The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
Open accessAbstract
Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered IRF1 function are associated with several cancers. Although the function of IRF1 in the immunobiology of cancer is emerging, IRF1-specific mechanisms regulating tumorigenesis and tissue homeostasis in vivo are not clear. Here, we found that mice lacking IRF1 were hypersusceptible to colorectal tumorigenesis. IRF1 functions in both the myeloid and epithelial compartments to confer protection against AOM/DSS-induced colorectal tumorigenesis. We further found that IRF1 also prevents tumorigenesis in a spontaneous mouse model of colorectal cancer. The attenuated cell death in the colons of Irf1-/- mice was due to defective pyroptosis, apoptosis, and necroptosis (PANoptosis). IRF1 does not regulate inflammation and the inflammasome in the colon. Overall, our study identified IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis.
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Cited by
Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734
Self-citationZheng, M., & Kanneganti, T. (2020) · Immunological Reviews · doi:10.1111/imr.12909 · Cited by 586
Self-citationWang, Y., & Kanneganti, T.-D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.038 · Cited by 545
Self-citationThe ‘cytokine storm’: molecular mechanisms and therapeutic prospects
Karki, R., & Kanneganti, T.-D. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.001 · Cited by 438
Self-citationTherapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Pandeya, A., & Kanneganti, T.-D. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.10.001 · Cited by 303
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Metadata
- Authors
- Karki, R., Sharma, B. R., Lee, E., Banoth, B., Malireddi, R. K. S., Samir, P., Tuladhar, S., Mummareddy, H., Burton, A. R., Vogel, P., & Kanneganti, T.-D.
- Venue
- JCI Insight
- Published
- 2020-06-18
- Volume
- 5
- Issue
- 12
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W3035771130
- Cited by
- 282
- References
- 57
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Karki, R., Sharma, B. R., Lee, E., Banoth, B., Malireddi, R. K. S., Samir, P., Tuladhar, S., Mummareddy, H., Burton, A. R., Vogel, P., & Kanneganti, T.-D. (2020). Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight. https://doi.org/10.1172/jci.insight.136720
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