Fischer, M., Friedman, G., Levi-Galibov, O., Nandakumar, S., Barki, D., Nevo, R., Brown, L. E., Zhang, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34081-3 · Cited by 79

Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair

Zhang, X., Zheng, S., Hu, C., Li, G., Lin, H., Xia, R., Ye, Y., He, R., Li, Z., Lin, Q., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02253-6 · Cited by 80

Functional heterogeneity of fibroblasts in primary tumors and metastases

Cheng, P. S. W., Zaccaria, M., & Biffi, G. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.005 · Cited by 78

Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer

Shakiba, M., & Tuveson, D. A. (2025) · Nature Immunology · doi:10.1038/s41590-025-02134-6 · Cited by 81

A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance

Zhou, J., Lyu, N., Wang, Q., Yang, M. J., Kimchi, E. T., Cheng, K., Joshi, T., Tukuli, A. R., Staveley-O’Carroll, K. F., & Li, G. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216457 · Cited by 73

Mechanisms of PDAC subtype heterogeneity and therapy response

Espinet, E., Klein, L., Puré, E., & Singh, S. K. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.08.005 · Cited by 70

PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration

Bell, A. T. F., Mitchell, J. T., Kiemen, A. L., Lyman, M. R., Fujikura, K., Lee, J. W., Coyne, E. M., Shin, S. M., Nagaraj, S., Deshpande, A. M., et al. (2024) · Cell Systems · doi:10.1016/j.cels.2024.07.001 · Cited by 77

Emerging strategies to investigate the biology of early cancer

Zhou, R., Tang, X., & Wang, Y. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00754-y · Cited by 72

Cancer-Associated Fibroblasts: Accomplices in the Tumor Immune Evasion

Hilmi, M., Nicolle, R., Bousquet, C., & Neuzillet, C. (2020) · Cancers · doi:10.3390/cancers12102969 · Cited by 66

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Chen, X., Zhou, Z., Xie, L., Qiao, K., Jia, Y., Liu, S., Yazgan, Z., Rossi, F., Liu, Y., Zhang, B., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.09.001 · Cited by 66

The current landscape of single-cell transcriptomics for cancer immunotherapy

Guruprasad, P., Lee, Y. G., Kim, K. H., & Ruella, M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201574 · Cited by 65

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma

Evan, T., Wang, V. M.-Y., & Behrens, A. (2022) · Oncogene · doi:10.1038/s41388-022-02448-x · Cited by 66

Loss of Rnf43 accelerates kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

Hosein, A. N., Dangol, G., Okumura, T., Roszik, J., Rajapakshe, K., Siemann, M., Zaid, M., Ghosh, B., Monberg, M., Guerrero, P. A., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.273 · Cited by 61

Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6

Lee, Y. E., Go, G.-Y., Koh, E.-Y., Yoon, H.-N., Seo, M., Hong, S.-M., Jeong, J. H., Kim, J.-C., Cho, D., Kim, T. S., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006130 · Cited by 61

Cellular Heterogeneity of Pancreatic Stellate Cells, Mesenchymal Stem Cells, and Cancer-Associated Fibroblasts in Pancreatic Cancer

Sunami, Y., Häußler, J., & Kleeff, J. H. (2020) · Cancers · doi:10.3390/cancers12123770 · Cited by 66

The fibroinflammatory response in cancer

Xiao, Z., & Puré, E. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00798-8 · Cited by 65

Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma

Schütz, S., Solé‐Boldo, L., Lucena-Porcel, C., Hoffmann, J. H. O., Brobeil, A., Lonsdorf, A. S., Rodríguez‐Paredes, M., & Lyko, F. (2023) · Nature Communications · doi:10.1038/s41467-023-41141-9 · Cited by 59

Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth

Donahue, K. L., Watkoske, H. R., Kadiyala, P., Du, W., Brown, K. L., Scales, M. K., Elhossiny, A. M., Espinoza, C. E., Opsahl, E. L. L., Griffith, B. D., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0100 · Cited by 60

Targeting TNF-α–producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling

Dixit, A. K., Sarver, A. G., Zettervall, J., Huang, H., Zheng, K., Brekken, R. A., & Provenzano, P. P. (2022) · JCI Insight · doi:10.1172/jci.insight.153242 · Cited by 61

Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis

Aney, K. J., Jeong, W., Vallejo, A. F., Burdziak, C., Chen, E., Wang, A., Koak, P., Wise, K., Jensen, K. B., Pe’er, D., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.043 · Cited by 56

Myeloid Cell Mediated Immune Suppression in Pancreatic Cancer

Kemp, S. B., di Magliano, M. P., & Crawford, H. C. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.006 · Cited by 64

Epigenetic regulation of cancer-associated fibroblast heterogeneity

Kehrberg, R. J., Bhyravbhatla, N., Batra, S. K., & Sushil Kumar, K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188901 · Cited by 57

Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer

Zhou, Z., Ren, Y., Yang, J., Liu, M., Shi, X., Luo, W., Fung, K.-M. A., Xu, C., Bronze, M. S., Zhang, Y., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.058 · Cited by 57

Tumor Cell Derived Lnc‐FSD2‐31:1 Contributes to Cancer‐Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR‐4736

Geng, X., Li, L., Luo, Y., Yang, W., Hu, J., Zhao, Z., Cheng, C., Zhang, T., Zhang, Y., Liu, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202203324 · Cited by 54

Fibroblasts as Turned Agents in Cancer Progression

Wieder, R. (2023) · Cancers · doi:10.3390/cancers15072014 · Cited by 55

Cancer-Associated Fibroblasts: Implications for Cancer Therapy

Maia, A. R. R., & Wiemann, S. (2021) · Cancers · doi:10.3390/cancers13143526 · Cited by 58

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysis

Byeon, S., du Toit‐Thompson, T., Gillson, J., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2023) · Cancer Medicine · doi:10.1002/cam4.6407 · Cited by 15

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321

Abstract 5353: Single cell RNA sequencing of pancreatic ductal adenocarcinoma reveals tumor heterogeneity

Noel, P., Lin, W., Borazanci, E. H., Amini, A., Muñoz, R. M., Rodela, E., Ng, S., Hoff, D. D. V., & Han, H. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-5353

Deciphering the heterogeneity of epithelial cells in pancreatic ductal adenocarcinoma: implications for metastasis and immune evasion

Liu, J., Li, H., Lin, X., Xiong, J., Wu, G., Ding, L., & Lin, B. (2025) · World Journal of Surgical Oncology · doi:10.1186/s12957-025-03793-3 · Cited by 1

Abstract C057: An integrative analysis of pancreatic cancer cells and cancer-associated fibroblasts using single cell transcriptomic analysis

Leem, G., Kim, S., Hwang, H. K., Jo, J. H., Lee, H. S., Chung, M. J., Park, J. Y., Park, S. W., Song, S. Y., Shin, E., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c057