The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
Abstract
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or triggers of ischemic preconditioning (IPC). To define the pathophysiological significance of sarcKATP channels, we conducted functional experiments using Kir6.2-deficient (KO) mice. Metabolic inhibition with glucose-free, dinitrophenol-containing solution activated sarcKATP current and shortened the action potential duration in ventricular cells isolated from wild-type (WT) but not KO mice. MitoKATP channel function was preserved in KO ventricular cells. In anesthetized mice, IPC reduced the infarct size in WT but not KO mice. Following global ischemia/reperfusion, the increase of left ventricular end-diastolic pressure during ischemia was more marked, and the recovery of contractile function was worse, in KO hearts than in WT hearts. Treatment with HMR1098, a sarcKATP channel blocker, but not 5-hydroxydecanoate, a mitoKATP channel blocker, produced a deterioration of contractile function in WT hearts comparable to that of KO hearts. These findings suggest that sarcKATP channels figures prominently in modulating ischemia/reperfusion injury in the mouse. The rapid heart rate of the mouse (>600 beats per minute) may magnify the relative importance of sarcKATP channels during ischemia, prompting caution in the extrapolation of the conclusions to larger mammals.
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Cites
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Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Preconditioning the myocardium: from cellular physiology to clinical cardiology
YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Ferdinandy, P., Schulz, R., & Baxter, G. F. (2007) · Pharmacological Reviews · doi:10.1124/pr.107.06002 · Cited by 744
ATP-sensitive potassium channelopathies: focus on insulin secretion
Ashcroft, F. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25495 · Cited by 623
Evidence for Mitochondrial K + Channels and Their Role in Cardioprotection
O’Rourke, B. (2004) · Circulation Research · doi:10.1161/01.res.0000117583.66950.43 · Cited by 444
Metadata
- Authors
- Suzuki, M., Sasaki, N., Miki, T., Sakamoto, N., Ohmoto-Sekine, Y., Tamagawa, M., Seino, S., Marbán, E., & Nakaya, H.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-02-15
- Volume
- 109
- Issue
- 4
- Pages
- 509-516
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4242710369
- Cited by
- 284
- References
- 36
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Suzuki, M., Sasaki, N., Miki, T., Sakamoto, N., Ohmoto-Sekine, Y., Tamagawa, M., Seino, S., Marbán, E., & Nakaya, H. (2002). Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci0214270
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