The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
T cell homeostatic proliferation elicits effective antitumor autoimmunity
Open accessAbstract
Development of tumor immunotherapies focuses on inducing autoimmune responses against tumorassociated self-antigens primarily encoded by normal, unmutated genes.We hypothesized that such responses could be elicited by T cell homeostatic proliferation in the periphery, involving expansion of T cells recognizing self-MHC/peptide ligands.Herein, we demonstrate that sublethally irradiated lymphopenic mice transfused with autologous or syngeneic T cells showed tumor growth inhibition when challenged with melanoma or colon carcinoma cells.Importantly, the antitumor response depended on homeostatic expansion of a polyclonal T cell population within lymph nodes.This response was effective even for established tumors, was characterized by CD8 + T cell-mediated tumorspecific cytotoxicity and IFN-γ production, and was associated with long-term memory.The results indicate that concomitant induction of the physiologic processes of homeostatic T cell proliferation and tumor antigen presentation in lymph nodes triggers a beneficial antitumor autoimmune response.
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Cited by
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mTOR , metabolism, and the regulation of T‐cell differentiation and function
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Therapeutic cancer vaccines: Are we there yet?
Klebanoff, C. A., Acquavella, N., Yu, Z., & Restifo, N. P. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00979.x · Cited by 271
Bracci, L., Moschella, F., Sestili, P., La Sorsa, V., Valentini, M., Canini, I., Baccarini, S., Maccari, S., Ramoni, C., Belardelli, F., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1209 · Cited by 256
Metadata
- Authors
- Dummer, W., Niethammer, A. G., Baccala, R., Lawson, B. R., Wagner, N., Reisfeld, R. A., & Theofilopoulos, A. N.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-07-15
- Volume
- 110
- Issue
- 2
- Pages
- 185-192
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4234147211
- Cited by
- 270
- References
- 37
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dummer, W., Niethammer, A. G., Baccala, R., Lawson, B. R., Wagner, N., Reisfeld, R. A., & Theofilopoulos, A. N. (2002). T cell homeostatic proliferation elicits effective antitumor autoimmunity. Journal of Clinical Investigation. https://doi.org/10.1172/jci0215175
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