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Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Open accessAbstract
6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 mug L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since the group maintained on 5 mug T(4)/day had normal levels of liver mitochondrial alpha glycerophosphate dehydrogenase. In confirmation of previous studies, PTU also reduced the fractional rate of deiodination of T(3). These observations provide a possible explanation of the many published observations indicating that PTU antagonizes the tissue effects of T(4) but not of T(3). The data suggest that monodeiodination of T(4) but not of T(3) is essential before hormonal effects can be manifested at the cellular level.
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“Propylthiouracil (PTU) inhibits D1, explaining some of its therapeutic benefit in this setting (14).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [14]
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Metadata
- Authors
- Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1972-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2493-2497
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292418
- OpenAlex
- W1758817371
- Cited by
- 258
- References
- 36
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Council of the City of New York
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- propylthiouracil, levothyroxine, triiodothyronine, T4 to T3 conversion, deiodination, thyroid hormone antagonism, alpha-glycerophosphate dehydrogenase, liver mitochondria, hypothyroidism
- MeSH terms
- Administration, Oral, Animals, Chromatography, Paper, Chromatography, Thin Layer, Glucosephosphate Dehydrogenase, Injections, Subcutaneous, Iodine Radioisotopes, Male, Mitochondria, Liver, Propylthiouracil, Thyroidectomy, Thyroxine, Triiodothyronine, Rats
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